missense,英語單詞,主要用作名詞、形容詞,作名詞時譯為“[生化] 錯義”,作形容詞時譯為“錯義的”。
基本介紹
- 外文名:missense
- 詞性:名詞、形容詞
- 英式發音:['mɪs,sens]
- 美式發音:['mɪs,sɛns]
missense,英語單詞,主要用作名詞、形容詞,作名詞時譯為“[生化] 錯義”,作形容詞時譯為“錯義的”。
錯義突變(missense mutation):是編碼某種胺基酸的密碼子經鹼基替換以後,變成編碼另一種胺基酸的密碼子,從而使多肽鏈的胺基酸種類和序列發生改變。錯義突變的結果通常能使多肽鏈喪失原有功能,許多蛋白質的異常就是由錯義突變引起的。由於...
錯義抑制基因 missense suppressor是能夠抑制錯義突變的抑制基因。由於錯義突變而被置換了的胺基酸因受到抑制而被進一步置換成其他胺基酸的結果,至少無義突變得到部分地回復。和無義突變抑制基因一樣,已知在大腸桿菌中可起因於tRNA基因,也...
錯義突變(missense mutation):鹼基對的置換使mRNA的某一個密碼子變成編碼另一種胺基酸的密碼子的突變稱為錯義突變。錯義突變可導致機體內某種蛋白質或酶在結構及功能發生異常,從而引起疾病。如人類正常血紅蛋白β鏈的第六位是谷氨酸,...
已在不同人種的家族性AD 中檢出了數十種誤義(missense) 突變。該基因的缺陷可影響APP 轉運和酶切加工。多於50%的早老基因錯義突變可引起早發性AD。研究 早老蛋白-1(Presenilin-1,PS1)的過度表達對tau蛋白磷酸化的影響:在NC-108...
We show that sodium channels with the missense mutation recover from inactivation more rapidly than normal and that the frameshift mutation causes the sodium channel to be non-functional.電生理研究顯示含有錯義突變的鈉離子通道...
5. Li J, Zhao T, Zhang Y, Zhang K …, Sun ZS. Performance evaluation of pathogenicity computation methods for missense variants. Nucleic Acids Research, 2018. (IF=11.147)6. Wang Y, Zeng C, Li J, Zhou ...
Both frameshift and missense mutations can be suppressed by intragenic suppressors.移碼突變和異義突變都能被基因內抑制基因所抑制。It is necessary to detect the large intragenic MMR genes deletions in the molecular detection of ...
[22]. Jianxi Xiao#, Haiming Cheng#, Teresita Silva, Jean Baum, Barbara Brodsky. Osteogenesis imperfecta missense mutations in collagen: structural consequences of a glycine to alanine replacement at a highly charged site. ...
3. Xiao Y, Zhang L, He K, Gao X, Yang L, He L, Ma G, Guo X*. Characterization of a novel missense mutation on murine Pax3 through ENU mutagenesis. J Genet Genomics. 2011; 38(8):333-9.4. Guo X, Mak ...
3.Zeng K, Zhang QG, Liang LP, Liang YH. Three Novel Missense Mutations of NF1 in Neurofibromatosis Type 1 Patient. J Clin Exp Dermatol Res, 2014,5:211.4.Liang YH, Zhang QG, Liu QX. Two Novel Missense ...
②錯義突變(missensemutation),鹼基置換使密碼子的意義改變,經轉錄和翻譯所對應的胺基酸改變。③無義突變(nonsensemutation),鹼基置換使密碼子成為終止密碼,導致肽鏈延長提前結束。④終止密碼突變(terminatorcodonmutation),鹼基置換使終止...
78. Xianyong Lan,Chuanying Pan,Liangzhi Zhang,Miao Zhao,Chunlei Zhang,Chuzhao Lei,Hong Chen*. A novel missense (A79V) mutation of goat PROP1 gene and its association with production traits. Molecular Biology ...