subtilisin,英語單詞,主要用作名詞,作名詞時譯為“[生化] 枯草桿菌蛋白酶”。
基本介紹
- 外文名:subtilisin
- 詞性:名詞
- 英式發音:[,sʌb'tɪlɪsɪn]
- 美式發音:[sʌbˈtɪləsɪn]

subtilisin,英語單詞,主要用作名詞,作名詞時譯為“[生化] 枯草桿菌蛋白酶”。
英文別名:SUBTILISIN A;PROTEASE ALKALINE;EC 3.4.21.14;alk-enzyme;bacillopeptidasea;bacillopeptidaseb;bacillussubtiliscarlsberg;Bacillussubtilisenzymefermentationproduc EINECS:232-752-2 分類 水解蛋白質肽鍵的一類酶的總稱。按其水解多肽的方式,可以將其分為內肽酶和外肽酶兩類。內肽酶將蛋白質分子內部切斷,...
1987年,Ikemura發現枯草桿菌素(subtilisin)的摺疊需要前肽(propeptide)的幫助。這類前肽常位於信號肽與成熟多肽之間,在蛋白質合成過程中與其介導的蛋白質多肽鏈是一前一後合成出來的,並以共價鍵相連線,是成熟多肽正確摺疊所必需的,成熟多肽完成摺疊後即通過水解作用與前肽脫離。Shinde和Inouye將這類前肽稱為...
(1) Using the subtilisin inhibitor eglin c as a template. Substitution of residues at each position 〓 and 〓 of eglin c with a basic residue using protein engineering could make eglin c a very strong inhibitor for both furin and even kexin. Based on the known crystal structures of ...
PCSK9是1號染色體的基因,表達產物是Proprotein Convertase Subtilisin/Kexin Type 9。基因標識 別名 Proprotein Convertase Subtilisin/Kexin Type 9 Subtilisin/Kexin-Like Protease PC9 NARC-1 NARC1 PC9 Convertase Subtilisin/Kexin Type 9 Preproprotein Hypercholesterolemia, Autosomal Dominant 3 Neural Apoptosis ...
4.You, L., & Arnold, F. H. (1996). Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide[J]. Protein engineering, 9(1), 77–83.5.Moore, J. C., Jin, H. M., Kuchner, O., & Arnold, F. H. (1997). Strategies for the in...
2008年,非水相體系中subtilisin Carlsberg催化固態棉纖維原位轉酯化改性的機理研究(50703016 )2007年,陽離子雜化矽溶膠體系製備及其表面性能研究(20674031)(3)部委級科研項目 2012年,提高與樹脂複合性能的漆酶引發麻纖維高效接枝疏水化改性及機理研究(20110093110003)2009年,阻燃纖維染色技術研發(2009GJ41021)2008...
品 牌 宣 言 金品質 共分享 企 業 願 景 努力讓國人多活十年 產品簡介 仁心康從上千株菌株中篩選得到枯草桿菌Subtilisin-QK,通過對枯草桿菌纖溶酶進行基因改造、最佳化進一步提高溶栓活性和靶向溶栓功效。仁心康致力於解決健康問題和生命質量的提升。品牌地址 河北省保定市安國市中藥產業園區安望路8號 ...
我們計畫研究的生物酶體系包括(1)subtilisin,(2)human DNA polymerase beta,(3)carbonic anhydrase 和(4)ribosome.結題摘要 在該項目經費的資助下,我們開展了分子模擬的創新性理論計算方法的發展和套用研究. 圍繞該領域的重點難點問題,即如何算得更大,算得更準,算得更快的問題, 我們發展了具有自身特色的...
13. BBXie, XL Chen, XY Zhang, HL He, YZ Zhong, BC Zhou. Predictingprotein interaction interfaces from protein sequences: case studies ofsubtilisin and phycocyanin. Proteins , 2008, 71(3):1461-1474。14. XLChen, BB Xie, J Tao Lu, HL He, YZ Zhong. A novel type of subtilase from the...
要用被切成平頭末端的DNA片段連線時,可以先用Klenow片段使粘性末端的單鏈補齊成為平頭,然後在DNA連線酶作用下把兩個DNA片段連線起來。發現過程 是漢斯·克列諾於1970年用枯草桿菌蛋白酶(subtilisin)處理大腸桿菌DNA聚合酶Ⅰ時,得到的兩個片段中分子量較大的一個。
包括前蛋白轉化酶枯草溶菌素9(proprotein convertase subtilisin/kexin type 9,PCSK9)抑制劑等,目前成本較高,可及性差。7.常用聯合用藥建議。(1)他汀與依折麥布聯合套用。兩種藥物分別影響膽固醇的合成和吸收,可產生良好協同作用。對於中等強度他汀治療膽固醇水平不達標或不耐受者,可考慮中/低強度他汀與依折麥...
①Du F, Hui Y, Zhang M, Linton MF, Fazio S, Fan D*. Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein.J Biol Chem.2011 Dec 16; 286 (50):43054-61.②Zhao W,Du F, Zhang M, Sun S, Yu H, Fan D*. A new recombinant ...
14.Yang YR, Zhu H, Fang N, Liang X, Zhong CQ, Tang XF, Shen P, Tang B*. (2008) Cold-adapted maturation of thermophilic WF146 protease by mimicking the propeptide binding interactions of psychrophilic subtilisin S41. FEBS Lett . 582(17):2620-2626.15.Bian Y, Liang X, Fang N, Tang...
7.Yan Jia, Hui Liu, Wei Bao, Meizhi Weng, Wei Chen, Yongjun Cai, Zhongliang Zheng, Guolin Zou. (2010). "Functional analysis of propeptide as an intramolecular chaperone for in vivo folding of subtilisin nattokinase."FEBS Letters 584: 4789-4796.8.MeiZhi Weng, ZhongLiang Zheng, Wei Bao, ...
10.Chenglin Wu,# Cong Xi,# Junhua Tong, Jing Zhao, Hualiang Jiang, Jiang Wang,* Yiping Wang,* and Hong Liu.* Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the ...
胰蛋白酶(Trypsin)、α-糜蛋白酶(α-Chymotrypsin)、蛋白酶K(Proteinase K)、枯草桿菌蛋白酶A(Subtilisin A)、膠原蛋白酶(Collagenase)、牛血清白蛋白均為Sigma(USA)產品。N-butyryl-L-homoserine lactone(C4-HSL)、N-hexanoyl-L-homoserine lactone(C6-HSL)、N-heptanoyl-L-homo...
1. Wu B, Toplak A, Nijens T, Queadflieg P, van der Laan, JM, Janssen DB “PEPTIDE FRAGMENT CONDENSATION USING A SUBTILISIN VARIANT WITH IMPROVED SYNTHESIS OVER HYDROLYSIS RATIO” International Patent Application No. PCT/NL2014/050707 所獲榮譽 河北省科學技術進步獎, 一等獎, 省級, 2022。社會...
[16] Yan Jia, Hui Liu, Wei Bao, Meizhi Weng, Wei Chen, Yongjun Cai, Zhongliang Zheng, Guolin Zou. Functional analysis of propeptide as an intramolecular chaperonefor in vivo folding of subtilisin nattokinase. FEBS Letters. 2010, 584(23):4789-4796.[17] Linna Fan, Yan Jia, Le Cui, ...
⒎ Srivastava R. Liu J.X.and Howell S.H.(2008). Proteolytic processing of a precursor protein for a growth promoting peptide by a subtilisin serine protease in Arabidopsis. Plant J. 56:219-227.⒏ Liu J.X.,Srivastava R. Che P. and Howell S.H. (2007). An ER stress response in ...
11.Aihua Deng, Jie Wu, Guoqiang Zhang, Tingyi Wen* .Molecular and structural characterization of a surfactant-stable high-alkaline protease AprB with a novel structural feature unique to subtilisin family. Biochimie . 2011, 93(4):783-791.12.Guoqiang Zhang, Peng Bao, Yun Zhang, Aihua Deng, ...
(5)Wang Y, Huang Y, Hobbs HH, Cohen JC. Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR. J Lipid Res. 2012 Sep;53(9):1932-43.(6)Bai L*, Wang Y*, Fan J*, Chen Y, Ji W, Qu A, Xu P, James DE & Xu T Dissecting ...
6,Zhong-Liang Zheng, Mao-Qing Ye, Zhen-Yu Zuo, Zhi-Gang Liu, Keng-Chang Tai, Guolin Zou*. Probing the importance of hydrogen bonds in the active site of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation. Biochem J. 2006, 395:509-515.(SCI,IF=4....
into Glutathione Transferase Generates High Glutathione Peroxidase Efficiency.Artificial selenoenzymes: Designed and redesigned.Functional mimicry of the active site of glutathione peroxidase by glutathione imprinted selenium-containing protein.Semisynthetic Tellurosubtilisin with Glutathione Peroxidase Activity.
1.Haijuan Fan,Zhihua Liu,Rongshu Zhang,Na Wang,Kai Dou,Gulijimila Mijiti,Guiping Diao,Zhiying Wang,Functional analysis of a subtilisin-like serine protease gene from biocontrol fungusTrichoderma harzianum,Journal of Microbiology,2014,52(2):129-138(論文)2.Shida Ji, Zhiying Wang, Jinjie Wang,...
2Dongxu Zhang, Miao Wang, Guocheng Du, Qingxin Zhao, Jing Wu* and Jian Chen. Surfactant protein of the Streptomyces subtilisin inhibitor family inhibits transglutaminase activation in Streptomyces hygroscopicus. Jounal of Agricultural and Food Chemistry. 2008,56(9):3403-8.3 Zhaofeng Li, Miao ...
DX Zhang, , GC Du, J Chen. Surfactant protein of the Streptomyces Subtilisin inhibitor family inhibits transglutaminase activation in Streptomyces hygroscopicus. Journal of Agricultural and Food Chemistry, 2008, 56: 3403-3408 LM Liu, GC Du, J Chen Enhancement of pyruvate production by osmotic-...
16. Yang YR, Zhu H, Fang N, Liang X, Zhong CQ, Tang XF, Shen P, Tang B*. (2008) Cold-adapted maturation of thermophilic WF146 protease by mimicking the propeptide binding interactions of psychrophilic subtilisin S41. FEBS Lett 582(17):2620-6.17. Shi W, Tang XF, Huang Y, Gan F...
3. Dongxu Zhang, Miao Wang, Guocheng Du, Qingxin Zhao, Jing Wu, Jian Chen. Surfactant Protein of the Streptomyces Subtilisin Inhibitor Family Inhibites Transglutaminase Activation in Streptomyces hygroscopicus.Journal of Agricultural and Food Chemistry. 2008, 56 (9): 3403–3408.4. 張東旭,堵國成,...
