黨永軍(重慶醫科大學藥學院院長)

黨永軍(重慶醫科大學藥學院院長)

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黨永軍，男，博士，教授，畢業於復旦大學，長江學者。

現任重慶醫科大學藥學院院長。

基本介紹

  • 中文名：黨永軍
  • 畢業院校：復旦大學
  • 學位/學歷：博士
  • 職業：教師
  • 專業方向：分子靶點鑑定和作用機制、小分子化合物特異性的靶向蛋白
人物經歷,研究方向,學術成果,

人物經歷

2000-2003年於復旦大學遺傳所獲博士學位;
2004-2009年約翰霍普金斯大學醫學院藥理和分子科學系博士後;
2010-2012年約翰霍普金斯大學醫學院藥理和分子科學系Faculty (Research associate)。
2012年復旦大學醫學院生化和分子生物學系研究員。
現任重慶醫科大學藥學院院長。

研究方向

（1）天然產物和藥物的分子靶點鑑定和作用機制研究；（2）以小分子化合物特異性的靶向蛋白用於基礎生物學的理論研究；（3）建立適於高通量篩選的細胞和動物模型用於新藥的篩選和研發。

學術成果

共發表SCI收錄的文章29篇，分別發表在Mol Cell、PNAS、JBC、RNA、JACS 、Nature Chemical Biology等期刊發表，文章被引超過830次。另獲美國授權專利一項。
代表論文：
  1. Dang Y, Schneider-Poetsch T, Eyler DE, Jewett JC, Bhat S, Rawal VH, Green R, and Liu JO. (2011) Inhibition of Eukaryotic Translation Elongation by the Antitumor Natural Product Mycalamide B.RNA17(8), 1578-1588
  2. Dang, Y., Low, W.K., Xu, J., Gehring, N.H., Dietz, H.C., Romo, D., and Liu, J.O. (2009). Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII.J Biol Chem284, 23613-23621.
  3. Dang, Y., Kedersha, N., Low, W.K., Romo, D., Gorospe, M., Kaufman, R., Anderson, P., and Liu, J.O. (2006). Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A.J Biol Chem281, 32870-32878.
  4. Low, W.K*.,Dang, Y*., Schneider-Poetsch, T., Shi, Z., Choi, N.S., Merrick, W.C., Romo, D., and Liu, J.O. (2005). Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.Mol Cell20, 709-722. *co-first author(Featured in the review by Dr. Jon Clardy in ACS Chemical Biology “ Stopping Trouble before It starts” 2005 Vol. 1 No. 1 p17; Highlighted in C & EN News “Protein Synthesis Nipped in the Bud” on December 19, 2005; Commented in “Faculty of 1000”)
  5. He, H*.,Dang, Y*., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., et al. (2003). Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.J Biol Chem278, 29278-29287. *co-first author
  6. Li W,Dang Y, Liu JO, Yu B. (2010). Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity.Bioorg Med Chem Lett. 20(10):3112-5.
  7. .Xu J,Dang Y, Ren YR, Liu JO. (2010). Cholesterol trafficking is required for mTOR activation in endothelial cells.Proc Natl Acad Sci U S A. 107(10):4764-9.
  8. Li, W.,Dang, Y., Liu, J.O., and Yu, B. (2009). Expeditious Synthesis of Hippuristanol and Congeners with Potent Antiproliferative Activities.Chemistry15, 10356-10359.
  9. Low, W.K.,Dang, Y., Bhat, S., Romo, D., and Liu, J.O. (2007a). Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity.Chem Biol14, 715-727.
  10. Low, W.K.,Dang, Y., Schneider-Poetsch, T., Shi, Z., Choi, N.S., Rzasa, R.M., Shea, H.A., Li, S., Park, K., Ma, G., et al. (2007b). Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A.Methods Enzymol431, 303-324.
  11. Hu, X.,Dang, Y., Tenney, K., Crews, P., Tsai, C.W., Sixt, K.M., Cole, P.A., and Liu, J.O. (2007). Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.Chem Biol14, 764-774.
  12. Peddibhotla, S.,Dang, Y., Liu, J.O., and Romo, D. (2007). Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics.J Am Chem Soc129, 12222-12231.
  13. (Highlighted in C&EN News “Tagging Natural Products” on Oct. 1, 2007)Wu, J.,Dang, Y., Su, W., Liu, C., Ma, H., Shan, Y., Pei, Y., Wan, B., Guo, J., and Yu, L. (2006). Molecular cloning and characterization of rat LC3A and LC3B--two novel markers of autophagosome.Biochem Biophys Res Commun339, 437-442.
  14. Titov DV, Gilman B, He QL, Bhat S, Low WK,Dang Y, Smeaton M, Demain AJ, Miller PS, Kugel JF, Goodrich JA & Liu JO, (2011) XPB, a subunit of TFIIH, is a target of the natural product triptolide.Nature Chemical Biology7(3):182-8.Featured as Cover
  15. Chamni S, He QL,Dang Y, Bhat S, Liu JO, and Romo D, (2011) Diazo Reagents with Small Steric Footprints for Simultaneous Arming/SAR Studies of Alcohol-Containing Natural Products via O–H Insertion.ACS Chemical Biology18;6(11):1175-81
  16. Schneider-Poetsch T, Ju J, Eyler DE,Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. (2010). Inhibition of Eukaryotic Translation Elongation via the Ribosomal E-site by Cycloheximide and Lactimidomycin.Nature Chemical Biology6(3):209-217 (IF=15.808)
  17. Liu JO, Titov D,Dang Y, and He QL. (2011) Regulator of Ras Depalmitoylation and Retrograde Trafficking: A New Hat for FKBP.Molecular Cell21;41(2):131-3
  18. Huang W, Ding L, Huang Q, Hu H, Liu S, Yang X, Hu X,Dang Y, Shen S, Li J, Ji X, Jiang S, Liu JO, Yu L. (2010) Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma. Hepatology52(2), 703 – 714
  19. Ren, Y.R., Pan, F., Parvez, S., Fleig, A., Chong, C.R., Xu, J.,Dang, Y., Zhang, J., Jiang, H., Penner, R., et al. (2008). Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.PLoS One3, e4009.(Highlighted in Johns Hopkins Gazette on Febrary 16, 2009 “ Old Meds Hold Promise As Therapy for Autoimmune Diseases”)授權發明專利：“Anticancer agents and use” United States Patent 7737134主持項目：自然基金面上項目（2013-2017） 項目批准號:31270830

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