馬文建，博士，教授、博士生導師。先後獲得山東大學學士學位、中科院生物物理所碩士學位、德國科隆大學博士學位，並完成美國NIH環境健康研究所博士後研究。現任天津轉基因生物安全指導委員會執法專家，擔任天津生物醫學工程學會、美國微生物學會(ASM)、細胞生物學會(ASCB)會員，參與德國斯普林格出版社《癌症百科全書》辭條編寫，兼任Cancer Letters等國際期刊審稿人。研究方向聚焦DNA損傷修復、腫瘤與衰老分子生物學及食品藥品安全檢測體系構建。主持國家自然科學基金“聚集型DNA損傷在不同細胞周期中的修復及抑癌機制研究”、國家重點研發計畫子課題“益生菌健康功能與基於腸道微生物組學的食品營養代謝機理研究”等科研項目。在PNAS、Nucleic Acids Research等期刊發表SCI論文40餘篇，總被引2000餘次，參與撰寫Springer《癌症百科全書》細胞周期檢查點、拓撲異構酶條目。指導學生完成“自噬相關基因TMED9在泛癌和結腸癌中的預後與免疫作用”“非天然核酸末端封閉策略構建抗外切酶降解型shRNA表達載體”等學位論文課題，獲“一種酵母定點雙DSB同步誘導模型的構建方法”等發明專利。
基本介紹
- 中文名：馬文建
- 學位/學歷：博士
主講課程,科研領域及方向,
主講課程
本科生：細胞生物學（英文）
研究生：新藥研究與開發；科技論文寫作等
科研領域及方向
DNA損傷修復/基因組穩定性機制
腫瘤、衰老的分子生物學及藥理學研究
食品/藥品安全檢測及體系構建
科研項目情況
國家重點研發項目“益生菌健康功能與基於腸道微生物組學的食品營養代謝機理研究”（2017-2020，2314萬），子課題負責人
天津市131創新型人才團隊“天津科技大學微生態調控與分子藥理學團隊”(2018-2020，120萬), 骨幹成員
天津市高等學校創新團隊“基於腸道微生態調控的食品營養功能和安全評價”（2018-2020,180萬），骨幹成員
天津市特聘教授科研啟動基金 (2015-2019，100萬)，項目負責人
天津市優秀人才基金（2015，30萬），項目負責人
國家自然科學基金“聚集型DNA損傷在不同細胞周期中的修復及抑癌機制研究”（2012-2015，60萬），項目負責人
天津市科委基金“MRTF-A激活CYP1A1轉錄調控類固醇激素代謝”（2011-2014，10萬），項目負責人
主要學術成果
在PNAS（影響因子9.6）和Nucleic Acids Research（影響因子10.2）等高水平SCI期刊上發表科研論文/專著40餘篇，引用2000餘次。2012年應國際著名的Springer出版公司邀請，擔任癌症百科全書兩個辭條的撰寫人。
近年代表性學術論文：
Liu Q., Zhang Z., Liu Y., Cui Z., Zhang T., Li Z., Ma W. Cancer cells growing on perfused 3D collagen model produced higher ROS level and were more resistant to cisplatin comparing to 2D model. J Appl Biomater Funct Mater. 2018 Jul;16(3):144-150.
Zhang R., Li H., Zhang S., Zhang Y., Wang N., Zhou H., He H., Hu G., Zhang T., Ma W. RXRα provokes tumor suppression through p53/p21/p16 and PI3K-AKT signaling pathways during stem cell differentiation and in cancer cells. Cell Death &Disease, 2018 May 10;9(5):532.
He H, Du F, He Y, Wei Z, Meng C, Xu Y, Zhou H, Wang N, Luo XG, Ma W, Zhang TC. The Wnt-β-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells. Oncotarget. 2018 Jan 4;9(20):15239-15251.
He H, Lai Y, Hao Y, Liu Y, Zhang Z, Liu X, Guo C, Zhang M, Zhou H, Wang N, Luo XG, Huo L, Ma W, Zhang TC. Selective p300 inhibitor C646 inhibited HPV E6-E7 genes, altered glucose metabolism and induced apoptosis in cervical cancer cells. Eur J Pharmacol. 2017 Oct 5;812:206-215.
Wang C, Li Z, Wang H, Qiu H, Zhang M, Li S, Luo X, Song Y, Zhou H, Ma W, Zhang T., Rapid biodegradation of aflatoxin B1 by metabolites of Fusarium sp. WCQ3361 with broad working temperature range and excellent thermostability. J Sci Food Agric，2017 Mar 1;97(4):1342~1348
He H, Wei Z, Du F, Meng C, Zheng D, Lai Y, Yao H, Zhou H, Wang N, Luo XG, Ma W, Zhang TC., Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells.，Cellular Signalling，2017 Feb 1;31：87~95
Zhang R, Wang N, Zhang LN, Huang N, Song TF, Li ZZ, Li M, Luo XG, Zhou H, He HP, Zhang XY, Ma W, Zhang TC，Knockdown of DNMT1 and DNMT3a Promotes the Angiogenesis of Human Mesenchymal Stem Cells Leading to Arterial Specific Differentiation., Stem Cells，2016 May ;34(5):1273~1283
Liao XH, Zheng L, He HP, Zheng DL, Wei ZQ, Wang N, Dong J, Ma W, Zhang TC. STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells. Cell Signal. 2015 Nov;27(11):2285-95.
Ma W, Westmoreland JW, and Resnick MA. Homologous recombination rescues ssDNA gaps generated by NER and reduced translesion DNA synthesis in G2 cells. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2895-904.
Covo S, Ma W, Westmoreland JW, Gordenin DA and Resnick MA. Understanding the origins of UV-induced recombination through manipulation of sister chromatid cohesion. Cell Cycle. 2012Nov;11(21) 3937-44Ma W, Halweg CJ, Menendez D, Resnick MA. Differential effects of PARP inhibition and depletion on single- and double-strand break repair in human cells are revealed with EBV. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5.
Ma W, Westmoreland JW, Gordenin DA and Resnick MA. Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease. PLoS Genetics, 2011 7(4): e1002059
Westmoreland JW, Ma W, Yan Y, Van Hulle K, Malkova A, and Resnick MA. RAD50 (RMX) is essential for efficient resection and recombinational repair of radiation-induced double-strand breaks but not crossovers. PLoS Genetics, 2009 Sep;5(9):e1000656
Ma W, Panduri V, Sterling J, Van Houten B, Gordenin DA, Resnick MA. The transition of closely-spaced lesions into double-strand breaks is prevented by an interaction between Pol32, Rad27/FEN1 and PCNA. Mol. Cell Biol. 2009 Mar;29(5):1212-21
Ma W, Resnick MA and Gordenin DA Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic Acids Research. 2008 Apr;36(6):1836-46
專著章節
Ma W (2012) Topoisomerases. Encyclopedia of Cancer, Edited by Dr. Manfred Schwab; New York: Springer, http://www.springerreference.com/docs/html/chapterdbid/177517.html
Ma W (2012) Cell cycle checkpoints. Encyclopedia of Cancer, Edited by Dr. Manfred Schwab; New York: Springer, http://www.springerreference.com/docs/html/chapterdbid/172653.html
Ma W, Westmoreland JW and Resnick MA. (2011) Characterizing resection at random and unique chromosome double-strand breaks and telomere ends. Methods in Molecular Biology. Vol. 745: 15-31
