武漢大學高等研究院教授，博士生導師。沈曉博士一直從事生物活性分子導向的有機合成方法學研究。主要成果包括：1、發展了幾個新型氟化學試劑和方法，並在國際上率先將光學純含氟亞碸亞胺引入到對映選擇性氟烷基化反應中；2、糾正了國際同行關於親核加成反應的一個錯誤觀點；3、實現了高效C-O鍵形成反應，並套用到糖苷化反應中；4、實現了鉬催化劑控制的E-選擇性關環複分解反應, 並套用於重要生理活性的大環化合物(例如三期臨床藥物Pacritinib)的合成中；5、發展了釕催化劑控制的Z-選擇性烯烴複分解反應，並套用到具有重要生理活性的血小板聚集體抑制劑、天然產物和大環多肽的合成中。
基本介紹
- 中文名：沈曉
- 國籍：中國
- 學位/學歷：博士
人物經歷,研究方向,主要成就,獲獎記錄,已發表論文,
人物經歷
2017.08-武漢大學高等研究院，教授，博導
2015.06-2017.07 美國波士頓學院，博士後，合作導師：Prof. Amir H. Hoveyda
2014.02-2015.05 美國哈佛大學，博士後，合作導師：Prof. Tobias Ritter
2013.07-2014.02 中科院上海有機化學研究所，研究助理
2008.09-2013.07 中科院上海有機化學研究所，博士，導師：胡金波研究員
研究方向
1、催化有機合成方法學:新型催化劑的設計合成和催化反應研究
2、元素有機化學：基於矽/氟元素的有機化學反應及其在重要生物活性分子和功能材料中的合成套用研究
主要成就
沈曉博士一直從事生物活性分子導向的有機合成方法學研究。主要成果包括：1、發展了幾個新型氟化學試劑和方法，並在國際上率先將光學純含氟亞碸亞胺引入到對映選擇性氟烷基化反應中；2、糾正了國際同行關於親核加成反應的一個錯誤觀點；3、實現了高效C-O鍵形成反應，並套用到糖苷化反應中；4、實現了鉬催化劑控制的E-選擇性關環複分解反應, 並套用於重要生理活性的大環化合物(例如三期臨床藥物Pacritinib)的合成中；5、發展了釕催化劑控制的Z-選擇性烯烴複分解反應，並套用到具有重要生理活性的血小板聚集體抑制劑、天然產物和大環多肽的合成中。
獲獎記錄
中國科學院優秀博士論文獎 (2014)
中國科學院院長特別獎 (2013)
中國科學院優秀畢業生 (2013)
獲邀參加第63屆諾貝爾獎獲得者大會 (2013)
入選愛思唯爾博士生獎全球45人名單 (2011)
中國科學院朱李月華優秀博士生獎 (2011)
先正達研究生獎學金 (2010)
已發表論文
1. X. Shen, T. T. Nguyen, M. J. Koh, D. Xu, A. W. H. Speed, R. R. Schrock, A. H. Hoveyda.* “Kinetically E-Selective Macrocyclic Ring-closing Metathesis” Nature 2017, 541, 380-385.
2. C. Xu, X. Shen, A. H. Hoveyda.* “In situ Methylene Capping: A General Strategy for Efficient Stereo-Retentive Catalytic Olefin Metathesis. The Concept, Methodological Implications and Applications to Synthesis of Biologically Active Compounds” J. Am. Chem. Soc. 2017, 139, 10919-10928. ( contributed equally).
3. C. Xu, Z. Liu, S. Torker, X. Shen, D. Xu, A.H. Hoveyda.* “Synthesis of Z- or E-Trisubstituted Allylic Alcohols and Ethers by Kinetically Controlled Cross-Metathesis with a Ru Catechothiolate Complex," J. Am. Chem. Soc. 2017, 139, 15640-15643.
4.F. Meng, X. Li, S. Torker, Y. Shi, X. Shen, Amir H. Hoveyda.* “Catalytic Enantioselective 1,6-Conjugate Additions of Propargyl and Allyl groups” Nature 2016, 537, 387-393.
5. T. T. Nguyen, M. J. Koh, X. Shen, F. Romiti, R. R. Schrock, A. H. Hoveyda.* “Kinetically Controlled E-Selective Catalytic Olefin Metathesis” Science 2016, 352, 569-575.
6. X. Shen, C. N. Neumann, C. Kleinlein, N. W. Goldberg, T. Ritter.* “Alkyl Aryl Ether Bond Formation with PhenoFluor” Angew. Chem. Int. Ed. 2015, 54, 5662-5665.
7. N. W. Goldberg, X. Shen, J. Li, T. Ritter.* “AlkylFluor: Deoxyfluorination of Alcohols” Org. Lett. 2016, 18, 6102-6104.
8. X. Shen, W. Miao, C. Ni, J. Hu.* “Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral α-Fluoro Carbanions” Angew. Chem. Int. Ed. 2014, 53, 775-779.
9.X. Shen, W. Zhang, C. Ni, Y. Gu, J. Hu.* “Tuning the Reactivity of Difluoromethyl Sulfoximines from Electrophilic to Nucleophilic: Stereoselective Nucleophilic Difluoromethylation of Aryl Ketones” J. Am. Chem. Soc. 2012, 134, 16999-17002.
10.X. Shen, W. Zhang, L. Zhang, T. Luo, X. Wan, Y. Gu, J. Hu.* “Enantioselective Synthesis of Cyclopropanes That Contain Fluorinated Tertiary Stereogenic Carbon Centers: A Chiral α-Fluoro Carbanion Strategy” Angew. Chem. Int. Ed. 2012, 51, 6966-6970.
11. X. Shen, L. Zhang, Y. Zhao, L. Zhu, G. Li, J. Hu.* “Nucleophilic Fluoromethylation of Aldehydes with Fluorobis(phenylsulfonyl)methane: The Importance of Strong Li-O Coordination and Fluorine Substitution for C-C Bond Formation” Angew. Chem. Int. Ed. 2011, 50, 2588-2592.
12. X. Shen, M. Zhou, C. Ni, W. Zhang, J. Hu.* “Direct Monofluoromethylation of O-, S-, N-, and P-Nucleophiles with PhSO(NTs)CH2F: Accelerating Effect of α-Fluorine Substitution” Chem. Sci. 2014, 5, 117-122.
13. X. Shen, Q. Liu, T. Luo, J. Hu.* “Nucleophilic Difluoromethylation of Epoxides with PhSO(NTBS)CF2H by a Preorganization Strategy” Chem. Eur. J. 2014, 20, 6795-6800.
14. X. Shen, J. Hu.* “Fluorinated Sulfoximines: Preparation, Reactions and Applications” Eur. J. Org. Chem. 2014, 4437-4451.
15. X. Shen, Q. Liu, W. Zhang, J. Hu.* “Stereoselective Synthesis of (Sulfonimidoyl)cyclopropanes with (R)-PhSO(NTs)CH2Cl and α,β-Unsaturated Weinreb Amides: Tuning the of Selectivity between C–Cl and C–S Bond Cleavage” Eur. J. Org. Chem. 2016, 906-909.
16. X. Shen, Q. Liu, C. Ni, J. Hu.* “Nucleophilic Difluoro(phenylsulfonimidoyl)- methylation of Unactivated Alkyl Bromides with PhSO(NTBS)CF2H: Facile Entry into gem-Difluoroalkenes” Chin. J. Chem. 2014, 32, 703-708.
17. X. Shen, C. Ni, J. Hu.* “Highly Stereoselective and One-Pot Synthesis of Tetra-substituted Monofluoroalkenes with Aldehydes and Fluorobis(phenyl- sulfonyl)methane” Chin. J. Chem. 2013, 31, 878-884.
18. X. Shen, C. Ni, J. Hu.* “Nucleophilic Fluoroalkylation of α,β-Unsaturated Carbonyl Compounds with α-Fluorinated Sulfones: Investigation of the Rever-sibility of 1,2-Additions and the Formation of 1,4-Adducts” Helv. Chim. Acta, 2012, 95, 2043-2051.
19. Q. Liu, X. Shen, C. Ni, J. Hu.* “Stereoselective Carbonyl Olefination with Fluorosulfoximines: Facile Access to Z or E Terminal Monofluoroalkenes” Angew. Chem. Int. Ed. 2017, 56, 619-623.
20. T. Luo, R. Zhang, X. Shen, W. Zhang, C. Ni, J. Hu.* “Brønsted acid-catalyzed 1,2-fluorine migration with fluoroepoxides” Dalton Trans. 2015, 44, 19636-19641.
21. T. Luo, R. Zhang, W. Zhang, X. Shen, T. Umemoto, J. Hu.* “Divergent Rearrangements of Cyclopropyl-Substituted Fluoroepoxides Involving C–F Bond Cleavage and Formation” Org. Lett. 2014, 16, 888-891.
22. Y. Zhao, C. Ni, F. Jiang, B. Gao, X. Shen, J. Hu.* “Copper-Catalyzed Debenzoylative Monofluoromethylation of Aryl Iodides Assisted by the Removable (2-Pyridyl)sulfonyl Group” Acs Catal. 2013, 3, 631-634.
