基本介紹
- 中文名：馮巍
- 國籍：中國
- 民族：漢族
- 性別：男
人物經歷,教育科研,研究方向,論文發表,
人物經歷
1997 - 2001 復旦大學化學系，化學學士
2001 - 2005 香港科技大學生物化學系，生物化學博士
2005 - 2007 香港科技大學生物化學系，博士後研究助理
2007 - 2009 香港科技大學生物化學系，研究助理教授
2009 - 入選中科院“百人計畫”，中科院生物物理研究所，研究員，博士生導師
教育科研
研究方向
基於液體核磁共振技術，結合其他結構生物學方法，研究與神經細胞內信號傳導、細胞極性以及胞內貨物運輸等相關的生物學問題：
1）參與神經信號傳導的支架蛋白的結構和功能研究；
2）調控細胞極性（不對稱性）的蛋白質複合物的結構和功能研究；
3）基於分子馬達的細胞內貨物運輸的結構機理研究。
論文發表
1. Yu, C.*,Feng, W.*, Wei, Z., Miyanoiri, Y., Wen, W., Zhao, Y., and Zhang M. (2009) “Myosin VI Undergoes Cargo-Mediated Dimerization” Cell 138, 537-548. (*: co-first authors)
2. Feng, W., and Zhang, M. (2009) “Organization and Dynamics of PDZ Domain-Related Supramodules in the Postsynaptic Density” Nature Rev. Neurosci. 10, 87-99.
3. Wu, H.*, Feng, W.*, Chen, J., Chan, L.-N., Huang, S., and Zhang, M. (2007) “PDZ Domains of Par-3 as Potential Phosphoinositide Signaling Integrators” Mol. Cell28, 886-898. (*: co-first authors)
4. Feng, W., Wu, H., Chan, L.-N., Zhang, M. (2007) “The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization” EMBO J. 26, 2786-2796.
5. Long, J.-F.*, Feng, W.*, Wang, R., Chan, L.-N., Ip, F., Xia, J., Ip, N., and Zhang, M. (2005) “Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem” Nature Struct. Mol. Biol. 12, 722-728. (*: co-first authors)
6. Feng, W., Long, J.-F., and Zhang, M. (2005) “A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2 / mLin-7 and Patj/Pals1 scaffold proteins.” Proc. Natl. Acad. Sci. USA. 102, 6861-6866.
7. Feng, W., Long, J.-F., Fan, J.-S., Suetake, T., and Zhang, M. (2004) “The tetrameric L27 domain complex as an organization platform for supramolecular assemblies” Nature Struct. Mol. Biol. 11, 475-480.
8. Feng, W., Shi, Y., Li, M., and Zhang, M. (2003) “Tandem PDZ repeats in glutamate receptor interacting proteins have a novel mode of PDZ domain-mediated target binding” Nature Struct. Biol. 10, 972-978.
