史向陽(東華大學教授)

史向陽(東華大學教授)

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史向陽，1970年8月生，東華大學化學化工與生物工程學院生物科學與技術研究所教授，博士生導師，校特聘教授，上海高校特聘教授（東方學者）。

2008年回國前，在美國密西根大學歷任博士後研究員、第二級副研究員、研究員和研究助理教授。美國化學會、中國化學會、中國生物材料委員會會員，上海市生物物理學會理事，美國密西根大學醫學和生物科學納米技術研究所客座研究員，首屆葡萄牙馬德拉大學“邀請納米技術主任（Invited Chair in Nanotechnology）。是Current Nanoscience、American Journal of Nanotechnology、Advances in Nano Research, An International Journal、Journal of Modern Textile Science and Engineering等期刊編委，也是Nat. Nanotechnol.、Nat. Commun.和 J. Am. Chem. Soc.等84個國際雜誌審稿人。

基本介紹

研究方向,榮譽及獲獎情況,主持與承擔主要項目情況,發表論著情況,國際交流與合作,主講課程,

研究方向

1.生物納米技術：以各種基於樹狀大分子或生物相容性高分子修飾或組裝的多種納米顆粒為醫學平台，研究各種癌症的早期診斷和治療。
2.新型納米材料和納米複合材料的合成、組裝、表面修飾、性能、及其在生物醫學中的套用。
3.靜電紡納米纖維在生物醫學和環境科學中的套用。

榮譽及獲獎情況

1. 2008年6月獲上海高校特聘教授（東方學者）稱號；
2. 2009年入圍首批SCOPUS尋找未來科學之星活動全國納米科學前10名；
3. 2010年獲首屆葡萄牙馬德拉大學“邀請納米技術主任（Invited Chair in Nanotechnology）”稱號；
4. 2011年獲教育部“新世紀優秀人才”支持計畫；
5. 2013 年獲上海高校特聘教授（東方學者）跟蹤支持計畫；
6. 2014年，第五屆中國僑界貢獻獎創新人才獎。
7. 2014年，中國紡織工程學會第15屆陳維稷優秀論文獎。

主持與承擔主要項目情況

  1. 利用樹狀大分子納米技術構建多功能納米雜化顆粒及其腫瘤CT/MRI雙模態成像診斷研究，國家自然科學基金面上項目 (項目批准號：21273032)，2013.1-2016.12，項目主持人，在研。
  2. 多功能樹狀大分子包裹的納米金顆粒作為平台用於癌細胞的CT成像研究，國家自然科學基金面上項目 (項目批准號：20974019)，2010.1-2012.12，項目主持人，結題。
  3. 多功能雜化納米水凝膠及其雙模態分子影像學套用，中德科學基金研究交流中心(GZ899)，2013.10-2016.9，項目主持人，在研。
  4. 樹狀大分子納米材料及其醫學套用，教育部新世紀人才支持計畫，2012.1 -2014.12，項目主持人，結題。
  5. 多功能樹狀大分子包裹的納米金顆粒作為腫瘤CT成像造影劑的研究，上海市科委浦江人才計畫（09PJ1400600），2009.7-2011.7，項目主持人，結題。
  6. 多功能磁性氧化鐵/金核殼納米探針的構建及其分子影像診斷套用，上海市科委納米專項（11nm0506400），2011.12 -2014. 9，項目主持人, 結題。
  7. 基於樹狀大分子的多功能腫瘤成像造影劑的研究, 上海高校特聘教授（東方學者）獎勵計畫，2008.6-2011.6，項目主持人，已結題。
  8. 納米生物醫用材料與技術，上海高校特聘教授（東方學者）跟蹤計畫支持， 2014.1-2016.12，項目主持人，在研。
  9. 葡萄牙馬德拉大學“邀請納米技術主任”基金 (由葡萄牙科技部FCT和Santander 銀行資助) ，項目主持人，2010-2018，在研。
  10. DENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors，葡萄牙科技部 (FCT)項目（PTDC/CTM-NAN/1748/2012）, 2013.4-2015.4, 項目主持人，結題。
  11. 人工納米生物機器構築與生物醫學套用的基礎研究，973計畫（2007CB936000），2007.7-2011.8，參與，已結題。
  12. 有機/無機納米複合修復材料及其口腔醫學套用開發，國家高技術研究發展計畫 (2012AA030309)，2012.1-2014.12，參與，已結題。

發表論著情況

史向陽教授的主要研究成果包括在納米醫學與生物技術、納米科學、材料化學、高分子化學和分析化學等領域內共發表或接受發表了269篇期刊論文，10篇書的章節，和228篇會議論文、摘要或報告，並獲授權中國發明專利57項。研究工作發表在Chem. Rev., Prog. Polym. Sci., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Small, Adv. Funct. Mater.和Biomaterials等等專業雜誌上。其中SCI收錄的論文有242篇，影響因子超過3.0以上的文章有182篇，影響因子超過7.0以上的文章有55篇。文章總引用數超過8282次，單篇引用最高次數為362次，H-index為51。
2011年以來發表的代表論著：
1. Han Wang, Linfeng Zheng, Chen Peng, Rui Guo, Mingwu Shen, Xiangyang Shi*, Guixiang Zhang*. Computed Tomography Imaging Of Cancer Cells Using Acetylated Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2011, 32, 2979-2988 (impact factor 8.387, citation #120).
2. Yin Wang, Rui Guo, Xueyan Cao, Mingwu Shen, Xiangyang Shi*. Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy. Biomaterials 2011, 32, 3322-3329 (citation #110, impact factor 8.387).
3. Xueyan Cao, Jingjing Chen, Shihui Wen, Chen Peng, Mingwu Shen, and Xiangyang Shi*. Effect of Surface Charge of Polyethyleneimine-Modified Multiwalled Carbon Nanotubes on the Improvement of Polymerase Chain Reaction. Nanoscale 2011, 3 (4), 1741-1747. (impact factor 7.760, citation #27).
4. Hong Yang, Yeming Zhuang, Yun Sun, Antao Dai, Xiangyang Shi,* Dongmei Wu, Fuyou Li, He Hu and Shiping Yang*. Targeted Dual Contrast T1- and T2-weighted Magnetic Resonance Imaging of Tumors using Multifunctional Gadolinium-Labeled Superparamagnetic Iron Oxide Nanoparticles. Biomaterials 2011, 32 (20), 4584-4593 (citation #108, impact factor 8.387).
5. Chen Peng, Linfeng Zheng, Qian Chen, Mingwu Shen, Rui Guo, Han Wang, Xueyan Cao, Guixiang Zhang,* Xiangyang Shi*. PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography. Biomaterials 2012, 33, 1107-1119 (impact factor 8.387, citation #153).
6. Yuebin Shan, Ting Luo, Chen Peng, Ruilong Sheng, Amin Cao,* Xueyan Cao, Mingwu Shen, Rui Guo, Helena Tomás, Xiangyang Shi*. Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors. Biomaterials 2012, 33, 3025-3035 (impact factor 8.387, citation #91).
7. Yunpeng Huang, Hui Ma, Shige Wang, Mingwu Shen,* Rui Guo, Xueyan Cao, and Xiangyang Shi*. Efficient catalytic reduction of hexavalent chromium using palladium nanoparticle-immobilized electrospun polymer nanofibers. ACS Appl. Mater. Interfaces 2012, 4(6), 3054-3061 (impact factor 7.145, citation #43).
8. Chen Peng, Kangan Li, Xueyan Cao, Tingting Xiao, Wenxiu Hou, Rui Guo, Mingwu Shen, Guixiang Zhang**, and Xiangyang Shi*. Facile Formation of Dendrimer-Stabilized Gold Nanoparticles Modified with Diatrizoic Acid for Enhanced Computed Tomography Imaging Applications. Nanoscale 2012, 4 (21), 6768 - 6778 (impact factor 7.760, citation #36, back cover of the issue).
9. Shige Wang, Fuyin Zheng, Yunpeng Huang, Yuting Fang, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. Encapsulation of Amoxicillin within Laponite-Doped Poly(lactic-co-glycolic acid) Nanofibers: Preparation, Characterization and Antibacterial Activity. ACS Appl. Mater. Interfaces 2012, 4, 6393−6401 (impact factor 7.145, citation #48).
10. Han Wang, Linfeng Zheng, Chen Peng, Mingwu Shen, Xiangyang Shi*, Guixiang Zhang.* Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human lung adencarcinoma. Biomaterials 2013, 34, 470-480 (impact factor 8.387, citation #68).
11. Fuyin Zheng, Shige Wang, Shihui Wen, Mingwu Shen,** Meifang Zhu, Xiangyang Shi*. Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Biomaterials 2013, 34, 1402-1412 (impact factor 8.387, citation #59).
12. Shihui Wen, Kangan Li, Hongdong Cai, Qian Chen, Yunpeng Huang, Chen Peng, Mingwu Shen, Guixiang Zhang*,and Xiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Dual Mode CT/MR Imaging Applications. Biomaterials 2013, 34, 1570-1580 (impact factor 8.387, citation #99).
13. Hongdong Cai, Xiao An, Jun Cui, Jingchao Li, Shihui Wen, Kangan Li, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang*, Xiangyang Shi*. Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications. ACS Appl. Mater. Interfaces 2013, 5 (5), 1722–1731 (impact factor 7.145, citation #71).
14. Qian Chen, Kangan Li , Shihui Wen, Hui Liu, Chen Peng, Hongdong Cai, Mingwu Shen, Guixiang Zhang**, Xiangyang Shi*. Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials 2013, 34, 5200-5209 (impact factor 8.387, citation #77).
15. Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* and Xiangyang Shi*. Polyethyleneimine-Mediated Synthesis of Folic Acid-Targeted Iron Oxide Nanoparticles for in Vivo Tumor MR Imaging. Biomaterials 2013, 34, 8382-8392 (impact factor 8.387, citation #84).
16. Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Facile One-Pot Synthesis of Fe3O4@Au Composite Nanoparticles for Dual Mode MR/CT Imaging Applications. ACS Appl. Mater. Interfaces 2013, 5(20), 10357-10366 (impact factor 7.145, citation #39).
17. Dengmai Hu, Yunpeng Huang, Hui Liu, Hong Wang, Shige Wang, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. TheAssembly of Dendrimer-Stabilized Gold Nanoparticles onto Electrospun Polymer Nanofibers for Catalytic Applications. J. Mater. Chem. A 2014, 2, 2323–2332 (Impact factor 8.262).
18. Jingchao Li, Yao He, Wenjie Sun, Hongdong Cai, Yunqi Pan, Mingwu Shen**, Jindong Xia***, Xiangyang Shi*. Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging. Biomaterials 2014, 35, 3666-3677 (impact factor 8.387, citation #75).
19. Shige Wang, Jingyi Zhu, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. Poly(amidoamine) Dendrimer-Enabled Simultaneous Stabilization and Functionalization of Electrospun Poly(γ-glutamic acid) Nanofibers. ACS Appl. Mater. Interfaces 2014, 6, 2153−2161 (impact factor 7.145, citation # 9).
20. Hui Liu+, Han Wang+, Yanhong Xu, Mingwu Shen, Jinglong Zhao, Guixiang Zhang*, Xiangyang Shi*. Synthesis of PEGylated Low Generation Dendrimer-Entrapped Gold Nanoparticles for CT Imaging Applications. Nanoscale 2014, 6(9), 4521-4526 (impact factor 7.760, citation #27).
21. Hui Liu+, Han Wang+, Yanhong Xu+, Rui Guo, Shihui Wen, Yunpeng Huang, Weina Liu, Mingwu Shen*, Jinglong Zhao, Guixiang Zhang*, and Xiangyang Shi*. Lactobionic Acid-Modified Dendrimer-Entrapped Gold Nanoparticles for Targeted CT Imaging of Human Hepatocellular Carcinoma. ACS Appl. Mater. Interfaces 2014, 6, 6944−6953 (impact factor 7.145, citation # 29).
22. Jingyi Zhu, Linfeng Zheng, Shihui Wen, Yueqin Tang, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*.Targeted Cancer Theranostics Using Alpha-Tocopheryl Succinate-Conjugated Multifunctional Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2014, 35, 7635-7646 (impact factor 8.387, citation #42).
23. Kai Li, Shige Wang, Shihui Wen, Yueqin Tang, Jipeng Li, Xiangyang Shi,* and Qinghua Zhao*. Enhanced In Vivo Antitumor Efficacy of Doxorubicin Encapsulated within Laponite Nanodisks. ACS Appl. Mater. Interfaces 2014, 6, 12328−12334 (impact factor 7.145, citation # 14).
24. Guoying Wang, Dina Maciel, Yilun Wu, João Rodrigues, Xiangyang Shi, Yuan Yuan, Changsheng Liu, Helena Tomás,* Yulin Li*. Amphiphilic Polymer-Mediated Formation of Laponite-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery. ACS Appl. Mater. Interfaces 2014, 6, 16687−16695 (impact factor 7.145, citation #15). Non-corresponding author.
25. Fanfan Fu, Jingyi Zhu, Shihui Wen, Mingwu Shen, Xiangyang Shi*. Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: Investigating the role played by PEG spacer. ACS Appl. Mater. Interfaces 2014, 6, 16416−16425 (impact factor 7.145, citation # 25).
26. Benqing Zhou, Linfeng Zheng, Chen Peng, Du Li, Jingchao Li, Shihui Wen, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Synthesis and characterization of PEGylated polyethyleneimine-entrapped gold nanoparticles for blood pool and tumor CT imaging. ACS Appl. Mater. Interfaces 2014, 6, 17190−17199 (impact factor 7.145, citation #21).
27. Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21 (impact factor 8.387, citation #56).
28. Lingdan Kong, Carla S. Alves, Wenxiu Hou, Jieru Qiu, Helmuth Möhwald, Helena Tomás,* Xiangyang Shi*. RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells. ACS Appl. Mater. Interfaces 2015, 7 (8), 4833-4843 (impact factor 7.145, citation #18).
29. Jia Yang, Yu Luo, Yanhong Xu, Jingchao Li, Zaixian Zhang, Han Wang, Mingwu Shen, Xiangyang Shi,* Guixiang Zhang*. Conjugation of iron oxide nanoparticles with RGD-modified dendrimers for targeted tumor MR imaging. ACS Appl. Mater. Interfaces 2015, 7(9), 5420-5428 (impact factor 7.145, citation #7).
30. Yu Luo, He Shen, Yongxiang Fang, Yuhua Cao, Jie Huang, Mengxin Zhang, Jianwu Dai,* Xiangyang Shi,* and Zhijun Zhang*. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl. Mater. Interfaces 2015, 7 (11), 6331–6339 (impact factor 7.145, citation #17).
31. Zheng Qiao, Xiangyang Shi*. Dendrimer-based molecular imaging contrast agents. Prog. Polym. Sci. 2015, 44, 1–27 (Impact factor 27.184, citation #18).
32. Yu Luo, Jia Yang, Yu Yan, Jingchao Li, Mingwu Shen,* Guixiang Zhang,* Serge Mignani, Xiangyang Shi*. RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of glioma. Nanoscale 2015, 7, 14538–14546 (impact factor 7.760, citation #12).
33. Hongdong Cai, Kangan Li, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen,* Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small 2015, 11 (35), 4584-4593 (impact factor 8.315, citation #13).
34. Yulin Li*, Dina Maciel, João Rodrigues*, Xiangyang Shi*, Helena Tomás*. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chem. Rev. 2015, 115 (16), 8564–8608 (impact factor 37.369, citation #18).
35. Lingzhou Zhao, Jingyi Zhu, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo, Xiangyang Shi*, and Jinhua Zhao*. Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide I for SPECT Imaging and Radiotherapy of Gliomas. ACS Appl. Mater. Interfaces 2015, 7 (35), 19798–19808 (impact factor 7.145, citation #3).
36. Jingyi Zhu, Lingzhou Zhao, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Mingwu Shen, Jinhua Zhao,* and Xiangyang Shi*. Radionuclide I-Labeled Multifunctional Dendrimers for Targeted SPECT Imaging and Radiotherapy of Tumors. Nanoscale 2015, 7, 18169-18178 (impact factor 7.760, citation #1).
37. Yongxing Zhang, Shihui Wen, Lingzhou Zhao, Du Li, Changcun Liu, Wenbin Jiang, Xiang Gao, Wentao Gu, Nan Ma, Jinhua Zhao*, Xiangyang Shi*, Qinghua Zhao*. Ultrastable polyethyleneimine-stabilized gold nanoparticles modified with polyethylene glycol for blood pool, lymph node and tumor CT imaging. Nanoscale 2016, 8, 5567–5577 (impact factor 7.760, citation #1).
38. Jingwen Chen, Yingqi Sun, Qian Chen, Le Wang, Suhe Wang, Yun Tang,* Xiangyang Shi*, Han Wang*. Multifunctional gold nanocomposites designed for targeted CT/MR/optical tri-modal imaging of human non-small cell lung cancer cells. Nanoscale 2016, 8, 13568–13573 (impact factor 7.760).
39. Xin Li, Zuogang Xiong, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater. Interfaces 2016, 8, 19883-19891 (impact factor 7.145).
40. Aijun Li, Benqing Zhou, Bei Xu, Rui Guo, Xiangyang Shi,* Xueyan Cao*. Mechanistic Studies of the Enhanced PCR Using PEGylated PEI-Entrapped Gold Nanoparticles. ACS Appl. Mater. Interfaces 2016, 8 (39), 25808–25817 (impact factor 7.145).

國際交流與合作

美國密西根大學（University of Michigan, Ann Arbor），美國喬治亞大學格里芬分校（University of Georgia, Griffin），美國伊利諾伊大學芝加哥分校（University of Illinois at Chicago），葡萄牙馬德拉大學 (Universidade da Madeira)，匈牙利徳布勒森大學（University of Debrecen），德國亞琛工業大學（RWTH Aachen），法國國家科學院（CNRS）。

主講課程

納米醫學 (博士研究生課程)，化學前沿（博士研究生課程），納米醫學與生物技術（功能材料專業生物材料方向本科生課程）。

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