肖玉玲(武漢大學藥學院副教授)

肖玉玲，美國羅德島大學藥學院 聯合培養博士生，武漢大學藥學院副教授。

研究領域: 融合合成化學和計算機輔助藥物設計技術開展針對抗病毒藥物和腫瘤蛋白相互作用靶點的藥物設計和發現工作，開展對功能蛋白結構域到活性小分子的“翻譯”研究，主要針對蛋白蛋白相互作用進行相應功能小分子的藥物設計與合成。承擔課題2項，發表論文24篇，參加國際國內學術會議2次，交流論文2篇。

基本介紹

• 中文名：肖玉玲
• 國籍：中國
• 職業：教師
• 畢業院校：武漢大學
• 學位/學歷：博士後/大學
• 專業方向：基於納米醫學技術的癌症早期診斷和治療
• 職務：副教授
• 學術代表作： 

基本情況

學習簡歷

2005-2009 武漢大學化學與分子科學學院 有機化學 理學博士

2007-2008 美國羅德島大學藥學院 聯合培養博士生
2009-2012 武漢大學藥學院 講師
2010 -2012 美國威斯康辛大學麥迪遜分校 博士後研究

工作簡歷

2012 -至今 武漢大學藥學院副教授

承擔課程

《藥用高分子材料》，《藥劑學》

主要科研領域課題與論文

科研領域

1）基於納米醫學技術的癌症早期診斷和治療；

2）小分子藥物及核酸藥物（基因及siRNA）的靶向傳輸及控制釋放研究。

科研課題

1.國家自然科學基金，青年基金，項目編號21204069 （項目主持人）

2. 湖北省自然科學基金，面上項目，項目編號 2012FFB04429 （項目主持人）

3. 教育部博士點基金，新教師類，項目編號 20100141120013 （項目主持人）

4. 湖北省自然科學基金，指導性計畫項目， 項目編號 2010CDZ006 （項目主持人）

5. 中央高校基本科研專項研究基金，項目編號4101042 （項目主持人）

主要論文

1.Yuling Xiao, Hao Hong, Alireza Javadi, et al. Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging.Biomaterials, 33(11): 3071-3082.(IF 7.6)

2. Yuling Xiao, Renata Jaskula-Sztul, Alireza Javadi, et al. Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy. Nanoscale, 2012, 4, 7185-7193. (IF 6.2)

3. Yuling Xiao, Hao Hong, Vyara Z. Matson, et al. Gold nanorods conjugated with doxorubicin and cRGD for combined anticancer drug delivery and PET imaging. Theranostics. 2012, 2(8):757-768. (IF 7.8)

4. Yuling Xiao, Qifeng Zhu, et al. Preparation and characterization of a novel pachyman-based pharmaceutical aid. II: A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs. Carbohydrate Polymers. 2009, 77: 612-620.

5. Yuling Xiao, Shucai Liang, Guofu Qiu, et al. Preparation, characterization and tableting properties of two new pachyman-based pharmaceutical aids: I. disintegrants in dispersible tablets. Polymers for Advanced Technologies. 2007, 18: 268-274.

6. Alireza Javadi, Yuling Xiao, and Gong S. Journal of Materials Chemistry. 2012, 22: 830-834.

7. Yang X, Hong H, Grailer JJ, Rowland IJ, Javadi A, Xiao Y, Yang Y, Zhang Y, Nickles RJ, Cai W, Steeber DA, Gong S. Biomaterials. 2011, 2(17):4151-60.

8. Liu H, Xiao Y, Xiong C, Wei A, Ruan J. Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation. European Journal of Pharmacology. 2011: 654(3), 209-216.

9. He X, Qiu G, Yang J, Xiao Y, Wu Z, Qiu G, Hu X. European Journal of Medicinal Chemistry. 2010: 45(9), 3818-3830.

10. He X, Zhong M, Zhang T, Yang J, Wu Z, Xiao Y, Guo H, Pan Y, Qiu G, Hu X. Synthesis and anticonvulsant activity of N-3-arylamide substituted,5-cyclopropanespirohydantoin derivatives European journal of medicinal chemistry. 2010: 45(12), 5870-7.

11. He X, Zhong M, Zhang T, Yang J, Wu Z, Xiao Y, Guo H, Qiu G, Hu X. Synthesis and anticonvulsant activity of -(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones . European Journal of Medicinal Chemistry. 2012: 48, 338-346.

12. Guo H, Zhang G, Zhang T, He X, Wu Z, Xiao Y, Pan Y, Qiu G, Liu P, Hu X. Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents European Journal of Medicinal Chemistry. 2011: 46(9), 3662-3674.

13. Guo H, Wu H, Yang J, Xiao Y, Altenbach H, Qiu G, Hu H, Wu Z, He X, Zhou D. Synthesis, characterization and biological evaluation of some 16E-arylidene androstane derivatives as potential anticancer agents Steroids. 2011: 76(7), 709-723.

14. Zhang J, Shao H, Xiao Y, Zhu Y, Liang S. Preparation and evaluation in vitro of salicylic acid-pachyman nanoparticles . Journal of Wuhan University of Technology, Materials Science Edition. 2011: 26(4), 606-610.

15. Wu Z, Lu Y, Luo M, He X, Xiao Y, Yang J, Pan Y, Qiu G, Guo H, Hu H, et al. Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: A novel class of acylides European Journal of Medicinal Chemistry 2010: 45(9), 3636-3644.

16. Wu Z, Lu Y, Luo M, He X, Xiao Y, Yang J, Pan Y, Qiu G, Xu Y, Huang W, et al. Synthesis and antibacterial activity of novel 4-carbamates of 6,11-di-O-methylerythromycin A. Journal of Antibiotics. 2010: 63(7), 343-350.

17. Zhu Q, Xu Z, Hao Y, Xiao Y, Xu W, Ke X, Teng H, Wu L, Qiu G, Liang S, et al. A facile method for preparation of novel cyclopropanespirohydantoins Letters in Organic Chemistry 2008: 5(6), 478-483.

18. Yang J, Qu Z, Xiao Y, Qiu G, Zhang T, Wu Z, He X, Hu X. Chemical composition and antioxidant activity of the essential oil of endemic Viola tianshanica. Natural Product Research. 2011: 25(17):1635-40.

19. Yang J, Xiao Y, He X, Qiu G, Hu X. Aesculetin-induced apoptosis through a ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells. Journal of Asian Natural Products Research. 2010: 12(3), 185-93.

20. Zhou D, Tuo W, Hu H , Xu J, Chen H , Rao Z, Xiao Y, Hu X, Liu P. Synthesis and activity evaluation of tilorone analogs as potential anticancer agents. European Journal of Medicinal Chemistry, 2013: 64, 432-441

21. Hu H , Rao Z, Xu J, Zhu Q, Hans-Josef Altenbach, Chen H, Zhou D, Xiao Y, Ke X, Guo H, Wu Z, Liu P, Hu X. 16-Morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: Synthesis, biological evaluation and in silico probe of ligand–receptor interaction. European Journal of Medicinal Chemistry, 2012: 56,332-347.