孫英傑，男，博士，中國農業科學院上海獸醫研究所研究員、博士生導師，現任禽病研究室副主任，入選國家級人才、中國農業科學院傑出青年英才、上海領軍人才"後備隊"。兼任福建農林大學博士生導師、上海微生物學會獸醫微生物專業委員會主任、中國畜牧獸醫學會公共衛生分會常務理事、中國畜牧獸醫學會禽病學分會理事，擔任《Journal of Integrative Agriculture》青年編委。主要從事動物副黏病毒分子致病機制研究，聚焦病毒感染誘導的固有免疫反應、代謝調控及細胞器應激等過程。主持國家重點研發計畫青年科學家項目等課題，以第一或通訊作者在《Cell Reports》《Plos Pathogens》《Journal of Virology》發表論文23篇，獲授權發明專利8件。1999年參與麻疹病毒RNA檢測方法研究，發現唾液標本RT-PCR陽性率達90.9%。2019年發現新城疫病毒V蛋白拮抗宿主先天性免疫的新機制。2023年在第三屆豬產業發展大會作專題學術報告，2025年在中國畜牧獸醫學會禽病學分會會議分享突破性成果。
基本介紹
- 中文名：孫英傑
- 學位/學歷：博士
- 職業：博士生導師
- 職務：禽病研究室副主任
- 主要成就：入選中國農業科學院傑出青年英才、上海領軍人才“後備隊”
- 所在單位：中國農業科學院上海獸醫研究所
- 職稱：研究員
研究方向,主要成就,代表論著,專利標準,
研究方向
主要研究方向是動物副黏病毒的分子致病機制。重點關注病毒感染後誘導的固有免疫反應、代謝調控、細胞器應激以及細胞死亡等生物過程，深入探討其在病毒複製和致病過程中的作用。
主要成就
主持國家重點研發計畫青年科學家項目等國家和省部級項目8項。以第一或通訊作者在《Cell Reports》, 《mBio》、《Plos Pathogens》、《Journal of Advanced Research》、《Journal of Virology》、《iScience》、《FASEB Journal》等SCI期刊發表論文23篇，獲授權發明專利8件，獲“王澤霖基金禽病研究創新獎”。
代表論著
[1] Hui Jiang, Yang Qu, Xianjin Kan, Mengqing Yang, Yabin Gong, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Venugopal Nair, Chan Ding*, Yingjie Sun*, Pexophagy-driven redox imbalance promotes virus-induced ferroptosis, Cell Reports, 2025, 44(6): 115783.
[2] Yongqi Guo, Menghang Wang, Ning Tang, Yubo Zhao, Lijing Wo , Dexin Liang, Rui Huangª, Yandong Tang*, Yingjie Sun* , Xin Yin*, Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes, Journal of Advanced Research, 2025.
[3] Yang Qu, Siyuan Wang, Hui Jiang, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Venugopal Nair, Zengqi Yang*, Yingjie Sun*, Chan Ding*, Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves, Plos Pathogens, 2024, 20(12): e1012737.
[4] Yifan Sun, Lanlan Tang, Xianjin Kan, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Venugopal Nair, Chan Ding* , Xiufan Liu* , Yingjie Sun* , Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells, Journal of Virology, 2024, 98(3): e0189723.
[5] Hui Jiang, Yanfeng Liu, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Chan Ding*, Yingjie Sun*, PEX5-mediated modulation of apoptotic pathways in response to Newcastle disease virus infection, Journal of Integrative Agriculture, 2024.
[6] Yang Qu, Siyuan Wang, Hui Jiang, Qingyi Wang, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Chan Ding*, Yingjie Sun*, Zengqi Yang*, The Ca2+-dependent phosphatase calcineurin dephosphorylates TBK1 to suppress antiviral innate immunity, Journal of Virology, 2024, 98(5): e0001624.
[7] Ning Tang, Pingyi Chen, Changrun Zhao, Panrao Liu, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Xiufan Liu, Tingrong Luo*, Yingjie Sun*, Chan Ding*, Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus Replication, Journal of Virology, 2023, 97(3): e0001623.
[8] Wei Wu, Yang Qu, Shengqing Yu, Sa Wang, Yuncong Yin, Qinfang Liu, Chunchun Meng, Ying Liao, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding*, Yingjie Sun*, Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity, mBio, 2021, 12(3): e0100521.
[9] Xianjin Kan, Yuncong Yin, Cuiping Song, Lei Tan, Xusheng Qiu, Ying Liao, Weiwei Liu, Songshu Meng, Yingjie Sun* and Chan Ding*, Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells, iScience, 2021, 24(8): 102837.
[10] Shanhui Ren, Zaib Ur Rehman, Bo Gao, Zengqi Yang, Jiyong Zhou, Chunchun Meng, Cuiping Song, Venugopal Nair, Yingjie Sun*, Chan Ding*, ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells, Plos Pathogens, 2020, 16(6):e1008514.
[11] Yuan Zhan, Shengqing Yu, Shen Yang, Xusheng Qiu, Chunchun Meng, Lei Tan, Cuiping Song, Ying Liao, Weiwei Liu, Yingjie Sun*, Chan Ding*, Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E, Plos Pathogens, 2020, 16(6):e1008610.
[12] Yingjie Sun†, Hang Zheng†, Shengqing Yu, Yunlei Ding, Wei Wu, Xuming Mao, Ying Liao, Chunchun Meng, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Fengyun Wu, and Chan Ding*, Newcastle disease virus V protein degrades mitochondrial antiviral-signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5, Journal of Virology, 2019;93(18):e00322-19
[13] Yingjie Sun, Luna Dong, Shengqing Yu, Xiaoxu Wang, Hang Zheng, Pin Zhang, Chunchun Meng, Yuan Zhan, Lei Tan, Cuiping Song, Xusheng Qiu, Guijun Wang, Ying Liao, and Chan Ding*, Newcastle disease virus induces stable formation of bona fide stress granules to facilitate viral replication through manipulating host protein translation, FASEB Journal, 2017, 31
[14] Yingjie Sun, Shengqing Yu, Na Ding, Chunchun Meng, Songshu Meng, Shilei Zhang, Yuan Zhan, Xusheng Qiu, Lei Tan, Hongjun Chen, Cuiping Song, Chan Ding*. Autophagy Benefits the Replication of Newcastle Disease Virus in Chicken Cells and Tissues. Journal of Virology, 2014, 88(1): 525-537.
專利標準
[1] A COMPOSITE MULTI-EPITOPE EXPRESSION CASSETTE, A RECOMBINANT VIRUS COMPOSED THEREOF AND APPLICATION THEREOF, 授權時間：2022.04.19，美國專利號：US 11,305,007,B2
[2] 一種重組表達載體、製備得到的I型鴨A型肝炎病毒樣顆粒、製備方法及套用。授權時間2023.05.05，中國專利號：ZL201910603170
[3] 一種複合多表位表達盒、其組成的重組病毒及套用。授權時間：2023.06.30，中國專利號：ZL202011211170.
[4] 一種表達Furin蛋白的細胞株及其在禽傳染性支氣管炎病毒培養中的套用。授權時間：2021.8, 中國專利授權號：ZL201910344592.1
[5] 穩定表達倉鼠TIGAR基因的BHK細胞系及其構建方法和套用。授權時間：2021.8, 中國專利授權號：ZL201910344592.1
[6] 一種鵝源線粒體抗病毒信號蛋白及其套用，2021-08-03，中國，ZL201810367202.8
[7] 雞IBV S1蛋白的CD8+ T細胞抗原表位多肽，2015-04-15，中國，201310317878.3
[8] 一種具有抗新城疫病毒活性的鵝源基因RIG-I及套用，2015-12-22，中國，ZL201210281895.1
