武志強，男，博士，中國農業科學院（深圳）農業基因組研究所研究員，博士生導師。
2012年博士畢業於中國科學院植物研究所，2012-2019年之間在瑞典、美國進行博士後研究，2019年11月加入基因組所。
主要研究領域：以植物細胞器為研究對象，利用組學大數據探索細胞器基因組的變異和突變機理，以及細胞核質互作的分子機制，並挖掘以細胞器為基礎的光合作用系統轉化以提高作物產量。目前，主持包括國家自然科學基金面上項目、深圳市優秀青年項目、農科院青年英才項目、中國農科院南繁育種等多個項目。
以第一作者或通訊作者在PNAS（2）、MBE、PBJ、BIB、MPE、TPJ、Genetics等國際知名期刊發表論文40餘篇，總被引達3200餘次，H 因子達25。擔任多個國際期刊的審稿人，先後對70多種SCI期刊雜誌進行200餘次審稿，使其在植物進化生物學領域得到國際同行的認可。
基本介紹
- 中文名：武志強
- 畢業院校：中國科學院植物研究所
- 學位/學歷：博士
- 職業：教師
- 職務：博士生導師
- 性別：男
- 職稱：研究員
人物經歷,工作經歷,教育經歷,科研成就,研究方向,研究進展,代表論文,
人物經歷
工作經歷
2019.11–至今 中國農業科學院（深圳）農業基因組研究所 Principle Investigator
2018.1-2019.12 美國科羅拉多州立大學 Postdoctoral Fellow
2016.5-2017.12 美國愛荷華州立大學 Postdoctoral Fellow
2014.5-2016.4 美國科羅拉多州立大學 Postdoctoral Fellow
2013.2-2014.4 美國德州理工大學 Postdoctoral Fellow
2012.2-2013.2 瑞典于默奧大學 Doctoral Fellow
教育經歷
2006.9–2012.1 中國科學院植物研究所 博士
2002.9–2006.7 雲南大學 學士
科研成就
研究方向
1. 進化生物學：以植物細胞器為研究對象，利用組學大數據探索細胞器基因組的變異和突變機理，以及細胞核質互作的分子機制，並挖掘以細胞器為基礎的基因編輯系統研究光合作用和呼吸作用系統轉化以提高作物產量。
2. 園藝物種基因組學：開展嶺南特色花卉如百合科、姜科、石竹目、薔薇科等多物種的全基因組以及花卉功能性狀基礎和分子育種的研究，從而為嶺南花卉物種的分子育種提供理論基礎。
研究進展
1. 闡述複雜植物線粒體基因組在種內變異的進化模式
線粒體是植物細胞的能量和動力工廠，研究其起源和進化對生命的認識具有重要的生物學意義。我們首次報導的被子植物物種具有複雜的線粒體基因組構造；也深入分析其線粒體基因組在RNA 轉錄水平的表達差異和基因編輯的分布；同時系統研究了線粒體基因組的拷貝數變化。這一系列的研究成果已經分別發表在美國科學院院刊PNAS、 BMC Genomics、 Heredity和G3: Genes, Genomes, Genetics等期刊雜誌。對豐富多樣的植物進行該研究，可以幫助我們解析複雜細胞器基因組的進化。我們將繼續以不同類群的植物為代表，深入這一課題的研究。
2. 對植物線粒體基因的轉移和基因轉換機制進行系統鑑定和分析
在進化的歷程中，細胞器和細胞核的基因組之間都經歷了基因組結構重塑和功能基因轉移/丟失的過程，但是關於細胞器基因功能性轉移至細胞核機制的假說一直缺乏有效的實驗證據。前期選取經濟作物禾本科內90個物種及其外類群為研究體系，以植物線粒體rpl5基因為研究對象，對該基因線上粒體和細胞核基因中的拷貝及轉移機制進行詳盡的研究。這一研究成果發表在Molecular Biology and Evolution上。我們將繼續以細胞器之間基因信息轉移為對象，從生命之樹的角度解讀基因轉移的多樣性和複雜性的機制。
3. 細胞核質互作研究
在多倍體物種形成中，單親遺傳的細胞器基因組和雙親遺傳的細胞核基因組之間在進化上存在核質互作的不平衡。使用基因組學和轉錄組學的數據，可以解析不同進化時間尺度內的各種多倍體在形成過程中該機制的變異。
代表論文
- 2023年
1. Shuo Zhang, Jie Wang, Wenchuang He, Shenglong Kan, Xuezhu Liao, David R Jordan, Emma S Mace, Yongfu Tao, Alan W Cruickshank, Robert Klein, Daojun Yuan, Luke R Tembrock*, Zhiqiang Wu*. Variation in mitogenome structural conformation in wild and cultivated lineages of sorghum corresponds with domestication history and plastome evolution. BMC Plant Biology. 2023. 23(1):91. (IF=5.260, JCR一區)
2. Wenchuang He, Kunli Xiang, Caijin Chen, Jie Wang, Zhiqiang Wu*. Master graph: an essential integrated assembly model for the plant mitogenome based on a graph-based framework. Briefings in Bioinformatics. 2023. 24(1):bbac522. (IF=13.994, JCR一區)
- 2022年
3. Xiaoni Zhang, Shengnan Lin, Dan Peng, Quanshu Wu, Xuezhu Liao, Kunli Xiang, Zehao Wang, Luke R. Tembrock, Mohammed Bendahmane, Manzhu. Bao, Zhiqiang Wu*, Xiaopeng Fu*. Integrated multi-omic data and analyses reveal the pathways underlying key ornamental traits in carnation flowers. Plant Biotechnology Journal. 2022. 20:1182–1196 (IF=13.263, JCR一區)
4. Zhiqiang Wu*, Xuezhu Liao, Xiaoni Zhang, Luke R. Tembrock, Amanda Broz. Genomic architectural variation of plant mitochondria—A review of multichromosomal structuring. Journal of Systematics and Evolution. 2022. 60(1):160–168. (IF=3.544, JCR一區)
5. Chanjuan Lai, Jie Wang, Shenglong Kan, Shuo Zhang, Pan Li, Wayne Gerald Reeve, Zhiqiang Wu*, Yonghua Zhang. Comparative analysis of mitochondrial genomes of Broussonetia spp. (Moraceae) reveals heterogeneity in structure, synteny, intercellular gene transfer, and RNA editing. Frontiers in Plant Science. 2022. 13:1052151 (IF=6.627, JCR一區)
6. Yi Zou, Weidong Zhu, Daniel B. Sloan, Zhiqiang Wu*. Long-read sequencing characterizes detailed patterns of mitochondrial and plastid genome variants in Arabidopsis msh1 mutants. The Plant Journal. 2022. 112(3):738-755 (IF=7.091, JCR一區)
7. Xuezhu Liao#, Yuanjun Ye#, Xiaoni Zhang#, Dan Peng, Mengmeng Hou, Gaofei Fu, Jianjun Tan, Jianli Zhao, Rihong Jiang, Yechun Xu, Jinmei Liu, Jinliang Yang, Wusheng Liu, Luke R. Tembrock, Genfa Zhu*, Zhiqiang Wu*. The genomic and bulked segregant analysis of Curcuma alismatifolia revealed its diverse bract pigmentation. aBIOTECH. 2022. 3(3):178-196.
8. Haoqi Wang, Xuezhu Liao, Luke R Tembrock, Zuoren Yang*, Zhiqiang Wu*. Evaluation of intracellular gene transfers from plastome to nuclear genome across progressively improved assemblies for Arabidopsis thaliana and Oryza sativa. Genes. 2022. (IF=4.141, JCR二區)
9. Sidan Hong, Jie Wang, Qun Wang, Guozhe Zhang, Yu Zhao, Qingqing Ma, Zhiqiang Wu*, Jin Ma*, Cuihua Gu*. Decoding the formation of diverse petal colors of Lagerstroemia indica by integrating the data from transcriptome and metabolome. Frontiers in Plant Science. 2022. 13:970023. (IF=6.627, JCR一區)
10. Xiaoni Zhang, Shengnan Lin, Quanshu Wu, Qijian Wang, Chunmei Shi, Manzhu Bao, Mohammed Bendahmane*, Xiaopeng Fu*, Zhiqiang Wu*. Floral primordium morphogenesis in double flower formation and transcriptomes reveal its networks in Dianthus chinensis. Horticultural Plant Journal. 2022. (Accepted). (IF=4.24, JCR一區)
11. Jie Wang, Wenchuang He, Xuezhu Liao, Jin Ma, Wei Gao, Haoqi Wang，Dili Wu, Luke R. Tembrock, Zhiqiang Wu*, Cuihua Gu*. Phylogeny, molecular evolution, and dating of divergences in Lagerstroemia (Lythraceae) using plastome sequences. Horticultural Plant Journal. 2022. (Online). (IF=4.24, JCR一區)
12. Shenglong Kan, Xuezhu Liao, Zhiqiang Wu*. The Roles of Mutation and Selection Acting on Mitochondrial Genomes Inferred from Intraspecific Variation in Seed Plants. Genes. 2022. 13:1036.
13. Jie Wang#, Gaofei Fu#, Luke R. Tembrock, Xuezhu Liao, Song Ge, Zhiqiang Wu*. Mutational meltdown or controlled chain reaction: the dynamics of rapid plastome evolution in the hyperdiversity of Poaceae. Journal of Systematics and Evolution. 2022.
14. Kunli Xiang, Wei Mao, Huanwen Peng, Andrey Erst*, Wenchuang He*, Zhiqiang Wu*. Organization, phylogenetic marker exploitation and gene evolution in the plastome of Thalictrum (Ranunculaceae). Frontiers in Plant Science. 2022. 13:897843. (IF=6.627, JCR一區)
15. Zhou Hong, Wenchuang He, Xiaojing Liu, Luke R. Tembrock, Zhiqiang Wu*, Daping Xu*, Xuezhu Liao*. Comparative Analyses of 35 Complete Chloroplast Genomes from the Genus Dalbergia (Fabaceae) and the Identification of DNA Barcodes for Tracking Illegal Logging and Counterfeit Rosewood. Forests. 2022. 13(4), 626. (IF=3.282, 林學JCR一區)
16. Liang Tang#, Xuezhu Liao#, Luke R Tembrock, Song Ge, Zhiqiang Wu*. A chromosome-scale genome and transcriptomic analysis of the endangered tropical tree Vatica mangachapoi (Dipterocarpaceae). DNA Research. 2022. 29(2):dsac005. (IF=4.477, JCR二區)
17. Guihua Huang#, Xuezhu Liao#, Qiang Han, Zaizhi Zhou, Kunnan Liang, Guangyou Li, Guang Yang, Luke R Tembrock, Xianbang Wang*, Zhiqiang Wu*. Integrated metabolome and transcriptome analyses reveal dissimilarities in the anthocyanin synthesis pathway between different developmental leaf color transitions in Hopea hainanensis (Dipterocarpaceae). Frontiers in Plant Science. 2022. 13:830413. (IF=6.627, JCR二區)
18. Yuanjun Ye#, Xiaoni Zhang#, Xueqing Chen, Yechun Xu, Jinmei Liu, Jianjun Tan, Wei Li, Luke R. Tembrock, Zhiqiang Wu*, Genfa Zhu*. The use of widely targeted metabolomics profiling to quantify differences in medicinally important compounds from five Curcuma (Zingiberaceae) species. Industrial Crops and Products. 2022. 175:114289. (IF=6.449 JCR一區)
- 2021年
19. Wenchuang He, Caijin Chen, Kunli Xiang, Jie Wang, Ping Zheng, Luke R Tembrock*, Deming Jin*, Zhiqiang Wu*. The history and diversity of rice domestication as resolved from 1464 complete plastid genomes. Frontiers in Plant Science. 2021. 12:781793. (IF=6.627, JCR二區)
20. Zhou Hong#, Xuezhu Liao#, Yuanjun Ye#, Ningnan Zhang, Zengjiang Yang, Weidong Zhu, Wei Gao, Joel Sharbrough, Luke R Tembrock, Daping Xu*, Zhiqiang Wu*. A complete mitochondrial genome for fragrant Chinese rosewood (Dalbergia odorifera, Fabaceae) with comparative analyses of genome structure and intergenomic sequence transfers. BMC Genomics. 2021. 22:672. (IF=4.547, JCR二區)
21. Basanta Bista#, Zhiqiang Wu#, Robert Literman, Nicole Valenzuela*. Thermosensitive sex chromosome dosage compensation in ZZ/ZW softshell turtles, Apalone spinifera. Philosophical Transactions of The Royal Society B. 2021. 376(1833):20200101. (IF=6.671, JCR二區)
22. Amanda K Broz#, Gus Waneka#, Zhiqiang Wu#, Matheus Fernandes Gyorfy, Daniel B Sloan*. Detecting de novo mitochondrial mutations in angiosperms with highly divergent evolutionary rates. Genetics. 2021. 218(1):iyab039. (IF=4.402, JCR二區)
- 2020年
23. Zhiqiang Wu#, Gus Waneka#, Amanda K Broz#, Connor R King, Daniel B Sloan*. MSH1 is required for maintenance of the low mutation rates in plant mitochondrial and plastid genomes. Proceedings of the National Academy of Sciences USA. 2020. 117(28):16448-16455. (IF=12.779, JCR一區)
24. Zhou Hong#, Zhiqiang Wu#, Kunkun Zhao, Zengjiang Yang, Ningnan Zhang, Junyu Guo, Luke R Tembrock, Daping Xu*. Comparative Analyses of Five Complete Chloroplast Genomes from the Genus Pterocarpus (Fabacaeae). International Journal of Molecular Sciences. 2020. 21(11):3758. (IF=6.208, JCR二區)
25. Gang Zheng#, Lingling Wei#, Li Ma#, Zhiqiang Wu#, Cuihua Gu*, Kai Chen. Comparative analyses of chloroplast genomes from 13 Lagerstroemia (Lythraceae) species: identification of highly divergent regions and inference of phylogenetic relationships. Plant Molecular Biology. 2020. 102:659–676. (IF=4.335, JCR二區)
26. Zhiqiang Wu#, Gus Waneka#, Daniel B Sloan*. The Tempo and Mode of Angiosperm Mitochondrial Genome Divergence Inferred from Intraspecific Variation in Arabidopsis thaliana. G3-Genes Genomes Genetics. 2020. 10:1077-1086. (IF=3.542, JCR三區)
- 2019年及之前
27. Zhiqiang Wu*, Daniel B Sloan. Recombination and intraspecific polymorphism for the presence and absence of entire chromosomes in mitochondrial genomes. Heredity. 2019. 122 (5), 647–659. (IF=3.832, JCR二區)
28. Cuihua Gu#, Li Ma#, Zhiqiang Wu#, Kai Chen, Yixiang Wang. Comparative analyses of chloroplast genomes from 22 Lythraceae species: inferences for phylogenetic relationships and genome evolution within Myrtales. BMC Plant Biology. 2019. 19:281. (IF=5.26, JCR二區)
29. Cuihua Gu, Bin Dong, Liang Xu, Luke R. Tembrock, Shaoyu Zheng, Zhiqiang Wu*. The Complete Chloroplast Genome of Heimia myrtifolia and Comparative Analysis within Myrtales. Molecules. 2018. 23 (4), 846. (IF=4.927, JCR三區)
30. Cuihua Gu, Luke R Tembrock, Shaoyu Zheng, Zhiqiang Wu*. The complete chloroplast genome of Catha edulis: a comparative analysis of genome features with related species. International Journal of Molecular Sciences. 2018. 19 (2):525. (IF=6.208, JCR二區)
31. Zhiqiang Wu, Daniel B Sloan, Colin W Brown, Mónica Rosenblueth, Jeffrey D Palmer, Han Chuan Ong*. Mitochondrial retroprocessing promoted functional transfers of rpl5 to the nucleus in grasses. Molecular Biology and Evolution. 2017. 34 (9):2340–2354. (IF=8.8, JCR一區)
32. Zhiqiang Wu*, Cuihua Gu, Luke R Tembrock, Dong Zhang, Song Ge. Characterization of the whole chloroplast genome of Chikusichloa mutica and its comparison with other rice tribe (Oryzeae) species. PloS One. 2017. 12 (5): e0177553. (IF=3.752, JCR三區)
33. Cuihua Gu#, Luke R Tembrock#, Nels G Johnson, Mark P Simmons, Zhiqiang Wu*. The Complete Plastid Genome of Lagerstroemia fauriei and Loss of rpl2 Intron from Lagerstroemia (Lythraceae). PLoS One. 2016. 11(3):e0150752. (IF=3.752, JCR三區)
34. Zhqiang Wu, Cuthbert JM, Taylor DR, Sloan DB. The massive mitochondrial genome of the angiosperm Silene noctiflora is evolving by gain or loss of entire chromosomes. Proceedings of the National Academy of Sciences USA. 2015.112 (30): 10185–10191. (Science雜誌對本文進行了報導). (IF=12.779, JCR一區)
35. Zhiqiang Wu*, Luke R Tembrock, Song Ge. Are differences in genomic data sets due to true biological variants or errors in genome assembly: an example from two chloroplast genomes. PLoS One. 2015. 10(2):e0118019. (IF=3.752, JCR三區)
36. Zhiqiang Wu*, Stone JD, Štorchová H, Sloan DB*. High transcript abundance, RNA editing, and small RNAs in intergenic regions within the massive mitochondrial genome of the angiosperm Silene noctiflora. BMC Genomics. 2015. 16: 938. (IF=4.547, JCR二區)
37. Zhiqiang Wu and Song Ge. The phylogeny of the BEP clade in grasses revisited: Evidence from the whole-genome sequences of chloroplasts. Molecular Phylogenetics and Evolution. 2012. 62: 573-578. (IF=5.019, JCR一區)
38. Li Wang#, Zhiqiang Wu#, Nadia Bystriakova, Stephen W Ansell, Qiao-Ping Xiang, Jochen Heinrichs, Harald Schneider, Xian-Chun Zhang. Phylogeography of the Sino-Himalayan fern Lepisorus clathratus on "the roof of the world". PLoS One. 2011. 6(9):e25896. (IF=3.752, JCR三區)
