馮良珠，博士，蘇州大學功能納米與軟物質研究院教授。
基本介紹
- 中文名：馮良珠
- 學位/學歷：博士
人物經歷,研究領域,榮譽獎勵,學術兼職,代表性論文,
人物經歷
教育經歷
2010/09-2015/06，蘇州大學，功能納米與軟物質研究院，理學博士
2013/09-2014/10，美國喬治亞理工學院，生物醫學工程系，聯合培養博士（CSC資助）
2006/09-2010/06，蘇州大學，基礎醫學與生物科學學院，理學學士
工作經歷
2015/10-2016/10，澳門大學，中華醫藥研究院，博士後
2016/11-2018/06，蘇州大學，功能納米與軟物質研究院，助理研究員
2018/07-2022/06，蘇州大學，功能納米與軟物質研究院，副研究員/蘇州大學優秀青年學者
2022/07-2023/06，蘇州大學，功能納米與軟物質研究院，研究員/蘇州大學優秀青年學者
2023/07-至今， 蘇州大學，功能納米與軟物質研究院，教授
研究領域
課題組在功能化生物材料的設計構建與增效腫瘤治療方面開展創新研究。先後發展了一系列新型碳酸鈣基微納載體用於腫瘤微酸回響性藥物控釋與免疫抑制性微環境調控；構建了多種離子型水凝膠用於提升肝癌消融治療的精準性與免疫原性；設計了多種仿生礦化腫瘤疫苗用於預防術後腫瘤復發與轉移這一臨床難題。迄今在Science Advances, Nature Communications, Chem, J. Am. Chem. Soc., Adv. Mater., Natl. Sci. Rev., Chem. Rev.等高水平學術期刊上發表第一/通訊作者論文60餘篇，文章的總他引18200餘次，SCI H-index為61；四次入選了美國美國科睿唯安公布的“全球高被引科學家名單”（Highly Cited Researchers，交叉領域，2019、2021-2023年）；受邀擔任了Materials Today Bio, Exploration, BMEMater等多個學術期刊的青年編委；主持/參與了國自然優秀青年基金、科技部重點研發計畫、江蘇省優秀青年基金等9項省部級科研項目資助。
榮譽獎勵
2023 國自然優秀青年基金
2023 科睿唯安-全球高被引科學家（交叉學科）
2022 科睿唯安-全球高被引科學家（交叉學科）
2022 江蘇省優秀青年基金
2021 科睿唯安-全球高被引科學家（交叉學科）
2019 科睿唯安-全球高被引科學家（交叉學科）
2016 江蘇省科學技術一等獎 （排名第五）
學術兼職
Young Editorial Board Members, Exploration (2023-)
Young Editorial Board Members, BMEMat (2022-)
ECR board member, Materials Today Bio (IF = 10.761, Q1, 2022-)
代表性論文
[24] Ziliang Dong, Lei Zhang, Dongxu Zhao, Chunjie Wang, Yu Hao, Quguang Li, Yunyun Zhang, Zhijuan Yang, Caifang Ni*, Zhuang Liu*, Liangzhu Feng*, Procoagulant CaCO3-embedded embolic microspheres can potentiate transcatheter arterial embolization of hepatocellular carcinoma. Nano Today, 2024, 55, 102216.
[23] Yan Liu*, Yu Hao, Jiahui Chen, Minming Chen, Jia Tian, Xiang Lv, Yefei Zhang, Xinxing Ma, Yehui Zhou, and Liangzhu Feng*, An Injectable Puerarin Depot Can Potentiate Chimeric Antigen Receptor Natural Killer Cell Immunotherapy Against Targeted Solid Tumors by Reversing Tumor Immunosuppression. Small, 2024, 2307521.
[22] Ziliang Dong, Yan Liu, Chunjie Wang, Yu Hao, Qin Fan, Zhijuan Yang, Quguang Li, Liangzhu Feng*, Zhuang Liu*, Tumor Microenvironment Modulating CaCO3-Based Colloidosomal Microreactors Can Generally Reinforce Cancer Immunotherapy. Adv. Mater., 2023, 2308254.
[21] Yan Liu*, Yu Hao, Xiang Lv, Yefei Zhang, Jiahui Chen, Jia Tian, Xinxing Ma, Yehui Zhou, Liangzhu Feng*, A Tetramethylpyrazine Releasing Hydrogel can Potentiate CAR-T Cell Therapy against Triple Negative Breast Cancer by Reprogramming Tumor Vasculatures. Fundam. Res., 2023, doi.org/10.1016/j.fmre.2023.05.016.
[20] Chunjie Wang, Lei Zhang, Zhijuan Yang, Dongxu Zhao, Zheng Deng, Jialu Xu, Yumin Wu, Yu Hao, Ziliang Dong, Liangzhu Feng*, Zhuang Liu*, Self-fueling ferroptosis-inducing microreactors based on pH-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy. Natl. Sci. Rew., 2023, 11, nwad257.
[19] Quguang Li, Ziliang Dong, Zhiqin Cao, Huali Lei, Chunjie Wang, Yu Hao, Liangzhu Feng,* Zhuang Liu*, A General Biomineralization Strategy to Synthesize Autologous Cancer Vaccines with cGAS-STING Activating Capacity for Postsurgical Immunotherapy. ACS Nano, 2023, 17, 10496-0510.
[18] Yujie Zhu, Zhijuan Yang, Zijian Pan, Yu Hao, Chunjie Wang, Ziliang Dong, Quguang Li, Yikai Han, Longlong Tian, Liangzhu Feng*, Zhuang Liu*, Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment. Sci. Adv., 2022, 8(31), abo5285.
[17] Yu Hao, Lei Zhang, Ziliang Dong, Chunjie Wang, Yu Chao, Dongxu Zhao, Yujie Zhu, Zhijuan Yang, Nailin Yang, Yikai Han, Liangzhu Feng*, Zhuang Liu*, Percutaneous implantation of ethanol fueled catalytic hydrogel suppresses tumor growth by triggering ferroptosis. Mater. Today, 2022, 55, 7-20.
[16] Zhijuan Yang, Yujie Zhu, Ziliang Dong, Yu Hao, Chunjie Wang, Quguang Li, Yumin Wu, Liangzhu Feng*, Zhuang Liu*, Engineering bioluminescent bacteria to boost photodynamic therapy and systemic anti-tumor immunity for synergistic cancer treatment. Biomaterials, 2022, 281, 121332.
[15] Chunjie Wang, Ziliang Dong, Yu Hao, Yujie Zhu, Jing Ni, Quguang Li, Bo Liu, Yikai Han, Zhijuan Yang, Jianmei Wan, Kai Yang, Zhuang Liu*, Liangzhu Feng*, Coordination Polymer-Coated CaCO3 Reinforces Radiotherapy by Reprogramming the Immunosuppressive Metabolic Microenvironment. Adv. Mater., 2022, 34(3), 2106520.
[14] Zhijuan Yang, Yujie Zhu, Ziliang Dong, Wei Li, Nailin Yang, Xianwen Wang, Liangzhu Feng*, Zhuang Liu*, Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses. Nat. Commun., 2021, 12, 4299.
[13] Yujie Zhu, Zhijuan Yang, Ziliang Dong, Yimou Gong, Yu Hao, Longlong Tian, Xianzhu Yang, Zhuang Liu*, Liangzhu Feng*, CaCO3-Assisted Preparation of pH-Responsive Immune-Modulating Nanoparticles for Augmented Chemo-Immunotherapy. Nano-Micro Lett., 2021, 13(1),1-18.
[12] Ziliang Dong, Liangzhu Feng*, Yu Hao, Quguang Li, Muchao Chen, Zhijuan Yang, He Zhao, Zhuang Liu*, Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress. Chem, 2020, 6(6), 1391-1407.
[11] Ziliang Dong, Liangzhu Feng*, Yu Chao, Yu Hao, Muchao Chen, Fei Gong, Xiao Han, Rui Zhang, Liang Cheng, Zhuang Liu*, Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy. Nano Lett., 2019, 19, 805-815.
[10] Ziliang Dong, Liangzhu Feng*, Yu Hao, Muchao Chen, Min Gao, Yu Chao, He Zhao, Wenwen Zhu, Jingjing Liu, Chao Liang, Qiao Zhang, and Zhuang Liu*, Synthesis of Hollow Biomineralized CaCO3-Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity. J. Am. Chem. Soc., 2018, 140, 2165–2178.
[9] Danlei Tao, Liangzhu Feng*, Yu Chao, Chao Liang, Xuejiao Song, Hairong Wang, Kai Yang, Zhuang Liu*, Covalent Organic Polymers Based on Fluorinated Porphyrin as Oxygen Nano-Shuttles for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy. Adv. Funct. Mater. 2018, 28, 1804901.
[8] Liangzhu Feng, Ziliang Dong, Chao Liang, Muchao Chen, Danlei Tao, Liang Cheng, Kai Yang, Zhuang Liu*, Iridium Nanocrystals Encapsulated Liposomes as Near-Infrared Light Controllable Nanozymes for Enhanced Cancer Radiotherapy. Biomaterials, 2018, 181, 81-91.
[7] Yicheng Zhang, Liangzhu Feng*, Jun Wang, Danlei Tao, Chao Liang, Liang Cheng, Erhong Hao*, Zhuang Liu*, Surfactant‐Stripped Micelles of Near Infrared Dye and Paclitaxel for Photoacoustic Imaging Guided Photothermal‐Chemotherapy. Small, 2018, 14, 1802991.
[6] Liangzhu Feng, Ziliang Dong, Danlei Tao, Yicheng Zhang, Zhuang Liu*, The acidic tumor microenvironment: a target for smart cancer nano-theranostics. Natl. Sci. Rev., 2018, 5, 269-286.
[5] Liangzhu Feng, Danlei Tao, Ziliang Dong, Qian Chen, Yu Chao, Zhuang Liu*, Meiwan Chen*, Near-infrared Light Activation of Quenched Liposomal Ce6 for Synergistic Cancer Phototherapy with Effective Skin Protection. Biomaterials, 2017, 127, 13-24.
[4] Liangzhu Feng, Min Gao, Danlei Tao, Qian Chen, Hairong Wang, Ziliang Dong, Meiwan Chen,* and Zhuang Liu*, Cisplatin-Prodrug-Constructed Liposomes as a Versatile Theranostic Nanoplatform for Bimodal Imaging Guided Combination Cancer Therapy. Adv. Funct. Mater., 2016, 26, 2207-2217.
[3] Ziliang Dong, Liangzhu Feng*, Wenwen Zhu, Xiaoqi Sun, Min Gao, He Zhao, Yu Chao, Zhuang Liu*, CaCO3 Nanoparticles as an Ultra-sensitive Tumor-pH-Responsive Nanoplatform Enabling Real-Time Drug Release Monitoring and Cancer Combination Therapy. Biomaterials, 2016, 110, 60-70.
[2] Liangzhu Feng#, Xianzhu Yang#, Xiaoze Shi, Xiaofang Tan, Rui Peng, Jun Wang*, Zhuang Liu*, Polyethylene glycol and polyethylenimine dual functionalized nano-graphene oxide for photothermally enhanced gene delivery. Small, 2013, 9 (11), 1989-1997.
[1] Liangzhu Feng, Shuai Zhang, Zhuang Liu*, Graphene based gene transfection, Nanoscale, 2011, 3 (3), 1252-1257.
