B.S. Department of Animal Science and Technology, Shandong Agricultural University, Tai’an, China
1996
中國農業大學動物科技學院生殖生物學碩士
Department of Animal Science and Technology of China Agricultural University, Beijing, China
2000
中國科學院動物學研究所生殖生物學國家重點實驗室生殖生物學博士
PH.D. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, China
工作經歷
2012-
同濟大學生命科學與技術學院 教授、博士生導師 Tongji University,Shanghai, China
2005-2012
北京生命科學研究所研究員
Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2004-2005
美國康乃狄克州大學助理教授
Assistant Professor at University of Connecticut ,USA
2004
美國坦普爾大學醫學院費爾斯腫瘤和分子生物學研究所助理科學家
Associate Scientist at Fels Institute for Cancer Research and Molecular Biology , Temple University School of Medicine ,USA
2002-2004
美國坦普爾大學醫學院費爾斯腫瘤和分子生物學研究所博士後
Post-doctoral Scientist at Fels Institute for Cancer Research and Molecular Biology , Temple University School of Medicine , USA
2000-2002
英國蘇格蘭愛丁堡大學羅斯林研究所基因表達與發育系博士後
Post-doctoral Scientist at Department of Gene Expression& Development of Roslin Institute, Britain
1998-2000
美國布朗大學醫學院羅得島州婦幼醫院不孕不育科研究員助理
Research Associate at Division of Reproductive Medicine and Infertility Women or Infants Hospital of Rhode Island, Brown University School of Medicine , USA
Liu W, Yin J, Kou X, Jiang Y, Gao H, Zhao Y, Huang B, He W, Wang H, Han Z, Gao S. (2014) Asymmetric reprogramming capacity of parental pronuclei in mouse zygotes. Cell Reports (in press)
Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z, Gao S. (2014) Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells. Cell Stem Cell 14(1):27-39.
Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhan Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, Gao S. (2013) Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 12(4):453-69. (Cover Story; Previewed by Cell Stem Cell)
Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S, Zhu B. (2012) Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation.Science 337(6097):971-5. (Co-correspondence)
Kang L, Wang J, Zhang Y, Kou Z, Gao S. (2009) iPS cells can support full term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 5(2):135-138. (Highlighted by Nature, Nature China; Selected as “Must Read” by Faculty 1000; Featured in TIME Magazine, Washington Post, Wall Street Journal, Xinhua News, USA Today, The Scientist, The Economist, ABC News, The Independent, Scientific America etc.)
Wang S, Kou Z, Jing Z, Zhang Y, Guo X, Dong M., Wilmut I, Gao S. (2010) Proteome of mouse oocytes at different developmental stages. Proc. Natl. Acad. Sci. USA 107(41):17639-44.
Liu Y, Cheng H, Gao S, Lu X, He F, Hu L, Hou D, Zou Z, Li Y, Zhang H, Xu J, Kang L, Wang Q, Yuan W, Gao S, Cheng T. (2013) Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. Leukemia. 2013 Oct 22. doi: 10.1038/leu.2013.304. [Epub ahead of print] (Co-correspondence)
Jiao J, Yang Y, Shi Y, Chen J, Gao R, Fan Y, Yao H, Liao W, Sun XF, Gao S. (2013) Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons. Hum Mol Genet. 22(21):4241-52.
Jiao J, Dang Y, Yang Y, Gao R, Zhang Y, Kou Z, Sun XF, Gao S. (2013) Promoting reprogramming by FGF2 reveals that the extracellular matrix is a barrier for reprogramming fibroblasts to pluripotency. Stem Cells 31(4):729-40.
Wang Y, Zheng C, Jiang Y, Zhang J, Chen J, Yao C, Zhao Q, Liu S, Chen K, Du J, Yang Z, Gao S. (2012) Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice. Cell Research 22(4):637-48.
Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, Chen S, Zhu B, Gao S. (2011) RCOR2 is a subunit of the LSD1 complex that regulates ES cell property and substitutes for SOX2 in reprogramming somatic cells into pluripotency. Stem Cells 29(5):791-801.
Wu T, Wang H, He J, Kang L, Jiang Y, Liu J, Zhang Y, Kou Z, Liu L, Zhang X, Gao S. (2011) Reprogramming of trophoblast stem cells into pluripotent stem cells by Oct4. Stem Cells 29(5):755-63.
Kang L, Wu T, Tao Y, Yuan Y, He J, Zhang Y, Luo T, Kou Z, Gao S. (2011) Viable mice produced from 3-factor induced pluripotent stem (iPS) cells through tetraploid complementation. Cell Research 21(3):546-9.
Hu J, Wang F, Yuan Y, Zhu X, Wang Y, Zhang Y, Kou Z, Wang S, Gao S. (2010) The novel importin-alpha family member Kpna7, is required for normal fertility and fecundity in the mouse. J. Biol. Chem. 285(43):33113-22.
Kou Z, Kang L, Yuan Y, Tao Y, Zhang Y, Wu T, He J, Wang J, Liu Z, Gao S. (2010) Mice cloned from induced pluripotent stem cells (iPSCs). Biol. Reprod. 83:238-243.
Zhao Q, Wang J, Zhang Y, Kou Z, Liu S and Gao S. (2010) Generation of histocompatible androgenetic embryonic stem cells using spermatogenic cells. Stem Cells 2010; 28(2):229-239.
Zhang M, Wang F, Kou Z, Zhang Y, Gao S. (2009) Defective chromatin structure in somatic cell cloned embryos. J. Biol. Chem. 284(37):24981-7.
Guo X, Gao S. (2009) LGN regulates meiotic spindle organization, anchoring and involves in cortical polarization during mouse oocytes maturation. Cell Research 19(7):838-48.
Wang Y, Jiang Y, Liu S, Sun X, Gao S. (2009) Generation of induced pluripotent stem cells from human beta-thalassemia fibroblast cells. Cell Research 19(9):1120-3.
Sung LY*, Gao S*, Shen H, Yu H, Song Y, Smith SL, Chang CC, Kuo L, Lian J, Tian XC, Tuck DP, Weissman SM, Yang X, Cheng T (2006) Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer. Nat. Genet. 38(11): 1323-1328. (* Co-first author)
