付向東，武漢大學長江學者講座教授。聘任崗位：生物化學與分子生物學。博士生導師。1957年11月7日生，1982年畢業於武漢大學病毒學學系。1988年獲凱西保留地（凱斯西儲）大學生物化學博士學位，1992年獲哈佛大學分子生物學博士後。現任美國加州大學聖地亞哥分校細胞與分子醫學系教授、美國先進科學協會會員，RNA協會會員、白血病與淋巴癌協會委員、美國生物醫學科學RayWu協會會員。
基本介紹
- 中文名：付向東
- 出生日期：1957年11月7日
- 職業：講座教授
- 畢業院校：凱西保留地（凱斯西儲）大學
人物經歷,學習經歷,工作經歷,研究方向,主要貢獻,
人物經歷
學習經歷
1977-1982: 武大病毒系， 本科。
1983-1988: Case Western Reserve University, Biochemistry, 博士。
1988-1992: Harvard University, 博後。
1983-1988: Case Western Reserve University, Biochemistry, 博士。
1988-1992: Harvard University, 博後。
工作經歷
1992-1998: Assistant Professor, UCSD
1998-2002: Associate Professor with Tenure, UCSD
2002-present: Full Professor, UCSD
2004-present: Lecture Professor, 武漢大學生科院。
2011-present: 千人計畫（B）。
主要社會兼職：
科技部蛋白質重大研究計畫專家組成員。
1998-2002: Associate Professor with Tenure, UCSD
2002-present: Full Professor, UCSD
2004-present: Lecture Professor, 武漢大學生科院。
2011-present: 千人計畫（B）。
主要社會兼職：
科技部蛋白質重大研究計畫專家組成員。
研究方向
RNA processing and regulation
microRNA biogenesis and functions
Transcription and mRNA processing coupling
Functional genomics
Genetics and epigenetics regulation of gene expression
microRNA biogenesis and functions
Transcription and mRNA processing coupling
Functional genomics
Genetics and epigenetics regulation of gene expression
主要貢獻
代表性論文
（部分或完全在武大完成的工作）:
1. Xue, Y-C., Zhou, Y., Wu, T-B., Zhu, T., Ji, X., Zhang, C., Kwon, Y-S., Yeo, G., Sun, H., Fu, X-D.*, and Zhang, Yi* (2009). Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Molecular Cell 36:996-1006. (*co-corresponding authors).
2.Ji, X and Fu, X-D. (2012). The mediator couples transcription and splicing. Molecular Cell 45:433-434.
3.Xiao, R., Tang, P., Yang, B., Huang, J., Zhou Y., Shao C-W., Li, H., Sun, H., Zhang, Y., and Fu, X-D. (2012). Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Molecular Cell 45:656-668.
4.Xue, Y-C., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., Jiang, L., Cai, Z., Sun, H., Zhang, K., Zhang, Y., Chen, J., and Fu, X-D. (2013) Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.Cell 152:82-96.
5. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C. L., Rui, X., Burge, C. B., and Fu, X-D. (2013). SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.Cell 153:855-868..
1. Xue, Y-C., Zhou, Y., Wu, T-B., Zhu, T., Ji, X., Zhang, C., Kwon, Y-S., Yeo, G., Sun, H., Fu, X-D.*, and Zhang, Yi* (2009). Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Molecular Cell 36:996-1006. (*co-corresponding authors).
2.Ji, X and Fu, X-D. (2012). The mediator couples transcription and splicing. Molecular Cell 45:433-434.
3.Xiao, R., Tang, P., Yang, B., Huang, J., Zhou Y., Shao C-W., Li, H., Sun, H., Zhang, Y., and Fu, X-D. (2012). Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Molecular Cell 45:656-668.
4.Xue, Y-C., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., Jiang, L., Cai, Z., Sun, H., Zhang, K., Zhang, Y., Chen, J., and Fu, X-D. (2013) Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.Cell 152:82-96.
5. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C. L., Rui, X., Burge, C. B., and Fu, X-D. (2013). SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.Cell 153:855-868..
