落繼先，女，博士，副教授，碩士生導師，現任職于山西大學。
基本介紹
- 中文名：落繼先
- 職業：教師
- 學位/學歷：博士
- 專業方向：生物學
- 任職院校：山西大學
人物經歷,研究方向,學術成果,
人物經歷
教育背景
2005.9-2010.7 東北師範旋講嚷大學 生命科學學院 遺傳與細胞研究所 碩博連讀
2000.9-2004.7 長春師範學院 生命科學學院 學士
研究背景
2014.1-至今 山西大學 生命科學學院 副教授
2012.11-2014.3 德州大學醫學分部（University of Texas Medical Branch） 訪問學者
2011.11-2015.2 山西大學生物學博士後
2010.7-2013.12 山西大學 生命科學學院 講師
研究方向
肺癌和白血病的故己龍轉移、浸潤機制研究與藥物研發
學術成果
主持的科研項目
[1] RhoGDI2的磷酸化在SDF-1引起的β1整合素介導的Jurkat細胞遷移過程中的作用研究，國家自然科學樂漏舟享青年基金；鎘影響華溪蟹蛻皮過程的分子機制，國家基金委博士後基金面上基金（2012M510773）；
[2] RhoGDI2在PSGL-1信號探笑府通路中的作用及機制研究，教育部新教師基金；
[3] SDF-1在白血病細胞浸潤中的作用機制研究船鴉欠滲，山西省回國留學人員科研資助項目（2017-012）；
[4] Rho在T細胞急性白血病元檔她中的作用機制研究和其在白血病靶向治療中的套用,山西省自然科學基金面上項目；
參與的科研項目
[1] 糖尿病人腫瘤易感性增高的生物學原理和分子機制以及腫瘤預防方法的研究，山西省自然科學基金面上項目，排名第二；
[2] 2015細胞中心體擴增的分子機制套多的研究，山西省國際科技合作計畫項目（2015081034），排名第三；
[3] 重組華溪蟹金屬硫蛋白在AUMO融合系統中的表達及其功能研究（高等學校博士學科點專項科研基金博導類，排名第三；
[4] PI3K激酶在L-選擇素和PSGL-1介導的白細胞起始黏附過程中的信號轉導作用研究，國家自然科學基金面上基金(30971498)，排名第三。
相關領域的第一作者論文
[1] Jixian Luo, Dan Wei,Dingyun Li, Lan Wang. Nitric oxide functions in stromal cell-derived factor-1-induced cytoskeleton changes and the migration of Jurkat cells.Oncology Letters.16(5):6685-6690. 2018.
[2] Jixian Luo. PI3K is a linker between L-selectin and PSGL-1 Signaling to IL-18 transcriptional activation at the promoter level.Inflammation. 41(2):555-561.2018.
[3] Jixian Luo, Dingyun Li, Dan Wei, Xiaoguang Wang, Lan Wang, Xianlu Zeng. RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.Molecular and Cellular Biochemistry.436(1-2):13-21. 2017.
[4] Jixian Luo, Koa Hosoki, Attila Bacsi, Zsolt Radak, Muralidhar L. Hegde, Sanjiv Sur, Tapas K. Hazra, Allan R. Brasier, Xueqing Ba, Istvan Boldogh. 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization. Free Radical Biology & Medicine. 73:430-8. 2014.
[5] Jixian Luo, Sihui Pei, Weixin Jing, Enmin Zou, Lan Wang. Cadmium inhibits molting of the freshwater crab Sinopotamon henanense by reducing the hemolymph ecdysteroid content and the activities of chitinase and N-acetyl-β-glucosaminidase in the epidermis. Comparative biochemistry and physiology. Part C. 169:1-6. 2014.
[6] Jixian Luo, Tingshuang Xu, Chunfeng Li, Xueqing Ba, Xiaoguang Wang, Yong Jiang, Xianlu Zeng. p85-RhoGDI2, a novel complex, is required for PSGL-1-induced β1 integrin-mediated lymphocyte adhesion to VCAM-1. The International Journal of Biochemistry & Cell Biology. 45(12): 2764-2773. 2013.
[7] Jixian Luo, Chunfeng Li, Tingshuang Xu, Wenai Liu, Xueqing Ba, Xiaoguang Wang, Xianlu Zeng. PI3K is involved in β1 integrin clustering by PSGL-1 and promotes β1 integrin-mediated Jurkat cell adhesion to fibronectin. Molecular and Cellular Biochemistry. 385(1-2): 287-295. 2013.
[8] Jixian Luo, Tingshuang Xu, Xiaoguang Wang, Xue Feng, Xueqing Ba, Xianlu Zeng. PI3K is involved in L-selectin- and PSGL-1-mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly. Journal of Cellular. Biochemistry. 110 (4): 910-919. 2010.
參與發表的SCI論文
[1] Yongquan Li, Huizhen Yang, Na Liu, Jixian Luo, Qian Wang, Lan Wang. Cadmium accumulation and metallothionein biosynthesis in cadmium-treated freshwater mussel Anodonta woodiana. PLoS One. 10(2):e0117037. 2015.
[2] Xueqing Ba, Attila Bacsi, Jixian Luo, Leopoldo Aguilera-Aguirre, Xianlu Zeng, Zsolt Radak, Allan R. Brasier, Istvan Boldogh.8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. Journal of Immunology. 192(5):2384-94. 2014.
[3] Tingshuang Xu, Wenai Liu, Jixian Luo, Chunfeng Li, Xueqing Ba, Khamal Kwesi Ampah, Xiaoguang Wang, Yong Jiang, Xianlu Zeng. Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1. PLoS One. 8(12):e81807. 2013.
[4] Wenwen Lei, Lan Wang, Dongmei Liu, Tuan Xu, Jixian Luo. Histopathological and biochemical alternations of the heart induced by acute cadmium exposure in the freshwater crab Sinopotamon yangtsekiense. Chemosphere. 84(5):689-94.2011.
[5] Lingling Cui, Cuixia Chen, Ting Xu, Juechao Zhang, Xin Shang, Jixian Luo, Liang Chen, Xueqing Ba, Xianlu Zeng. c-Abl Kinase is required for β-2 integrin-medated neutrophil adhesion. Journal of Immunology. 182 (5): 3233-3242. 2009.
[6] Ting Xu, Liang Chen, Xin Shang, Lingling Cui, Jixian Luo, Cuixia Chen, Xueqing Ba and Xianlu Zeng. Critical role of Lck in L-selectin signaling induced by sulfatides engagement. Journal of Leukocyte Biology. 84 (8): 1192-1201. 2008.
[7] Cuixia Chen, Xin Shang, Lingling Cui, Ting Xu, Jixian Luo, Xueqing Ba, Xianlu Zeng. L-selectin ligation-induced CSF-1 genetranscription is regulated by AP-1 in a c-Abl kinase-dependent manner. Human Immunology. 69 (8): 501-509. 2008.
[8] Cuixia Chen, Xin Shang, Ting Xu, Lingling Cui, Jixian Luo, Xueqing Ba, Shui Hao and Xianlu Zeng. c-Abl is required for the signaling transduction induced by L-selectin ligation. European Journal of Immunology. 37 (11): 3246-3258. 2007.
[3] Jixian Luo, Dingyun Li, Dan Wei, Xiaoguang Wang, Lan Wang, Xianlu Zeng. RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.Molecular and Cellular Biochemistry.436(1-2):13-21. 2017.
[4] Jixian Luo, Koa Hosoki, Attila Bacsi, Zsolt Radak, Muralidhar L. Hegde, Sanjiv Sur, Tapas K. Hazra, Allan R. Brasier, Xueqing Ba, Istvan Boldogh. 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization. Free Radical Biology & Medicine. 73:430-8. 2014.
[5] Jixian Luo, Sihui Pei, Weixin Jing, Enmin Zou, Lan Wang. Cadmium inhibits molting of the freshwater crab Sinopotamon henanense by reducing the hemolymph ecdysteroid content and the activities of chitinase and N-acetyl-β-glucosaminidase in the epidermis. Comparative biochemistry and physiology. Part C. 169:1-6. 2014.
[6] Jixian Luo, Tingshuang Xu, Chunfeng Li, Xueqing Ba, Xiaoguang Wang, Yong Jiang, Xianlu Zeng. p85-RhoGDI2, a novel complex, is required for PSGL-1-induced β1 integrin-mediated lymphocyte adhesion to VCAM-1. The International Journal of Biochemistry & Cell Biology. 45(12): 2764-2773. 2013.
[7] Jixian Luo, Chunfeng Li, Tingshuang Xu, Wenai Liu, Xueqing Ba, Xiaoguang Wang, Xianlu Zeng. PI3K is involved in β1 integrin clustering by PSGL-1 and promotes β1 integrin-mediated Jurkat cell adhesion to fibronectin. Molecular and Cellular Biochemistry. 385(1-2): 287-295. 2013.
[8] Jixian Luo, Tingshuang Xu, Xiaoguang Wang, Xue Feng, Xueqing Ba, Xianlu Zeng. PI3K is involved in L-selectin- and PSGL-1-mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly. Journal of Cellular. Biochemistry. 110 (4): 910-919. 2010.
參與發表的SCI論文
[1] Yongquan Li, Huizhen Yang, Na Liu, Jixian Luo, Qian Wang, Lan Wang. Cadmium accumulation and metallothionein biosynthesis in cadmium-treated freshwater mussel Anodonta woodiana. PLoS One. 10(2):e0117037. 2015.
[2] Xueqing Ba, Attila Bacsi, Jixian Luo, Leopoldo Aguilera-Aguirre, Xianlu Zeng, Zsolt Radak, Allan R. Brasier, Istvan Boldogh.8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. Journal of Immunology. 192(5):2384-94. 2014.
[3] Tingshuang Xu, Wenai Liu, Jixian Luo, Chunfeng Li, Xueqing Ba, Khamal Kwesi Ampah, Xiaoguang Wang, Yong Jiang, Xianlu Zeng. Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1. PLoS One. 8(12):e81807. 2013.
[4] Wenwen Lei, Lan Wang, Dongmei Liu, Tuan Xu, Jixian Luo. Histopathological and biochemical alternations of the heart induced by acute cadmium exposure in the freshwater crab Sinopotamon yangtsekiense. Chemosphere. 84(5):689-94.2011.
[5] Lingling Cui, Cuixia Chen, Ting Xu, Juechao Zhang, Xin Shang, Jixian Luo, Liang Chen, Xueqing Ba, Xianlu Zeng. c-Abl Kinase is required for β-2 integrin-medated neutrophil adhesion. Journal of Immunology. 182 (5): 3233-3242. 2009.
[6] Ting Xu, Liang Chen, Xin Shang, Lingling Cui, Jixian Luo, Cuixia Chen, Xueqing Ba and Xianlu Zeng. Critical role of Lck in L-selectin signaling induced by sulfatides engagement. Journal of Leukocyte Biology. 84 (8): 1192-1201. 2008.
[7] Cuixia Chen, Xin Shang, Lingling Cui, Ting Xu, Jixian Luo, Xueqing Ba, Xianlu Zeng. L-selectin ligation-induced CSF-1 genetranscription is regulated by AP-1 in a c-Abl kinase-dependent manner. Human Immunology. 69 (8): 501-509. 2008.
[8] Cuixia Chen, Xin Shang, Ting Xu, Lingling Cui, Jixian Luo, Xueqing Ba, Shui Hao and Xianlu Zeng. c-Abl is required for the signaling transduction induced by L-selectin ligation. European Journal of Immunology. 37 (11): 3246-3258. 2007.
