基本介紹
- 外文名：christine nardini
- 技術職務：研究員
- 專業名稱：計算生物學
- 性別：女
簡介,研究工作,
簡介
姓名 christine nardini
所系名稱 上海生命科學研究院計算生物學研究所
性別 女
專業名稱 計算生物學
技術職務 研究員
研究方向 臨床基因網路
研究工作
Thank to the innovative approaches to genetic (genomics), medicine is facing the tangible possibility to shift its conventional approach toward personalized medicine. This is an evidence based science, able to improve dramatically the efficiency of prevention and treatments by reducing side effects and empowering therapeutic approaches. This science is rooted in the concept of genomic profile, that is the ensemble not only of specific genes variants (genotype), but also of specific patterns of (disrupted) genes' activation, typical of each unique patient-and-disease complex. Knowing the genomic profile of an individual in a given condition might allow to define a better targeted therapeutic approach.
However, the identification of disrupted patterns in a genomic profile is extremely complex, and different approaches as well as different samples under study can highlight different and sometimes non-overlapping sets of genes responsible for the complex changes that are undergoing in a cell during a disease. Thus, the translation of these concepts into medical practice represents still and important challenge.
Our research focuses on the identification of approaches that try to resolve such apparent incongruities, notably using gene network reverse engineering approaches and systemic approaches, in strong connection with the use of experimental data.
The objective is two-fold:
* identify approaches that can use diverse gene signatures as a source of information enrichment to build more complex, multidimensional (networks vs lists) gene signatures
* use these approaches to get insight into the functioning of innovative/alternative medical approaches
指導研究生情況
·2003-2005 - PhD in Electronics and Informatics at University of Bologna. Supervisor: Prof. Luca Benini.
·2003-2004 – Visiting researcher at the Computer Science Department at Stanford University (CA, USA), with Prof Giovanni de Micheli. For the development of data mining algorithms to be applied to microarrays for gene expression analyses.
·1999 National Habilitation to Engineers Professional Activity.
·1992-1998 –Master Degree in Electrical Engineering – Biomedical specialization at the University of Bologna (90/100). Tutor: Prof. Mauro Ursino
·1992 – BS Degree at Istituto N. Copernico in Bologna (60/60).
Employment record
since 02/2008 Research group leader of the Clinical Genomic Network group, in a joint appointment of the Max-Planck-Society and the Chinese Academy of Sciences, at the PICB, Shanghai.
2007. Collaborator at the Telethon Institute for Genetics and Medicine (Naples, Italy) with the Systems Biology Lab
2006- 2007. Research Assistant at the Department of Electronic Informatics and Systems (DEIS) at the University of Bologna (Italy).
2006-2008. Professor for the module of systems biology-biosensors at the International Master of Bioinformatics, University of Bologna, Italy.
1999 - 2002. Field Engineer in the Cardiac Rhythm Management Division at Medtronic S.p.A. for assistance during implant and follow-up of patients with implantable devices for brady/tachy arrhythmias. Education activity on brady/tachy arrhythmias and cardiac stimulation for nurses and medical doctors in various hospitals in the regions of Emilia Romagna and Marche.
Teaching experience
Systems biology module in the course Biosensors at the International Master of Bioinformatics, University of Bologna, Italy
