光壽紅，中國科學技術大學教授，中組部“青年千人計畫”首批入選者，中國科學院“百人計畫”入選者。
基本介紹
- 中文名：光壽紅
- 國籍：中國
- 職業：教授
- 畢業院校：中國科學技術大學
- 主要成就：中國科學院“百人計畫”入選者。
個人簡介,Publications,
個人簡介
1996年在中國科學技術大學生物系獲得學士學位，1996-1999年師從中國科大施蘊渝院士進行多肽的溶液構象研究，並獲得碩士學位。1999-2004年，在美國威斯康星大學癌症研究所師從Janet Mertz教授，研究真核生物中病毒起源的無內含子RNA的表達和調控機制，並獲得博士學位。2005-2010年，作為博士後在威斯康星大學遺傳系Scott Kennedy助理教授實驗室，從事模式生物中小干擾RNA的功能和調控機理的研究。進一步研究小干擾RNA的功能和調控機制。在包括Nature和Science在內的國際著名期刊上發表論文12篇（其中第一作者6篇），2篇論文被Faculty of 1000 Biology收錄並給予高度評價，曾獲得中國科學院院長獎及美國心臟協會博士後獎。於2011年建立中國科學技術大學分子遺傳學實驗室。
Publications
1. Feng X, and Guang S. (2013) Small RNAs, RNAi and the Inheritance of Gene Silencing in Caenorhabditis elegans. J Genet Genomics. 2013 Apr 20;40(4):153-60.
2. Sam Guoping Gu, Julia Pak, Shouhong Guang, Jay M. Maniar, Scott Kennedy, and Andrew Fire, (2012) Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint. Nature Genetics 44:157-164.
3. Burkhart, K.B., Guang, S., Bochner, A.F., and Kennedy, S., (2011) A pre-mRNA–associating factor links endogenous siRNAs to chromatin regulation. PLoS Genetics7(8).
4. Guang, S., Bochner, A.F., Pavelec, D.M., Burkhart, K.B., Burton, N., and Kennedy, S., (2010) Small regulatory RNAs inhibit RNA Polymerase II during the elongation phase of transcription. Nature, 465:1097-1101
5. Guang, S., Bochner, A.F., Pavelec, D.M., Burkhart, K.B., Harding, S., Lachowiec, J., and Kennedy, S., (2008) An Argonaute transports siRNAs from the cytoplasm to the nucleus. Science321:537-541 Research Article
6. Guang, S., Felthauser, A., and Mertz, J. (2005) Binding of hnRNP L to the pre-mRNA processing enhancer (PPE) of herpes simplex virus’ thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs. Mol. Cell. Biol.25:6303-6313.
7. Guang, S. and Mertz, J.E. (2005) PPE-like elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes. Nucleic Acid Res.33(7):2215-2226.
8. Zeng, W., Zhang, X., Tu, X., Guang, S., Xiao, Y., and Shi, Y. (2001) Expression and purification of the DNA-binding domain of the human transcription factor E2F1. Protein Expr. Purif.21(1):99-104.
9. Xia, Y.L., Wu, J.H., Guang, S., and Shi, Y. (2000) Proton NMR investigation of heme and surrounding proton in low-spin cyanide-ligated bacterial hemoglobin from vitreoscilla.Sci. China Ser (China). C43(1):57-67.
10. Xia, Y.L., Wu, J.H., Guang, S., and Shi, Y. (1998) The application of nuclear magnetic resonance in paramagnetic metallic protein - a vitreoscilla hemoglobin. Acta Biophysica Sinica (China)14(3):392-400.
11. Guang, S., Wu, J.H., Yu, T., Xia, Y.L., and Shi, Y. (1998) Solution structure of a fragment of the dimerization domain of DP-1 determined by 1H-nuclear magnetic resonance and distance geometry. Biochim. Biophys. Acta - Protein Structure and Molecular Enzymology1429(1):18-28.
12. Guang, S., Wu, J.H., Tao, L., Xia, Y.L., and Shi, Y. (1998) Solution structure of a fragment of the dimerization domain of E2F-1 determined by circular dichroism, 1H-nuclear magnetic resonance and distance geometry. Biochim. Biophys. Acta - Protein Structure and Molecular Enzymology1388(1):111-122.
