Andrew Teschendorff

Andrew Teschendorff，計算生物所研究員。

簡歷：

1990.10--1995.07英國愛丁堡大學數學物理學學士; 1995.10--1996.07英國劍橋大學理論物理碩士; 1996.10--2000.05英國劍橋大學超弦理論博士; 2000.07--2001.07英國電信公司實驗室複雜性研究組; 2001.09--2003.08華威大學數學所研究助理; 2003.09--2008.08劍橋研究所英國癌症研究資深研究人員; 2008.09--2013.09倫敦大學學院癌症研究所首席研究人員; 2013.10-至今中科院-馬普學會計算生物學夥伴研究所研究組長

研究方向：

計算系統基因組學

職稱：

研究員

職務：

計算生物所研究組長、博士生導師

代表論著：

1.Teschendorff AE, Li L, Yang Z. Denoising perturbation signatures reveals an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine treated ER+ breast cancer. Genome Biology 2015, 16:61.; 2.Banerji CR, Severini S, Caldas C, Teschendorff AE. Intra-Tumour Signalling Entropy Determines Clinical Outcome in Breast and Lung Cancer. PLoS Comput Biol 2015, 11(3):e1004115.; 3.Yuan T, Jiao Y, de Jong S, Ophoff RA, Beck S, Teschendorff AE. An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging. PLoS Genet 11(2):e1004996.; 4.Banerji, C. R., et al. (2015). "β-Catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy." Journal of the Royal Society, Interface / the Royal Society 12(102): 20140797.; 5.Shen B, Teschendorff AE, Zhi D, Xia J. Biomedical data integration, modeling, and simulation in the era of big data and translational medicine. Biomed Res Int. 2014;2014:731546. doi: 10.1155/2014/731546. Epub 2014 Jul 24. PubMed PMID: 25147813; PubMed Central PMCID: PMC4131419.; 6.Anjum S, Fourkala EO, Zikan M, Wong A, Gentry-Maharaj A, Jones A, Hardy R, Cibula D, Kuh D, Jacobs IJ, Teschendorff AE, Menon U, Widschwendter M. A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. Genome Med. 2014 Jun 27;6(6):47. doi: 10.1186/gm567. eCollection 2014. PubMed PMID: 25067956; PubMed Central PMCID: PMC4110671.; 7.Gomez-Cabrero D, Abugessaisa I, Maier D, Teschendorff A, Merkenschlager M, Gisel A, Ballestar E, Bongcam-Rudloff E, Conesa A, Tegnér J. Data integration in the era of omics: current and future challenges. BMC Syst Biol. 2014;8 Suppl 2:I1. doi: 10.1186/1752-0509-8-S2-I1. Epub 2014 Mar 13. PubMed PMID: 25032990; PubMed Central PMCID: PMC4101704.; 8.Teschendorff AE, Liu X, Caren H, Pollard SM, Beck S, Widschwendter M, Chen L. The dynamics of DNA methylation covariation patterns in carcinogenesis. PLoS Comput Biol. 2014 Jul 10;10(7):e1003709. doi: 10.1371/journal.pcbi.1003709. eCollection 2014 Jul. PubMed PMID: 25010556; PubMed Central PMCID: PMC4091688.; 9.Ma Z, Teschendorff AE, Yu H, Taghia J, Guo J. Comparisons of non-Gaussian statistical models in DNA methylation analysis. Int J Mol Sci. 2014 Jun 16;15(6):10835-54. doi: 10.3390/ijms150610835. PubMed PMID: 24937687; PubMed Central PMCID: PMC4100184.; 10.Jiao Y, Widschwendter M, Teschendorff AE. A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies differential gene expression modules under epigenetic control. Bioinformatics. 2014 Aug 15;30(16):2360-6. doi: 10.1093/bioinformatics/btu316. Epub 2014 May 2. PubMed PMID: 24794928.; 11.Steegenga WT, Boekschoten MV, Lute C, Hooiveld GJ, de Groot PJ, Morris TJ, Teschendorff AE, Butcher LM, Beck S, Müller M. Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. Age (Dordr). 2014 Jun;36(3):9648. doi: 10.1007/s11357-014-9648-x. Epub 2014 May 2. PubMed PMID: 24789080; PubMed Central PMCID: PMC4082572.; 12.Teschendorff AE, Sollich P, Kuehn R. Signalling entropy: A novel network-theoretical framework for systems analysis and interpretation of functional omic data. Methods. 2014 Jun 1;67(3):282-93. doi: 10.1016/j.ymeth.2014.03.013. Epub 2014 Mar 24. PubMed PMID: 24675401.; 13.Pan S, Wu D, Teschendorff AE, Hong T, Wang L, Qian M, Wang C, Wang X. JAK2-centered interactome hotspot identified by an integrative network algorithm in acute Stanford type A aortic dissection. PLoS One. 2014 Feb 24;9(2):e89406. doi: 10.1371/journal.pone.0089406. eCollection 2014. PubMed PMID: 24586754; PubMed Central PMCID: PMC3933461.; 14. * Feber A, Guilhamon P, Lechner M, Fenton T, Wilson GA, Thirlwell C, Morris TJ, Flanagan AM, Teschendorff AE, Kelly JD, Beck S. Using high-density DNA methylation arrays to profile copy number alterations. Genome Biol. 2014 Feb 3;15(2):R30. doi: 10.1186/gb-2014-15-2-r30. PubMed PMID: 24490765; PubMed Central PMCID: PMC4054098.