張琚(南開大學分子生物學研究所研究員)

張琚(南開大學分子生物學研究所研究員)

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1956年4月生,天津市人。南開大學分子生物學研究所研究員。博士(奧地利)。南開大學生物化學專業本科及碩士研究生畢業。

基本介紹

  • 中文名:張琚
  • 職業:教授
  • 性別:女
  • 所屬部門:生物化學和分子生物學系
人物簡介,主要學術論文,

人物簡介

姓名:張琚
張琚教授張琚教授
性別:女
職稱:教授
所屬部門:生物化學和分子生物學系
研究方向:雌激素在相關疾病中的作用機制;前列腺癌血清學分子標誌物的篩選;具有雌激素樣活性中藥與相關疾病的防治
1989.5-1994-1在奧地利因斯布魯克大學生物化學所讀博士學位,從牛肝線粒體膜上分離純化了一種NAD+糖水解酶,胺基酸序列分析證明其是一未知蛋白。此研究成果分別在《FEBSLETTER》和《Biochemistry》上發表。1994.1獲奧地利理學博士學位。1994.1-1996.1在奧地利因斯布魯克大學泌尿醫院前列腺研究中心作博士後,在體外成功地培養了前列腺的平滑肌細胞,為前列腺基質增生病因及治療藥物的研究奠定了基礎。1996年在南開大學分子生物學研究所任研究員。1998.9-1998.12再次赴德國柏林泌尿醫院進修。從事金屬蛋白酶及其抑制劑在前列腺基質細胞中的表達及調節的研究。1999年初被聘為南開大學生命科學院博士生導師。現專職從事科研工作。研究方向主要為:“前列腺增生基質病變的分子機制”“前列腺癌微小轉移的分子生物指標”“金屬蛋白酶在前列腺癌轉移中的作用”。自1995年至今就前列腺研究領域在國際國內雜誌上發表了20餘篇學術論文。

主要學術論文

:張立國、石建黨、馮劍利、李鐘、張琚. Type IV collagenase (matrix metalloproteinase-2 and-9) in prostate cancer. PROSTATE CANCER AND PROSTATIC DISEASES 7-4-327.2005-1-1
吳荃,周穎,陳林峰,石建黨,王春雨,苗琳,Mocker, H; Park, I;李鐘,張琚. Benign prostatic hyperplasia (BPH) epithelial cell line BPH-1 induces aromatase expression in prostatic stromal cells via prostaglandin E2. JOURNAL OF ENDOCRINOLOGY
王春雨,石建黨,閆春和,吳荃,Klocker, H; Park, I;李鐘,張琚. Development of a cell-isolation method for human prostatic smooth muscle cells based on cell type-specific activation of the SM22 gene promoter. BJU INTERNATIONAL
Zhang, J; Qi, HX; Wang, HJ; Hu, P; Ou, LL; Guo, SH; Li, J; Che, YZ;Yu,YT; Kong, DL. Engineering of vascular grafts with genetically modified bone marrow mesenchymal stem cells on poly (propylene carbonate) graft. ARTIFICIAL ORGANS
張智松王亮梅玫朱彥杜小玲李鐘Irwin Park張琚石建黨. Both nongenomic and genomic effects are involved in estradiol’s enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells. The Prostate
樊官偉高秀梅王宏朱彥張琚胡黎明Yan-Fang Su, Li-Yuan Kang,張伯禮. The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estr. Journal of Steroid Biochemistry & Molecular Biology
周穎肖向茜陳林鋒楊睿石建黨杜小玲Helmut Klocker, Irwin Park李鐘張琚. Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats. Asian Journal of Andrology
Irwin I Park, Qiang Zhang, Victoria Liu,張琚, Chung Lee. Estrogen at low concentrations acts through distinct pathways in normal versus BPH-derived prostate stromal cells. the Journal of Clinical Endocrinology
張立國王春雨楊睿石建黨符蓉陳林鋒Helmut Klocker張琚. Real-time quantitative RT-PCR assay of prostate-specific antigen and prostate-specific membrane antigen in peripheral blood for detection of prostate cancer micrometastasis. Urol Oncol
張智松段磊杜小玲馬洪順Irwin Park李鐘張琚石建黨. The proliferative effect of estradiol on human prostate stromal cells is mediated through activation of ERK. The Prostate
吳荃石建黨陳林鋒王春雨Irwin Park李鐘張琚. Regulation of proliferation and differentiation of prostatic stromal cells by estradiol through prostateic epithelial cells (BPH-1) in a paracrine manner. The BJU International
劉樹業Yu XD, Song CJ, Lu W, Zhang JD, Shi XR, Duan Y張琚. Cloning and expression of special F protein from human liver. World Journal of Gastroenterology
牛遠傑馬騰驤張琚徐勇韓瑞發孫光. Androgen and prostatic stroma. ChinaAsian J Androl
Zhou W, Park I, Pins M, Kozlowski JM, Jovanovic B,張琚,李鐘, Ilio K. Dual regulation of proliferation and growth arrest in prostatic stromal cells by transforming growth factor-beta1. Endocrinology
張琚Klaus Jung, Michael Lein, Glen Kristiansen, Birgit Rudolph, Steffen Hauptmann, Dietmar Schnorr, Stefan A. Loening, and Ralf Lichtenhagen. Differential expression of matrix metalloproteinases and their tissue inhibitors in human primary cultured prostatic cells and malignant prostate cell lines. The Prostate
牛遠傑徐勇張琚BAI.H.YANG馬騰驤. Proliferation and differentiation of prostatic stromal cells. BJU International
Simone T. Boesch, Stefan Corvin,張琚, Hermann Rogatsch, George Bartsch, and Helmut Klocker. Modulation of the Differentiation Status of Cultured Prostatic Smooth Muscle Cells by an a1-Adrenergic Receptor Antagonist. The ProstateFibroblast Growth Factor Levels in Cancer Cell and in Sera of Patients suffering from Proliferative Disorders of the Prostate. The Prostate 31--223-233.1997-1-1
張琚, Michael W. Hess, Martin Thurnher, Alfred Hobisch, Christian Radmayr, Marcus V. Cronauer, Anton Hittmair, Zoran Culig, Georg Bartsch and Helmut Klocker. Human prostatic smooth muscle Cell in culture: Estradiol enhances expression of smooth muscle cell-specific markers. The prostate
Zoran culig, Alfred hobisch, Marcus V. Cronauer, Christian Radmayr, Anton Hittmair,張琚, Martin Thurnher, Georg Bartsch and Helmut Klocker. Regulation of prostatic growth and function by peptide growth factors. The prostate
Mathias ziegler, Dierk Jorcke,張琚, Rainer Schneider, Helmut Klocker, Bernhard Auer, Manfred Schweiger. Characterization of Detergent-Solubilized Beef Liver Mitochodrial NAD?glycohydrolase and its Truncated Hydrosoluble Form. Biochemistry 35-16-5207-12.1996-4-23
張琚, Mathias Ziegler, Rainer Schneider, Helmut Klocker, Bernhard Auer, Manfred Schweiger. identification and purification of a bovine liver mitochondrial NAD?glycohydrolase. FEBS LETTERS
楊睿,張立國,符蓉,王春雨,劉樹業,石建黨,張琚. 實時定量PCR技術檢測前列腺癌微小轉移的研究. 南開大學學報
於林,王春雨,楊睿,王亮,石建黨*,張琚. TAT-GFP-ERB融合蛋白的原核表達與鑑定. 南開大學學報
周穎,楊睿,石建黨*,劉傑,杜小玲,王克明,張琚*. BPH間質細胞增殖和表型轉化與雌激素受體α表達的關係. 解剖學報
苗琳,石建黨*,周穎,杜小玲,吳荃,王克明,張琚*. BPH-1通過分泌PGE2上調前列腺間質細胞ERR?的表達. 中國生物化學與分子生物學報
張智松,劉傑,杜小玲,段磊,張琚*,石建黨. 雌激素快速激活MAPK途徑促進前列腺間質細胞的增殖. 中國生物化學與分子生物學報
Rui Yang, Yu-Xia Ma, Lin-Feng Chen, Ying Zhou1, Zhan-Po Yang, Yan Zhu, Xiao-Ling Du, Jian-Dang Shi*, Hong-Shun Ma, Ju Zhang*. Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia. Asian Journal of Andrology
苗琳;周穎;石建黨;杜小玲;焦鴻麗;張琚. 雌二醇通過TGFβ1促進前列腺間質細胞MMP-2的表達. 中國生物化學與分子生物學報 25-8-712-718.2009-8-1
Lin Miao, Jiandang Shi , Chun-Yu Wang, Yan Zhu, Xiaoling Du, Hongli Jiao, Zengnan Mo, Helmut Klocker, Chung Lee, Ju.Zhang. Estrogen receptor-related receptor alpha mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells. Mol Endocrinol
Rui Yang, Da Xu, Jiandang Shi*, Helmut Klocker, Chung Lee, Ju Zhang*. Tanshinone IIA inhibits estrogen/androgen induced prostatic stromal hyperplasia. The Journal of Urology --.
Lin Yu, Jiandang Shi, Chun Yu Wang, Helmut klocker, Doris Mayer*, Ju Zhang*. Estradiol promotes the invasive potency of prostate cancer cells in a paracrine manner through stimulation of prostatic stromal cells. The Journal of Urology --.
Z.S. Zhang, L. Wang, H.S. Ma, X.L. Du, J. Zhang*, J.D. Shi* . nongenomic and genomic effects are involved in estradiol’s enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells(AUA). The Journal of Urology --.2009-5-28
Y. Zhou, X.Q. Xiao, R. Yang, J.D. Shi*, X.L. Du, J. Zhang*. Dynamic changes of stromal cell in the process of estrogen/androgen induced prostatic stromal hyperplasia in castrated rats. The Journal of Urology --.2009-5-28
賈金銘;馬衛國;焦擁政;王家輝;羅少波;張琚;張智松. 癃必消膠囊對體外培養的人前列腺增生間質細胞作用機制的實驗研究. 中國中西醫結合雜誌
劉樹業;杜智;商國強;賈艷慧;段纓;宋佐莉;張琚.. 肝癌中C53的表達及臨床病理表現初探. 分子診斷與治療雜誌 1-2-104-107.2009-7-1
馬衛國;賈金銘;焦擁政;王家輝;羅少波;張琚;石建黨;張智松. 癃必消膠囊對體外培養的人前列腺增生間質細胞Fibronectin和Collagen IV基因表達的影響. 中國男科學雜誌
馬衛國;賈金銘;焦擁政;王家輝;羅少波;張琚;石建黨;張智松. 癃必消膠囊對體外培養的人前列腺增生間質細胞TGF-β1和Smoothelin基因表達的影響. 中華男科學雜誌
袁慶東;肖向茜;梁承;張琚;趙建國. 電針用於治療大鼠實驗性前列腺增生症的機制研究. 中國康復醫學雜誌 23-6-532-534.2008-6-1
樊官偉;王虹;張琚;高秀梅. 植物雌激素的臨床價值. 國外醫藥(植物藥分冊)
Iris E.Eder,Stefan Corvin,Christoph Maneschg,Marcus V.Cronauer,Georg Bartsch Jr,Ju Zhang,Arnulf Stenzl,Georg Bartsch,Helmut Klocker.. Selective culture conditions for different types of primary human bladder cells. World J Urol 18--371-375.2000-8-1
樊官偉,張琚,高秀梅. 選擇性雌激素受體調節劑. 醫學分子生物學雜誌
Yu Lin; Wang Chunyu; Shi Jiandang; Miao Lin; Du Xiaoling; Mayer Doris; Ju Zhang*. Estrogens Promote Invasion of Prostate Cancer Cells in a Paracrine Manner through Up-Regulation of Matrix Metalloproteinase 2 in Prostatic Stromal Cells. Endocrinology
Linjian Mo, Ju Zhang, Jiandang Shi, Qiang Xuan, Xiaoli Yang, Min Qin,Chung Lee, Helmut Klocker, Qingdi Quentin Li and Zengnan Mo. Human Kallikrein 7 Induces Epithelial?Mesenchymal Transition-like Changes in Prostate Carcinoma Cell. Anticancer Research.
YunFeng Cui , ZhongLian Li , ErPeng Zhao , YanFeng Jia , DongHua Li , Ju Zhang and NaiQiang Cui. Overexpression of Sterol Carrier Protein 2 in Patients with Hereditary Cholesterol Gallstones. BMC Gastroenterology 11--1-10.2011-2-2
彭雁飛,師瑩,王亮,石建黨*,楊小麗,張琚*. 用腺病毒載體包裝不同分化程度平滑肌細胞特異性啟動子的策略分離鑑定人前列腺間質細胞亞群. 南開大學學報
Lin Yu, Jiandang Shi, Sa Cheng, Yan Zhu, Xiulan Zhao, Kuo Yang, Xiaoling Du,Helmut klocker,Xiaoli Yang,Ju Zhang*. Estrogen promotes prostate cancer cell migration via paracrine release of ENO1 from stromal cells. Molecular Endocrinology
杜小玲,寧召臣,王春雨,石建黨,張琚*. 類固醇激素受體輔助調節因子ARA55和TGFβ1在前列腺癌細胞中作用分子機制的研究. 南開大學學報(自然科學版)
Lin Miao, Sina Grebhardt, Jiandang Shi, Isabelle Peipe, Ju Zhang, Doris Mayer. Prostaglandin E2 stimulates S100A8 expression by activating protein kinaseA and CCAAT/enhancer-binding-protein-beta in prostate cancer cells . The International Journal of Biochemistry & Cell Biology --1

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