dominant negative mutation，醫學術語，顯性負突變。
基本介紹
- 中文名：顯性負突變
- 外文名：dominant negative mutation
顯性負突變：在廣義上，凡一對等位基因中因其中一個突變或丟失所致的另一個正常等位基因的功能活性喪失，都稱為顯性負突變。換言之，顯性負突變即雜合的突變產生了純合突變的效應。例如，在某些腫瘤中，抑癌基因p53的一個等位基因的失活導致另一個正常等位基因也失去活性。
dominant negative mutation，醫學術語，顯性負突變。
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4. Hõrak, H#., Sierla, M#., Tõldsepp, K#., Wang, C#., Nuhkat, M., Wang, Y.H., Valk, E., Pechter, P., Merilo, E., Overmyer, K., Loog, M., Brosché, M., Schroeder, J.I., Kangasjärvi, J., and Kollist, H (2016). A dominant mutation in HT1 uncovers ...
5.Lee SC*, Sim N, Clement M, Yadav S, Pervaiz S. Dominant negative Rac1N17 attenuates human melanoma M14 cell apoptosis sensitivity by upregulation of heat shock protein 27: a functional proteomic study. Proteomics. 7:4112-4122, 2007 6.Lee SC*, Pervaiz S. Apoptosis in the pathogenesis ...
常染色體顯性遺傳夜間額葉癲癇（Autosomal dominant nocturnal frontal lobe epilepsy, ANDFLE），又稱特發性局灶性癲癇綜合徵，是一種與睡眠相關的單基因遺傳性癲癇綜合徵。臨床表現為睡眠中成串運動性發作，包括手足痙攣、軀體強直、肌張力不全樣運動及發聲症狀（如呼喊、尖叫），多起病於兒童期，常被誤診為睡
Xiangyu Ma, Liping Guan, Wei Wu,...Ye Yin, ...(2015) Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa. Scientific Report. 2015 Mar 18;5:9236. doi: 10.1038/srep09236.Zhang H1, Gao Y, Jiang F,...Yin Y,...(2015)Non-invasive ...