基本介紹
- 中文名：CD86
- 外文名：CD86
- 領域：生物
- 性質：名詞
簡介,表達,
簡介
CD86與誘導劑CD28和抑制劑CTLA4相互作用，是誘導T淋巴細胞增殖及產生IL-2的主要協同因子。
表達
CD86在HD的R-S細胞、Ki-1淋巴細胞、EBV轉化的B淋巴母細胞樣細胞上均有表達。
CD86
The protein CD86 (Cluster of Differentiation 86) is a molecule expressed on antigen-presenting cells that provide costimulatory signals necessary for T cell activation and survival. It is the ligand for two proteins at the cell surface of T cells, CD28 antigen and CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). CD86 is also known as B7.2. Its principal mode of action is by binding to CD28. Along with CD80, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells.
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with CTLA-4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
