吳允昆

本科畢業於武漢大學生命科學學院細胞生物學專業，博士畢業於美國University of Alabama at Birmingham，並進行了短期的博士後工作，曾榮獲美國生物物理學會研究生科研成就獎。隨後在美國HHMI / UTSouthwestern Medical Center從事科研工作。2011年任中國科學院福建物質結構研究所課題組長，博士生導師，曾擔任所學術委員會和學位委員會委員。2017年加入福建師範大學生命科學學院任“閩江學者”特聘教授。研究成果以第一作者或通訊作者發表在Nature 和 Nature Structural & Molecular Biology、Nature Communications 和 Biomaterials等雜誌上，獲發明專利授權十餘項。曾入選國家重大人才計畫“青年項目”、中國科學院“百人計畫”、福建省“百人計畫”等。

基本介紹

• 中文名：吳允昆
• 國籍：中國
• 民族：漢
• 畢業院校：武漢大學、美國University of Alabama at Birmingham、美國HHMI/ UT Southwestern Medical Center

研究方向

(1) 生物大分子結構、功能與套用

(2) 基於結構的納米運載體和分子調控劑等藥物研發

主要成就

主要代表性論文：

Wu Y, Yang Y, Ye S, Jiang Y. Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+-gated K+ Channel. Nature 2010 466(7304):393-7.

Wu Yunkun, Sha Bingdong. Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p. Nature Structural & Molecular Biology 2006 13(7):589-93.

Wu X, Zhao Y, Zhang H, Yang W, Yang J, Sun L, Jiang M, Wang Q, Wang Q, Ye X, Zhang X, Wu Y. Mechanism of regulation of the Helicobacter pylori Cagβ ATPase by CagZ. Nature Communications. 2023 Jan30;14(1):479. doi: 10.1038/s41467-023-36218-4.

Li S, Zhao Y, ZhaoZ, Wu X, Sun L, Liu Q, Wu Y.Crystal structure of GRAS domain of SCARECROW-LIKE 7 in Oryza sativa. Plant Cell. 2016 May;28(5):1025-34 DOI: 10.1105/tpc.16.00018 (highlighted article)

Zhang L, Zeng Z, Hu C, Bellis SL, Yang W, Su Y, ZhangX, WuY. Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines. Biomaterials 2016Jan，77:307-19.

Zhang L, Fan Y, Wu Y. Inositol basednone-viral vectorsfor transgene expression in human cervical carcinoma and hepatoma cell lines. Biomaterials 35(6):2039-50.

Zhang L, Hu C, Yang W, Liu X, Wu Y. Chemical Synthesis,Versatile Structures and Functions of Tailorable Adjuvants for Optimizing Oral Vaccination. ACS Applied Materials & Interfaces 2016Dec 28;8(51):34933-34950. doi: 10.1021/acsami.6b10470.

Chen F, Xiao F, Zhang W, Lin C, Wu Y. Highly Stable and NIR Luminescent Ru-LPMSN Hybrid Materials for Sensitive Detection of Cu2+ in Vivo. ACS Appl Mater Interfaces. 2018 Aug 15;10(32):26964-26971.doi:10.1021/acsami.8b08887.

Chen Fangman, Zhang Fan, Shao Dan, Zhang Weibin, Zhen Liqin, Wang Wei, Yang Wendi, Wang Zheng, Chen Jianxin, Dong Wenfei, Xiao Fangnan, Wu Yunkun. Bioreducible and traceable Ru(III) prodrug-loadedmesoporous silicananoparticles for sequentially targeted nonsmall cell lungcancer chemotherapy. Applied Materials Today, 2020, 19：100558.

Lifei Chen, Pu Chen, Shengping Li, Meiqin Jiang, Hong Zhang, Leiqing Chen, Xiaojing Huang, Yayu Chen, Lifang Sun, Panpan Dong, Pingdong Lin, Yunkun Wu. Crystal Structure of the Disease-Specific Protein ofRice StripeVirus. J Agric Food Chem, 2022, 70(27):8469-8480.DOI: 10.1021/acs.jafc.2c02165

Chunhua Zhu, YayuChen, Michail N. Isupov, Littlechild A.Jennifer, Lifang Sun, Xiaodong Liu,Qianchao Wang, Hui Gong, Panpan Dong, NaZhang, Yunkun Wu. Structural insights into a novel esterase fromthe EastPacific Rise and its improved thermostability by a semirational design. J Agric Food Chem, 2021, 69 (3), 1079-1090. doi:10.1021/acs.jafc.0c06338.Epub 2021 Jan 14.

Zhang L, Yang W, Hu C, Wang Q, Wu Y. Properties and applications of nanoparticle/microparticle conveyors with adjuvant characteristics suitable for oral vaccination. Int J Nanomedicine. 2018 May21;13:2973-2987. doi: 10.2147/IJN.S154743.

Zhang L, Bellis SL, Fan Y, Wu Y.Using Inositol as a Biocompatible Ligand for Efficient Transgene Expression.International Journal of Nanomedicine.2015:10 2871-84.

Zhang L, Hu C, FanY, Wu Y. Binary gene vectors based on hyperbranched poly(L-lactide-co-polyglycerol) and polyethylenimine for prolonged transgene expression via co-assembly with DNA into fiber core–shell triplexes. J. Mater. Chem. B 1(45),6271-6282

Wang Q, Jiang M, Isupov MN, Chen Y, Littlechild JA, Sun L,Wu X, Wang Q, Yang W, Chen L, Li Q, Wu Y. The crystal structure of Arabidopsis BON1 provides insights into the copine protein family. Plant J. 2020 Aug;103(3):1215-1232. doi: 10.1111/tpj.14797.Epub 2020 Jun13.PMID: 32369638

Wang Q, Chen Y, LiS, Yang W, Sun L, Jang M, Wu X, Wang Q,Chen L, Wu Y. Ca2+-based allosteric switches and shape shifting in RGLG1 VWA domain. Comput Struct Biotechnol J. 2020 Mar30;18:821-833. doi:10.1016/j.csbj.2020.03.023.

Sun L, Miao Y, Wang Z, Chen H, Dong P, Zhang H, Wu L,Jiang M, Chen L,Yang W, Lin P, Jing D, Luo Z, Zhang Y, Jung YS, Wu X, QianY, Wu Y. Structural insight into African swine fever virus I73Rprotein reveals it as a Z-DNA binding protein. Transbound Emerg Dis. 2022 Mar21. doi: 10.1111/tbed.14527.

Lifei Chen, Leiqing Chen, Huan Chen, Hong Zhang, PanPan Dong, Lifang Sun, Xiaojing Huang, Pingdong Lin, Linjiao Wu, Dingding Jing, Yingjuan Qian, Yunkun Wu. Structural insights into the CP312R protein of the African swine fever virus. Biochem Biophys Res Commun,2022,624:68-74. DOI:10.1016/j.bbrc.2022.07.091

Wu X, Zhao Y, Sun L, Jiang M, Wang Q, Wang Q, Yang W, WuY. Crystal structure of CagV, the Helicobacter pylorihomologue of the T4SS protein VirB8. FEBS J. 2019Nov;286(21):4294-4309. doi: 10.1111/febs.14971.

Zhao Y, Ye X, Su Y, Sun L,She F, Wu Y. Crystal structure confirmation of JHP933 as a nucleotidyltransferase superfamily protein from Helicobacter pylori strain J99. PLoS One 2014Aug 7;9(8):e104609.doi: 10.1371/journal.pone.0104609.

Jiang M, Sun L,Isupov MN, Littlechild JA, Wu X, Wang Q, Wang Q, Yang W, Wu Y. Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response1. FEBS J. 2019 Jul;286(14):2809-2821.doi:10.1111/febs.14846.

Lifang Sun, Yintao Su, Yanhe Zhao, Zheng-qing Fu, Yunkun Wu. Crystal Structure of Major Envelope Protein VP24 from White Spot Syndrome Virus. Scientific Reports.2016 Aug 30;6:32309. doi:10.1038/srep32309.

Sun L, Zou X, Jiang M, Wu X, Chen Y, Wang Q, Wang Q, Chen L, Wu Y. The crystal structure of the TCP domain of PCF6 in Oryzasativa L. reveals an RHH-like fold. FEBS Lett. 2020 Jan 3.doi: 10.1002/1873-3468.13727

Xiao F, Xiao Y, Chen F, Liu X, LinC, Chen J, Wu Y. Facile synthesis of Silicon quantumdot-Gadolinium: A potential fluorescent/T1-T2 multimodal imaging agent. Talanta. 2019 Jul1;199:336-346. doi:10.1016/j.talanta.2019.02.041.

Weibin Zhang, Chunhua Zhu, Fangnan Xiao, Xiaodong Liu, Anhua Xie, Fangman Chen, Panpan Dong, Pingdong Lin, Chenyang Zheng, Hong Zhang, Hui Gong, Yunkun Wu. pH-controlled release of antigens using mesoporous silicananoparticles delivery system for developing a fish oral vaccine. Front Immunol, 2021,12 (1173), 1-13. doi: 10.1016/j.mcp.2021.101708.