基本介紹
- 中文名：肖武漢
- 性 別： 男
- 職 稱：研究員
- 學 歷：研究生
個人經歷,主要研究興趣,研究方向,代表論著,
個人經歷
1997年在中國科學院水生生物研究所獲博士學位。
1994年至1998年在中國科學院水生生物研究所任助理研究員；
1998年10月至2003年10月在美國西北大學(Northwestern University)做博士後, 任研究助理(Research Associate);
2003年10月至2005年12月在美國西北大學醫學院任研究助理教授（Research Assistant Professor, Faculty member)；
2005年12月，在中國科學院水生生物研究所任研究員;
2006年8月至10月在美國匹茲堡大學（University of Pittsburgh) 任研究顧問（Research Consultant)。
2006年入選中國科學院“百人計畫”。
主要研究興趣
1．低氧信號傳導及其分子調控機制。
2. 魚類耐低氧的遺傳基礎。
3. 腫瘤相關基因的功能、遺傳調控與表觀遺傳調控。
研究方向
分子毒理學
代表論著
1. Hu B, Zhang W, Feng X, Ji W, Xie X, Xiao W*. Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis. Developmental Biology.
2. Wang J, Zhang W, Ji W, Liu X, Ouyang G, Xiao W*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology.
3. Chen Z, Liu X, Mei Z, Wang Z*, Xiao W*. EAF2 suppresses HIF-1alpha transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology.
4. Zhang W, Ji W, Liu X, Ouyang G, Xiao W*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology.
5. Ji W, Wang J, Zhang W, Liu X, Ouyang G, Xiao W*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal.
6. Liu J, Zhang D, Xie X, Ouyang G, Liu X, Sun Y, Xiao W*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development.
7. Xie X, Liu J, Hu B, Xiao W*. Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis. PLos One.
8. Wan X, Hu B, Liu J, Feng X, Xiao W*. Zebrafish mll gene is essential for hematopoiesis. Journal of Biological Chemistry.
9. Feng X, Liu X, Zhang W, Xiao W*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal.
10. Ji W, Zhang W, Xiao W*. E2F-1 directly regulates Thrombospondin 1 expression. PLoS One
11. Wan X, Ji W, Mei X, Zhou J, Liu JX, Fang C, Xiao W*. Negative feedback regulation of Wnt4 signaling by EAF1 and EAF2/U19. PLoS One
12. Zhou J, Feng X, Ban B, Liu J, Wang Z*, Xiao W*. The elongation factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation. Journal of Biological Chemistry
13. Liu JX, Hu B, Wang Y, Gui JF, Xiao W*. Zebrafish eaf1 and eaf2/u19 Mediate Effective Convergence and Extension Movements through the Maintenance of wnt11 and wnt5 Expression. Journal of Biological Chemistry
14. Xiao W, Ai J, Habermacher G, Volpert O, Yang X, Zhang AY, Hahn J, Cai X, Wang Z*. U19/Eaf2 binds to and stabilizes von Hippel-Lindau protein. Cancer Research.
15. Xiao W, Zhang Q, Habermacher G, Yang X, Zhang AY, Cai X, Hahn J, Liu J, Pins M, Doglio L, Dhir R, Gingrich J, Wang Z*. U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Oncogene.
16. Xiao W., F. Jiang, Z. Wang*. ELL binding regulates U19/EAF2 intracellular localization, stability and transactivation. Prostate.
17. Xiao W, Q. Zhang, F. Jiang, M. Pins, JM. Kozlowski, Z. Wang*. Suppression of prostate tumor growth by U19 – a novel testosterone-regulated apoptosis inducer. Cancer Research.
18. Xiao, W*, Y. P. Zhang and H. Liu. Molecular systematics of Xenocyprinae (Teleostei: Cyprinidae):Taxonomy, biogeography and coevolution of a special group restricted in East-Asia. Molecular Phylogenetics and Evolution,
