韓世清(韓世清)

韓世清，男，1965年生，江蘇南京人，博士，現任南京工業大學生物與製藥工程學院研究員。

基本介紹

• 中文名：韓世清
• 國籍：中國
• 出生日期：1965年
• 畢業院校：中國科學院上海有機化學研究所
• 學位/學歷：博士
• 職務：研究員

人物經歷

教育經歷

1982-1986，南京師範大學，理學學士； 1986-1989，中國科學院大連化學物理研究所，理學碩士； 1996-1999，中國科學院上海有機化學研究所，理學博士； 1999-2000，美國Texas A&M University大學，博士後； 2000-2002，美國 University of North Carolina at Chapel Hill大學，博士後。

工作經歷

1989-1996，中國科學院大連化學物理研究所，助理研究員； 2002-2002， 上海藥明康德PharmaTech新藥研發公司，高級研究員Senior Scientist II，項目負責人Project Manager, 科研組長Group Header； 2002-2003，瑞士羅氏Roche製藥(巴塞里亞Basilea藥物)中國研發中心，科研處囑鴉辨長Division Header； 2003-2005，美國朽拒希禮來Eli Lilly製藥公司上海（開拓者化學)研發中心，總監Director； 2005起， 南京工業大學生物與製藥工程學院，研究員(Professor)。

研究領域

生物工程專業英語、高等有機化學戀櫃估鍵、科技英語論文寫作、生精凶嬸轎物有機化學、環境工程概論、藥汗只物合成反應。生物有機化學和藥物化學領域(包括有機藥物分子全合成，化學反應方法學和生物合成方法學研究)。

研究成果

抗細菌生物被膜活性的YycG組氨酸激酶小分子抑制劑的設計與合成；

綠色有機合成反應新催化體系的建立及套用於藥物分子的合成。

首次提出特製醇腈酶顆粒在單一有機相溶媒中催化合成手性氰醇的新方法及連續流動酶合成裝置，以及新型醇腈酶的發現，首次完成國際上未能成功的手性雜環氰醇和手性氟取代氰醇的合成，得到該領域國際專家的關注引用和評述(被Chem. Rev. , Curr. Opin. Chem. Biol., Curr. Opin. Biotech., Curr. Org. Chem., Top. Curr. Chem., Tetra. Asymm.等作為該領域重要承漏民的研究進展評述，被Highlight 和引述數百次，Methods in Organic Synthesis兩次收錄)；

生物催化合成（S）-丁呋洛爾等手性藥物；

完成抗癌新藥秋水仙鹼和鬼臼毒素系列衍生物的發明；

醇類選擇性分子氧氧化新催化劑的發明；半乳糖氧化酶模擬反應的機理研究，用原位紫外和ESR技術捕捉到催化劑活性價態；辯地跨

國際上第一個將雜多酸催化劑用於飽和烴的羥化反應並且套用原位紅外技術捕捉到催化劑活性物種；

在PharmaTech, Basilea和Eli Lilly公司負責完成研究項目約50個，設計合成了10000多個藥物活性分子用於新藥的篩選；

發表論文

一、藥物化學代表性論文：

1. Zhihui Lv, Dan Zhao, Jun Chang, Huayong Liu, Xiaofei Wang, Jinxin Zheng, Renzheng Huang, Zhiwei Lin, Yongpeng Shang, Lina Ye, Yang Wu, Shiqing Han(通訊作者) and Di Qu , Anti-bacterial and Anti-biofilm Evaluation of Thiazolopyrimidinone Derivatives Targeting the Histidine Kinase YycG Protein of Staphylococcus epidermidis, Frontiers in Microbiology, 2017, 8, 1-10.

2. Huayong Liu, Yanfeng Zhao, Dan Zhao, Ting Gong, Youcong Wu, Haiyan Han, Tao Xu, Andreas Peschel, Shiqing Han(通訊作者), and Di Qu, Antibacterial and anti-biofilm activities of thiazolidione derivatives against clinical staphylococcus strains, Emerging Microbes and Infections, 2015, 4, e1; doi:10.1038/emi.2015.1

3. Huayong Liu, Dan Zhao, Jun Chang, Liang Yan, Fuju Zhao, Youcong Wu, Tao Xu, Ting Gong, Li Chen, Nianan He, Yang Wu, Shiqing Han(通訊作者), Di Qu, Efficacy of novel antibacterial compounds targeting histidine kinase YycG protein, Appl Microbiol Biotechnol, 2014, 98, 6003-6013.

4. Dan Zhao, Chen Chen, Huayong Liu, Likang Zheng, Yao Tong, Di Qu, Shiqing Han(通訊作者), Biological evaluation of halogenated thiazolo[3,2-a]pyrimidin- 3-one carboxylic acid derivatives targeting the YycG histidine kinase, European Journal of Medicinal Chemistry, 2014, 87, 500-507.

5. Dan Zhao, Likang Zheng, Huayong Liu, Guozhen He, Di Qu, Shiqing Han(通訊作者), Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis, Medicinal Chemistry Research, 2013, 22, 3743–3750.

6. Jie Zhang, Likang Zheng, Dan Zhao, Huayong Liu, Di Qu, Shiqing Han(通訊作者), Synthesis and Biological Evaluation of Halogenated 2-Arylimino-3 -arythia- zolidine-4-ones Containing Benzoic Acid Fragments as Antibacterial Agents, Letters in Drug Design & Discovery, 2013, 10 (10), 928-934.

7. Renzheng Huang, Likang Zheng, Huayong Liu, Bin Pan, Jian Hu, Tao Zhu, Wei Wang, Danbin Jiang, Yang Wu, Youcong Wu, Shiqing Han(通訊作者), and Di Qu, Thiazolidione derivatives targeting the histidine kinase YycG are effective against both planktonic and biofilm-associated Staphylococcus epidermidis, Acta Pharmacologica Sinica, 2012, 33, 418-425.

8. Bin Pan, Renzheng Huang, Likang Zheng, Chen Chen, Shiqing Han(通訊作者), Di Qu, Mingli Zhu, Ping Wei, Thiazolidione derivatives as novel antibiofilm agents: design, synthesis, biological evaluation, and structure-activity relationships, European Journal of Medicinal Chemistry, 2011, 46(3), 819-824.

9. Bin Pan, Ren-Zheng Huang, Shiqing Han(通訊作者), Di Qu, Ming-Li Zhu, Ping Wei and Han-Jie Ying, Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl- thiazolidine-4-ones, Bioorganic & Medicinal Chemistry Letters, 2010, 20(8), 2461-2464.

10. Shiqing Han, Zhiyan Xiao, Kenneth F. Bastow and Kuo-Hsiung Lee, Antitumor Agents Part 230: C4’-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhabitors, Bioorganic & Medicinal Chemistry Letters, 2004, 14(11), 2979-2982.

11. Zhiyan Xiao, Shiqing Han, Kenneth F. Bastow and Kuo-Hsiung Lee, Antitumor Agents Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents, Bioorganic & Medicinal Chemistry Letters, 2004, 14(6), 1581-1584.

12. Shiqing Han, Hamel-E, Bastow-KF, Mcphail-AT, Brossi-A, Lee-KH, Antitumor Agents Part 215:Antitubulin Effects of Cytotoxic B-Ring Modified Allocolchicinoids, Bioorganic & Medicinal Chemistry Letters, 2002, 12(20), 2851-2853.

二、綠色化學與製藥新技術代表性論文：

13. Xin Wang, Xiaotong Li, Renhe Hua, Zhao Yang, Ren Gu, Sai Ding, Pengyi Li, Shiqing Han(通訊作者), Elemental Sulfur-Mediated Decarboxylative Redox Cyclization Reaction: Copper-Catalyzed Synthesis of 2-Substituted Benzothiazoles, Synlett, 2018, 29, 219-224.

14. Xin Wang, Dazhuang Miao, Xiaotong Li, Renhe Hua, Zhao Yang, Ren Gu, Shiqing Han(通訊作者), Elemental Sulfur Mediated Cyclization via Redox Strategy: Synthesis of Benzothiazoles from o-Chloronitrobenzenes and Benzyl chlorides, Tetrahedron, 2017, 73, 5194-5199.

15. Zhao Yang, Renhe Hu, Xiaotong Li, Xin Wang, Ren Gu, Shiqing Han(通訊作者), One-pot Copper-Catalyzed Synthesis of 2-Substituted Benzothiazoles from 2-Iodoanilines, Benzyl Chlorides and Elemental Sulfur, Tetrahedron Letters, 2017, 58, 2366～2369.

16. Haifeng Gan, Dazhuang Miao, Qiang Pan, Renhe Hu, Xiaotong Li, and Shiqing Han(通訊作者), S8-Mediated Cyclization of 2-Amino Phenols/Thiophenols with Arylmethyl Chloride: Approach to Benzoxazoles and Benzothiaz, Chemistry – An Asian Journal, 2016, 11, 1770-1774.

17. Xiaotong Li, Qiang Pan, Renhe Hu, Xin Wang, Zhao Yang, and Shiqing Han(通訊作者), S8-Mediated One-Pot Synthesis of Thioamides from Benzyl Chlorides and Amines, Asian Journal of Organic Chemistry, 2016, 5, 1353-1358.

18. Xiaotong Li, Renhe Hu, Yao Tong, Qiang Pan, Dazhuang Miao, Shiqing Han(通訊作者), An Efficient Route for the Synthesis of Benzimidazoles via a Hydrogen-Transfer Strategy between o-nitroanilines and Alcohols, Tetrahedron Letters, 2016, 57, 4645-4649.

19. Renhe Hu, Xiaotong Li, Yao Tong, Dazhuang Miao, Qiang Pan, Zengqiang Jiang, Haifeng Gan, Shiqing Han(通訊作者), Catalyst-Free Synthesis of 2-Arylbenzothiazoles in an Air/DMSO Oxidant System, Synlett, 2016, 27, 1387-1390.

20. Qiang Pan, Chun-Yang He, Shiqing Han(通訊作者), Xingang Zhang, Palladium-Catalyzed Direct Thienylation of Monobromide-Substituted Difluorinated Benzothiadiazoles for Organic Photovoltaics, Synlett, 2015, 26, 2175-2179.

21. Zeng-qiang Jiang, Da-zhuang Miao, Yao Tong, Qiang Pan, Xiao-tong Li, Ren-he Hu, Shiqing Han(通訊作者), One-Pot Base-Mediated Synthesis of Functionalized Aza-Fused Polycyclic Quinoline Derivatives, Synthesis, 2015, 47, 1913-1921.

22. Dazhuang Miao, Xuesong Shi, Guozhen He, Yao Tong, Zengqiang Jiang, Shiqing Han(通訊作者), One-pot synthesis of 2-arylbenzoxazole derivatives via Cu(I) catalyzed C-N/C-O coupling of N-(2-chloro-phenyl)-2-halobenzamides and primary amines, Tetrahedron, 2015, 71, 431-435.

23. Yao Tong, Qiang Pan, Zengqiang Jiang, Dazhuang Miao, Xuesong Shi, Shiqing Han(通訊作者), A simple approach to benzothiazoles from 2-chloronitrobenzene, elemental sulfur, and aliphatic amine under solvent-free and catalyst-free conditions, Tetrahedron Letters, 2014, 55, 5499-5503.

24. Zengqiang Jiang, Jie Zhang, Yao Tong, Xuesong Shi, Dazhuang Miao, Shiqing Han(通訊作者), One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives through Copper-Catalyzed Cascade Reactions, Chin. J. Org. Chem. 2014, 34, 1845-1850.

25. Guozhen He, Yuan Huang, Yao Tong, Jie Zhang, Dan Zhao, Shuangli Zhou, Shiqing Han(通訊作者),Substrate-Promoted Ligand-Free CuI Catalyzed S-Arylation of 2-Mercapto- benzothiazoles with Aryl Iodides in Water, Tetrahedron Letters, 2013, 54, 5318–5321.

26. Ming Jin, Dan Zhao, Guozhen He, Yao Tong, Shiqing Han(通訊作者), Substrate-promoted copper-catalyzed N-arylation of amino alcohols with aryl iodides in water, Chinese Journal of Catalysis, 2013, 34 (9), 1651-1655.

27. Yuan Huang, Wei Chen, Dan Zhao, Chen Chen, Huiqing Yin, Likang Zheng, Ming Jin, Shiqing Han(通訊作者), Copper(I)-Catalyzed Intramolecular Direct C-Arylation of Azoles with Aryl Bromides, Chinese Journal of Chemistry, 2013, 31, 1007-1010.

28. Jie Zhang, Zengqiang Jiang, Dan Zhao, Guozhen He, Shuangli Zhou, Shiqing Han(通訊作者),Transition-Metal-Free TEMPO Catalyzed Aerobic Oxidation of Alcohols to Carbonyls Using an Efficient Br2 Equivalent under Mild Conditions, Chinese Journal of Chemistry, 2013, 31, 794-798.

29. Huiqing Yin, Ming Jin, Wei Chen, Chen Chen, Likang Zheng, Ping Wei and Shiqing Han(通訊作者), Solvent-free Copper-catalyzed N-Arylation of Amino Alcohols and Diamines with Aryl Halides, Tetrahedron Lett. 2012, 53(10), 1265-1270.

30. Jingxian Zhang, Huiqing Yin, Shiqing Han(通訊作者), Copper-Catalyzed N-Arylations of Nitrogen-Containing Heterocycles in Water, Chin. J. Org. Chem., 2012, 32(8), 1429-1433.

31. Jingxian Zhang, Rui Zhang, Bin Tao, Shiqing Han(通訊作者), George Li, Preparation of novel pyridazine-4-boronic acid pinacol esters and imidazole-4-boronic acid pinacol esters through palladium-catalyzed cross-coupling reactions, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244, 625-ORGN.

32. Xinyu Li, Cheng Li, Wenjing Zhang, Xiang Lu, Shiqing Han, and Ran Hong﹡, Highly Stereoselective 7-Endo-Trig/Ring Contraction Cascade To Construct Pyrrolo[1,2-a] quinoline Derivatives, Org. Lett. 2010, 12(8), 1696-1699.

33. Yi Hu, Ping Wei, He Huang, Shi-Qing Han and Ping-Kai Ouyang, Microwave-Assisted Gewald Synthesis of 2-Aminothiophenes using Functional Ionic Liquid as Soluble Support. Heterocycles, 2006, 68(2), 375-380.

34. Yi Hu, Ping Wei, He Huang, Shi-Qing Han and Ping-Kai Ouyang, Synthesis of 2-aminothiophenes on ionic liquid phase support using the gewald reaction, Synthetic Communications, 2006, 36 (11), 1543-1548.

三、生物酶催化手性合成代表性論文：

35. Shiqing Han(通訊作者), Chaosen Chu, Synthesis of Chiral Drugs by (R)-Oxynitrilase-Catalyzed Transformation, J. Biotechnology, 2008, 136S, 396- 397.

36. Shiqing Han(通訊作者), Pingkai Ouyang, Ping Wei and Yi Hu, Enzymatic Synthesis of (R)-Cyanohydrins by Novel (R)-Oxynitrilase from Vicia Sativa L., Biotechnology Letters, 2006, 28(23), 1909-1912.

37. 褚朝森，韓世清 (通訊作者)，韋萍，新手性試劑(1R, 2S)-2-氨基醇的合成，化學試劑，2009，31(2),125-127.

38. 褚朝森，韓世清 (通訊作者)，韋萍，(R)-醇腈酶催化法合成(R)-(-)-1-(2-萘基)-2-N-甲基氨基乙醇，高校化學工程學報, 2008, (6),999-1003.

39. 韓世清 (通訊作者)，褚朝森，韋萍，（R）-醇腈酶催化合成手性藥物光學活性（S）-丁呋洛爾, 精細化工，2008，25(11),1106-1109。

40. 褚朝森，韓世清 (通訊作者)，韋萍，醇腈酶催化合成手性氰醇的研究進展，化工生產與技術，2007，14（6），55-59。

41. Chen-PR, Gu-JX, Wei-ZL, Shiqing Han, Li-ZY, Lin-GQ, Asymmetric Synthesis aided by Biocatalysts, Chin. J. Chem. 2003, 21(8), 983-993.

42. Chen-PR Shiqing Han Lin-GQ Li-ZY, A Practical High Through-Put Continuous Process for the Synthesis of Chiral Cyanohydrins, Journal Of Organic Chemistry, 2002, 67(23), 8251-8253.

43. Shi-Qing Han, Peiran Chen, Guo-Qiang Lin, Hao Huang and Zu-Yi Li, (R)-Oxynitrilase-catalyzed Hydrocyanation: the First Synthesis of Optically Active Fluorinated Mandelonitriles, Tetrahedron Asymmetry, 2001, 12, 843.

44. Peiran Chen, Shi-Qing Han, Guo-Qiang Lin, Hao Huang and Zu-Yi Li, A Study of Asymmetric Hydrocyanation of Heteroaryl Carboxaldehydes catalyzed by (R)-Oxynitrilase under Micro-aqueous Conditions, Tetrahedron Asymmetry, 2001, 12(23), 3273-3279.

45. Guo-Qiang Lin, Shi-Qing Han and Zu-Yi Li, Enzymatic Synthesis of (R)-Cyanohydrins by Three (R)-Oxynitrilase Sources in Micro-aqueous Organic Medium, Tetrahedron, 1999, 55, 3531.

46. Shi-Qing Han, Guo-Qiang Lin and Zu-Yi Li, Synthesis of (R)-Cyanohydrins by Crude (R)-Oxynitrilase-catalyzed Reactions in Micro-aqueous Medium, Tetrahedron: Asymmetry, 1998, 9(11), 1835.

四、早期科研代表性論文：

47. 韓世清﹡，楊振雲，鄭祿彬，富勒烯C60/C70的製備化學，化學通報，1996, (5), 11。

48. 韓世清﹡，曹國英，奚祖威，常溫下環己烷的液相羥基化反應，催化學報，1995, 16(6), 514。

49. 韓世清﹡，曹國英，奚祖威，鉬釩磷雜多化合物過氧化氫體系催化飽和烴的羥化反應，催化學報，1995, 16(5), 392。

50. 韓世清﹡，奚祖威，黃家壁，雙齒銅(Ⅱ)絡合物催化作用下分子氧對醇類的選擇性氧化，分子催化，1991, 5(4), 316。

51. 韓世清﹡，奚祖威，黃家壁，醇類催化氧化反應的機理研究—半乳糖氧化酶化學模擬體系，分子催化，1991, 5(3), 248。

申請專利

1. 韓世清;童耀;潘強;蔣增強;苗大狀, 一種合成2-取代苯並噻唑衍生物的方法，中國發明專利, 201410205413.3(已授權)。

2. 韓世清;苗大狀;史雪松;蔣增強;童耀;黃媛;潘強，一鍋法合成二苯二氮卓雜環衍生物的方法，中國發明專利, 201410206756.1。

3. 韓世清;蔣增強;童耀;苗大狀;潘強;史雪松;黃媛，一種5-甲腈-吡咯[1,2-a]喹啉衍生物的合成方法，中國發明專利, 201410205415.2。

4. 韓世清;蔣增強;張傑;童耀;何國珍;周雙利;趙丹，一種合成5-甲腈-吡咯[1,2-a]喹啉衍生物的方法，中國發明專利, 201410205394.4(已授權)。

5. 韓世清;蔣增強;張傑;童耀;何國珍;周雙利;趙丹，一種合成吡咯[1,2-a]喹喔啉衍生物的方法,中國發明專利, 201310239066.1。

6. 韓世清;蔣增強;張傑;童耀;何國珍;周雙利;趙丹，吡咯[1,2-a]喹喔啉衍生物的合成方法，中國發明專利, 201310238303.2(已授權)。

7. 韓世清;方淑瑩；何國珍，製備亞磺醯基-1-氫-苯並咪唑衍生物的方法,中國發明專利, 201310669517.5(已授權)。

8. 韓世清;何國珍；張傑；趙丹；周雙利，一種小分子cathepsin D 抑制劑的製備方法，中國發明專利, 201310130670.0(已授權)。

9. 韓世清;張傑；蔣增強；趙丹；何國珍；周雙利，一種選擇性催化分子氧氧化水楊醇製備水楊醛的方法，中國發明專利, 201210570307.6(已授權)。

10. 韓世清;鄭禮康;金明;張敬先;趙丹;何國珍，一種4-噻唑烷酮羧酸衍生物及其製備方法和用途，中國發明專利, 201110174465.5。

11. 豐樹山;韓世清;何明芳;成永之. 一種新穎激活氟代喹啉-3羧酸的7-位鹵素的方法及其和仲胺縮合形成側鏈的用途, 中國發明專利, 201010157258.4(已授權)。

12. 韓世清, 瞿滌, 潘斌, 朱明莉, 吳暘, 黃仁政. 3-羰基-6-乙氧甲醯基-噻唑並嘧啶類化合物及其合成方法和用途, 中國發明專利, ZL 200910183297.9(已授權)。

13. 韓世清，姜岷，李兆亮，王軍，韋萍，歐陽平凱. 包含鑭系雙齒配合物的二元複合催化劑及其製備方法和用途，中國發明專利, ZL 200810022784.2(已授權)。

14. 林國強，陳沛然，韓世清，李祖義，黃浩，一類手性雜芳基氰醇及其衍生物的製備方法和用途，中國發明專利, 01105269.4。

15. 林國強，韓世清，李祖義，一種新酶源的醇腈裂解酶催化合成光學活性氰醇化合物，中國發明專利, ZL 99113884.8(已授權)。

16. 林國強，韓世清，李祖義，手性氰醇化合物及其衍生物和製備方法，中國發明專利, 99113883.X。

17. 林國強，韓世清，李祖義，氰醇裂解酶催化合成光學活性氰醇化合物，中國發明專利, ZL 98110818.0 (已授權)。

2. Huayong Liu, Yanfeng Zhao, Dan Zhao, Ting Gong, Youcong Wu, Haiyan Han, Tao Xu, Andreas Peschel, Shiqing Han(通訊作者), and Di Qu, Antibacterial and anti-biofilm activities of thiazolidione derivatives against clinical staphylococcus strains, Emerging Microbes and Infections, 2015, 4, e1; doi:10.1038/emi.2015.1

3. Huayong Liu, Dan Zhao, Jun Chang, Liang Yan, Fuju Zhao, Youcong Wu, Tao Xu, Ting Gong, Li Chen, Nianan He, Yang Wu, Shiqing Han(通訊作者), Di Qu, Efficacy of novel antibacterial compounds targeting histidine kinase YycG protein, Appl Microbiol Biotechnol, 2014, 98, 6003-6013.

4. Dan Zhao, Chen Chen, Huayong Liu, Likang Zheng, Yao Tong, Di Qu, Shiqing Han(通訊作者), Biological evaluation of halogenated thiazolo[3,2-a]pyrimidin- 3-one carboxylic acid derivatives targeting the YycG histidine kinase, European Journal of Medicinal Chemistry, 2014, 87, 500-507.

5. Dan Zhao, Likang Zheng, Huayong Liu, Guozhen He, Di Qu, Shiqing Han(通訊作者), Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis, Medicinal Chemistry Research, 2013, 22, 3743–3750.

6. Jie Zhang, Likang Zheng, Dan Zhao, Huayong Liu, Di Qu, Shiqing Han(通訊作者), Synthesis and Biological Evaluation of Halogenated 2-Arylimino-3 -arythia- zolidine-4-ones Containing Benzoic Acid Fragments as Antibacterial Agents, Letters in Drug Design & Discovery, 2013, 10 (10), 928-934.

7. Renzheng Huang, Likang Zheng, Huayong Liu, Bin Pan, Jian Hu, Tao Zhu, Wei Wang, Danbin Jiang, Yang Wu, Youcong Wu, Shiqing Han(通訊作者), and Di Qu, Thiazolidione derivatives targeting the histidine kinase YycG are effective against both planktonic and biofilm-associated Staphylococcus epidermidis, Acta Pharmacologica Sinica, 2012, 33, 418-425.

8. Bin Pan, Renzheng Huang, Likang Zheng, Chen Chen, Shiqing Han(通訊作者), Di Qu, Mingli Zhu, Ping Wei, Thiazolidione derivatives as novel antibiofilm agents: design, synthesis, biological evaluation, and structure-activity relationships, European Journal of Medicinal Chemistry, 2011, 46(3), 819-824.

9. Bin Pan, Ren-Zheng Huang, Shiqing Han(通訊作者), Di Qu, Ming-Li Zhu, Ping Wei and Han-Jie Ying, Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl- thiazolidine-4-ones, Bioorganic & Medicinal Chemistry Letters, 2010, 20(8), 2461-2464.

10. Shiqing Han, Zhiyan Xiao, Kenneth F. Bastow and Kuo-Hsiung Lee, Antitumor Agents Part 230: C4’-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhabitors, Bioorganic & Medicinal Chemistry Letters, 2004, 14(11), 2979-2982.

11. Zhiyan Xiao, Shiqing Han, Kenneth F. Bastow and Kuo-Hsiung Lee, Antitumor Agents Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents, Bioorganic & Medicinal Chemistry Letters, 2004, 14(6), 1581-1584.

12. Shiqing Han, Hamel-E, Bastow-KF, Mcphail-AT, Brossi-A, Lee-KH, Antitumor Agents Part 215:Antitubulin Effects of Cytotoxic B-Ring Modified Allocolchicinoids, Bioorganic & Medicinal Chemistry Letters, 2002, 12(20), 2851-2853.

二、綠色化學與製藥新技術代表性論文：

13. Xin Wang, Xiaotong Li, Renhe Hua, Zhao Yang, Ren Gu, Sai Ding, Pengyi Li, Shiqing Han(通訊作者), Elemental Sulfur-Mediated Decarboxylative Redox Cyclization Reaction: Copper-Catalyzed Synthesis of 2-Substituted Benzothiazoles, Synlett, 2018, 29, 219-224.

14. Xin Wang, Dazhuang Miao, Xiaotong Li, Renhe Hua, Zhao Yang, Ren Gu, Shiqing Han(通訊作者), Elemental Sulfur Mediated Cyclization via Redox Strategy: Synthesis of Benzothiazoles from o-Chloronitrobenzenes and Benzyl chlorides, Tetrahedron, 2017, 73, 5194-5199.

15. Zhao Yang, Renhe Hu, Xiaotong Li, Xin Wang, Ren Gu, Shiqing Han(通訊作者), One-pot Copper-Catalyzed Synthesis of 2-Substituted Benzothiazoles from 2-Iodoanilines, Benzyl Chlorides and Elemental Sulfur, Tetrahedron Letters, 2017, 58, 2366～2369.

16. Haifeng Gan, Dazhuang Miao, Qiang Pan, Renhe Hu, Xiaotong Li, and Shiqing Han(通訊作者), S8-Mediated Cyclization of 2-Amino Phenols/Thiophenols with Arylmethyl Chloride: Approach to Benzoxazoles and Benzothiaz, Chemistry – An Asian Journal, 2016, 11, 1770-1774.

17. Xiaotong Li, Qiang Pan, Renhe Hu, Xin Wang, Zhao Yang, and Shiqing Han(通訊作者), S8-Mediated One-Pot Synthesis of Thioamides from Benzyl Chlorides and Amines, Asian Journal of Organic Chemistry, 2016, 5, 1353-1358.

18. Xiaotong Li, Renhe Hu, Yao Tong, Qiang Pan, Dazhuang Miao, Shiqing Han(通訊作者), An Efficient Route for the Synthesis of Benzimidazoles via a Hydrogen-Transfer Strategy between o-nitroanilines and Alcohols, Tetrahedron Letters, 2016, 57, 4645-4649.

19. Renhe Hu, Xiaotong Li, Yao Tong, Dazhuang Miao, Qiang Pan, Zengqiang Jiang, Haifeng Gan, Shiqing Han(通訊作者), Catalyst-Free Synthesis of 2-Arylbenzothiazoles in an Air/DMSO Oxidant System, Synlett, 2016, 27, 1387-1390.

20. Qiang Pan, Chun-Yang He, Shiqing Han(通訊作者), Xingang Zhang, Palladium-Catalyzed Direct Thienylation of Monobromide-Substituted Difluorinated Benzothiadiazoles for Organic Photovoltaics, Synlett, 2015, 26, 2175-2179.

21. Zeng-qiang Jiang, Da-zhuang Miao, Yao Tong, Qiang Pan, Xiao-tong Li, Ren-he Hu, Shiqing Han(通訊作者), One-Pot Base-Mediated Synthesis of Functionalized Aza-Fused Polycyclic Quinoline Derivatives, Synthesis, 2015, 47, 1913-1921.

22. Dazhuang Miao, Xuesong Shi, Guozhen He, Yao Tong, Zengqiang Jiang, Shiqing Han(通訊作者), One-pot synthesis of 2-arylbenzoxazole derivatives via Cu(I) catalyzed C-N/C-O coupling of N-(2-chloro-phenyl)-2-halobenzamides and primary amines, Tetrahedron, 2015, 71, 431-435.

23. Yao Tong, Qiang Pan, Zengqiang Jiang, Dazhuang Miao, Xuesong Shi, Shiqing Han(通訊作者), A simple approach to benzothiazoles from 2-chloronitrobenzene, elemental sulfur, and aliphatic amine under solvent-free and catalyst-free conditions, Tetrahedron Letters, 2014, 55, 5499-5503.

24. Zengqiang Jiang, Jie Zhang, Yao Tong, Xuesong Shi, Dazhuang Miao, Shiqing Han(通訊作者), One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives through Copper-Catalyzed Cascade Reactions, Chin. J. Org. Chem. 2014, 34, 1845-1850.

25. Guozhen He, Yuan Huang, Yao Tong, Jie Zhang, Dan Zhao, Shuangli Zhou, Shiqing Han(通訊作者),Substrate-Promoted Ligand-Free CuI Catalyzed S-Arylation of 2-Mercapto- benzothiazoles with Aryl Iodides in Water, Tetrahedron Letters, 2013, 54, 5318–5321.

26. Ming Jin, Dan Zhao, Guozhen He, Yao Tong, Shiqing Han(通訊作者), Substrate-promoted copper-catalyzed N-arylation of amino alcohols with aryl iodides in water, Chinese Journal of Catalysis, 2013, 34 (9), 1651-1655.

27. Yuan Huang, Wei Chen, Dan Zhao, Chen Chen, Huiqing Yin, Likang Zheng, Ming Jin, Shiqing Han(通訊作者), Copper(I)-Catalyzed Intramolecular Direct C-Arylation of Azoles with Aryl Bromides, Chinese Journal of Chemistry, 2013, 31, 1007-1010.

28. Jie Zhang, Zengqiang Jiang, Dan Zhao, Guozhen He, Shuangli Zhou, Shiqing Han(通訊作者),Transition-Metal-Free TEMPO Catalyzed Aerobic Oxidation of Alcohols to Carbonyls Using an Efficient Br2 Equivalent under Mild Conditions, Chinese Journal of Chemistry, 2013, 31, 794-798.

29. Huiqing Yin, Ming Jin, Wei Chen, Chen Chen, Likang Zheng, Ping Wei and Shiqing Han(通訊作者), Solvent-free Copper-catalyzed N-Arylation of Amino Alcohols and Diamines with Aryl Halides, Tetrahedron Lett. 2012, 53(10), 1265-1270.

30. Jingxian Zhang, Huiqing Yin, Shiqing Han(通訊作者), Copper-Catalyzed N-Arylations of Nitrogen-Containing Heterocycles in Water, Chin. J. Org. Chem., 2012, 32(8), 1429-1433.

31. Jingxian Zhang, Rui Zhang, Bin Tao, Shiqing Han(通訊作者), George Li, Preparation of novel pyridazine-4-boronic acid pinacol esters and imidazole-4-boronic acid pinacol esters through palladium-catalyzed cross-coupling reactions, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244, 625-ORGN.

32. Xinyu Li, Cheng Li, Wenjing Zhang, Xiang Lu, Shiqing Han, and Ran Hong﹡, Highly Stereoselective 7-Endo-Trig/Ring Contraction Cascade To Construct Pyrrolo[1,2-a] quinoline Derivatives, Org. Lett. 2010, 12(8), 1696-1699.

33. Yi Hu, Ping Wei, He Huang, Shi-Qing Han and Ping-Kai Ouyang, Microwave-Assisted Gewald Synthesis of 2-Aminothiophenes using Functional Ionic Liquid as Soluble Support. Heterocycles, 2006, 68(2), 375-380.

34. Yi Hu, Ping Wei, He Huang, Shi-Qing Han and Ping-Kai Ouyang, Synthesis of 2-aminothiophenes on ionic liquid phase support using the gewald reaction, Synthetic Communications, 2006, 36 (11), 1543-1548.

三、生物酶催化手性合成代表性論文：

35. Shiqing Han(通訊作者), Chaosen Chu, Synthesis of Chiral Drugs by (R)-Oxynitrilase-Catalyzed Transformation, J. Biotechnology, 2008, 136S, 396- 397.

36. Shiqing Han(通訊作者), Pingkai Ouyang, Ping Wei and Yi Hu, Enzymatic Synthesis of (R)-Cyanohydrins by Novel (R)-Oxynitrilase from Vicia Sativa L., Biotechnology Letters, 2006, 28(23), 1909-1912.

37. 褚朝森，韓世清 (通訊作者)，韋萍，新手性試劑(1R, 2S)-2-氨基醇的合成，化學試劑，2009，31(2),125-127.

38. 褚朝森，韓世清 (通訊作者)，韋萍，(R)-醇腈酶催化法合成(R)-(-)-1-(2-萘基)-2-N-甲基氨基乙醇，高校化學工程學報, 2008, (6),999-1003.

39. 韓世清 (通訊作者)，褚朝森，韋萍，（R）-醇腈酶催化合成手性藥物光學活性（S）-丁呋洛爾, 精細化工，2008，25(11),1106-1109。

40. 褚朝森，韓世清 (通訊作者)，韋萍，醇腈酶催化合成手性氰醇的研究進展，化工生產與技術，2007，14（6），55-59。

41. Chen-PR, Gu-JX, Wei-ZL, Shiqing Han, Li-ZY, Lin-GQ, Asymmetric Synthesis aided by Biocatalysts, Chin. J. Chem. 2003, 21(8), 983-993.

42. Chen-PR Shiqing Han Lin-GQ Li-ZY, A Practical High Through-Put Continuous Process for the Synthesis of Chiral Cyanohydrins, Journal Of Organic Chemistry, 2002, 67(23), 8251-8253.

43. Shi-Qing Han, Peiran Chen, Guo-Qiang Lin, Hao Huang and Zu-Yi Li, (R)-Oxynitrilase-catalyzed Hydrocyanation: the First Synthesis of Optically Active Fluorinated Mandelonitriles, Tetrahedron Asymmetry, 2001, 12, 843.

44. Peiran Chen, Shi-Qing Han, Guo-Qiang Lin, Hao Huang and Zu-Yi Li, A Study of Asymmetric Hydrocyanation of Heteroaryl Carboxaldehydes catalyzed by (R)-Oxynitrilase under Micro-aqueous Conditions, Tetrahedron Asymmetry, 2001, 12(23), 3273-3279.

45. Guo-Qiang Lin, Shi-Qing Han and Zu-Yi Li, Enzymatic Synthesis of (R)-Cyanohydrins by Three (R)-Oxynitrilase Sources in Micro-aqueous Organic Medium, Tetrahedron, 1999, 55, 3531.

46. Shi-Qing Han, Guo-Qiang Lin and Zu-Yi Li, Synthesis of (R)-Cyanohydrins by Crude (R)-Oxynitrilase-catalyzed Reactions in Micro-aqueous Medium, Tetrahedron: Asymmetry, 1998, 9(11), 1835.

四、早期科研代表性論文：

47. 韓世清﹡，楊振雲，鄭祿彬，富勒烯C60/C70的製備化學，化學通報，1996, (5), 11。

48. 韓世清﹡，曹國英，奚祖威，常溫下環己烷的液相羥基化反應，催化學報，1995, 16(6), 514。

49. 韓世清﹡，曹國英，奚祖威，鉬釩磷雜多化合物過氧化氫體系催化飽和烴的羥化反應，催化學報，1995, 16(5), 392。

50. 韓世清﹡，奚祖威，黃家壁，雙齒銅(Ⅱ)絡合物催化作用下分子氧對醇類的選擇性氧化，分子催化，1991, 5(4), 316。

51. 韓世清﹡，奚祖威，黃家壁，醇類催化氧化反應的機理研究—半乳糖氧化酶化學模擬體系，分子催化，1991, 5(3), 248。

申請專利

1. 韓世清;童耀;潘強;蔣增強;苗大狀, 一種合成2-取代苯並噻唑衍生物的方法，中國發明專利, 201410205413.3(已授權)。

2. 韓世清;苗大狀;史雪松;蔣增強;童耀;黃媛;潘強，一鍋法合成二苯二氮卓雜環衍生物的方法，中國發明專利, 201410206756.1。

3. 韓世清;蔣增強;童耀;苗大狀;潘強;史雪松;黃媛，一種5-甲腈-吡咯[1,2-a]喹啉衍生物的合成方法，中國發明專利, 201410205415.2。

4. 韓世清;蔣增強;張傑;童耀;何國珍;周雙利;趙丹，一種合成5-甲腈-吡咯[1,2-a]喹啉衍生物的方法，中國發明專利, 201410205394.4(已授權)。

5. 韓世清;蔣增強;張傑;童耀;何國珍;周雙利;趙丹，一種合成吡咯[1,2-a]喹喔啉衍生物的方法,中國發明專利, 201310239066.1。

6. 韓世清;蔣增強;張傑;童耀;何國珍;周雙利;趙丹，吡咯[1,2-a]喹喔啉衍生物的合成方法，中國發明專利, 201310238303.2(已授權)。

7. 韓世清;方淑瑩；何國珍，製備亞磺醯基-1-氫-苯並咪唑衍生物的方法,中國發明專利, 201310669517.5(已授權)。

8. 韓世清;何國珍；張傑；趙丹；周雙利，一種小分子cathepsin D 抑制劑的製備方法，中國發明專利, 201310130670.0(已授權)。

9. 韓世清;張傑；蔣增強；趙丹；何國珍；周雙利，一種選擇性催化分子氧氧化水楊醇製備水楊醛的方法，中國發明專利, 201210570307.6(已授權)。

10. 韓世清;鄭禮康;金明;張敬先;趙丹;何國珍，一種4-噻唑烷酮羧酸衍生物及其製備方法和用途，中國發明專利, 201110174465.5。

11. 豐樹山;韓世清;何明芳;成永之. 一種新穎激活氟代喹啉-3羧酸的7-位鹵素的方法及其和仲胺縮合形成側鏈的用途, 中國發明專利, 201010157258.4(已授權)。

12. 韓世清, 瞿滌, 潘斌, 朱明莉, 吳暘, 黃仁政. 3-羰基-6-乙氧甲醯基-噻唑並嘧啶類化合物及其合成方法和用途, 中國發明專利, ZL 200910183297.9(已授權)。

13. 韓世清，姜岷，李兆亮，王軍，韋萍，歐陽平凱. 包含鑭系雙齒配合物的二元複合催化劑及其製備方法和用途，中國發明專利, ZL 200810022784.2(已授權)。

14. 林國強，陳沛然，韓世清，李祖義，黃浩，一類手性雜芳基氰醇及其衍生物的製備方法和用途，中國發明專利, 01105269.4。

15. 林國強，韓世清，李祖義，一種新酶源的醇腈裂解酶催化合成光學活性氰醇化合物，中國發明專利, ZL 99113884.8(已授權)。

16. 林國強，韓世清，李祖義，手性氰醇化合物及其衍生物和製備方法，中國發明專利, 99113883.X。

17. 林國強，韓世清，李祖義，氰醇裂解酶催化合成光學活性氰醇化合物，中國發明專利, ZL 98110818.0 (已授權)。