韓際宏，男，博士，南開大學生命科學學院教授、博士生導師。1987年從南開大學化學專業本科畢業，1989年同校化學專業碩士畢業，後赴美國留學。1995年獲得美國康乃爾大學醫學院生物化學博士學位。
基本介紹
- 中文名：韓際宏
- 國籍：中國
- 性別：男
- 學歷：博士
工作經歷,學會成員,代表論著,主要學術論文,
工作經歷
1999-2005: 助理教授 (Assistant Professor of Pathology), 血管生物學中心, 康乃爾大學醫學院, 美國紐約(Center of Vascular Biology, Weill Medical College of Cornell University, New York, USA)
2005-2007: 副教授 (Associate Professor of Pathology), 血管生物學中心, 康乃爾大學醫學院, 美國紐約
2006-至今: 中國國家自然科學基金藥物藥理學、臨床醫學基礎學科基金申請評審專家
2007-至今: 天津南開大學生命科學學院特聘教授、生物化學與分子生物學系系主任
2009-至今： 973計畫項目首席科學家，長江學者特聘教授
學會成員
American Association for the Advancement of Science
American Heart Association
American Society for Investigate Pathology
American Society for Biochemistry and Molecular Biology
Federation of American Society for Experimental Biology
代表論著
Martensson J, Han J, Griffith OW, Meister A. 1993. Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs. Proceedings of the National Academy of Sciences, USA 90:317-21
Rusakow LS, Han J, Hayward MA, Griffith OW. 1995. Pulmonary oxygen toxicity in mice is characterized by alterations in ascorbate redox status. Journal of Applied Physiology 79:1769-76
Ito K, Bian H, Molina M, Han J, Magram JS, Bolir DL, Nagy Z. 1996. HLA-DR4-IE chimeric class II transgenic, murine class II deficient mice are susceptible to experimental allergic encephalomyelitis. Journal of Experimental Medicine 183:2635-44
Han J, Febbraio M, Hajjar DP, Nicholson AC. 1997. Native and modified low density lipoproteins increase the functional expression of macrophage class B scavenger receptor, CD36. The Journal of Biological Chemistry 272:21654-9
Han J, Nicholson AC. 1998. Lipoproteins modulate expression of the macrophage scavenger receptor. The American Journal of Pathology 152:1647-54
Han J, Hajjar DP, Tauras JM, Nicholson AC. 1999. Cellular cholesterol regulates the expression of macrophage scavenger type B receptor, CD36. Journal of Lipid Research 40:830-8
Han J, Hajjar DP, Tauras JM, Feng J, Gotto AM Jr, Nicholson AC. 2000. Transforming growth factor beta-1 (TGFbeta-1) and TGFbeta-2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma. The Journal of Biological Chemistry 275:1241-6
Han J, Feng J, Pearce SFA, Silverstein RL, Gotto AM Jr, Hajjar DP, Nicholson AC. 2000. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPARgamma. Journal of Lipid Research 40:688-96
Nicholson AC, Febbraio M, Han J, Silversterin RL, Hajjar DP. 2000. CD36 in Atherosclerosis. The role of a class B macrophage scavenger receptor. Annals of New York Academy of Science 902:128-33
Nicholson AC, Han J, Febbraio M, Pearce SFA, Gotto AM Jr, Hajjar DP. 2001. CD36, the Macrophage class B scavenger receptor: Regulation and role in atherosclerosis. pp41-47, Atherosclerosis and Autoimmunity, Y. Shoenfeld, D. Harats and G. Wick, editors, Elsevier Science B.V.
Nicholson AC, Han J, Febbraio M, Silverstein RL, Hajjar DP. 2001. Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis. Annals of New York Academy of Science 947:224-9
Han J, Nicholson AC, Zhou X, Feng J, Gotto AM Jr, Hajjar DP. 2001. Oxidized LDL decreases macrophage expression of scavenger receptor B-I (SR-BI). The Journal of Biological Chemistry 276:16567-72
Han J, Hajjar DP, Zhou X, Gotto AM Jr, Nicholson AC. 2002. Regulation of peroxisome proliferator-activated receptor-?-mediated gene expression. A new mechanism of action for high density lipoprotein. The Journal of Biological Chemistry 277:23582-6
Febbraio M, Gotto AM Jr, Han J, Nicholson AC, Sharma K, Podrez EA, Hoff HF, Hazen SL, Smith JD, Hajjar DP, Silverstein RL. 2002. Regulation of CD36 by PPAR-gamma: Pro- or anti-Atherogenic? International Symposium on PPARgamma: From Basic Science to Clinical Application. Fruchart JC, Gorro AM Jr, Paoletti R, Staels B, Catapano AL, Eds. Kluwer Academic Publisher
Han J, Markle RA, Summers BD, Yokoyama T, Hajjar KA, Hajjar DP, Gotto AM Jr, Nicholson AC. 2003. Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells. Journal of Cellular Biochemistry 90:23-32
Sun L, Nicholson AC, Hajjar DP, Gotto AM Jr, Han J. 2003. Adipogenic differentiating agents regulate expression of fatty acid binding protein (aP2) and CD36 in macrophages. Journal of Lipid Research 44:1877-86
Han J, Zhou X, Hajjar DP, Gotto AM Jr, Nicholson AC. 2004. Pitavastatin down-regulates expression of the macrophage type B scavenger receptor, CD36. Circulation 109:790-6
Han J (通信作者), Parsons M, Zhou X, Nicholson AC, Gotto AM Jr, Hajjar DP. 2004. Functional interplay between the macrophage scavenger receptor class B type I (SR-BI) and pitavastatin (NK-104). Circulation 110:3472-9
Han J (通信作者), Zhou X, Parsons M, Nicholson AC, Gotto AM Jr, Yokoyama T, Hajjar DP. 2005. Regulation of macrophage scavenger receptor expression-New pleiotropic effects of statins. pp265-269. Advances in Heart Disease, International Academy of Cardiology. Asher Kimchi, Ed. International Proceeding
Nicholson AC, Zhou X, He W, Gotto AM Jr, Hajjar DP, Han J. 2007. Anti-adipogenic action of pitavastatin occurs through the coordinate regulation of PPARgamma?and Pref-1 expression. British Journal of Pharmacology 151:807-15
Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X. 2007. Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by the homeoprotein pre-B-cell leukemia transcription factor-1. Immunity 27:952-64
Zhou X, He W, Huang Z, Gotto AM Jr, Hajjar DP, Han J. 2008. Genetic deletion of low density lipoprotein receptor impairs mouse macrophage ABCA1 expression-A SREBP-1 dependent mechanism. Journal of Biological Chemistry 283:2129-38
Huang Z, He W, Zhou X, Hajjar DP, Nicholson AC, Gotto AM Jr, Han J. 2008. Activation of PPARalpha induces hepatic LDL receptor expression. British Journal of Pharmacology 155:596-605
Nakaya H, Summers BD, Nicholson AC, Gotto AM Jr, Hajjar DP, Han J. 2009. Atherosclerosis in LDLR knockout mice is inhibited, but not reversed by the PPARgamma ligand pioglitazone. American Journal of Pathology. 174:2007-14
Zhou X, Yin Z, Guo X, Hajjar DP, Han J. 2010. Inhibition of ERK1/2 and activation of LXR synergistically induce macrophage ABCA1 expression and cholesterol efflux. Journal of Biological Chemistry 285:6316-6326
He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O'Brien RL, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. 2010. Naturally activated Vgamma4 T cells play a protective role in tumor immunity through expression of eomesodermin. The Journal of Immunology. 185:126-33
Dong P, Xie T, Zhou X, Hu W, Chen Y, Duan Y, Li X, Han J. 2011. Induction of macrophage scavenger receptor type BI expression by tamoxifen and 4-hydroxytamoxifen. Atherosclerosis 218:435-42
Hao J, Dong S, Xia S, He W, Jia H, Zhang S, Wei J, O'Brien RL, Born WK, Wu Z, Wang P, Han J, Hong Z, Zhao L, Yin Z. 2011. Regulatory role of Vgamma1 gammadeltaT cells in tumor immunity through IL-4 production. The Journal of Immunology. 187:4979-86
Zhao N, Hao J, Ni Y, Luo W, Liang R, Cao G, Zhao Y, Wang P, Zhao L, Tian Z, Flavell R, Hong Z, Han J, Yao Z, Wu Z, Yin Z. 2011. Vgamma4?gammadeltaT cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis. The Journal of Immunology. 187:5007-14
Zheng W, Wang Z, Song L, Zhao Q, Zhang J, Li D, Wang S, Han J, Zheng XL, Yang Z, Kong D. 2012. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials. 33:2880-91
Hu W, Zhou X, Jiang N, Duan Y, Chen Y, Li X, Yin Z, He G, Yao Z, Zhu Y, Hajjar DP, Han J. 2012. Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. Atherosclerosis. 222:434-43.
Duan Y, Chen Y, Hu W, Li X, Zhou X, Yin Z, Kong D, Hajjar DP, Liu L, Liu Q, Han J. 2012. PPAR? activation by ligands and dephosphorylation induces PCSK9 and LDLR expression The Journal of Biological Chemistry ARTNO: M112.350181, Epub. 2012 May 16
主要學術論文
1.Zheng WT, Wang ZH, Song LJ, Zhao Q*, Zhang J, Li D, Wang SF, Zheng XL, Han JH, Yang ZM, Kong DL*. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery mode. Biomaterials 33-10-2880-2891. 2012-4-1
