夏成才，山東第一醫科大學藥學院教授（四級崗）、碩士生導師。1996年至2000年就讀於青島化工學院化學工程專業，獲學士學位；2003年至2006年獲浙江工業大學生物化工碩士學位；2012年至2016年獲浙江工業大學藥物化學博士學位。現為中國醫藥教育協會臨床用藥評價委員會委員、山東生物醫學工程學會醫美藥分子工程專業委員會委員。
2006年起歷任泰山醫學院藥學院助教、講師，2014年晉升副教授，2021年晉升教授。主要從事有機合成方法學、藥物合成新工藝及合理藥物設計研究，擔任Org. Lett.、Adv. Synth. Catal.等期刊審稿人。2019年獲評泰安市第十四批拔尖人才及山東省高等學校科學技術獎（第1完成人），主持國家級科研項目6項，包括山東省醫藥衛生科技發展計畫、自然科學基金等，累計經費超5000萬元。以通訊作者在Adv. Synth. Catal.、Org. Lett.等期刊發表SCI論文18篇，涉及電化學氧化反應、鐵催化合成等方向。
基本介紹
- 中文名：夏成才
- 國籍：中國
- 職業：大學教授
學習經歷,工作經歷,研究方向,學術任職,獲獎情況,主持科研課題,學術作品,
學習經歷
1996.09—2000.07 青島化工學院，化學工程，學士
2003.09—2006.06 浙江工業大學，生物化工，碩士
2012.09—2016.01 浙江工業大學，藥物化學，博士
工作經歷
2006.07—2008.11 泰山醫學院藥學院，助教
2008.12—2014.11 泰山醫學院藥學院，講師
2014.12—2021.07 山東第一醫科大學藥學院，副教授
2021.08—至今 山東第一醫科大學藥學院，教授
研究方向
1. 有機合成方法學及藥物合成新工藝研究
2. 合理藥物設計、合成與生物活性研究
學術任職
1. 中國醫藥教育協會臨床用藥評價委員會，委員
2. 山東生物醫學工程學會醫美藥分子工程專業委員會，委員
3. Org. Lett., Org. Chem. Front., Adv. Synth. Catal., Org. Biomol. Chem.等期刊審稿人
獲獎情況
1. 泰安市第十四批拔尖人才，泰安市，2019。
2. 山東省高等學校科學技術獎，定位基團導向C-X鍵構建及在有機合成中的套用研究。
第1完成人，2019。
3. 山東省研究生優秀科研成果獎二等獎2項，三等獎2項。
4. 山東省優秀碩士論文指導老師，4篇。
主持科研課題
1. 山東第一醫科大學學術提升計畫，2019LJ003，創新藥物早期成藥性及臨床前研究，2019-2024，5000萬，參與。
2. 山東省醫藥衛生科技發展計畫項目，5-取代-1,3-二芳基-1,2,4-三氮唑類化合物設計、合成及活性研究，2021.01-2022.12，2萬元，主持。
3. 山東省自然基金面上項目（聯合專項），ZR2017LB006，苯並[e]吡咯[1,2-a]氮雜卓衍生物的合成及生物活性研究, 2017.08-2019.12，6萬元，主持。
4. 山東省高等學校科技計畫項目，J17KA248，磺醯胺席夫鹼導向的C-H活化反應C-S鍵形成研究，2017.08-2018.12，3.5萬元，主持。
5. 山東省醫藥衛生科技發展計畫，2015WSB31006，3-烷基取代喹諾酮衍生物的設計、合成及抑菌活性研究，2015/12-2018/12，2萬元，主持。
6. 泰安市科技發展計畫，201440774-02，對氯苯基硼酸酯及其系列產品清潔化生產工藝研究，2014/01-2016/12，3萬元，主持。
學術作品
近五年代表性論文（限第一作者和通訊作者）：
1. Xiao Yu, Shengjie Song, Zenghui Zhang, Yi Liu, Mei Zhang, Wenjing Zhu, Guiyun Duan, Pengfei Zhang, Yafei Ji, and Chengcai Xia*. Electrochemical Oxidative Carbon-atom Multi-functionalization and N-cyanation of Imine: Synthesis of (Z)-N'-cyano-N-carbamimidothioate. Adv. Synth. Catal., 2023, doi.org/10.1002/adsc.202300224
2. Mei Zhang, Xiao Yu, Wenjing Zhu, Yi Liu, Zenghui Zhang, Jinbo Zhao, Chengcai Xia,* and Ke Li*. Iron-Catalyzed Synthesis of Benzosultams from N‑Phenyl‑N‑(prop-2-yn-1-yl)benzenesulfonamide and Benzenesulfonyl Hydrazine. Org. Lett., 2023, 25, 603−607.
3. Yi Liu, Wenjing Zhu, Xiao Yu, Hongyan Liu, Zenghui Zhang, Mei Zhang, Jinbo Zhao, Yacong Wang,* and Chengcai Xia,*. Synthesis of Ethyl 3-(1-Acetyl-3-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-2,2-difluoropropanoate from N-Allyl-N’-benzylideneacetohydrazide and Ethyl 2-Bromo-2,2-difluoroacetate. Adv. Synth. Catal., 2022, 364, 4300– 4304.
4. Xiao Yu, Zhihong Ma,* Wenjing Zhu, Hongyan Liu, Zenghui Zhang, Yi Liu, Mei Zhang, Jinbo Zhao, Pengfei Zhang, and Chengcai Xia*.Tandem Reduction, Ammonolysis, Condensation, and Deamination Reaction for Synthesis of Benzothiadiazines and 1‑(Phenylsulfonyl)‑1H‑benzimidazoles. J. Org. Chem. 2022, 87, 14738−14752.
5. Xiao Yu, Wenjing Zhu, Hongyan Liu, Yi Liu, Hongshuang Li, Junfen Han,* Guiyun Duan, Zhushuang Bai, Pengfei Zhang and Chengcai Xia* Practical chemoselective aromatic substitution: the synthesis of N-(4-halo-2-nitrophenyl) benzenesulfonamide through the efficient nitration and halogenation of N-phenylbenzenesulfonamide. Org. Biomol. Chem., 2022, 20, 5444–5451.
6. Zenjing Zhu, Yu Chen, Xiao Yu, Hongyan Liu, Zheng Zhang, Fuqiang Wen, Yi Liu, Pengfei Zhang, Chengcai Xia,* and Furong Li*. Synthesis of (E)-1-(phenyldiazenyl)cyclohexyl Benzoate from N-(cyclohexylideneamino)aniline and Benzoyl Peroxide. ChemistrySelect, 2022, 7, e202104597.
7. Hongyan Liu, Zengfen Pang*, Liqiang Hao, Jian Sun, Zheng Zhang, Fuqiang Wen, and Chengcai Xia*. Sulfonylimination of Proline with Sulfonylazides Involving Aldehyde-Induced Decarboxylation Coupling. Org. Lett., 2021, 23, 4, 1234–1238.
8. Jian Sun, Haoyi Sun, Liqiang Hao, Hongyan Liu, Zheng Zhang, Fuqiang Wen, Hongshuang Li, Guiyun Duan, Guirong You, Chengcai Xia*. Metal-Free Synthesis of Pyrrole-imidazole Alkaloids via a Tandem C−N, C−C coupling Protocol. Adv. Synth. Catal., 2021, 363, 7, 1882–1886.
9. Hongyan Liu, Bin Zhang, Wei Zhao, Xiao Yu, Wenjing Zhu, Chengcai Xia,* and Yanmeng Zhou*.Base-Mediated Coupling Reactions of Benzenesulfonyl Azides with Proline: Synthesis of Proline-Derived Benzenesulfonamides. ACS Omega 2021, 6, 34796−34804.
10. Liqiang Hao, Hongyan Liu, Zheng Zhang, Fuqiang Wen, Chengcai Xia,* Zengfen Pang*. Cascade reaction to 1H-pyrazoles from hydrazonesvia sodium nitritepromoted dual C–C/C–N formation, annulation and aromatization with 1,2-dichloroethane. Chinese Chemical Letters, 2021 (32) 2309–2312.
11. Xiaojun Li, Shangtie Liao, Yu Chen, Chengcai Xia,* and Guodong Wang. Cobalt(II) nitrate promoted cyclization of benzoyl hydrazone for the synthesis of 2,5-diphenyl-1,3,4-oxadiazole derivatives. Journal of Chemical Research, 2021, 1038-1041.
12. Xiaopan Fu, Yangyang Wang, Jinyue Yang, Gaorong Wu, Chengcai Xia*, Ji, Yafei. Fully Substituted Pyrazoles Assis ted Palladium-Catalyzed Late-Stage Arylation of C(sp(2))-H Bond. Chin. J. Org. Chem., 2020, 40, 4305–4314.
13. Lili Zhang, Kezuan Deng, Gaorong Wu, Jinyue Yang, Shibiao Tang, Xiaopan Fu,*, Chengcai Xia*, and Yafei Ji*. Ruthenium(II)-Catalyzed α-Fluoroalkenylation of Oxime Ethers with gem-Difluorostyrenes via C–H Activation and C–F Cleavage. J. Org. Chem., 2020, 85, 19, 12670–12681.
14. Liqiang Hao, Guodong Wang, Jian Sun, Jun Xu, Hongshuang Li, Guiyun Duan, Chengcai Xia*, and Pengfei Zhang. From Phenylhydrazone to 1H-1,2,4-Triazoles via Nitrification, Reduction and Cyclization. Adv. Synth. Catal., 2020, 362, 8, 1657-1662.
15. Xiaobo Xu, Chengcai Xia*, Xiaojun Li, Jian Sun and Liqiang Hao. Visible-light-induced aerobic C3-H fluoroalkoxylation of quinoxalin-2(1H)-ones with fluoroalkyl alcohols. RSC Adv., 2020, 10, 2016–2026.
16. Guodong Wang, Jian Sun, Kai Wang, Junfen Han, Hongshuang Li, Guiyun Duan, Guirong You, Furong Li and Chengcai Xia*. Palladium-catalyzed direct C-H nitration and intramolecular C-H functionalization for the synthesis of 3-nitro-1-(phenylsulfonyl)-1H-indazole derivatives. Org. Chem. Front., 2019, 6, 1608–1612.
17. Xiaopan Fu, Jinyue Yang, Kezuan Deng, Lingyan Shao, Chengcai Xia* and Yafei Ji*. Tandem C−C/C−N Formation via Palladium-Catalyzed C−H Activation/Styrenation and Sequential Annulation of O‑Methylketoxime with Styrenes. Org. Lett. 2019, 21, 3505−3509.
18. Zhenjiang Wei, Sijia Qi, Yanhao Xu, Hao Liu, Junzhen Wu, Hongshuang Li, Chengcai Xia,* and Guiyun Duana*. Visible Light-Induced Photocatalytic C& H Perfluoroalkylation of Quinoxalinones under Aerobic Oxidation Condition. Adv. Synth. Catal. 2019, 361, 5490– 5498.
19. Jian Sun, Guodong Wang, Liqiang Hao, Junfen Han, Hongshuang Li, Guiyun Duan, Guirong You, Furong Li, and Chengcai Xia*. Copper-Catalyzed Tandem C- H/N-H Activation, Cyclization [4+2] and Dehydration of Arylamides with Formamide: Synthesis of 4(3H)-Quinazolinones Derivatives. ChemCatChem 2019, 11, 2799–2802.
20. Guirong You, Dan Xi, Jian Sun, Liqiang Hao and Chengcai Xia*. Transition-metal- and oxidant-free three-component reaction of quinoline N-oxides, sodium metabisulfite and aryldiazonium tetrafluoroborates via a dual radical coupling process. Org. Biomol. Chem., 2019, 17, 9479–9488.
21. Xiaobo Xu, Zhengzhou Chu and Chengcai Xia *. Transition-metal free oxidative C–H etherification of acylanilines with alcohols through a radical pathway. Org. Biomol. Chem., 2019, 17, 6346–6350.
22. Ke-Zuan Deng, Li-Li Zhang, Ye-Feng Chen, He-Xin Xie, Xiao-Bo Xu, Cheng-Cai Xia * and Ya-Fei Ji*. Copper-mediated direct thiolation of aryl C–H bonds with disulfides. Org. Biomol. Chem., 2019, 17, 7055–7065.
23. Junfen Han, Guodong Wang, Jian Sun, Hongshuang Li, Guiyun Duan, Furong Li, Chengcai Xia*. Photoredox-catalyzed perfluoroalkylation of aminoquinolines with hypervalent iodine(III) reagents that contain perfluoroalkanoate. Catalysis Communications, 2019, 118, 81–85.
24. Junfen Han, Kai Wang, Guirong You, Guodong Wang, Jian Sun, Guiyun Duan, Chengcai Xia*. Heterogeneous copper-catalyzed CeS coupling via insertion of sulfur dioxide: A novel and regioselective approach for the synthesis of sulfurcontaining compounds. Catalysis Communications. 2019, 128: 105708.
25. Junfen Han, Guodong Wang, Jian Sun, Hongshuang Li, Guiyun Duan, Furong Li, Chengcai Xia*. Solid-supported Pt-catalyzed remote C-H etherification of arylamines: A simple and practical approach for the synthesis of aromatic ethers. Catalysis Communications. 2019,129: 105722.
26. Qingqing Liu, Xinxin Luo, Shujie Wei, Youzhao Wang, Jiaxin Zhu, Yi Liu, Fenglei Quan, Meng Zhang, Chengcai Xia*. Palladium-catalyzed direct ortho CAX bond construction via C-H activation of azobenzenes: Synthesis of (E)-1,2-b(2,6-dibromo(chloro)-phenyl)diazene. Tetrahedron Letters 2019, 60, 1715–1719.
27. Xiao-Pan Fu, Shi-Biao Tang, Jin-Yue Yang, Li-Li Zhang, Cheng-Cai Xia,* and Ya-Fei Ji*. Cascade Reaction for the Synthesis of Carbolines from O-Methyl-ketoximes and Styrenes via Palladium-Catalyzed C–H Activation and Sequential Annulation. Eur. J. Org. Chem. 2019, 5974–5977.
28. Ruize Zhang, Guodong Wang, Hongshuang Li, Guiyun Duan*, Kai Wang and Chengcai Xia*. Strong-acid Cation Exchange Resin Catalyzed Synthesis of Bis(indolyl)methanes in Water. Chinese Journal of Organic Chemistry，2019，39(5): 1429–1435.
29. Guirong You, Kai Wang, Xiaodan Wang, Guodong Wang, Jian Sun, Guiyun Duan, and Chengcai Xia*. Visible-Light-Mediated Nickel(II)-Catalyzed C–N Cross-Coupling in Water: Green and Regioselective Access for the Synthesis of Pyrazole-Containing Compounds. Org. Lett.,2018, 20, 4005-4009.
30. Shaofan Wang, Qipeng Zhao, Guodong Wang, Kai Wang, and Chengcai Xia*. Palladium-catalyzed Direct O-Nitrification of Azobenzenes with Co(NO3)2•6H2O via C-H Activation. Chin. J. Org. Chem. 2018, 38, 1849-1854.
31. Guodong Wang, Junfen Han, Kai Wang, Hongshaung Li, Guiyun Duan, Chengcai Xia*, Furong Li. Methoxylation on the C5 and C6 positions of quinolines with methanol. Catalysis Communications, 2018, 114, 37-41.
