楊帆(上海交通大學醫學院，仁濟醫院海洋藥物研究)

楊帆，男，1985年生於江西。博士，美國化學學會(ACS)會員。現任職於上海交通大學醫學院附屬仁濟醫院海洋藥物重點實驗室；2012畢業於上海第二軍醫大學，獲藥物化學博士學位，從事多種海洋生物的抗腫瘤和抗感染活性成分的提取分離、結構鑑定、結構修飾工作以及小分子藥物先導化合物的全合成及結構最佳化。

基本介紹

• 中文名：楊帆
• 國籍：中國
• 出生地：江西
• 出生日期：1985年

個人簡介

於2011年赴美國國家天然產物中心，密西西比大學從事聯合培養課題：1.西沙海綿中抗瘧疾和抗利什曼蟲活性先導化合物的發現；2.生物轉化工作，利用真菌結構改造海綿次生代謝產物；3.Rapamycin的結構修飾工作。

Dr. Fan Yang is a Research Scientist of Marine Natural Product Chemistry with Research Center for Marine Drugs at Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University. Dr. Yang’s research is actively involved in the isolation, structural characterization and synthesis of bioactive secondary metabolites from marine sponges.

研究方向

1.海綿活性次生代謝產物的發現以及結構鑑定

2.抗腫瘤、抗感染活性海洋天然產物的結構修飾以及全合成

發表論文

1.Fan Yang, Mark T. Hamann, Yike Zou,Ming-Yu Zhang, Xiao-Bin Gong, Jian-Ru Xiao, Wan-Sheng Chen, Hou-Wen Lin*, AntimicrobialMetabolites from Paracel Islands Sponge Agelasmauritiana, Journal of natural products, 75, 774-778, 2012.

2.Fan Yang, Hong-Jun Zhang, Yuan-YuanZhang, Wan-Sheng Chen, Hai-Long Yuan, Hou-Wen Lin*, A Hepatitis B VirusInhibitoryNeolignan from Herpetospermumcaudigerum, Chemical & Pharmaceutical Bulletin, 58, 3, 402-404, 2010.

3.Fan Yang, Hong-Jun Zhang, Xiang-FangLiu, Wan-Sheng Chen, Hai-Feng Tang, Hou-Wen Lin*. Oxygenated Steroids fromMarine Bryozoan Biflustragrandicella,Biochemical Systematics and Ecology, 37, 686–689, 2009.

4.Fan Yang, Hong-Jun Zhang, Jiao-Tao Chen,Shu-Juan Piao, Wan-Sheng Chen, Hou-Wen Lin*. New Cytotoxic Oxygenated Sterolsfrom Marine Bryozoan Bugulaneritina.Natural Product Research, 25, 16, 1505-11, 2011.

5.Wei-Hua Jiao, Xiao-Jun Huang, Ji-Si Yang, FanYang，Shu-Juan Piao, HaoGao, Jia Li, Wen-CaiYe,Xin-Sheng Yao, Wan-Sheng Chen, Hou-Wen Lin*.DysidavaronesA-D, New Sesquiterpene Quinones from the Marine Sponge Dysideaavara. Organic letters, 14,1, 202–205, 2012.

6.Xiang-Fan Liu, Yun-Long Song, Hong-Jun Zhang, Fan Yang, Hao-Bing Yu, Wei-Hua Jiao, Shu-Juan Piao, Wan-Sheng Chen,Hou-Wen Lin*.Simplextones A and B,UnusualPolyketides from the Marine Sponge Plakortis simplex. Organic letters, 13, 12, 3154-7, 2011.

7.Shu-Juan Piao, Hong-Jun Zhang, Hai-Yan Lu, FanYang, Wei-Hua Jiao, Yang-Hua Yi, Wan-Sheng Chen, Hou-Wen Lin*. Hippolides A-H, Acyclic ManoalideDerivatives from the Marine Sponge Hippospongialachne. Journal of natural products, 74, 5, 1248-54, 2011.

8.Hong-Jun Zhang, Yang-Hua Yi, Gen-Jin Yang, Ming-Ye Hu, Gui-Dong Cao, Fan Yang, Hou-Wen Lin*. Proline-ContainingCyclopeptides from the Marine Sponge Phakelliafusca. Journal of natural products, 73, 4, 650–655, 2010.

9.Hong-Jun Zhang, Yang-Hua Yi, Fan Yang, Wan-Sheng Chen, Hou-Wen Lin*.Sesterterpenesand a New Sterol from the Marine Sponge Phyllospongiafoliascens.Molecules,15, 2, 834-841, 2010.

10.Xiang-Fang Liu, Yang Shen, Fan Yang, Mark T. Hamann, Wei-Hua Jiao, Hong-Jun Zhang, Wan-Sheng Chen, Hou-Wen Lin*. SimplexolidesA−E and Plakorfuran A, Six Butyrate Derived Polyketides from the Marine Sponge Plakortis simplex. Tetrahedron, 68,4635-4640, 2012.