黃靜(湖南大學生物學院教授)

黃靜，女，博士，湖南大學生物學院教授、博士生導師。

基本介紹

• 中文名：黃靜
• 畢業院校：武漢大學
• 學位/學歷：博士
• 專業方向：化學生物
• 任職院校：湖南大學
• 職務：湖南大學生物學院教授、博士生導師

人物經歷

教育經歷

2001-2005 湖南農業大學 套用化學專業本科

2005-2010 武漢大學 化學生物學博士

工作經歷

2010 -2015在美國國立衛生研究院（NIH）從事博士後研究

2016年至今 湖南大學生物學院，化學生物學與納米醫學研究所

2017年至今 化學生物感測與計量國家重點實驗室

研究領域

1、抗癌靶向小分子的篩選及其生物活性研究

2、基因損傷修復機理與基因組的穩定性

3、化學生物感測探針

科研項目

1. 國家自然科學基金青年項目，21708007，DNA轉位酶FANCM抑制劑的篩選及其在DNA交聯損傷修復通路中的作用研究，2018.01-2020.12，主持。

2. 國家自然科學基金面上項目，31871365，基於DNA纖維螢光原位雜交技術的DNA交聯損傷修復研究，2019.01-2022.12，主持。

3. 國家自然科學基金海外合作項目，21828701，泛素化組蛋白H4探針的設計合成以及在基因損傷修復中的套用，2019.01-2020.12

4. 黃靜，湖南省自然科學基金青年項目，2018JJ3030，基於活性氧激活的RNA G-四鏈體探針的設計、合成及其生物活性研究，2018.01-2020.12，主持。

學術成果

Jing Huang*, Jing Zhang, Marina A. Bellani, Durga Pokharel, Julia Gichimu, Ryan C. James, Himabindu Gali, Chen Ling, Zhijiang Yan, Dongyi Xu, Junjie Chen, Amom Ruhikanta Meetei, Lei Li, Weidong Wang, Michael M. Seidman*, Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2, Cell Reports, 2019, 27, 1794-1808.

Lu Liu, Yaya Zhang, Jia Zhou, Jihuan Yang, Cheng Zhong, Yueshou Zhang, Yu Luo, Yang Fua, Jing Huang*, Zhibin Song*, Yiyuan Peng, Design of a quinazolinone-based environment-sensitive fluorescent dye: Solvatochromic fluorescence and application for one-photon and two-photon bioimaging, Dyes and Pigments, 2019, 165, 58-64.

Marina A Bellani, Jing Huang, Manikandan Paramasivam, Durga Pokharel, Julia Gichimu, Jing Zhang, Michae M. Seidman*, Imaging cellular responses to antigen tagged DNA damage, DNA Repair, 2018, 71, 183-189.

Jing Huang, Himabindu Gali, Julia Gichimu, Marina A. Bellani, Durga Pokharel, Manikandan Paramasivam, Michael M. Seidman*, Single Molecule Analysis of Laser Localized Psoralen Adducts, Journal of Visualized Experiments, 2017，122, e55541.

Chen Ling, Jing Huang, Zhijiang Yan, Yongjiang Li, Mioko Ohzeki, Masamichi Ishiai, Dongyi Xu, Minoru Takata, Michael Seidman*, and Weidong Wang*, Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks, Cell Discovery, 2016, 2, 16047.

Florian Rohleder#, Jing Huang#, Yutong Xue, Jochen Kuper, Adam Round, Michael Seidman*, Weidong Wang*, and Caroline Kisker*, FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks, Nucleic Acids Research, 2016, 44, 3219–3232.

Jing Huang, Himabindu Gali, Manikandan Paramasivam, Parameswary Muniandy, Julia Gichimu, Marina A. Bellani and Michael M. Seidman*, Single molecule analysis of laser localized interstrand crosslinks. Frontiers in Genetics, 2016, 7.

Taraswi Banerjee, Joshua A. Sommers, Jing Huang, Michael M. Seidman, Robert M. Brosh, Jr*, Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress. Current Biology, 2015, 25, 2830-2838.

Xiaolin Li, Evandro Fei Fang, Morten Scheibye-Knudsen, Honghua Cui, Lu Qiu, Jian Li, Yuping He, Jing Huang, Vilhelm A Bohr, Tzi Bun Ng*, Hongwei Guo*, Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis, Science Report，2014, 4, 6434.

Jing Huang, Shuo Liu, Marina A. Bellani, Arun Kalliat Thazhathveetil, Chen Ling, Johan P. de Winter, Yinsheng Wang, Weidong Wang, and Michael M. Seidman*, “The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks”, Molecular Cell. 2013, 52, 434–446.

Daniel R. McNeill, Manikandan Paramasivam, Jakita Baldwin, Jing Huang, Vaddadi N. Vyjayanti, Michael M. Seidman and David M. Wilson III*, “NEIL1responds and binds to psoralen-induced DNA interstrand crosslinks”, Journal of Biological Chemistry, 2013, 288, 12426-12436.

Venkateswarlu Popuri, Jing Huang, Mahesh Ramamoorthy, Takashi Tadokoro, Deborah L Croteau, Vilhelm A Bohr*, RECQL5 plays co-operative and complementary roles with WRN syndrome helicase, Nucleic Acids Research, 2013, 41, 881-899.

Xiaolin Wang#, Jing Huang#, Yangyang Zhou, Shengyong Yan, Xiaocheng Weng, Xiaojun Wu, Minggang Deng, Xiang Zhou*，Conformational Switching of G-Quadruplex DNA by Photoregulation，Angewandte Chemie International Edition, 2010 , 49, 5305-539.

Bai Minghui, Huang Jing, Zheng Xiaolong, Song Zhibin, Tang Miru, Mao Wuxiang, Yuan Libo, Wu Jun, Weng Xiaocheng, Zhou Xiang*, Highly Selective Suppression of Melanoma Cells by Inducible DNA Cross-Linking Agents: Bis(catechol) Derivatives, Journal of the American Chemical Society, 2010 , 132, 15321-15327.

Yuhao Du, Jing Huang, Xiaocheng Weng, Xiang Zhou*, Specific recognition of DNA by small molecules.Current Medicinal Chemistry, 2010, 17, 173-189.

Liang Xu, Dan Zhang, Jing Huang, Minggang Deng, Ming Zhang, Xiang Zhou *，High fluorescence selectivity and visual detection of G-quadruplex structures by a novel dinuclear ruthenium complex, Chemical Communications, 2010, 46 :743-745.

Yuhao Du, Xiaocheng Weng, Jing Huang, Dan Zhang, Heng Ma, Dong Chen, Xiang Zhou*, Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA, Bioorganic & Medicinal Chemistry, 2010, 18, 4149-4153.

Jing Huang, Ming Wang, Yangyang Zhou; Xiaocheng Weng, Liang Shuai, Xiang Zhou *, Deqing Zhang, Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission, Bioorganic & Medicinal Chemistry, 2009 , 17, 7743-7748.

Jing Huang#, Guorui Li#, Zhiguo Wu, Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou *, Guangfu Yang, Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex, Chemical Communications, 2009, 8, 902-904.

Ming Zhang, Jing Huang, Minggang Deng, Xiaocheng Weng, Heng Ma, Xiang Zhou *, Sensitive and Visual Detection of Adenosine by a Rationally Designed FokI-Based Biosensing Strategy, Chemistry – An Asian Journal, 2009, 4,1420-1423.

Lin Wu, Li Yang, Jing Huang, Lixia Zhang, Xiaocheng Weng, Xiaolian Zhang, Chao Shen, Xiang Zhou *, Congyi Zheng, Cationic Ester Porphyrins Cause High Levels of Phototoxicity in Tumor Cells and Induction of Apoptosis in HeLa Cells，Chemistry & Biodiversity, 2009 , 6, 1066-1076.

Shao R Wang, Dan Zhang, Feng L Luo, Lin Liu, Xiao C Weng, Jing Huang, Guo R Li, Xiao L Zhang, Xiang Zhou *, Some cationic porphyrins: synthesis, stabilization of G-quadruplexes, and down-regulation of c-myc in Hep G2 cells，Journal of Porphyrins & Phthalocyanines, 2009, 13, 865-875.

Guorui Li#, Jing Huang#, Ming Zhang, Yangyang Zhou, Dan Zhang, Zhiguo Wu, Shaoru Wang, Xiaocheng Weng, Xiang Zhou *, Guangfu Yang, Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand, Chemical Communications, 2008, 38,4564-4566.

Zhibin Song, Xiaocheng Weng, Liwei Weng, Jing Huang, Xiaolin Wang, Minghui Bai, Yangyang Zhou, Guangfu Yang, Xiang Zhou *, Synthesis and Oxidation-Induced DNA Cross-Linking Capabilities of Bis(catechol) Quaternary Ammonium Derivatives, Chemistry - A European Journal, 2008, 14, 5751-5754.

Lixia Zhang, Jing Huang, Lige Ren, Minghui Bai, Lin Wu, Baoping Zhai, Xiang Zhou *, Synthesis and evaluation of cationic phthalocyanine derivatives as potential inhibitors of telomerase, Bioorganic & Medicinal Chemistry, 2008, 16 303-312.

Boqiao Fu#, Jing Huang#, Lige Ren, Xiaocheng Weng, Yangyang Zhou, Yuhao Du， Xiaojun Wu, Xiang Zhou *, Guangfu Yang, Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands, Chemical Communications, 2007, 31, 3264-3266.

An-Ming Zhang#, Jing Huang#, XiaoCheng Weng, JinXi Li, Lige Ren, ZhiBin Song, XiaoQin Xiong, Xiang Zhou *, XiaoPing Cao, Yan Zhou, A water-soluble, octacationic zinc phthalocyanine as molecular probe for nucleic acid secondary structure, Chemistry & Biodiversity, 2007, 4, 215-223.

Lixia Zhang, Lige Ren, Minghui Bai, Liwei Weng, Jing Huang, Lin Wu, Minggang Deng, Xiang Zhou *, Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups, Bioorganic & Medicinal Chemistry, 2007, 15, 6920-6926.

XiaoCheng Weng, Jing Huang, Song Wu, LiGe Ren, LiWei Weng, ShuGao Zhu, Xiang Zhou *, Specific recognition of loop DNA by dicationic Porphyrins，Chemistry & Biodiversity, 2007, 4, 1501-1507.

Lige Ren, Anming Zhang, Jing Huang, Ping Wang, Xiaocheng Weng, Lixia Zhang, Feng Liang, Zheng Tan, Xiang Zhou *, Quaternary ammonium zinc phthalocyanine: Inhibiting telomerase by stabilizing G quadruplexes and inducing G-quadruplex structure transition and formation, Chembiochem, 2007, 8, 775-780.

Xiaocheng Weng, Lige Ren, Liwei Weng, Jing Huang, Shugao Zhu, Xiang Zhou*, Linhong Weng, Synthesis and biological studies of inducible DNA cross-linking agents, Angewandte Chemie International Edition, 2007, 46, 8020-8023.

獎勵榮譽

2017 湖南省“青年百人”計畫

2014美國國立衛生研究院（NIH）優秀博士後研究員獎

2013美國國立衛生研究院（NIH）優秀博士後研究員獎