劉忠(暨南大學副研究員碩導)

劉忠，博士、副研究員、博士生導師，廣東省傑出青年科學基金獲得者、廣東特支計畫科技創新青年拔尖人才、廣州市珠江科技新星、暨南“雙百英才”傑出青年學者。現任基因工程藥物國家工程研究中心副總經理、化妝品研發中心總監，廣東省化妝品學會副理事長、常務副秘書長、化妝品原料與天然產物專委會主任委員，廣東省生物醫學工程學會常務理事、副秘書長。主要研究方向為功能化妝品研究與開發，腫瘤、炎症與自身免疫性疾病靶向創新藥物研究與開發。作為項目負責人主持了國家自然科學基金、廣東省自然科學基金項目、廣東省科技 計畫國際合作項目、廣州市科技計畫重點項目等科研項目 12 項，與多家化妝品 及製藥企業合作開展了產品開發。已在 SCI 國際期刊發表研究論文 50 余篇，申請專利 9 項。

基本介紹

• 中文名：劉忠
• 國籍：中國
• 民族：漢   
• 出生地：江西 
• 職業：暨南大學教授
• 畢業院校：中山大學 博士
• 職稱：副研究員  博士生導師
• 學位： ：博士 
• 學歷：：研究生 
• 職稱：：

人物經歷

2003/9 - 2008/12，中山大學，博士

1999/9 - 2003/6，中山大學，學士

近 5 年獲得的榮譽稱號

1. 廣東省自然科學傑出青年基金獲得者
   
2. 廣東特支計畫科技創新青年拔尖人才
   
3. 廣州市珠江科技新星
   
4. “暨南雙百英才計畫”傑出青年
   

主講課程

《高級生物化學》

《酶工程》

《細胞信號轉導理論與技術》

《基因工程》

研究方向

主要研究方向

功能化妝品研究與開發，腫瘤、炎症與自身免疫性疾病靶向創新藥物研究與開發。作為項目負責人主持了國家自然科學基金、廣東省自然科學基金項目、廣東省科技 計畫國際合作項目、廣州市科技計畫重點項目等科研項目 12 項。已在 SCI 國際期刊發表研究論文 50 余篇，申請專利 9 項。

主要貢獻

承擔課題

1. 國家自然科學基金青年科學基金項目（81001449）， 2011-2013
   
2. 廣東省科技計畫對外科技合作項目（2013B051000061）， 2014-2016
   
3. 廣東省自然科學基金面上項目（S2012010008494）， 2012-2014
   
4. 廣東省自然科學基金博士啟動項目（10451063201005506）， 2010-2012
   
5. 廣州市珠江科技新星項目（201610010108）， 2016-2019
   
6. 廣州市科技計畫套用基礎研究重點項目（12C32071601） ， 2011-2013
   
7. 藥用資源化學與藥物分子工程教育部重點實驗室資助課題（CMEMR2015-B08）， 2015-2018
   
8. 天然藥物及仿生藥物國家重點實驗室資助課題（K20120208）， 2012-2013
   
9. 暨南大學科研培育與創新基金躍升計畫項目（21615413） ， 2015-2016
   
10. 暨南大學引進優秀人才科研啟動基金（51209005）， 2009-2011
    
    

主要論文

[1] Hu LB#, Wang Y#, Chen Z, Fu, LS, Wang S, Zhang XY, Zhang PC, Lu XP, Jie HY, Li MM*, Wang YF*, Liu Z*, Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway. Oxid Med Cell Longev. 2019, 2019: 9675450.

[2] Wu Y#, Zhang XY#, Li HQ, Deng PF, Li HR, He TQ, Rong JH, Zhao JH*, Liu Z*, A core/shell stabilized polysaccharide-based nanoparticle with intracellular environment-sensitive drug delivery for breast cancer therapy. J Mater Chem B. 2018, 6:6646-6659.

[3] Wang Y#, Zhou PJ#, Qin SR#, Xu DD, Liu YK, Fu WY, Ruan BB, Zhang L, Zhang Y, Wang XY, Pan YW, Wang S, Yan HZ, Qin JH, Wang XY, Liu QY, Du ZY*, Liu Z*, Wang YF*. The curcumin analogs 2-pyridyl cyclohexanone induces apoptosis via inhibition of the JAK2-STAT3 pathway in human esophageal squamous cell carcinoma cells. Front Pharmacol. 2018, 9:820.

[4] Liu Q#, Xiao XH#, Hu LB, Jie HY, Wang Y, Ye WC*, Li MM*, Liu Z*. Anhuienoside C ameliorates collagen-induced arthritis through inhibition of MAPK and NF-κB signaling pathways. Front Pharmacol. 2017, 8:299.

[5] Zhang L#, Wang XY#, Zhou PJ#, He Z, Yan HZ, Xu DD, Wang Y, Fu WY, Ruan BB, Wang S, Chen HX, Liu QY, Zhang YX, Liu Z*, Wang YF*. Use of immune
modulation by human adipose-derived mesenchymal stem cells to treat experimental arthritis in mice. Am J Transl Res. 2017, 9(5): 2595-2607.

[6] Xie ZZ#, Li MM#, Deng PF, Wang S, Wang L, Lu XP, Hu LB, Chen Z, Jie HY, Wang YF, Liu XX*, Liu Z*. Paris saponin-induced autophagy promotes breast cancer cell apoptosis via the Akt/mTOR signaling pathway. Chem-Biol Interact. 2017, 264:1-9.

[7] Liu Z#, Liu G#, Zhang GL#, Li J, He YQ, Zhang SS, Wang Y, He WY, Cheng GH, Yang X, Xu J, Wang J*, Binding of human recombinant mutant soluble ectodomain of FGFR2IIIc to c subtype of FGFRs: implications for anticancer activity. Oncotarget, 2016, 7(42):68473-68488.

[8] Shao FY#, Wang S#, Li, HY#, Chen WB, Wang GC, Ma DL, Wong NS, Xiao H, Liu QY, Zhou GX, Li YL, Li MM*, Wang YF*, Liu Z*. EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells. Oncotarget, 2016, 7(6):6790-6808.

[9] Li H#, Li M#, Wang G, Shao F, Chen W, Xia C, Wang S, Li Y*, Zhou G* and Liu Z*. EM23, a natural sesquiterpene lactone from Elephantopus mollis, induces apoptosis in human myeloid leukemia cells through thioredoxin- and reactive oxygen species-mediated signaling pathways, Front Pharmacol, 2016, 7:77.

[10] Xu DD#, Zhou PJ#, Wang Y#, Zhang Y, Zhang R, Zhang L, Chen SH, Ruan BB, Xu HP, Fu WY, Hu CZ, Tian L, Qin JH, Wang S, Wang X, Liu QY, Ren Z, Gu XQ, Li YH, Liu Z*, Wang YF*. miR-150 suppresses the proliferation and tumorigenicity of leukemia stem cells by targeting the Nanog signaling pathway, Front Pharmacol, 2016, 7:439.

[11] Fan Z#, Sun ZH#, Liu Z#, Chen YC, Liu HX, Li HH, Zhang WM. Dichotocejpins A-C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110. Mar Drugs. 2016, 14(9):164.

[12] Shao FY#, Du ZY#, Ma DL, Chen WB, Fu WY, Ruan BB, Rui W, Zhang JX, Wang S, Wong NS, Xiao H, Li MM, Liu X, Liu QY, Zhou XD, Yan HZ, Wang YF, Chen CY, Liu Z*, Chen HY*. B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting
mitochondrion-dependent pathways and triggering autophagy. Oncotarget, 2015, 6(31):30939-30956.

[13] Xu JJ#, Liu Z#, Tang W#, Wang GC, Chung HY, Liu QY, Zhuang L, Li MM*, Li YL*. Tangeretin from citrus reticulate inhibits respiratory syncytial virus replication and associated inflammation in vivo. J Agric Food Chem. 2015, 63 (43):9520– 9527.

[14] Xu GG, Liu X, Lin YQ, He GS, Wang WJ, Xiong W, Luo HY, Liu Z*, Zhao JH*. Thermal hydrolysis of poly(L-lactic acid) films and cytotoxicity of water-soluble degradation products. J Appl Polym Sci. 2015, 132(25), DOI: 10.1002/app.42064.

[15] Qiu XX#, Zhong MG#, Xiang YF, Qu C, Pei Y, Zhang YJ, Yang CR, Gasteiger J, Xu J, Liu Z*, Wang YF*. Self-Organizing Maps for the Classification of Gallic Acylate Polyphenols as HSV-1 Inhibitors. Med Chem. 2014, 10, 388-401.

[16] Wang R#, Shao FY#, Liu Z*, Zhang JX, Wang SX, Liu JY, Liu H, Chen HY, Liu KS, Xia M, Wang YF*. The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways. Chem-Biol Interact. 2013, 205(1): 1-10.

[17] Zhong MG#, Xiang YF#, Qiu XX, Liu Z*, Kitazato K*, Wang YF*. Natural products as a source of anti-herpes simplex virus agents, RSC Adv. 2013, 3(2): 313-328.

[18] Zhang WJ#, Liu Z#, Li SM, Lu YZ, Chen YC, Zhang HB, Zhang GT, Zhu YG, Zhang GY, Zhang WM, Liu JS, Zhang CS*. Fluostatins I-K from the South China Sea-Derived Micromonosporarosaria SCSIO N160. J Nat Prod. 2012, 75 (11): 1937-1943.

[19] Liu JY#, Liu Z#, Wang DM, Li MM, Wang SX, Wang R, Chen JP, Wang YF*, Yang DP*. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem-Biol Interact. 2011, 190(2-3): 91-101.

[20] Wang SX#, Ju HQ#, Liu KS, Zhang JX, Wang X, Xiang YF, Wang R, Liu JY, Liu QY, Xia M, Xing GW, Liu Z*, Wang YF*. SNX -2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells. Biosci Biotech Bioch. 2011, 75(8): 1540-1545.

[21] Liu Z#, Huang SL#, Li MM, Huang ZS, Lee KS*, Gu LQ*. Inhibition of thioredoxin reductase by mansonone F analogues: implications for anticancer activity. Chem-Biol Interact. 2009, 177(1): 48-57.

[22] Liu Z, Du ZY, Huang ZS, Lee KS*, Gu LQ*. Inhibition of thioredoxinreductase by curcumin analogs. Biosci Biotech Bioch. 2008, 72(8): 2214-2218.

[23] Qiu X#, Liu Z#, Shao WY, Liu X, Jing DP, Yu YJ, An LK, Huang SL, Bu XZ*, Huang ZS, Gu LQ. Synthesis and evaluation of curcumin analogues as potential thioredoxinreductase inhibitors. Bioorg Med Chem. 2008, 16(17): 8035-8041.

[24] Huang P, Chen A, He W, Li Z, Zhang G, Liu Z, Liu G, Liu X, He S, Xiao G, Huang F, Stenvang J, Brünner N, Hong A, Wang J. BMP-2 induces EMT and breast cancer stemness through Rb and CD44. Cell Death Discov. 2017,3:17039.

[25] Yuan N, Xu L, Zhang L, Ye H, Zhao J, Liu Z, Rong J. Superior hybrid hydrogels of polyacrylamide enhanced by bacterial cellulose nanofiber clusters. Mater Sci Eng C. 2016,67:221-30.

[26] Zhang Y, Zhou SY, Yan HZ, Xu DD, Chen HX, Wang XY, Wang X, Liu YT, Zhang L, Wang S, Zhou PJ, Fu WY, Ruan BB, Ma DL, Wang Y, Liu QY, Ren Z, Liu Z, Zhang R, Wang YF. miR-203 inhibits proliferation and self-renewal of leukemia stem cells by targeting survivin and Bmi-1. Sci Rep. 2016,6:19995.

[27] Wang WJ, Wang L, Liu Z, Jiang RW, Liu ZW, Li MM, Zhang QW, Dai Y, Li YL, Zhang XQ, Ye WC. Antiviral benzofurans from Eupatorium chinense. Phytochemistry. 2016, 122:238-45.

[28] Lu D, Dong D, Liu Z, Wang Y, Wu B. Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes:identification of main contributing enzymes. Expert Opin Drug Metab Toxicol. 2015,11(7):1029-40.

[29] Liu Q, Zhu XZ, Feng RB, Liu Z, Wang GY, Guan XF, Ou GM, Li YL, Wang Y, Li MM, Ye WC, Crude triterpenoid saponins from Anemone laccida (Di Wu) exert anti-arthritic efects on type II collagen-induced arthritis in rats. Chin Med. 2015, 10:20.

[30] Feng RB, Fan CL, Liu Q, Liu Z, Zhang W, Li YL, Tang W, Wang Y, Li MM, Ye WC. Crude triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate

lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non‑alcoholic fatty liver disease model. Chin Med. 2015, 10:23.

[31] Chen H, Liu X, Clayman ES, Shao F, Xiao M, Tian X, Fu W, Zhang C, Ruan B, Zhou P, Liu Z, Wang Y, Rui W. Synthesis and evaluation of a CBZ-AAN-Dox prodrug and its in vitro effects on SiHa cervical cancer cells under hypoxic conditions. Chem Biol Drug Des. 2015:86(4):589-98.

[32] Tian YX, Shen YD, Zhang XZ, Ye LB, Li ZH, Liu Z, Zhang JJ, Wu SG. Design Some New Type-I c-met Inhibitors Based on Molecular Docking and Topomer CoMFA Research. Mol Inform, 2014, 33(8):536-543.

[33] Zhang W, Ma L, Li S, Liu Z, Chen Y, Zhang H, Zhang G, Zhang Q, Tian X, Yuan C, Zhang S, Zhang W, Zhang C. Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032. J Nat Prod. 2014, 77:1887-1892.

[34] Liu C, Liu Z, Li M, Li X, Wong YS, Ngai SM, Zheng W*, Zhang Y, Chen T*. Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PLoS One. 2013, 8(1):e53945

[35] Yang XW, Peng K, Liu Z, Zhang GY, Li J, Wang N*, Steinmetz A, Liu Y*. Strepsesquitriol, a Rearranged Zizaane-Type Sesquiterpenoid from the Deep-Sea-Derived Actinomycete Streptomyces sp. SCSIO 10355. J Nat Prod. 2013, 76 (12),:2360-2363.

[36] Qin J*, Lan W, Liu Z, Huang J, Tang H, Wang H*. Synthesis and biological evaluation of 1, 3-dihydroxyxanthone mannich base derivatives as anticholinesterase agents. Chem Cent J. 2013, 7(1):78.

[37] Wu ZC, Li S, Nam SJ, Liu Z, Zhang C*. Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete nocardiopsis sp. CNX037. J Nat Prod. 2013, 76 (4):694-701.

[38] Wu X, Lan P, Liu Z, Ruan ZX, Wang H, Wang GC, Ye WC, Li YL*. 3D-QSAR studies of natural steroidal saponins as anticancer agents in human nasopharyngeal carcinoma epithelial cells. Lett Drug Des Discov. 2013, 10(3):245-252.

[39] Zhang W, Liu Z, Li S, Yang T, Zhang Q, Ma L, Tian X, Zhang H, Huang C, Zhang S, Ju J, Shen Y, Zhang C*. Spiroindimicins A-D:new bisindole alkaloids from a deep-sea-derived actinomycete. Org Lett, 2012, 14 (13), 3364-3367.

[40] He F, Liu Z, Yang J, Fu P, Peng J, Zhu WM*, Qi SH*. A novel antifouling alkaloid from halotolerant fungus Penicillium sp. OUCMDZ-776, Tetrahedron Lett. 2012, 53(18):2280-2283.

[41] Li MM, Wu S, Liu Z, Zhang W, Xu J, Wang Y, Liu JS, Zhang DM, Tian HY, Li YL*, Ye WC*. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012, 83(9):1251-1260.

[42] Liu KS, Ding WC, Wang SX, Liu Z, Xing GW, Wang Y, Wang YF*. The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo. Oncol Rep. 2012, 27(6):1904-1910.

[43] Liu KS, Liu H, Qi JH, Liu QY, Liu Z, Xia M, Xing GW, Wang SX*, Wang YF*. SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer Lett. 2012, 318(2):66-74.

[44] Zhang XQ, Xu FF, Wang L, Huang MY, Liu Z, Zhang DM, Wang GC, Li YL, Ye WC*, Two pairs of new diastereoisomeric flavonolignans from the seeds of Hovenia acerba. Phytochem Lett. 2012, 5(2):292-296.

[45] Liu XT, Schwan WR, Volk TJ, Rott M, Liu M, Huang P, Liu Z, Wang Y, Zitomer NC, Sleger C, Hartsel S, Monte A*, Zhang L*. Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium. J Nat Prod. 2012, 75(9):1534-1538.

[46] Liu KS, Zhang Y, Ding WC, Wang SX, Xiang YF, Yang P, Chen ZP, Zheng K, Liu Z, Xia M, Wang YF*. The selective Hsp90 inhibitor BJ-B11 exhibits potent antitumor activity via induction of cell cycle arrest, apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells. Int J Oncol. 2012, 41:2276-2284.

[47] Zhai QQ, Gong GQ, Liu Z, Luo Y, Xia M, Xing GW, You XF, Wang YF*. Preclinical

pharmacokinetic analysis of SNX-2112, a novel Hsp90 inhibitor, in rats. Biomed Pharmacother. 2011, 65(2):132-136.

[48] Sun F, Liu JY, He F, Liu Z, Wang R, Wang DM, Wang YF*, Yang DP*. In-vitro antitumor activity evaluation of hyperforin derivatives. J Asian Nat Prod Res. 2011, 13(8):688-699.

[49] Ju HQ, Wang SX, Xiang YF, Liu Z, Liu JY, Chen ZP, Zeng FL, Xia M, Liu ZH, Xing GW*, Wang SY*, Wang YF*. BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway. Eur J Pharmacol. 2011, 666:26-34.

[50] Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC*. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Org Lett. 2010, 12(21):5040-5043.

[51] Zhou GX*, Mo SY, He HX, Shi JG, Ye WC, Liu Z. Jiang RW*, Molecular structure and tautomerization of the 1:1 complex of luteoskyrin and rugulosin J Mol Struct. 2010, 979(1):86-91.

[52] Tian HY, Wang L, Zhang XQ, Wang Y, Zhang DM, Jiang RW, Liu Z, Liu JS, Li YL, Ye WC*. Bufogargarizins A and B two novel 19-norbufadienolides with unprecedented skeletons from the venom of bufo bufo gargarizans. Chem Eur J. 2010, 16(36):10989-10993.

[53] Zhai QQ, Gong GQ, Luo Y, Wang QD, Xia M, Xing GW, Li YC, Jiang JH, Liu Z, Liu QY, Wang YF*. Determination of SNX-2112, a selective Hsp90 inhibitor in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats. J Pharm Biomed Anal. 2010, 53(4):1048-1052.

[54] Du ZY, Bao YD, Liu Z, Qiao W, Ma L, Huang ZS*, Gu LQ*, Chan ASC. Curcumin analogs as potent aldose reductase inhibitors. Arch Pharm (Weinheim). 2006, 339(3):123-128.

[55] Li MM, Liu Z, Zhang ZL, Ma L*. Inhibitory effects of curcumin derivatives on nonenzymatic glucosylation in vitro. Front Chem China. 2006, 1(2):227-231.

[56] Wang YF, Ma L, Li Z, Du ZY, Liu Z, Qin JK, Wang XD, Huang ZS, Gu LQ*, Chen ASC.
Synergetic inhibition of metal ions and genistein on alpha-glucosidase. FEBS Lett. 2004, 576(1-2):46-50.