張健存，博士，研究員。
基本介紹
- 中文名：張健存
- 性別：男
- 學歷：博士
- 職稱：研究員
- 國籍：中國
基本信息,簡歷,研究領域,代表論著,
基本信息
姓 名: 張健存
性 別: 男
職 務:
職 稱: 研究員
學 歷: 博士
通訊地址: 廣州科學城國際企業孵化器
簡歷
1985-1990 美國University of Pittsburgh有機化學博士
1984-1985 中山大學英語培訓中心英語培訓
1980-1984 復旦大學學
2005- 至今 中國科學院廣州生物醫藥與健康研究院，研究員
2000-2004 上海交通大學藥學院，教授
2002-2004 清華源興生物醫藥與科技公司，首席科學官
1992-2001 Gilead Sciences公司，資深科學家
1990-1992 Duke大學博士後
研究領域
我們的研究套用現代化學技術致力於研究和開發人類和社會需求的創新藥物。
包括
1. 研究和開發新型特別是以核苷類小分子為基礎的化學藥物;
2. 合理設計和合成及天然產物的合成和修飾小分子抗癌藥物
3.寡聚核苷酸衍生物的設計和合成
4. 藥物合成工藝及新有機合成方法的研究。
代表論著
(1) Yu Zhao, Deyao Li, Liwen Zhao, Jiancun Zhang* A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamides in PEG-400 Synthesis
(2) Liwen Zhao, Kemei Tao, Haitian Li and Jiancun Zhang* Practical one-pot protocol for the syntheses of 2-chloro-pyrrolo[3,2-d]pyrimidines Tetrahedron, 2011, in print
(3) Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang,* and Qiang Zhu* A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines. J. AM. CHEM. SOC
(4) YIN BIAOLIN; LIU ZHAOGUI; ZHANG JIANCUN; LI ZHENGRONG N,N '-Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds Synthesis
(5) Baishan Jiang, Kemei Tao, Wang Shen,*, Jiancun Zhang,* Facile synthesis of 2-bromoindoles by ligandfree CuI-catalyzed intramolecular crosscoupling of gem- dibromoolefins. Tetrahedron Letters.
(6) Li, Deyao; Zhao, Yu; Ye, Liu; Chen, Chaonan; Zhang, Jiancun. A Formal Total Synthesis of Fostriecin by a Convergent Approach. Synthesis
(7) Zhao Lingli, Jin Changjiang, Chu Youjun, Varghese Chris, Hua Shasha, Yan Feng, Miao Yong, Liu Jing, Mann David, Ding Xia, Zhang Jiancun, Wang Zhiyong, Dou Zhen, Yao Xuebiao*. Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity. Journal of Biological Chemistry
(8) Kemei Tao, Jianlong Zheng, Zhaogui Liu, Wang Shen,* Jiancun Zhang * Facile synthesis of benzoxazoles from 1,1-dibromoethenes. Tetrahedron Letters
(9)Zhaogui Liu , Deyao Li , Biaolin Yin， Jiancun Zhang*，Highly stereoselective synthesis of 20-deoxy-b-ribonucleosides via a 3’-(N-acetyl)-glycyl- directing group. Tetrahedron Letters
(10) Yin, Biao-Lin; Liu, Zhao-Gui; Zhang, Jian-Cun; Li, Zheng-Rong: N, N′-Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds Tetrahedron Letters
(11) Liu Ye, Qian Chen,* Jiancun Zhang,*, and V_eronique Michelet*, PtCl2- Catalyzed Cycloisomerization of 1,6-Enynes for the Synthesis of Substituted Bicyclo[3.1.0]hexanes. J. Org.Chem
(12)Wen Lu Liu, Jiancun Zhang *, Fa Qin Jiang, and Lei Fu，Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues. Arch. Pharm. Chem. Life Sci.
(13) Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang *, Qiang Zhu * An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas. Tetrahedron Letters
(14) Jianlong Zheng, Biaolin Yin, Wenming Huang, Xiaopeng Li, Hequan Yao, Zhaogui Liu, Jiancun Zhang, Sheng Jiang. Efficient and selective cleavage of the t-butoxycarbonyl group from di-t-butylimidodicarbonate using catalytic bismuth(III) bromide in acetonitrile. Tetrahedron Letters
(15) Kai Yuan, Na Li, Kai Jiang, Tongge Zhu, Yuda Huo, Chong Wang, Jing Lu, Andrew Shaw, Kelwyn Thomas, Jiancun Zhang, David Mann, Jian Liao, Changjiang Jin, and Xuebiao Yao, PinX1 Is a Novel Microtubule-binding Protein Essential for Accurate Chromosome Segregation, Journal of Biological Chemistry,
(16) Biaolin Yin, Zhaogui Liu, Mingjun Yi, and Jiancun Zhang*, A n efficient method for the synthesis of disubstituted thioureas via the reaction of N, N’-di-Boc-substituted thiourea with alkyl and aryl amines under mild conditions, Tetrahedron Lett.
(17) Chen Yao, Peng Yingdan, Jiancun Zhang, Lei fu，Syntheses and biological evaluations of novel selenonucleosides, Nucleoside, Nucleotide and Nuclei Acids”
(18) YIN Biao-Lin, CHEN Li, XU. Han-hong, ZHANG. Jian-Cun, WU. Yu-Lin, Synthesis and Bio-activities of Pyrazole, Pyridine Substituted Tonghaosu Analogs. Chinese Journal of Chemistry
(19) J. Zhang, J. Shaw and M. Matteucci “an Oligonucleotide Containing a Pentathymidine 3’-thioformacetal Unit: Synthesis and Binding Studies” Bioorganic and Medicinal Chemistry Letters
(20) J. Zhang and M. Matteucci “2-Thioquinolines as Masked Sulfhydryls, the development of a Novel Sulfur Protecting group” Tetrahedron Letters
(21) J. Zhang and M. Matteucci “Synthesis of a PH-mediated N-Acylsulfamide Linked Dinucleotide and Its Incorporation into an Oligonucleotide” Bioorganic and Medicinal Chemistry Letters
(22) J. Zhang, T. Terhost and M. Matteucci “Synthesis and Preliminary Hybridization study of a Boranophosphate-linked Oligonucleotide” Tetrahedron Letters
(23) J. Zhang and M. Matteucci “a Mild Method for the Synthesis of 3’-Thioformacetal Dinucleotide: the Development of Diphenylphosphinate Acetal as a Glycosylating agents” Tetrhedron Letters
(24) M. C. Pirrung, J. Zhang, K. Lackey, D. D. Sternbach and F. Brown “Reactions of a Cyclic Rhodium Carbenoid with Aromatic Compounds and Vinyl ethers” J. Org. Chem.
(25) M. C. Pirrung, J. Zhang and A. T. Morehead, Jr “Dipolar Cycloaddition of Rhodium Carbenoids to Digonal Carbon. Synthesis of Isoeuparin” Tetrahedron Letters
(26) D. P. Curran, W. Shen, J. Zhang, S. V. Geib and C.-H. Lin “Controlling Stereochemistry in Radical addition and Cycloaddition reactions with Oppolzer’s Camphor Sulam” Heterocycles
(27) M. C. Pirrung and J. Zhang “Asymmetric Cycloaddition Reactions of Diazocompounds Mediated by a Binaphthophosphate Rhodium Catalyst” Tetrahedron Letters
(28) J. Zhang and D. P. Curran “the Cycloadditive Route to syn 1,2-Diols. The Total Syntheses of Brevicomin and (-)-Pestalotin” J. Chem. Soc., Perkin Trans.
(29) M.C. Pirrung, J. Zhang and A. T. McPhail “Dipolar Cycloadditions of Cyclic Rhodium Carbenoids to Aromatic heterocycles” J. Org. Chem
(30) D. P. Curran and J. Zhang “Nucleophilic Addition and reduction of 5-Acyl and 5-Formyl-isoxazolines. A General preparation of syn and anti -dihydroxylcarbonyls” J. Chem. Soc., Perkin Trans
(31) D. P. Curran, W. Shen, J. Zhang and T. A. Heffner “Asymmetric Radical Addition, Cycloaddition and Annulation reactions with Oppolzer’s Camphor Sultam” J. Am. Chem. Soc.
(32) J. Zhang “Nucleosides, Nucleotides and Nucleic Acids” and “Peptides and Proteins” in “Natural Products Synthesis”, Li Shaoshun Ed. 2004, chemistry industry publisher
(32) K. Tao, Y. Zhou and J.Zhang “A Practical Synthesis of Fulvoxamine” Chinese Pharmaceutical industry
(34) 劉舒暢，張健存，陳賽娟. BCR-ABL蛋白激酶抑制劑的研究進展. 中國醫藥工業雜誌
(35) 冉 旭, 白 永, 陳 堯, 姜發琴, 張健存, 傅 磊. 疊氮無環核苷的製備、表征及活性測試.中國新藥雜誌.
(36) 陳 堯, 冉 旭, 張健存, 傅 磊. 苄基保護的L - 核苷的製備. 化學研究與套用
(37) 張 璇, 張健存. 抗腫瘤新藥——Combretastatin A4 磷酸酯.中國藥房
(38) 盧 寧, 彭英丹, 傅 磊, 張健存. 西多福韋的合成.中國新藥雜誌
(39) 陶克美，周 勇，張健存.馬來酸氟伏沙明的合成. 中國醫藥工業雜誌
(40) 王戰會，李進，丁彥青，何玫，劉壯俊，王慧君，張克，楊潔，馬世武，唐小平，何建國，潘武賓，秦華，蔣英麗，郝彬，盧潔，馬愛妞，李惠麗，趙文娟，徐宇虹，張健存，王永祥，王小寧，周向軍，侯金林. 人類感染的SARS病毒來源於果子狸的分子病毒學依據. 研究快報 2003
