吳明軒，河南鄭州人，博士研究生，現為西湖大學生命科學學院教師。
基本介紹
- 中文名：吳明軒
- 國籍：中國
- 職業：科研工作者，大學教師
- 畢業院校：上海交通大學，普林斯頓大學
- 學歷：博士研究生
個人簡介,代表論文,
個人簡介
2004-2010年就讀於上海交通大學生命科學與技術學院基地班，先後獲得學士和碩士學位，導師為周虎臣教授和白林泉教授。畢業後赴美就讀於普林斯頓大學化學系，師從Dorothea Fiedler教授，於2015年獲得博士學位。隨後師從Philip A. Cole教授，於2015-2017年在約翰霍普金斯大學醫學院以及2017-2019年在哈佛醫學院布萊根婦女醫院從事博士後工作。將於2019年9月入職西湖大學組建化學生物學課題組。
代表論文
1.M. Wu, D. Hayward, J. H. Kalin, Y. Song, J. W.R. Schwabe and P. A. Cole. “Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex”eLife,2018, 7:e37231.
2. J. H. Kalin, M. Wu, A. V. Gomez, Y. Song, J. Das, D. Hayward, N. Adejola,M. Wu, I. Panova, H. J. Chung, E. Kim, H. J. Roberts, J. M. Roberts, P. Prusevich, J. R. Jeliazkov, S. S. R. Burman, L. Fairall, C. Milano, A. Eroglu, C. M. Proby, A. T. Dinkova-Kostova, W. W. Hancock, J. J. Gray, J. E. Bradner, S. Valente, A. Mai, N. M. Anders, M. A. Rudek, Y. Hu, B. Ryu, J. W.R. Schwabe, A. Mattevi, R. M. Alani, P. A. Cole. “Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.”Nat. Commun.,2018, 8:53.
3.M. Wu, L. S. Chong, D. H. Perlman, A. C. Resnick, D. Fiedler. “The inositol polyphosphates intersect with protein signaling and metabolic networks via two distinct mechanisms.”Proc. Natl. Acad. Sci. USA,2016,113, E6757.
4.M. Wu, L. S. Chong, S. Capolicchio, H. J. Jessen, A. Resnick, D. Fiedler. “Probing diphosphoinositol polyphosphate function with non-hydrolyzable analogs.”Angew. Chem. Int. Ed.2014, 53,7192-7197.
5.M. Wu, B. E. Dul, A. J. Trevisan, D. Fiedler. “Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers.”Chem. Sci.2013,4, 405-410.
6. C.-X. Liu, Q.-Q. Yin, H.-C. Zhou, Y.-L. Wu, J.-X. Pu, L. Xia, W. Liu, X. Huang, T. Jiang,M.-X. Wu, L.-C. He, Y.-X. Zhao, X.-L. Wang, W.-L. Xiao, H.-Z. Chen, Q. Zhao, A.-W. Zhou, L.-S. Wang, H.-D. Sun, G.-Q. Chen. “Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.”Nat. Chem. Biol.2012,8, 486-493.
7.M. Wu, Q. Meng, M. Ge, L. Bai, H. Zhou. “2,3,6-Trideoxy sugar nucleotides: synthesis and stability.”Tetrahedron Lett.2011,52, 5799-5801.
