高芹芹

高芹芹

高芹芹,女,1983年10月出生,研究員,博士生導師,現任蘇州大學附屬第一醫院胎兒醫學研究所副所長(主持工作)。2008-2013年就讀於華東師範大學生命醫學研究所並獲得博士學位,2013年加入蘇州大學附屬第一醫院胎兒醫學研究所,2017年聘為副研究員,2022年晉升研究員。入選江蘇省雙創人才、333高層次人才培養工程第二層次、高層次衛生“六個一工程”拔尖人才。主要從事母胎源性疾病及妊娠併發症機制研究,主持國家自然科學基金4項、科技部課題1項等國家級項目5項及省市級項目10餘項。研究成果獲江蘇省科學技術進步獎二等獎(第一完成人)、蘇州市科學技術進步獎一等獎等省部級科技獎勵7項。在《Cell Research》《Nature Communications》《Nucleic Acids Research》等期刊發表論文40餘篇,其中8篇影響因子超10分,授權發明專利3項,參編中英文專著4部。擔任《Clinical Science》《Journal of Hypertension》等期刊編委及評審專家。

研究方向,主要成就,

研究方向

母胎源性疾病早期發育起源及獲得性性狀跨代傳遞的表觀遺傳機制

主要成就

1、 Gao Q*#, Li H, Ding H, Chen X, Zhou X, Tao J, Xu Z. Hyper-methylation of AVPR1A and PKCΒ gene associated with insensitivity to arginine vasopressin in human pre-eclamptic placental vasculature. EBioMedicine. 2019 Jun;44:574-581.(第一兼通訊作者)
2、Gao Q*#, Fan X, Xu T, Tao J, Xu Z. Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein. Clin Epigenetics. 2019 May 28;11(1):84. (第一兼通訊作者)
3、Fan X, Xu T, Ding H, Li H, Yang Y, Tao J, Xu Z, Gao Q#. DNA methylation-reprogrammed oxytocin receptor underlies insensitivity to oxytocin in pre-eclamptic placental vasculature. J Cell Mol Med. 2019 Jun;23(6):4118-4126. (通訊作者)
4、 Huifang Zhang, Gao Q*, Shuo Tan, Jia You, Cong Lyu, Jun Qin, Jiwen Li and Jiemin Wong.SET8 Prevents Excessive DNA Methylation by Methylation-Mediated Degradation of UHRF1 and DNMT1. Nucleic Acids Res. 2019 Aug 10. pii: gkz626. (共同第一作者)
5、Gao Q*, Zhu X, Chen J, Mao C, Zhang L, Xu Z. Upregulation of P53 promoted G1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia. J Hypertens. 2016 Jul;34(7):1380-8. (第一作者)
6、 Liu X*, Gao Q*, Li P, Zhao Q, Zhang J, Li J, Koseki H, Wong J. UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. Nat Commun. 2013; 4:1563. (共同第一作者)
7、 Gao Q*, Tang J, Li N, Sun M, Xu Z. What is precise pathophysiology in development of hypertension in pregnancy? Drug Discov Today. 2018 Feb;23(2):286-299.(第一作者)
8、 Gao Q*, Lv J, Li W, Zhang P, Tao J, Xu Z. Disrupting the circadian photo-period alters the release of follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol in maternal and fetal sheep. J Reprod Dev. 2016 Oct 18;62(5):487-493. (第一作者)
9、 Gao Q*, Lin Jiang, Jie Chen, Xiaolin Zhu, and Zhice Xu. Epigenetic code and potential epigenetic-based therapies against chronic diseases in developmental origins. Drug Discov Today. 2014 Nov; 19(11):1744-50. (第一作者)
10、Gao Q*, Tang J, Li N, Zhou X, Li Y, Liu Y, Wu J, Yang Y, Shi R, He A, Li X, Zhang Y, Chen J, Zhang L, Sun M, Xu Z. A novel mechanism of angiotensin II-regulated placental vascular tone in the development of hypertension in preeclampsia. Oncotarget. 2017 May 9;8(19):30734-30741. (第一作者)
11、 Gao Q*, Tang J, Li N, Zhou X, Sun M, Xu Z. New conception for the development of hypertension in preeclampsia. Oncotarget. 2016;7(48):78387-78395.(第一作者)
12、 Chen J*, Gao Q*, Jiang L, Fan X, Mao C, Xu Z. The NOX2-derived reactive oxygen species damaged endothelial nitric oxide system via suppressed BKCa/SKCa in preeclampsia. Hypertens Res. 2017;40(5):457-464.(共同第一作者)
13、 He Y*, Gao Q*, Han B, Tao J, Chen J, Xu Z. Progesterone suppressed vasoconstriction in human umbilical vein via reducing calcium entry. Steroids. 2016 Apr;108:118-25.(共同第一作者)
14、 Zhu X*, Gao Q*, Tu Q, Zhong Y, Zhu D, Mao C, Xu Z. Prenatal hypoxia enhanced angiotensin II-mediated vasoconstriction via increased oxidative signaling in fetal rats. Reprod Toxicol. 2016 Apr;60:21-8. (共同第一作者)
15、 Gu X, He A, Fan X, Yang Y, Gao Q#, Xu Z#. Regulation of Cerebral Arterial BKCa Channels by Angiotensin II Signaling in Adult Offspring Exposed to Prenatal High Sucrose Diets. Biosci Rep. 2017 Jun 21;37(3)(共同通訊作者)
16、Yuxian Yang, Hongmei Ding, Miao Sun, Gao Q#, and Zhice Xu. Impact of prenatal hypoxia on fetal bone growth and osteoporosis in ovariectomized offspring rats. Reprod Toxicol. 2018 Jun;78:1-8.(共同通訊作者)
17、Zhang J*, Gao Q*, Li P, Liu X, Jia Y, Wu W, Li J, Dong S, Koseki H, Wong J. S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance. Cell Res. 2011 Dec;21(12):1723-39. (共同第一作者)

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