基本介紹
- 中文名：宋慶鑫
- 學位/學歷：博士/研究生
- 職業：教師
- 職稱：教授
個人簡介,研究方向,發表論文,
個人簡介
2006年本科畢業於瀋陽農業大學，2006-2013 年在中國科學院遺傳與發育生物學研究所攻讀博士學位，期間主要研究種子油脂合成調控的分子機理。2013年-2018 年，在美國德克薩斯大學奧斯汀分校從事博士後研究，主要從表觀遺傳修飾和轉錄調控網路兩個角度研究雜種優勢和多倍體化形成的遺傳機制。2018 年9 月作為南京農業大學高層次引進人才到農學院任教授。研究論文主要發表在《Nature Genetics》、《Plant Cell》、《PNAS》、《Genome Biology》、《Molecular Plant》、《Nature Communications》等國際主流期刊。
入選國家青年人才、江蘇雙創團隊領軍人才和江蘇特聘教授；主持國家重點研發計畫青年科學家項目和國家自然科學基金委面上項目等；獲得中國農學會青年科技獎和中科院遺傳發育所“20年20人”等榮譽；擔任Industrial Crops & Products雜誌副主編、 Genome Biology和Frontiers in Plant Science等雜誌編委；常年擔任Nature Communications、Genome Biology、Molecular Plant、Nucleic Acids Research等雜誌審稿人。
研究方向
在自然進化和人工馴化過程中，作物的形態發生巨大變化。實驗室主要以大豆為材料，綜合利用生物信息學、群體遺傳學和基因編輯等手段，研究表觀遺傳在多倍體作物進化和馴化中的作用以及鑑定與作物重要農藝性狀相關的遺傳和表觀遺傳位點，進一步通過人工設計對農作物進行改良並探索創製多倍體新物種。
發表論文
Cao S, Chen K, Lu K, Chen S, Zhang X, Shen C, Zhu S, Niu Y, Fan L, Chen, ZJ*, Xu J*, Song Q*. (2023) Asymmetric variation in DNA methylation during domestication and de-domestication of rice The Plant Cell. 35:3429-3443
Zhang M, Zhang X, Jiang X, Qiu L, Jia G, Wang L, Ye W, Song Q*. (2022) iSoybean: a database for the mutational fingerprints of soybean. Plant Biotechnology Journal, 20:1435-1437
Cao S, Wang L, Han T, Ye W, Liu Y, Sun Y, Moose SP, Song Q*, Chen ZJ*. (2022) Small RNAs mediate transgenerational inheritance of genome-wide trans-acting epialleles in maize. Genome Biology, 23:53
Yuan J, Sun H, Wang Y, Li L, Chen S, Jiao W, Jia G, Wang L, Mao J, Ni Z, Wang X, Song Q*. (2022) Open chromatin interaction maps reveal functional regulatory elements and chromatin architecture variations during wheat evolution. Genome Biology. 23:34
Wang L, Jia G, Jiang X, Cao S, Chen ZJ, Song Q*. (2021) Altered chromatin architecture and gene expression during polyploidization and domestication of soybean. The Plant Cell. 33: 1430-1446
Yuan J, Jiao W, Liu Y, Ye W, Wang X, Liu B, Song Q*, Chen ZJ*. (2020) Dynamic and reversible DNA methylation changes induced by genome separation and merger of polyploid wheat. BMC Biology. 18:171
Liu Y#, Yuan J#*, Jia G, Ye W, Chen ZJ*, Song Q*. (2020) Histone H3K27 dimethylation landscapes contribute to genome stability and genetic recombination during wheat polyploidization. Plant Journal. doi: 10.1111/tpj.15063
Chen ZJ#*, Sreedasyam A#, Ando A#, Song Q#, De Santiago LM#, Hulse-Kemp AM, Ding M, Ye W, Kirkbride RC, Jenkins J, Plott C, Lovell J, Lin YM, Vaughn R, Liu B, Simpson S, Scheffler BE, Wen L, Saski CA, Grover CE, Hu G, Conover JL, Carlson JW, Shu S, Boston LB, Williams M, Peterson DG, McGee K, Jones DC, Wendel JF, Stelly DM, Grimwood J* and Schmutz J. (2020) Genomic diversifications of five Gossypium allopolyploid species and their impact on cotton improvement. Nature Genetics. 52:525-533
Song Q#, Ando A#, Jiang N, Ikeda Y and Chen ZJ*. (2020) Single-cell RNA-seq analysis reveals ploidy-dependent and cell-specific transcriptome changes in Arabidopsis female gametophytes. Genome Biology. 21:178
Yin D#*, Ji C#, Song Q#, Zhang W#, Zhang X, Zhao K, Chen CY, Wang C, He G, Liang Z, Ma X, Li Z, Tang Y, Wang Y, Li K, Ning L, Zhang H, Zhao K, Li X, Yu H, Lei Y, Wang M, Ma L, Zheng H, Zhang Y, Zhang J*, Hu W* and Chen ZJ*. (2020) Comparison of Arachis monticola with Diploid and Cultivated Tetraploid Genomes Reveals Asymmetric Subgenome Evolution and Improvement of Peanut. Advanced Science. 7:1901672
Song Q#, Huang TY#, Yu HH, Ando A, Mas P, Ha M, Chen ZJ*. (2019) Diurnal regulation of SDG2 and JMJ14 by circadian clock oscillators orchestrates histone modification rhythms in Arabidopsis. Genome Biology. 20:170
Song Q, Ando A, Xu D, Fang L, Zhang T, Huq E, Qiao H, Deng XW*, Chen ZJ*. (2018) Diurnal down-regulation of ethylene biosynthesis mediates biomass heterosis. PNAS. 115: 5606-5611.
Song Q, Zhang T, Stelly D and Chen ZJ*. (2017) Epigenomic and functional analyses revealed roles of epialleles in the loss of photoperiod sensitivity during domestication of allotetraploid cottons. Genome Biology. 18:99.
Song Q, Guan X and Chen ZJ*. (2015) Dynamic Roles for Small RNAs and DNA Methylation during Ovule and Fiber Development in Allotetraploid Cotton. PLoS Genetics 11:e1005724.
Miller M#, Song Q#, Shi X, Juenger TE and Chen, ZJ*. (2015) Natural variation in timing of stress-responsive gene expression predicts heterosis in intraspecific hybrids of Arabidopsis. Nature Communications 6:7453.
Song Q and Chen, ZJ*. (2015) Epigenetic and developmental regulation in plant polyploids. Current Opinion Plant Biology 24:101-109.
Song QX#, Li QT#, Liu YF, Zhang FX, Ma B, Zhang WK, Man WQ, Du WG, Wang GD, Chen SY* and Zhang JS*. (2013) Soybean GmbZIP123 gene enhances lipid content in the seeds of transgenic Arabidopsis plants. Journal of Experimental Botany 64:4329-4341.
Song QX, Lu X, Li QT, Chen H, Hu XY, Ma B, Zhang WK, Chen SY* and Zhang JS*. (2013) Genome-wide analysis of DNA methylation in soybean. Molecular Plant 6:1961-1974.
Song QX, Liu YF, Hu XY, Zhang WK, Ma B, Chen SY* and Zhang JS*. (2011) Identification of miRNAs and their target genes in developing soybean seeds by deep sequencing. BMC Plant Biology 11:5.
Li QT, Lu X, Song QX, Chen HW, Wei W, Tao JJ, Bian XH, Shen M, Ma B, Zhang WK, Bi YD, Li W, Lai YC, Lam SM, Shui GH, Chen SY* and Zhang JS*. (2017) Selection for a Zinc-Finger Protein Contributes to Seed Oil Increase during Soybean Domestication. Plant Physiology 173:2208-2224.
Saski CA*, Scheffler BE, Hulse-Kemp AM, Liu B, Song Q, Ando A, Stelly DM, Scheffler JA, Grimwood J, Jones DC, Peterson DG, Schmutz J and Chen ZJ. (2017) Sub genome anchored physical frameworks of the allotetraploid Upland cotton (Gossypium hirsutum L.) genome, and an approach toward reference-grade assemblies of polyploids. Scientific Reports 7:15274.
Zheng D, Ye W, Song Q, Han F, Zhang T and Chen ZJ*. (2016) Histone Modifications Define Expression Bias of Homoeologous Genomes in Allotetraploid Cotton. Plant Physiology 172:1760-1771.
Ko DK, Rohozinski D, Song Q, Taylor SH, Juenger TE, Harmon FG and Chen ZJ*. (2016) Temporal Shift of Circadian-Mediated Gene Expression and Carbon Fixation Contributes to Biomass Heterosis in Maize Hybrids. PLoS Genetics 12:e1006197.
Zhang T*, Hu Y, Jiang W, Fang L, Guan X, Chen J, Zhang J, Saski CA, Scheffler BE, Stelly DM, Hulse-Kemp AM, Wan Q, Liu B, Liu C, Wang S, Pan M, Wang Y, Wang D, Ye W, Chang L, Zhang W, Song Q, Kirkbride RC, Chen X, Dennis E, Llewellyn DJ, Peterson DG0, Thaxton P, Jones DC, Wang Q, Xu X, Zhang H, Wu H, Zhou L, Mei G, Chen S, Tian Y, Xiang D, Li X, Ding J, Zuo Q, Tao L, Liu Y, Li J, Lin Y, Hui Y, Cao Z, Cai C, Zhu X, Jiang Z, Zhou B, Guo W*, Li R* and Chen ZJ*. (2015) Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement. Nature Biotechnology 33:531-537.
Tuttle JR, Nah G, Duke MV, Alexander DC, Guan X, Song Q, Chen ZJ, Scheffler BE and Haigler CH*. (2015) Metabolomic and transcriptomic insights into how cotton fiber transitions to secondary wall synthesis, represses lignification, and prolongs elongation. BMC Genomics 16:477.
Guan X, Song Q and Chen ZJ*. (2014) Polyploidy and small RNA regulation of cotton fiber development. Trends Plant Science 19:516-528.
Guan X, Nah G, Song Q, Udall JA, Stelly DM and Chen ZJ*. (2014) Transcriptome analysis of extant cotton progenitors revealed tetraploidization and identified genome-specific single nucleotide polymorphism in diploid and allotetraploid cotton. BMC Research Notes 7:493.
Liu YF, Li QT, Lu X, Song QX, Lam SM, Zhang WK, Ma B, Lin Q, Man WQ, Du WG, Shui GH, Chen SY* and Zhang JS*. (2014) Soybean GmMYB73 promotes lipid accumulation in transgenic plants. BMC Plant Biolology 14:73.
Zou HF, Zhang YQ, Wei W, Chen HW, Song QX, Liu YF, Zhao MY, Wang F, Zhang BC, Lin Q, Zhang WK, Ma B, Zhou YH, Zhang JS* and Chen SY*. (2013) The transcription factor AtDOF4.2 regulates shoot branching and seed coat formation in Arabidopsis. Biochemical Journal 449:373-378.
Ma B, He SJ, Duan KX, Yin CC, Chen H, Yang C, Xiong Q, Song QX, Lu X, Chen HW, Zhang WK, Lu TG, Chen SY* and Zhang JS*. (2013) Identification of rice ethylene-response mutants and characterization of MHZ7/OsEIN2 in distinct ethylene response and yield trait regulation. Molecular Plant 6:1830-1848.
Hao YJ, Wei W, Song QX, Chen HW, Zhang YQ, Wang F, Zou HF, Lei G, Tian AG, Zhang WK, Ma B, Zhang JS* and Chen SY*. (2011) Soybean NAC transcription factors promote abiotic stress tolerance and lateral root formation in transgenic plants. Plant Journal 68:302-313.
Hao YJ, Song QX, Chen HW, Zou HF, Wei W, Kang XS, Ma B, Zhang WK, Zhang JS* and Chen SY*. (2010) Plant NAC-type transcription factor proteins contain a NARD domain for repression of transcriptional activation. Planta 232:1033-1043.
