曹松，1966年10月生。華東理工大學藥學院教授、博士生導師。
基本介紹
- 中文名：曹松
- 國籍：中國
- 民族：漢族
- 出生地：不詳
- 出生日期：1966年10月
- 畢業院校：華東師範大學化學系
個人簡介,研究方向,獲獎成果,代表性論著,
個人簡介
分別在華東師範大學化學系、南京大學化學化工學院、華東理工大學化學與製藥學院獲得學士、碩士、博士學位。2000年起在華東理工大學化學與製藥學院從事科研與教學工作。2006.4-2007.4由教育部公派以訪問學者身份赴美國西北大學化學系從事帕金森藥物的設計與合成。
作為項目負責人承擔了上海科委科技創新和攻關項目；負責國家自然科學基金面上項目“合成含二氟甲基(CF2)的結構多樣性小分子的新策略”和“過渡金屬催化的多氟芳烴的碳氟鍵的活化：碳氫化及官能團化”兩項；負責十二五科技支撐計畫一項；作為課題組副組長負責國家863一項課題(第一階段、滾動階段、加強階段)以及國家973的子課題一項。
以主要作者在國內外核心學術雜誌如Chem Commun、Adv Synth Catal、ChemCatChem、Green Chem、Eur. J Org. Chem、Tetrahedron、Org Biomol Chem、Tetrahedron Lett、Synlett、J Agric and Food Chem、J Fluorine Chem等發表論文五十多篇；授權國家發明專利一項，申請中國發明專利四項、國際專利一項。現指導博士後、博士和碩士研究生多名。
Tetrahedron、Tetrahedron Letters和中國化學的常邀審稿人；Org Biomol Chem、Chem Comm、Chem Soc Rev、Chem Rev、J Fluorine Chem、J Agric Food Chem、BMCL及有機化學等期刊的審稿人。2009年Vol. 13, No. 18的Current Organic Chemistry的Guest Editor，編輯一期5篇由國際上不同領域的多組分專家寫的綜述的多組分反應的專刊。
研究方向
1.作用靶標特異的仿生農藥化學：昆蟲生長調節劑(苯甲醯脲類幾丁質抑制劑、具有蛻皮激素活性的非甾醇類二芳醯肼類化合物)；含惡二唑噠嗪酮類化合物拒食劑；魚尼丁受體氟蟲雙醯胺、氯蟲苯甲醯胺類化合物。
2.高效有機合成方法學(新型多組分反應的設計；多組分反應在農藥、醫藥中的套用；點擊化學參與的多組分反應)。
3.新型含氟砌塊的多組分反應；含氟活性化合物的合成。碳氟鍵的活化及官能團化。
獲獎成果
“芳香雜環及含氟仿生農藥的分子設計、合成製備及構效關係”獲2003年度教育部自然科學一等獎(第二完成人)
“含氟芳香精細化學品及氟化試劑的關鍵技術、理論與套用及產業化”獲2008年度國家科技進步獎二等獎(第四完成人)
代表性論著
以下為近期以第一作者或通訊作者在SCI發表的論文：
2013年
Novel Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles via a One-pot Three-Component Reaction of Boronic acids, Azides and Active methylene ketones
Jian Zhang, Guanyi Jin, Senhan Xiao, Jingjing Wu,Song Cao*
Tetrahedron, 2013, online
NiCl2(PCy3)2-catalyzed hydrodefluorination of fluoroarenes with LiAl(O-t-Bu)3H
Juan Xiao, Jingjing Wu, Wenwen Zhao,Song Cao*
J Fluorine Chem, 2013, online
2012年
One-pot Three Component Synthesis of Polyfluoroarylated ArylacetatesviaVNSAr-SNArReaction
Yang Xiong, Jingjing Wu, Senhan Xiao,Song Cao*
Chin J Chem2012, 30, 2747-2751
(Invited,Dedicated to the 60th Anniversary of East China University of Science and Technology)
One-Pot, Three-Component Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Starting from Primary Alcohols
Guanyi Jin, Jian Zhang, Dan Fu, Jingjing Wu,Song Cao*
Eur J Org Chem, 2012, 5446-5449
Synthesis ofunsymmetrical biaryl ethersthrough nickel-promotedcoupling ofpolyfluoroarenes with arylboronic acidsand oxygen
Jian Zhang, Jingjing Wu, Yang Xiong,Song Cao*
Chem Commun, 2012, 48, 8553-8555
Oxidation of benzylic methylenes to ketones with Oxone-KBr in aqueous acetonitrile under transition metal free conditions
Lixia Yin, Jingjing Wu, Juan Xiao,Song Cao*
Tetrahedron Letters, 2012, 53, 4418-4421
Synthesis and Insecticidal Activities of Novel Analogues of Flubendiamide Containing a Hexafluoroisopropanol Moiety
Mingxi Wu, Wenwen Zhao, Guanyi Jin, Qingchun Huang,Song Cao*
Chin J Chem2012, 30, 1310-1314
(Invited, Dedicated to Professor Jun Zhou on the occasion of his 80th birthday)
Highly efficient NiCl2/NiCl2(PCy3)2co-catalyzed hydrodefluorination of fluoroarenes and trifluorotoluenes with superhydride
Wenwen Zhao, Jingjing Wu,Song Cao*
Adv Synth Catal, 2012,354(4), 574-578
Synthesis of Difluoromethyl-Containing α-Acyloxycarboxamide Derivatives through a Passerini Reaction and Desulfonylation
Jingjing Wu, Wenwen Zhao,Song Cao*
Eur J Org Chem, 2012, 1380–1387
2011年
Synthesis of novelgem-difluoromethylene-containing 1,2,3-triazoles via click reaction
Wenwen Zhao, Hui Li, Jian Zhang,Song Cao*
Chin J Chem2011,29,2763-2768
(Invited, Dedicated to Professor Weiyuan Huang on the occasion of his 90th birthday)
Nickel-Catalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride (Lithium Triethylborohydride)
Jingjing Wu andSong Cao*
ChemCatChem,2011, 3(10), 1582-1586
Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation
Jingjing Wu, Hui Li,Song Cao*
Beilstein J Org Chem,2011, 7, 1070–1074
(Invited, Thematic Series: Multicomponent Reaction)
ZnCl2-catalyzed hydrodefluorination of gem-difluoromethylene derivatives with lithium aluminum hydride
Jianhang Cheng, Jingjing Wu,Song Cao*
Tetrahedron Letters, 2011, 52, 3481-3484
Novel synthesis of difluoromethyl-containing 1,4-disubstituted 1,2,3-triazoles via a click-multicomponent reaction and desulfanylation strategy
Jian Zhang, Jingjing Wu, Li Shen, Guanyi Jin,Song Cao*
Adv Synth Catal, 2011, 353(4), 580-584
One-pot synthesis of difluoromethyl-containing dihydropyrimidinones catalyzed by Yb(PFO)3under solvent and dehydrating agent free conditions
Mingxi Wu, Jinlong Yu, Wenwen Zhao, Jingjing Wu,Song Cao*
J Fluorine Chem, 2011, 132, 155-159
Non-catalytic conversion of C-F bonds ofgem-difluoromethylene derivatives to C-H bonds with lithium aluminum hydrideunder room temperature
JingJing Wu, JianHang Cheng, Jian Zhang, Li Shen, XuHong Qian andSong Cao*
Tetrahedron, 2011, 67,285-288
2010年
K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions
Li Shen,Song Cao*, Jingjing Wu, Hui Li, Jian Zhang, Mingxi Wu, Xuhong Qian*
Tetrahedron Letters, 2010, 51, 4866-4869
A mild and efficient synthesis of monofluorinateda-lactam pseudopeptides via a novel dehydrofluorination of Ugi products
Nianjin Liu,Song Cao*, Jingjing Wu, Li Shen, Jinlong Yu, Jian Zhang, Hui Li, Xuhong Qian*
Mol Divers, 2010, 14, 501-506
An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions
Hui Li, Jinlong Yu,Song Cao*, Li Shen, Mingxi Wu, Jianhang Cheng, Xuhong Qian*
ScienceChinaChemistry, 2010, 53(7), 1509-1513
Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Cachannels CaV1.3 and CaV1.2
Che-Chien Chang,Song Cao, Soosung Kang, Li Kai, Xinyong Tian, Prativa Pandey, Sara F. Dunne, Chi-Hao Luan, D. James Surmeier, Richard B. Silverman (第二作者)
Bioorg Med Chem, 2010, 18, 3147-3158
A General Strategy for Construction of Difluoromethyl Compound Library and its Application in Synthesis of Pseudopeptides bearing Terminal Difluoromethyl Group
Jingjing Wu,Song Cao*, Nianjin Liu, Li Shen, Jinlong Yu, Jian Zhang, Hui Li and Xuhong Qian
Org Biomol Chem, 2010, 8, 2386-2391
Synthesis and Insecticidal Activity of Heptafluoroisopropyl-Containing Benzoylphenylurea Structures
Jian Zhang, Xiuhong Tang, Isaac Ishaaya,Song Cao*, Jingjing Wu, Jinlong Yu, Hui Li, Xuhong Qian
J Agric Food Chem,2010, 58(5), 2736-2740
2009年
Multicomponent Reactions Based on Fluoro-ContainingBuilding Blocks
Jingjing Wu andSong Cao*
Curr Org Chem, 2009, 13(18), 1791-1840
(Invited, Guest Editor, Thematic Series: Multicomponent Reaction)
A revisit to the Hantzsch reaction: Unexpected products beyond 1,4-dihydropyridines
Li Shen,Song Cao*, Jingjing Wu, Jian Zhang, Hui Li, Nianjin Liu and Xuhong Qian*
Green Chemistry,2009, 11, 1414-1420
New gem-difluoromethylene-containing isocyanide as a useful building block for the synthesis of difluorinated pseudopeptides via Ugi reaction
Nianjin Liu,Song Cao*Li Shen, Jingjing Wu, Jinlong Yu, Jian Zhang, Hui Li, Xuhong Qian*
Tetrahedron Letters, 2009, 5, 1982-1985
2008年
One-Pot Synthesis of Trifluoromethyl-Containing Pyrazoles via Sequential Yb(PFO)3- Catalyzed Three-Component Reaction and IBX-Mediated Oxidation
Li Shen, Jian Zhang,Song Cao*, Jinlong Yu, Nianjin Liu, Jingjing Wu, Xuhong Qian*
Synlett2008, 19, 3058-3062
Ytterbium (III) Perfluorooctanoate-catalyzed One-pot Three-component Synthesis of Fully Substituted Pyrazoles under Solvent-free Conditions
Li Shen,Song Cao*, Nianjin Liu,Jingjing Wu, Xin Feng, Xuhong Qian*
Synlett2008, 9, 1341-1344
One-Pot Three Component Synthesis of Heteroaryled arylacetates via VNSAr-SN Reaction using N-Methylpyrrolidone as General Solvent
Song Cao*, Jingjing Wu, Lina Li, Longjie Zhu, Jian Zhang, Jinlong Yu, Xuhong Qian
Org Biomol Chem, 2008, 6 (7), 1293-1297
Solvent-Free Ugi Four-Component Condensation: Application to Synthesis of Philanthotoxins-12 Analogues
Nianjin Liu,Song Cao*, Jingjing Wu, Jinlong Yu, Li Shen, Xin Feng and Xuhong Qian*
Tetrahedron, 2008, 64(18), 3877-4142
Synthesis of Thiohydantoins under One-Pot Three-Component Solvent-Free Conditions
Song Cao*, Longjie Zhu, Chuanmeng Zhao, Xiuhong Tang, Huajun Sun, Xin Feng, Xuhong Qian
Monatshefte fur Chemie, 2008, 139, 923-926
2007-2001年
An Efficient and Practical Method for the Synthesis of 1-(2,6-Difluorobenzoyl)-3-[2’-alkyl-3’- oxopyridazin-4’-yl]ureas as Potential Chitin Synthesis Inhibitors
SongCao, Deli Lu, Chuanmeng Zhao, LinaLi,Qingchun Huang,XuhongQian*
Monatshefte fur Chemie, 2006, 137(6), 779-784
Syntheses, Antifeedants and QSAR Analysis of New Oxa(thia)diazolyl 3(2H)-Pyridazinones
Song Cao, Na Wei, Chuanmeng Zhao, Lina Li, Qingchun Huang, Xuhong Qian*
J of Agric and Food Chem, 2005, 53, 3120-3125
Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2H)-Pyridazinones
Song Cao, Xuhong Qian*, Gonghua Song, Bing Chai, Zhisheng Jiang
J of Agric and Food Chem, 2003, 51, 152-155
Synthesis of 3-Aryl-1,3,5-pentanetricarboxylic acid trialkyl esters via a Tandem Addition- Rearrangement-Addition Reaction
Song Cao*, Zheng Zhang, Ai-Long Fan,Zi-Ming Huang
Monatshefte fur Chemie, 2003, 134, 529-532
Syntheses and insecticidal activity of new 2-(5-(trifluoromethyl)pyridyloxymethyl)-1,3,4– oxadiazoles
Song Cao, Xuhong Qian*, Gonghua Song, Qingchun Hung
J of Fluorine Chem, 2002, 117, 63-66
N’-tert-butyl-N’-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazines, A Novel Nonsteroidal Ecdysone Agonist: Syntheses , Conformational and Crystal Structure Analysis
Song Cao, Xuhong Qian*, Gonghua Song
Canadian J of Chem, 2001, 79, 272-278
A Novel and Practical Amination of 4,5-Dichloropyridazinones via Hydrazine Hydrate Reduction
Song Cao, Xuhong Qian*, Gonghua Song, Xiayu Huang
Chemistry Letters, 2001, 1, 54-55
