柳軍璽

柳軍璽 ： 男 學 歷： 博士研究生 職 稱： 研究員： 1997年蘭州大學藥學院藥學專業本科畢業；1997-2001年先後在中國農科院蘭州畜牧與獸藥研究所和中國農科院上海獸醫研究所工作，從事化學藥物的合成研究；2006年中科院蘭州化學物理研究所分析化學專業博士研究生畢業留所工作，從事天然產物化學研究，副研究員，碩士生導師。

研究方向： 天然產物化學及中藥化學的提取分離、結構鑑定及天然產物結構衍生和藥理活性化合物篩選以及基於天然產物的藥物分析研究。

獲獎及榮譽： 獲得甘肅省科技進步獎一等獎2項，二等獎1項，三等獎1項，甘肅省藥學會藥學發展獎一等獎1項，二等獎1項。

承擔科研項目： 承擔包括國家自然基金、中科院西部之光、甘肅省科技支撐在內的多項科研項目。

代表論著： [1] Yali Chen, Ruxia Li, Rongrong Gao, Qian Yan, Mei Zhong, Junxi Liu*, Quanyi Zha, Duolong Di. Total content determination for the effective fraction of the alkaloids in Dicranostigma leptopodum (Maxim.) Fedde by highperformance liquid chromatography and ultraviolet-visible spectrophotometry. Anal. Methods, 2016, 8: 2645-2652.

[2] Lijuan Chen, Hua Tian, Meng Li, Chao Ge, Fangyu Zhao, Lixing Zhang, Hong Li, Junxi Liu, Tingpu Wang, Ming Yao, Jinjun Li*，Derivate isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis, Tumour Biol, 2016, 37: 5951-5961.

[3] Meng Li, Lixing Zhang, Chao Ge, Lijuan Chen, Tao Fang, Hong Li, Hua Tian, Junxi Liu, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li*, An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma. Oncotarget, 2015, 6(28): 25149-25160.

[4] Mei Zhong, Yunbin Jiang, Yali Chen, Qian Yan, Junxi Liu*, Duolong Di, Asymmetric total synthesis of (S)-isocorydine, Tetrahedron: Asymmetry, 2015, 26(20): 1145-1149.

[5] Yali Chen, Min Li, Jianjun Liu, Qian Yan, Mei Zhong, Junxi Liu*, Duo long Di, Jinxia Liu. Simultaneous determination of the content of isoquinoline alkaloids in Dicranostigma leptopodum (Maxim) Fedde and the effective fractionation of the alkaloids by high-performance liquid chromatography with diode array detection. Journal of Separation Science, 2015, 38(1): 9-17.

[6] Yali Chen, Qian Yan, Mei Zhong, Quanyi Zhao, Junxi Liu*, Duolong Di, Jinxia Liu. Study on pharmacokinetics and tissue distribution of the isocorydine derivative (AICD) in rats by HPLC-DAD method. Acta Pharm Sin B, 2015, 5(3): 238-245.

[7] Yanjuan Liu, Xiaofen Chen, Junxi Liu, Duolong Di*, Three-phase solvent systems for the comprehensive separation of a wide variety of compounds from Dicranostigma leptopodum by high-speed counter-current chromatography. Journal of Separation Science, 2015, 38(12): 2038-2045.

[8] Mei Zhong, Yanjuan Liu, Junxi Liu*, Duolong Di, Mengrou Xu, Yaya Yang, Wenguang Li, Yali Chen, Jinxia Liu, Isocorydine derivatives and their anticancer activities. Molecules, 2014, 19(8): 12099-12115.

[9] Mei Zhong, Yuxi Ma, Junxi Liu*, Duolong Di, A new quaternary protoberberine alkaloid isolated from Dicranostigma leptopodum (Maxim) Fedde, Natural Product Research, 2014, 28(8): 507-510.

[10] Yanjuan Liu, Junxi Liu*, Duolong Di, Min Li, Yan Fen, Structural and mechanistic bases of the anticancer activity of natural aporphinoid alkaloids. Current Topics in Medicinal Chemistry, 2013, 13(17): 2116-2126.

[11] Yun Liu, Junxi Liu, Xiaoming Sun, Duolong Di, Evaluation of polydopamine supported nano-polytetrafluoroethylen as novel material for solid phase extraction, New J. Chem., 2012, 36(11): 2376-2382.

[12] Dong Pei, Dahu Liu, Junxi Liu, Duolong Di, Chemical investigation of the pollen of Brassica napus, Chemistry of Natural Compounds, 2012, 48(2): 310-312.

[13] Mingrui Shi, Dong Pe, Junxi Liu, Duolong Di, Chemical constituents from Sphallerocarpus gracilis, Biochemical Systematics and Ecology, 2012, 40:1-3.