王洪睿 ，男，博士，廈門大學生命科學學院教授、博士生導師。
基本介紹
- 中文名：王洪睿
- 學位/學歷：博士
- 職業：教師
- 專業方向：蛋白翻譯後修飾與腫瘤發生髮展
- 任職院校：廈門大學生命科學學院
個人經歷,研究方向,學術成果,
個人經歷
1992年，清華大學獲學士學位；
1994年，清華大學獲碩士學位；
1996年，中國科學院生物物理研究所獲博士學位；
1996-1999年，美國加州理工大學博士後；
1999-2002年，加拿大多倫多西乃山醫院研究所博士後；
2002-2008年，加拿大多倫多西乃山醫院研究所高級研究助理；
2008年至今，廈門大學985平台特聘教授。
1992, B.Sc., Biochemistry, Tsinghua University;
1994, M.Sc., Biochemistry, Tsinghua University;
1996, Ph.D., Molecular Biology, Institute of Biophysics, Chinese Academy of Science;
1996-1999, Postdoctoral Scholar, Division of Biology, California Institute of Technology, Pasadena, USA;
1999-2002, Postdoctoral Fellow, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada;
2002-2008, Senior Research Associate, Samuel Lunenfeld Research Institute, Mount Sinai, Hospital, Toronto, Canada;
2008-Present, Professor of School of Life Sciences, Xiamen University.
研究方向
蛋白翻譯後修飾與腫瘤發生髮展：蛋白質的泛素化和類泛素化修飾對於調節各種細胞和機體生物學活性都起著十分重要的作用，其調控的紊亂會導致包括神經退行性疾病和癌症在內的多種重大疾病的發生。我們致力於研究蛋白質泛素化和類泛素化修飾在調控細胞生長、死亡、自噬以及腫瘤發生髮展中的作用和分子機理。同時，在分子機理研究的基礎上，以在腫瘤發生髮展中起重要作用的泛素連線酶為靶點，進行抗腫瘤新型靶向藥物的研發，以期獲得癌症治療的新的先導化合物。
Protein post-translational modifications such as ubiquitination and ubiquitin-like modification are key regulatory mechanisms that control various biological processes. Dysregulation of protein modification results in development of many human diseases like neurodegenerative disease and cancer. Our research interest has been focused on mechanism studies of ubiquitination and ubiquitin-like modification in regulation of cell proliferation, cell death, autophagy, and tumorigenesis. We are also working on identifying small-molecule modulators of E3 ubiquitin ligases that are critical for cancer development, which is emerging as a promising drug discovery strategy.
學術成果
代表性論文 (Selected Publications)
1. Maoyuan Tian#, Taoling Zeng#, Mingdong Liu, Shang Han, Huayue Lin, Qi Lin, Li Li, Tingting Jiang, Gao Li, Hong Lin, Ting Zhang, Qiaofeng Kang, Xianming Deng*, Hong-Rui Wang*. A cell-based high-throughput screening method for modulators of E3 ligases using ubiquitin-reference-technique (URT) technique. J Biol Chem, 2019, 294(8): 2880-2891.
2. Mingdong Liu#, Taoling Zeng#, Xin Zhang#, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao*, Hong-Rui Wang*.ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. Nature Communications, 2018, 9:4139
3. Zeng T#, Wang Q#, Fu J#, Lin Q, Bi J, Ding W, Qiao Y, Zhang S, Zhao W, Lin H,Wang M, Lu B, Deng X, Zhou D, Yin Z*, Wang HR*.Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis. Cell Reports, 2014,7(3):871-82.
4. Wang M#, Guo L#, Wu Q#, Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, RenL, Zhang S, Pei Y, Yin Z, Ding F, Wang HR*.ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance. Nature Communications, 2014, 5:4901.
5. Xie P#, Zhang M#, He S#, Lu K, Chen Y, Xing G, Lu Y, Liu P, Li Y, Wang S, Chai N, Wu J, Deng H, Wang HR, Cao Y, Zhao F, Cui Y, Wang J, He F*, Zhang L*. The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis. Nat Commun. 2014 May 13;5:3733.
6. Lin H#, Lin Q#, Liu M#, Lin Y, Wang X, Chen H, Xia Z, Lu B, Ding F, Wu Q, Wang HR*. PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis. Oncogene. 2014 Mar 27;33(13): 1629-39.
7. Ding F, Yin Z, Wang HR*. Ubiquitination in Rho signaling. Curr Top Med Chem, 2011, 11(23): 2879-87
8. Tian M#, Bai C#, Lin Q, Lin H, Liu M, Ding F, Wang HR*.Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity. FEBS lett, 2011, 585(14): 2199-04.
9. Wang L#, Liu YT, Hao R, Chen L, Chang Z, Wang HR, Wang ZX, Wu JW*. Molecular mechanism of the negative regulation of Smad1/5 by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem, 2011, 286(18): 15883-94.
10. Wiesner S*, Ogunjim AA, Wang HR, Rotin D, Sicheri F, Wrana JL*, Forman-Kay JD*. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell, 2007, 130(4):651-662
11. Wang HR#, Ogunjimi AA, Zhang Y, Ozdamar B, Bose R, Wrana JL*. Degradation of RhoA by Smurf1 ubiquitin ligase. Methods Enzymol, 2006, 406:437-47.
12. Ozdamar B#, Bose R#, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL*. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science, 2005, 307(5715):1603-9.
13.Zhang Y, Wang HR, Wrana JL. Smurf1: a link between cell polarity and ubiquitination. Cell Cycle, 2004, 3(4):391-2.
14.Wang HR, Zhang Y, Ozdamar B, Ogunjimi AA, Alexandrova E, Thomsen GH, Wrana JL. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science, 2003, 302(5651):1775-9.
15.Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL.TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat Cell Biol, 2001, 3(6):587-95.
