范瑞芳(華南師範大學生命科學院教授)

范瑞芳，女，畢業於北京理工大學，華南師範大學生命科學院教授、博士研究生導師。

基本介紹

• 中文名：范瑞芳
• 國籍：中國
• 畢業院校：北京理工大學
• 職業：教師
• 主要成就：獲國家發明專利一項

個人簡歷

華南師範大學生命科學院教授，博士研究生導師，1991年本科畢業於河南師範大學，2000年碩士畢業於北京理工大學，2007年從中科院廣州地球化學所博士畢業，2010年9月-2012年3月獲國家留學基金委資助，赴美國加州公共衛生局（California Department of Public Health）訪學一年半。華南師範大學-番禺中心醫院基礎與轉化醫學聯合實驗室客座教授，廣東省環境科學學會生態毒理學與環境毒理學分會委員，廣東省環境誘變劑協會理事，國家自然科學基金、科技部、教育部以及廣東省等國家和省級項目評審專家，長期擔任Environment International, Environmental Science & Technology, Toxicology等國際知名雜誌的審稿人。

長期從事環境持久性有機污染物人群暴露監測、環境污染物毒理及對人體健康的影響機制研究。主持國家和省部級基金10餘項，在國內外發表中英文論文90餘篇，其中80篇被SCI及EI收錄，引用合計1000餘次，H指數為19。

獲國家發明專利一項：液相色譜串聯質譜分析尿液中苯和甲苯四種代謝產物的方法，授權專利號：ZL-201310067770.3，授權日期：2014年4月2日。

教育經歷

1991年本科畢業於河南師範大學

2000年碩士畢業於北京理工大學

2007年從中科院廣州地球化學所博士畢業

研究方向

（1）環境有機污染物污染與人體健康的關係以環境中常見的有機污染物，如多環芳烴、揮發性有機污染物、環境雌激素為研究對象，進行普通以及職業暴露人群的暴露監測，通過環境衛生流行病學研究方法尋找環境污染物暴露與人群健康有害結局之間的關係。

（2）環境污染物的毒理效應與機制研究以大鼠、小鼠以及細胞為模型，研究多酚類環境雌激素的長期環境暴露的神經毒性效應及其分子機制。

講授課程

現代儀器分析技術，研究生，必修課

物理化學，本科生，必修課

承擔課題

[1] 國家自然科學基金（21777048），2018.01-2021.12，64萬元，主持，在研。

[2] 國家自然科學基金重點項目（41731279），2018.01-2022.12，60/323萬元，子課題負責人，在研。

[3] 國家自然科學基金 (21477041)，2015.01-2018.12, 87萬元，主持，已結題。

[4] 廣州市科技計畫項目 (201510010107)， 2015.06-2018.06，20萬，主持，已結題。

論文專著

論文專著(第一作者，通訊作者，近5年)：

按照以下格式，按照時間倒序列出，論文中所有作者都要列出。

(1) Jianhua Tan, Hongxuan Kuang, Xuejing Lv, Yingwei Zeng, Wenji Zhou, Qilai Xie*, Ruifang Fan*. Distribution characteristics and health risk assessment of a novel antibacterial alternative in personal care products: chloroxylenol. Science of the Total Environment, 2021, 786, 147524. （IF₂₀₁₉=6.551, 一區）

(2) Hongxuan Kuang, Zhilin Li, Xuejing Lv, Peiqiong Wu, Jianhua Tan, Qiurong Wu, Wenhui Jiang, Qihua Pang, Ruifang Fan*. Exposure to volatile organic compounds may be associated with oxidative DNA damage-mediated childhood asthma. Ecotoxicology and Environmental Safety, 2021, 210: 111864. (IF₂₀₁₉=4.872)

(3) Congcong Wang, Jiaying He, Tongfei Xu, Hongyu Han, Zhimin Zhu, Lingxue Meng, Qihua Pang*, Ruifang Fan*. Bisphenol A(BPA), BPS and BPB-induced oxidative stress and apoptosis mediated by mitochondria in human neuroblastoma cell lines, Ecotoxicology and Environmental Safety, 2021, 207:111299. (IF₂₀₁₉=4.872)

(4) Lingxue Meng, Jian Liu, Congcong Wang, Zedong Ouyang, Jiahua Kuang, Qihua Pang*, Ruifang Fan*. Sex specific neurotoxic effects of BPA and its analogs on primary hippocampal neurons attenuated by EGCG, Chemosphere, 2021, 264, 128450. (IF₂₀₁₉=5.778)

(5) Hongxuan Kuang, Jian Liu, Yingwei Zeng, Wenji Zhou, Peiqiong Wu, Jianhua Tan, Yonghong Li, Qihua Pang, Wenhui Jiang, Ruifang Fan*. Co-exposure to polycyclic aromatic hydrocarbons, benzene and toluene may impair lung function by increasing oxidative damage and airway inflammation in asthmatic children. Environmental Pollution, 2020, 266,115220. (IF₂₀₁₉=6.792,一區)

(6) Yonghong Li, XueJing Lv, Jian Liu, Jianying HeLingxue Meng, Hongxuan Kuang, Caihui Cha, Qihua Pang*, Ruifang Fan*, Association between 10 urinary heavy metals exposure and attention deficit hyperactivity disorder for children, Environmental Science and Pollution Research, 2020, 27:31233–31242. （SCI, IF₂₀₁₉=3.056）

(7) Haibin Zhang, Zhouyu Wang, Lingxue Meng, Hongxuan Kuang, Jian Liu, Xuejing Lv, Qihua Pang, Ruifang Fan, Maternal exposure to environmental bisphenol A impairs the neurons in hippocampus across generations, Toxicology, 2020, 432:152393. (IF₂₀₁₉=4.099)

(8) Hongxuan Kuang, Yanyan Dai, Yonghong Li, Caihui Cha, Wenhui Jiang, Qihua Pang, Haibin Zhang, Ruifang Fan*. The association among blood BPDE-DNA adducts, serum interleukin-8 (IL-8) and overall DNA damage for children with pulmonary disease. International Journal of Environmental Health Research, 2019, 1-12. (SCI, IF₂₀₁₈=1.465)

(9) Hongxuan Kuang, Yonghong Li, Wenhui Jiang, Peiqiong Wu, Jianhua Tan, Haibin Zhang, Qihua Pang, Ruifang Fan*. Simultaneous determination of urinary 31 VOC metabolites，8-hydroxy-2′-deoxyguanosine and trans-3′-hydroxy-cotinine by UPLC-MS/MS: The effect of isotoped internal standards on elimination of matrix effect, Analytical and Bioanalytical Chemistry, 2019, 411:7841-7855. (SCI, IF₂₀₁₈=3.286)

(10) Haibing Zhang, Kuanghong Xuan, Yifan Luo, Shuhua Liu, Lingxue Meng, Qihua Pang, Ruifang Fan*. Low-dose bisphenol A exposure impairs learning and memory ability with alterations of neuromorphology and neurotransmitters in rats, Science of the Total Environment, 2019, 697:134036. （SCI, IF₂₀₁₈=5.589，一區）

(11) Qihua Pang#, Yanru Li#, Lingxue Meng, Guanyong Li, Zhiwei Luo, Ruifang Fan*. Neurotoxicity of BPA, BPS and BPB for the hippocampal cell line (HT-22): an implication for the replace of BPA in plastics，Chemosphere, 2019, 226:545-552. (SCI, IF₂₀₁₈=5.108, 2區)

(12) Laiguo Chen, Guocheng Hu, Ruifang Fan*, Yanshan Lv, Yanyan Dai, Zhencheng Xu*. Association of PAHs and BTEX exposure with lung function and respiratory symptoms among non-occupational population near the coal-chemical industry in Northern China. Environment International, 2018, 120:480-488. (SCI, IF₂₀₁₈=7.943, 1區)

(13) Yanru Li, Haibin Zhang, Hongxuan Kuang, Ruifang Fan*, Caihui Cha*, Guanyong Li, Zhiwei Luo, Qihua Pang. Relationship between Bisphenol A exposure and Attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Environmental Pollution, 2018, 235:141-149. (SCI, IF₂₀₁₈=5.714)

(14) Yuanxiu Zhou, Zhouyu Wang, Minghan Xia, Siyi Zhuang, Xiaobing Gong*, Jianwen Pan, Chuhua Li, Ruifang Fan*, Qihuang Pang, Shaoyou Lu. Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: An implication for children exposed to environmental level of BPA, Environmental Pollution, 2017, 229:40-48. (SCI, IF₂₀₁₇=4.358)

(15) Yanshan Lv#, Shaoyou Lu#, Yanyan Dai, Caiyan Rui, Yongjun Wang, Yanru Li, Yuanxiu Zhou, Qihua Pang, Ruifang Fan. Higher dermal exposure of cashiers to BPA and its association with DNA oxidative damage, Environment International, 2017, 98:69-74. (SCI, IF₂₀₁₇=7.297, 1區).

(16) Yanshan Lv, Caiyan Rui, Yanyan Dai, Qihua Pang, Yanru Li, Ruifang Fan, Shaoyou Lu. Children exposure to BPA through dust and the association of urinary BPA, triclosan with oxidative stress in Guangzhou, China. Environmental Science: processes & impact, 2016, 18: 1492-1499. (SCI, IF₂₀₁₆=2.592)

(17) Shaoyou Lu, Lu Ren, Jianzhang Fang, Jiajia Ji, Guihua Liu, Jianqing Zhang, Huimin Zhang, Ruorong Luo, Kai Lin, Ruifang Fan*. Trace elements can increase urinary 8-hydroxy-2’-deoxyguanosine level: a case study of college students in Guangzhou, China. Environmental Science and Pollution Research, 2016, 23:8484–8491. (SCI, IF₂₀₁₆=2.741)

獲獎記錄

曾獲得華南師範大學 “科研工作優秀獎”“優秀教師”“優秀班主任”等榮譽，培養的多名研究生獲得“國家獎學金”、“廣東省優秀學生（研究生）”以及校級“優秀碩士論文”等獎勵和榮譽稱號；2019年指導本科生獲得“第15屆《挑戰杯》廣東大學生課外學術科技作品競賽二等獎”。