陸勇軍

陸勇軍

陸勇軍，男，博士，中山大學生命科學學院教授、博士生導師。

基本介紹

  • 中文名：陸勇軍
  • 國籍：中國
  • 學位/學歷：博士
  • 專業方向：病原細菌/人體微生物組與宿主互作等
  • 任職院校：中山大學
研究方向,講授課程,論文專著,

研究方向

病原細菌/人體微生物組與宿主互作-以效應蛋白為中心
微生物與其宿主之間的相互作用是生物物種間最複雜的相互作用之一。一方面，在與人類或者其它動植物宿主億萬年共同進化的過程中，共棲微生物（Commensal）成功適應了宿主環境，並對宿主的發育、免疫及神經系統都產生重要的影響；另一方面，病原菌（Pathogens）則能突破宿主的免疫屏障，實現感染。雖然抗生素和疫苗的發明使我們能對付大多數的病原細菌(Pathogenic bacteria)，但是，病原細菌也逐漸發展出了抵抗抗生素的策略，出現了超級抗性菌，使病原細菌特別是耐藥性細菌又一次成為人類的重大威脅；同時，病原細菌還發展出了精巧複雜的毒力系統，以適抹去辣應鴉滲備宿主體宙連內環境、躲避或克服宿主的免疫體系，導致各種感染症甚至癌症等，其中最重要的毒力系統就是細菌的分微頁罪泌系統(Secretion System)。通過相當於細菌“武器”的分泌系統，細菌可以向宿主體內分泌數量眾多、功能各異的毒力蛋白-效應蛋白（Effector proteins，也就是細菌的“子彈”），效應蛋白與宿主細胞表面或宿主細胞中的各種靶點蛋白相互作用，改變宿主的各種信號傳導途徑如細胞凋亡、自噬和細胞周期等，從而適應宿主環境，克服宿主免疫系統的攻擊，達到讓細菌自身在宿主內增殖的目的。
研究微生物和宿主相互作用的學科稱為細胞微生物學（Cellular Microbiology），細菌效應蛋白功能的闡明是該學科研究的重點。（1）闡明效應蛋白的生化功能，可以讓我們更深入理解病原細菌致病以及適應宿主環境的騙拒她踏分子機制；（2）以這些效應蛋白為工具，發現宿主固有免疫（Innate Immunity）調控的新途徑，是免疫學的新領域；（3）效應蛋白本身還可以作為抗菌藥物作用的理想靶位點，研發針對這些效應蛋白的活性先導物（相當於鈍化或收繳細菌的“子彈”），有可能獲得避免耐藥性產生的新型抗生素；（4）可以運用合成生物學（Synthetic Biology）策略在微生物細胞、癌細胞或免疫細胞中構建效應蛋白調控迴路(Circuit) ，實現對疾病相關細胞活性的人工調控。
圍繞以上方向，我們的研究興趣具體如下（詳見主頁中的“研究興趣”欄目）：
（1）效應蛋白的生化功能及宿主免疫反應機制以目前臨床上典型的胞內病原細菌嗜肺軍團菌（Legionella pneumophila）、結核分枝桿菌（Mycobacterium tuberculosis）以及重要的植物病原細菌茄科勞爾氏菌（Ralstonia solanacearum）為模型，重點研究其致病的關鍵效應蛋白的表達調控及其生化功能，闡明這些蛋白與宿主靶蛋白相互作用進而調整宿主免疫系統的分子機制。
（2）靶向效應蛋白的抗結核藥物研製結核分枝桿菌是結核病的病原，感染了我國近三分之一的人口，是國人健康的重大威脅，急需新的抗結核藥物。我們以結核分枝桿菌關鍵效應蛋白為靶點，建立相應的篩選系統，從微生物代謝產物中篩選效應蛋白的抑制劑，並研究其作用機制，期望獲得新型的、能避免耐藥產生的新型抗結核藥物。
（3）腸道微生物組與宿主的互作及其分子機制腸道菌群是腸道內寄居的種類繁多的微生物的總稱。腸道微生物是代謝的重要參與者，同時代謝產生的脂肪酸等促進腸道上皮細胞生長與分化。腸道菌群之間可以通過如分泌系統分泌的效應蛋白和群感效應（Quorum sensing）等維持菌群的平衡。腸道菌群失調（dysbiosis）會增加疾病的易感性，包括胃腸道諒殼妹疾病、代謝類疾病（如肥胖、糖尿病等）、免疫類疾病、精神類疾病和癌症等。對腸道微生物組與疾病關係的研究，將為開發基於微生物的疾病診斷、疾病干預、治療和益生菌產品的研發等提供基礎。我們綜合運用基因組學、代謝組學和生物信息學技術，研究腸道微夜糠定嫌生物組（microbiome）或腸道細菌及其效應蛋白和代謝產物與炎症和癌症等的發生、發展的關聯性及其分子機制；同時，運用合成生物學的相關策略，建立重要腸道菌的分子遺傳作業系統，以期實現對腸道細菌功能的精準調控。

講授課程

1. 主講本科生課程：必修課“生物技術學”、必修課“生物技術綜合實驗”
2. 參講本科生課程：“生命科學引論”、逸仙學院教育部拔尖創新人才培養試驗班課程“生物學前沿學術專題”
3. 合講研究生課程“細胞微生物學”

論文專著

一、部分論文（2009--）
  1. Qin Zeng, Junli Gong, Xiyuan Liu, Chen Chen, Xiaobo Sun, Huijuan Li, Yifan Zhou, ChunPing Cui, Yuge Wang, Yu Yang, Aimin Wu, Yaqing Shu, Xueqiang Hu, Zhengqi Lu, Song Guo Zheng*, Wei Qiu*, Yongjun Lu*.Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis.Neurochemistry International,2019(129)104468.
  2. He L, Lin Y, Ge ZH, He SY, Zhao BB, Shen D, He JG, Lu YJ*. TheLegionella pneumophilaeffector WipA disrupts host F-actin polymerisation by hijacking phosphotyrosine signaling.Cellular Microbiology. 2019 Jan 31:e13014. doi: 10.1111/cmi.13014.
  3. Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao, Dongni Chen, Meng Gao, Qinglin Wang, Bin Wang, Haihong Huang⁎,Yongjun Lu⁎, Yu Lu⁎.Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold.Bioorganic Chemistry, 2019, 85:229–239.
  4. Jia-Hua Huang, Jian-Ming Lv, Qiao-Zhen Wang, Jian Zou, Yong-Jun Lu, Qing-Lin Wang, Dong-Ni Chen, Xin-Sheng Yao, Hao Gao and Dan Hu. Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A.Organic & Biomolecular Chemistry, 2019 Jan 2; 17(2):248-251.
  5. LUO X-W, LIN Y, LU Y-J, Zhou XF, Liu YH. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008 [J].Chinese Journal of Natural Medicines, 2019, 17(2): 149-154.
  6. Sun yunhao, Li Pai, Shen Dong, Wei Qiaoling, He Jianguo, Lu Yongjun*. TheRalstonia solanacearumeffector RipN suppresses plant PAMP-triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD+ ratio in Arabidopsis.Molecular Plant Pathology.2019,20(4):533-546. First published, 2018,Nov 30. doi: 10.1111/mpp.12773.
  7. Gong JL, Qiu W, Zeng Q, Liu XY, Sun XB, Li HJ, Yang Y, Wu AM, Bao J, Wang YG, Shu YQ, Hu XQ, Bellanti JA, Zheng SG, Lu YJ*, Lu ZQ*. Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: A Chinese pilot study.Multiple Sclerosis Journal, 2018, Aug 16:1352458518790396.
  8. Yu Dai, Yun Lin, Xiaoyan Pang, Xiaowei Luo, Limbadri salendra, Junfeng Wang，Xuefeng Zhou, Yongjun Lu, Bin Yang, Yonghong Liu. Peptides from the Soft Coral-associated FungusSimplicilliumsp. SCSIO41209.Phytochemistry, 2018, 154:56–62。
  9. Qian Jia, Yun Lin, Xue-jing Gou, Lei He, Dong Shen, Dong-ni Chen, Wei Xie *, Yong-jun Lu*. Legionella pneumophila effector WipA, a bacterial PPP protein phosphatase with PTP activity.Acta Biochimica et Biophysica Sinica. 2018, 50(6):547-554.
  10. GONG Junli, SUN Xiaoming, LIN Zhiyong, LU Hongfeng, LU Yongjun. Geochemical and microbial characters of sediment from the gas hydrate area in the Taixinan Basin, South China Sea.Acta Oceanol. Sin., 2017, 36(9):52–64.
  11. Senhua Chen, Meng Ding; Weiyang Liu; Xishan Huang, Zhaoming Liu, Yongjun Lu, Hongju Liu, Zhigang She. Anti-inflammatory Meroterpenoids from the Mangrove Endophytic FungusTalaromyces amestolkiaeYX1.Phytochemistry, 2017 Nov 30;146:8-15.
  12. Hui Cui, Yun Lin, Mingchu Luo, Yongjun Lu, Xishan Huang, and Zhigang She. Diaporisoindoles A−C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic FungusDiaporthesp. SYSU-HQ3.Organic Letters, 2017, Oct 20;19(20):5621-5624.
  13. Qianqian Ji, Caiping Guo, Chen Xie, Yingdan Wu, Pei Zhang, Hui Li, Yongjun Lu*. Genetically engineered cell lines for a1-antitrypsin expression.Biotechnology Letters, 2017, 39:1471-1476.
  14. Senhua Chen, Liqing He, Dongni Chen, Runlin Cai, Yuhua，Long, Yongjun Lu* and Zhigang She*. Talaramide A, an Unusual Alkaloid from the Mangrove Endophytic FungusTalaromycessp. (HZ-YX1) as Inhibitor of Mycobacterial PknG.New Journal of Chemistry, 2017, 146:8-15.
  15. Liu Z, Chen S, Qiu P, Tan C, Long Y, Lu Y, She Z. (+)- and (-)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungusAscomycotasp. SK2YWS-L.Organic & Biomolecular Chemistry. 2017, 15(48):10276-10280.
  16. Sun Yunhao, Li Pai, Deng Mengying, Shen Dong, Dai Guangyi, Yao Nan, Lu Yongjun*. TheRalstonia solanacearumeffector RipAK suppresses plant hypersensitive response by inhibiting the activity of host catalases. Cellular Microbiology, 2017, 19: e12736.
  17. Dongni Chen, Shuangshuang Ma, Lei He, Peibo Yuan, Zhigang She and Yongjun Lu*. Sclerotiorin inhibits protein kinase G fromMycobacterium tuberculosisand impairs mycobacterial growth in macrophages.Tuberculosis, 2017,103:37-43.
  18. Chunbin Tan, Zhaoming Liu, Senhua Chen, Xishan Huang, Hui Cui, Yuhua Long, Yongjun Lu and Zhigang She. Antioxidative Polyketones from the Mangrove-Derived FungusAscomycotasp. SK2YWS-L.Scientific report, 2016 Nov 4;6:36609.
  19. Meng-ying Deng, Yun-hao Sun, Pai Li, Bei Fu, Dong Shen, Yong-jun Lu*. The phytopathogenic virulent effector protein RipI induces apoptosis in budding yeastSaccharomyces cerevisiae.Toxicon, 2016, 121:109-118.
  20. Bei-bei Zhao, Xiang-hui Li, Yong-lun Zeng and Yong-jun Lu*. ClpP-deletion impairs the virulence of Legionella pneumophila and the optimal translocation of effector proteins.BMC Microbiology, 2016, 16(1):174-185.
  21. Hui Cui, Yayue Liu, Yang Nie, Zhaoming Liu, Zhengrui Zhang, Yongjun Lu, Lei He, Xishan Huang *, Zhigang She*. Polyketides from the Mangrove-Derived Endophytic FungusNectriasp. HN001 and Their α-Glucosidase Inhibitory Activity.Marine Drugs,2016, 14(5)：86.
  22. Liu, Zhaoming; Chen, Yan; Chen, Senhua; Liu, Yayue; Lu, Yongjun; Chen, Dongni; Lin, Yongcheng; Huang, Xishan; She, Zhigang. Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic FungusAspergillus terreusH010.Organic Letters, 2016, 18:1406-1409.
  23. Dong-ni Chen, Hong Chen, Zhi-gang She, Yong-jun Lu*. Identification of Bostrycin Derivatives on Inhibition of MptpB Phosphatase fromMycobacterium tuberculosis.Medicinal Chemistry, 2016;12(3):296-302.
  24. Li J, Xue YY, Yuan J, Lu YJ, Zhu X, Lin YC, Liu L*. Lasiodiplodins from Mangrove Endophytic FungusLasiodiplodiasp. 318#.Natural Product Research, 2016, 30(7), 755-760.
  25. Senhua Chen, Zhaoming Liu, Hanxiang Li, Guoping Xia, Yongjun Lu, Lei He, Shaodong Huang, Zhigang She. β-Resorcylic acid derivatives with a-glucosidase inhibitory activity fromLasiodiplodiasp. ZJ-HQ1, an endophytic fungus in the medicinal plantAcanthus ilicifolius,Phytochem. Lett. 2015,13, 141–146.
  26. Senhua Chen, Zhaoming Liu, Yayue Liu, Yongjun Lu, Lei He, Zhigang She. New Depsidones and Isoindolones from the Mangrove Endophytic FungusMeyerozyma guilliermondii(HZ-Y2) Isolated from the South China Sea,Beilstein J. Org. Chem.2015,11,1187–1193.
  27. Liu Y, Yang Q, Xia G, Huang H, Li H, Ma L, Lu Y, He L, Xia X, She Z. Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus,Penicilliumsp. HN29-3B1.J Nat Prod. 2015，78(8):1816-22.
  28. He Lei, Deng Qing-li, Chen Mou-tong, Wu Qing-ping, Lu Yong-jun*. Proteomics analysis ofListeria monocytogenesATCC 19115 in response to simultaneous triple stresses.Archives of Microbiology, 2015, 197(6):833-841.
  29. Yayue Liu, Senhua Chen, Zhaoming Liu, Yongjun Lu, Guoping Xia, Hongju Liu, Lei He and Zhigang She. Bioactive Metabolites from Mangrove Endophytic FungusAspergillussp. 16-5B.Marine Drugs, 2015, 13: 3091-3102.
  30. Ze'en Xiao, Shao'e Lin, Chunbin Tan, Yongjun Lu, Lei He, Xishan Huang, Zhigang She. Asperlones A and B, Dinaphthalenone Derivatives from a Mangrove Endophytic FungusAspergillussp. 16-5C.Marine Drugs,2015, 13: 366-378.
  31. Sun Meng-yi, Lu Yong-jun*. A simple method for constructing magneticEscherichia coli.BioRxiv, 2014, October 10, doi: https://doi.org /10.1101/ 010249
  32. Yayue Liu, Guoping Xia, Hanxiang Li, Lin Ma, Bo Ding , Yongjun Lu , Lei He , Xuekui Xia *, Zhigang She*, Vermistatin Derivatives with α-Glucosidase Inhibitory Activity from the Mangrove Endophytic FungusPenicilliumsp. HN29-3B1.Planta Med., 2014, 80, 912-917.
  33. Li Jing，Yang Xin, Lin Yingying, Yuan Jie, Lu Yongjun, Zhu Xun, Li Jun, Li Mengfeng, Lin Yongcheng, He Jianguo, Liu Lan. Meroterpenes and azaphilones from marine mangrove endophytic fungusPenicillium303#.Fitoterapia, 2014, 97:241-246.
  34. Guoping Xia, Jia Li, Hanxiang Li, Yuhua Long, Shao’e Lin, Yongjun Lu, Lei He, Yongcheng Lin, Lan Liu and Zhigang She. Alterporriol-Type Dimers from the Mangrove Endophytic Fungus,Alternaria sp. (SK11), and Their MptpB Inhibitions.Marine Drugs, 2014, 12：2953-2969.
  35. Li HX, Jiang J, Liu Z, Lin S, Xia G, Xia X, Ding B, He L, Lu Y*, She Z*. Peniphenones A-D from the Mangrove FungusPenicillium dipodomyicolaHN4-3A as Inhibitors ofMycobacterium tuberculosisPhosphatase MptpB.J Nat Prod. 2014,77(4): 800−806.
  36. Ding B, Yuan J, Huang X, Wen W, Zhu X, Liu Y, Li H, Lu Y, He L, Tan H, She Z. New dimeric members of the phomoxanthone family: phomolacton-exanthones A, B and deacetylphomoxanthone C isolated from the fungusPhomopsissp.Marine Drugs. 2013 , 11(12):4961-72.
  37. Du J, Xiao K, Li L, Ding X, Liu H, Lu Y, Zhou S. Temporal and spatial diversity of bacterial communities in coastal waters of the South china sea.PLoS One. 2013, 8(6):e66968.
  38. Xiao Z, Huang H, Shao C, Xia X, Ma L, Huang X, Lu Y, Lin Y, Long Y, She Z. Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungusAspergillussp. 085242.Organic Letters.2013, 15(10):2522-5.
  39. Du J, Li L, Ding X, Hu H, Lu Y, Zhou S. Isolation and characterization of a novel cyanophycin synthetase from a deep-sea sediment metagenomic library.Appl Microbiol Biotechnol.2013, 97(19):8619-28.
  40. Huang, Xishan; Huang, Hongbo; Li, Hanxiang; Sun, Xuefeng; Huang, Huarong; Lu, Yongjun; Lin, Yongcheng; Long, Yuhua*; She, Zhigang *. Asperterpenoid A, a New Sesterterpenoid as an Inhibitor ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B from the Culture ofAspergillussp. 16-5c.OrganicLetters. 2013，15（4）：721-723.
  41. Huang C, Jin H, Song B, Zhu X, Zhao H, Cai J, Lu Y, Chen B, Lin Y. The cytotoxicity and anticancer mechanisms of alterporriol L, a marine bianthraquinone, against MCF-7 human breast cancer cells.Appl Microbiol Biotechnol. 2012, 93(2):777-85.
  42. Ding X, Yin B, Qian L, Zeng Z, Yang Z, Li H, Lu Y, Zhou S. Screening for novel quorum-sensing inhibitors to interfere with the formation ofPseudomonas aeruginosabiofilm.J Med Microbiol. 2011, 60(Pt 12):1827-34.
  43. Hanxiang Li, Hongbo Huang, Changlun Shao, Huarong Huang, Jieyi Jiang, Xun Zhu,Yayue Liu Lan Liu,Yongjun Lu, Mengfeng Li, Yongcheng Lin,and Zhigang She. Cytotoxic Norsesquiterpene Peroxides from the Endophytic FungusTalaromyces flavusIsolated from the Mangrove PlantSonneratia apetala.Journal of Natural Products，2011, 74, 1230–1235.
  44. Cai-Huan Huang, Jia-Hui Pan, Bin Chen, Miao Yu, Hong-Bo Huang, Xun Zhu,Yong-Jun Lu, Zhi-Gang She and Yong-Cheng Lin. Three Bianthraquinone Derivatives from the Mangrove Endophytic FungusAlternariasp. ZJ9-6B from the South China Sea.Marine Drugs, 2011, 9(5):832-843.
  45. Hongbo Huang, Xiaojun Feng,Ze’en Xiao, Lan Liu, Hanxiang Li, Lin Ma, Yongjun Lu, Jianhua Ju, Zhigang She, and Yongcheng Lin. Azaphilones and p-Terphenyls from the Mangrove Endophytic FungusPenicillium chermesinum(ZH4-E2) Isolated from the South China Sea.Journal of Natural Products，2011 74, 997–1002.
  46. Huixian Li, Yali Huang, Jiong Zhang, Jikun Du, Hongming Tan, Yongjun Lu, Shining Zhou. Identification and characterization of a novel methionine c-lyase gene from deep-sea sediment metagenomic library.World J Microbiol Biotechnol, 2011, 27:2729–2736.
  47. Jikun Du, Kai Xiao, Yali Huang, Huixian Li, Hongming Tan, Lixiang Cao, Yongjun Lu ,Shining Zhou. Seasonal and spatial diversity of microbial communities in marine sediments of the South China Sea.Antonie van Leeuwenhoek, 2011,100（3）：317-331.
  48. Fenju Lai, Rentian Wu, Jiafeng Wang, Chunming Li, Lan Zou, Yongjun Lu and Chun Liang. Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast.FEMS Yeast Research,2011 Feb;11(1):72-9.
  49. Lijuan Ma, Yuanliang Zhai, Daorong Feng, Tsz-choi Chan, Yongjun Lu, Xinrong Fu, Jiafeng Wang, Yanhong Chen, Jianna Li, Ke Xu, and Chun Liang. Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Phenotypic Screen inSaccharomyces cerevisiae.Cell Cycle, 2010,9(21):4399-4410.
  50. Hong-Bo Huang, Xiao-Jun Feng, Lan Liu, Bin Chen, Yong-Jun Lu, Lin Ma, Zhi-Gang She, Yong-Cheng Lin. Three Dimeric Naphtho-γ-Pyrones from the Mangrove Endophytic FungusAspergillus tubingensisIsolated fromPongamia pinnata.Planta Medica, 2010,76: 1888–1891
  51. Kai-Kai Li, Yong-Jun Lu, Xiao-Hong Song, Zhi-Gang She, Xi-Wei Wu, Lin-Kun An,Chuang-Xing Ye, Yong-Cheng Lin. The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea.Bioorganic & Medicinal Chemistry Letters, 2010,20: 3326–3328.
  52. Xiang-hui Li, Yong-lun Zeng, Ye Gao, Xiao-cong Zheng, Qin-fen Zhang, Shi-ning Zhou, Yong-jun Lu*. The ClpP protease homologue is required for the transmission traits and cell division of the pathogenLegionella pneumophila.BMC Microbiology,2010, 10(1):54.
  53. Zhen Xu, Xue Cheng, Jiafeng Wang, Yuanliang Zhai, Yongjun Lu and Chun Liang. ATP-Dependent Pre-Replicative ComplexAssembly Is Facilitated by Adk1p in Budding Yeast.J. Biological Chemistry, 2010 ,285(39):29974-80.
  54. Jiafeng Wang, Rentian Wu, Yongjun Lu and Chun Liang. Ctf4p Facilitates Mcm10p to Promote Initiation of DNA Replication in Budding Yeast.Biochemical and Biophysical Research Communications, 2010, 395:336–341.
  55. Chun-ling Xu, Jia-feng Wang, Ye Gao, Huang-yu Lin, Lin Du, Shan-shan Yang, Si-mei Long, Zhi-gang She, Xiao-ling Cai, Shi-ning Zhou, Yong-jun Lu*. The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeastSaccharomyces cerevisiae.FEMS Yeast Research,2010, 10（3）: 297–308.
  56. Yiguang Chen, Jiahui Pan, Fan Liu, JianXiang Yang, Caihuan Huang, Xiaolin Cai, Yongjun Lu, Zhigang She and Yongcheng Lin. A new indene derivative from the marine fungusPhomopsissp. (No. GX7-4A).Chem Nat Commpd. 2010,2:1-2.
  57. Wen-han Zhu, Lan Luo, Jia-yi Wang, Xiao-hong Zhuang, Ling Zhong, Kang Liao, Yan Zeng, Yong-jun Lu* . Complete nucleotide sequence of pCTX-M360, an intermediate plasmid between pEL60 and pCTX-M3, from a multidrug resistantKlebsiella pneumoniaeisolated in China. Antimicrobial Agents and Chemotherapy, 2009, 53(12):5291-5293
  58. Ming-jia Yu, Jun Ren, Yong-lun Zeng, Shi-ning Zhou and Yong-jun Lu*. TheLegionella pneumophilaDps homolog is regulated by iron and involved in multiple stress tolerance.Journal of Basic Microbiology，2009, 49: 1–8.
二、 主編教材：《生物技術綜合實驗》, 2017，中山大學出版社，第1版；2019年第二次印刷。

講授課程

1. 主講本科生課程：必修課“生物技術學”、必修課“生物技術綜合實驗”
2. 參講本科生課程：“生命科學引論”、逸仙學院教育部拔尖創新人才培養試驗班課程“生物學前沿學術專題”
3. 合講研究生課程“細胞微生物學”

論文專著

一、部分論文（2009--）
  1. Qin Zeng, Junli Gong, Xiyuan Liu, Chen Chen, Xiaobo Sun, Huijuan Li, Yifan Zhou, ChunPing Cui, Yuge Wang, Yu Yang, Aimin Wu, Yaqing Shu, Xueqiang Hu, Zhengqi Lu, Song Guo Zheng*, Wei Qiu*, Yongjun Lu*.Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis.Neurochemistry International,2019(129)104468.
  2. He L, Lin Y, Ge ZH, He SY, Zhao BB, Shen D, He JG, Lu YJ*. TheLegionella pneumophilaeffector WipA disrupts host F-actin polymerisation by hijacking phosphotyrosine signaling.Cellular Microbiology. 2019 Jan 31:e13014. doi: 10.1111/cmi.13014.
  3. Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao, Dongni Chen, Meng Gao, Qinglin Wang, Bin Wang, Haihong Huang⁎,Yongjun Lu⁎, Yu Lu⁎.Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold.Bioorganic Chemistry, 2019, 85:229–239.
  4. Jia-Hua Huang, Jian-Ming Lv, Qiao-Zhen Wang, Jian Zou, Yong-Jun Lu, Qing-Lin Wang, Dong-Ni Chen, Xin-Sheng Yao, Hao Gao and Dan Hu. Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A.Organic & Biomolecular Chemistry, 2019 Jan 2; 17(2):248-251.
  5. LUO X-W, LIN Y, LU Y-J, Zhou XF, Liu YH. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008 [J].Chinese Journal of Natural Medicines, 2019, 17(2): 149-154.
  6. Sun yunhao, Li Pai, Shen Dong, Wei Qiaoling, He Jianguo, Lu Yongjun*. TheRalstonia solanacearumeffector RipN suppresses plant PAMP-triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD+ ratio in Arabidopsis.Molecular Plant Pathology.2019,20(4):533-546. First published, 2018,Nov 30. doi: 10.1111/mpp.12773.
  7. Gong JL, Qiu W, Zeng Q, Liu XY, Sun XB, Li HJ, Yang Y, Wu AM, Bao J, Wang YG, Shu YQ, Hu XQ, Bellanti JA, Zheng SG, Lu YJ*, Lu ZQ*. Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: A Chinese pilot study.Multiple Sclerosis Journal, 2018, Aug 16:1352458518790396.
  8. Yu Dai, Yun Lin, Xiaoyan Pang, Xiaowei Luo, Limbadri salendra, Junfeng Wang，Xuefeng Zhou, Yongjun Lu, Bin Yang, Yonghong Liu. Peptides from the Soft Coral-associated FungusSimplicilliumsp. SCSIO41209.Phytochemistry, 2018, 154:56–62。
  9. Qian Jia, Yun Lin, Xue-jing Gou, Lei He, Dong Shen, Dong-ni Chen, Wei Xie *, Yong-jun Lu*. Legionella pneumophila effector WipA, a bacterial PPP protein phosphatase with PTP activity.Acta Biochimica et Biophysica Sinica. 2018, 50(6):547-554.
  10. GONG Junli, SUN Xiaoming, LIN Zhiyong, LU Hongfeng, LU Yongjun. Geochemical and microbial characters of sediment from the gas hydrate area in the Taixinan Basin, South China Sea.Acta Oceanol. Sin., 2017, 36(9):52–64.
  11. Senhua Chen, Meng Ding; Weiyang Liu; Xishan Huang, Zhaoming Liu, Yongjun Lu, Hongju Liu, Zhigang She. Anti-inflammatory Meroterpenoids from the Mangrove Endophytic FungusTalaromyces amestolkiaeYX1.Phytochemistry, 2017 Nov 30;146:8-15.
  12. Hui Cui, Yun Lin, Mingchu Luo, Yongjun Lu, Xishan Huang, and Zhigang She. Diaporisoindoles A−C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic FungusDiaporthesp. SYSU-HQ3.Organic Letters, 2017, Oct 20;19(20):5621-5624.
  13. Qianqian Ji, Caiping Guo, Chen Xie, Yingdan Wu, Pei Zhang, Hui Li, Yongjun Lu*. Genetically engineered cell lines for a1-antitrypsin expression.Biotechnology Letters, 2017, 39:1471-1476.
  14. Senhua Chen, Liqing He, Dongni Chen, Runlin Cai, Yuhua，Long, Yongjun Lu* and Zhigang She*. Talaramide A, an Unusual Alkaloid from the Mangrove Endophytic FungusTalaromycessp. (HZ-YX1) as Inhibitor of Mycobacterial PknG.New Journal of Chemistry, 2017, 146:8-15.
  15. Liu Z, Chen S, Qiu P, Tan C, Long Y, Lu Y, She Z. (+)- and (-)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungusAscomycotasp. SK2YWS-L.Organic & Biomolecular Chemistry. 2017, 15(48):10276-10280.
  16. Sun Yunhao, Li Pai, Deng Mengying, Shen Dong, Dai Guangyi, Yao Nan, Lu Yongjun*. TheRalstonia solanacearumeffector RipAK suppresses plant hypersensitive response by inhibiting the activity of host catalases. Cellular Microbiology, 2017, 19: e12736.
  17. Dongni Chen, Shuangshuang Ma, Lei He, Peibo Yuan, Zhigang She and Yongjun Lu*. Sclerotiorin inhibits protein kinase G fromMycobacterium tuberculosisand impairs mycobacterial growth in macrophages.Tuberculosis, 2017,103:37-43.
  18. Chunbin Tan, Zhaoming Liu, Senhua Chen, Xishan Huang, Hui Cui, Yuhua Long, Yongjun Lu and Zhigang She. Antioxidative Polyketones from the Mangrove-Derived FungusAscomycotasp. SK2YWS-L.Scientific report, 2016 Nov 4;6:36609.
  19. Meng-ying Deng, Yun-hao Sun, Pai Li, Bei Fu, Dong Shen, Yong-jun Lu*. The phytopathogenic virulent effector protein RipI induces apoptosis in budding yeastSaccharomyces cerevisiae.Toxicon, 2016, 121:109-118.
  20. Bei-bei Zhao, Xiang-hui Li, Yong-lun Zeng and Yong-jun Lu*. ClpP-deletion impairs the virulence of Legionella pneumophila and the optimal translocation of effector proteins.BMC Microbiology, 2016, 16(1):174-185.
  21. Hui Cui, Yayue Liu, Yang Nie, Zhaoming Liu, Zhengrui Zhang, Yongjun Lu, Lei He, Xishan Huang *, Zhigang She*. Polyketides from the Mangrove-Derived Endophytic FungusNectriasp. HN001 and Their α-Glucosidase Inhibitory Activity.Marine Drugs,2016, 14(5)：86.
  22. Liu, Zhaoming; Chen, Yan; Chen, Senhua; Liu, Yayue; Lu, Yongjun; Chen, Dongni; Lin, Yongcheng; Huang, Xishan; She, Zhigang. Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic FungusAspergillus terreusH010.Organic Letters, 2016, 18:1406-1409.
  23. Dong-ni Chen, Hong Chen, Zhi-gang She, Yong-jun Lu*. Identification of Bostrycin Derivatives on Inhibition of MptpB Phosphatase fromMycobacterium tuberculosis.Medicinal Chemistry, 2016;12(3):296-302.
  24. Li J, Xue YY, Yuan J, Lu YJ, Zhu X, Lin YC, Liu L*. Lasiodiplodins from Mangrove Endophytic FungusLasiodiplodiasp. 318#.Natural Product Research, 2016, 30(7), 755-760.
  25. Senhua Chen, Zhaoming Liu, Hanxiang Li, Guoping Xia, Yongjun Lu, Lei He, Shaodong Huang, Zhigang She. β-Resorcylic acid derivatives with a-glucosidase inhibitory activity fromLasiodiplodiasp. ZJ-HQ1, an endophytic fungus in the medicinal plantAcanthus ilicifolius,Phytochem. Lett. 2015,13, 141–146.
  26. Senhua Chen, Zhaoming Liu, Yayue Liu, Yongjun Lu, Lei He, Zhigang She. New Depsidones and Isoindolones from the Mangrove Endophytic FungusMeyerozyma guilliermondii(HZ-Y2) Isolated from the South China Sea,Beilstein J. Org. Chem.2015,11,1187–1193.
  27. Liu Y, Yang Q, Xia G, Huang H, Li H, Ma L, Lu Y, He L, Xia X, She Z. Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus,Penicilliumsp. HN29-3B1.J Nat Prod. 2015，78(8):1816-22.
  28. He Lei, Deng Qing-li, Chen Mou-tong, Wu Qing-ping, Lu Yong-jun*. Proteomics analysis ofListeria monocytogenesATCC 19115 in response to simultaneous triple stresses.Archives of Microbiology, 2015, 197(6):833-841.
  29. Yayue Liu, Senhua Chen, Zhaoming Liu, Yongjun Lu, Guoping Xia, Hongju Liu, Lei He and Zhigang She. Bioactive Metabolites from Mangrove Endophytic FungusAspergillussp. 16-5B.Marine Drugs, 2015, 13: 3091-3102.
  30. Ze'en Xiao, Shao'e Lin, Chunbin Tan, Yongjun Lu, Lei He, Xishan Huang, Zhigang She. Asperlones A and B, Dinaphthalenone Derivatives from a Mangrove Endophytic FungusAspergillussp. 16-5C.Marine Drugs,2015, 13: 366-378.
  31. Sun Meng-yi, Lu Yong-jun*. A simple method for constructing magneticEscherichia coli.BioRxiv, 2014, October 10, doi: https://doi.org /10.1101/ 010249
  32. Yayue Liu, Guoping Xia, Hanxiang Li, Lin Ma, Bo Ding , Yongjun Lu , Lei He , Xuekui Xia *, Zhigang She*, Vermistatin Derivatives with α-Glucosidase Inhibitory Activity from the Mangrove Endophytic FungusPenicilliumsp. HN29-3B1.Planta Med., 2014, 80, 912-917.
  33. Li Jing，Yang Xin, Lin Yingying, Yuan Jie, Lu Yongjun, Zhu Xun, Li Jun, Li Mengfeng, Lin Yongcheng, He Jianguo, Liu Lan. Meroterpenes and azaphilones from marine mangrove endophytic fungusPenicillium303#.Fitoterapia, 2014, 97:241-246.
  34. Guoping Xia, Jia Li, Hanxiang Li, Yuhua Long, Shao’e Lin, Yongjun Lu, Lei He, Yongcheng Lin, Lan Liu and Zhigang She. Alterporriol-Type Dimers from the Mangrove Endophytic Fungus,Alternaria sp. (SK11), and Their MptpB Inhibitions.Marine Drugs, 2014, 12：2953-2969.
  35. Li HX, Jiang J, Liu Z, Lin S, Xia G, Xia X, Ding B, He L, Lu Y*, She Z*. Peniphenones A-D from the Mangrove FungusPenicillium dipodomyicolaHN4-3A as Inhibitors ofMycobacterium tuberculosisPhosphatase MptpB.J Nat Prod. 2014,77(4): 800−806.
  36. Ding B, Yuan J, Huang X, Wen W, Zhu X, Liu Y, Li H, Lu Y, He L, Tan H, She Z. New dimeric members of the phomoxanthone family: phomolacton-exanthones A, B and deacetylphomoxanthone C isolated from the fungusPhomopsissp.Marine Drugs. 2013 , 11(12):4961-72.
  37. Du J, Xiao K, Li L, Ding X, Liu H, Lu Y, Zhou S. Temporal and spatial diversity of bacterial communities in coastal waters of the South china sea.PLoS One. 2013, 8(6):e66968.
  38. Xiao Z, Huang H, Shao C, Xia X, Ma L, Huang X, Lu Y, Lin Y, Long Y, She Z. Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungusAspergillussp. 085242.Organic Letters.2013, 15(10):2522-5.
  39. Du J, Li L, Ding X, Hu H, Lu Y, Zhou S. Isolation and characterization of a novel cyanophycin synthetase from a deep-sea sediment metagenomic library.Appl Microbiol Biotechnol.2013, 97(19):8619-28.
  40. Huang, Xishan; Huang, Hongbo; Li, Hanxiang; Sun, Xuefeng; Huang, Huarong; Lu, Yongjun; Lin, Yongcheng; Long, Yuhua*; She, Zhigang *. Asperterpenoid A, a New Sesterterpenoid as an Inhibitor ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B from the Culture ofAspergillussp. 16-5c.OrganicLetters. 2013，15（4）：721-723.
  41. Huang C, Jin H, Song B, Zhu X, Zhao H, Cai J, Lu Y, Chen B, Lin Y. The cytotoxicity and anticancer mechanisms of alterporriol L, a marine bianthraquinone, against MCF-7 human breast cancer cells.Appl Microbiol Biotechnol. 2012, 93(2):777-85.
  42. Ding X, Yin B, Qian L, Zeng Z, Yang Z, Li H, Lu Y, Zhou S. Screening for novel quorum-sensing inhibitors to interfere with the formation ofPseudomonas aeruginosabiofilm.J Med Microbiol. 2011, 60(Pt 12):1827-34.
  43. Hanxiang Li, Hongbo Huang, Changlun Shao, Huarong Huang, Jieyi Jiang, Xun Zhu,Yayue Liu Lan Liu,Yongjun Lu, Mengfeng Li, Yongcheng Lin,and Zhigang She. Cytotoxic Norsesquiterpene Peroxides from the Endophytic FungusTalaromyces flavusIsolated from the Mangrove PlantSonneratia apetala.Journal of Natural Products，2011, 74, 1230–1235.
  44. Cai-Huan Huang, Jia-Hui Pan, Bin Chen, Miao Yu, Hong-Bo Huang, Xun Zhu,Yong-Jun Lu, Zhi-Gang She and Yong-Cheng Lin. Three Bianthraquinone Derivatives from the Mangrove Endophytic FungusAlternariasp. ZJ9-6B from the South China Sea.Marine Drugs, 2011, 9(5):832-843.
  45. Hongbo Huang, Xiaojun Feng,Ze’en Xiao, Lan Liu, Hanxiang Li, Lin Ma, Yongjun Lu, Jianhua Ju, Zhigang She, and Yongcheng Lin. Azaphilones and p-Terphenyls from the Mangrove Endophytic FungusPenicillium chermesinum(ZH4-E2) Isolated from the South China Sea.Journal of Natural Products，2011 74, 997–1002.
  46. Huixian Li, Yali Huang, Jiong Zhang, Jikun Du, Hongming Tan, Yongjun Lu, Shining Zhou. Identification and characterization of a novel methionine c-lyase gene from deep-sea sediment metagenomic library.World J Microbiol Biotechnol, 2011, 27:2729–2736.
  47. Jikun Du, Kai Xiao, Yali Huang, Huixian Li, Hongming Tan, Lixiang Cao, Yongjun Lu ,Shining Zhou. Seasonal and spatial diversity of microbial communities in marine sediments of the South China Sea.Antonie van Leeuwenhoek, 2011,100（3）：317-331.
  48. Fenju Lai, Rentian Wu, Jiafeng Wang, Chunming Li, Lan Zou, Yongjun Lu and Chun Liang. Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast.FEMS Yeast Research,2011 Feb;11(1):72-9.
  49. Lijuan Ma, Yuanliang Zhai, Daorong Feng, Tsz-choi Chan, Yongjun Lu, Xinrong Fu, Jiafeng Wang, Yanhong Chen, Jianna Li, Ke Xu, and Chun Liang. Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Phenotypic Screen inSaccharomyces cerevisiae.Cell Cycle, 2010,9(21):4399-4410.
  50. Hong-Bo Huang, Xiao-Jun Feng, Lan Liu, Bin Chen, Yong-Jun Lu, Lin Ma, Zhi-Gang She, Yong-Cheng Lin. Three Dimeric Naphtho-γ-Pyrones from the Mangrove Endophytic FungusAspergillus tubingensisIsolated fromPongamia pinnata.Planta Medica, 2010,76: 1888–1891
  51. Kai-Kai Li, Yong-Jun Lu, Xiao-Hong Song, Zhi-Gang She, Xi-Wei Wu, Lin-Kun An,Chuang-Xing Ye, Yong-Cheng Lin. The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea.Bioorganic & Medicinal Chemistry Letters, 2010,20: 3326–3328.
  52. Xiang-hui Li, Yong-lun Zeng, Ye Gao, Xiao-cong Zheng, Qin-fen Zhang, Shi-ning Zhou, Yong-jun Lu*. The ClpP protease homologue is required for the transmission traits and cell division of the pathogenLegionella pneumophila.BMC Microbiology,2010, 10(1):54.
  53. Zhen Xu, Xue Cheng, Jiafeng Wang, Yuanliang Zhai, Yongjun Lu and Chun Liang. ATP-Dependent Pre-Replicative ComplexAssembly Is Facilitated by Adk1p in Budding Yeast.J. Biological Chemistry, 2010 ,285(39):29974-80.
  54. Jiafeng Wang, Rentian Wu, Yongjun Lu and Chun Liang. Ctf4p Facilitates Mcm10p to Promote Initiation of DNA Replication in Budding Yeast.Biochemical and Biophysical Research Communications, 2010, 395:336–341.
  55. Chun-ling Xu, Jia-feng Wang, Ye Gao, Huang-yu Lin, Lin Du, Shan-shan Yang, Si-mei Long, Zhi-gang She, Xiao-ling Cai, Shi-ning Zhou, Yong-jun Lu*. The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeastSaccharomyces cerevisiae.FEMS Yeast Research,2010, 10（3）: 297–308.
  56. Yiguang Chen, Jiahui Pan, Fan Liu, JianXiang Yang, Caihuan Huang, Xiaolin Cai, Yongjun Lu, Zhigang She and Yongcheng Lin. A new indene derivative from the marine fungusPhomopsissp. (No. GX7-4A).Chem Nat Commpd. 2010,2:1-2.
  57. Wen-han Zhu, Lan Luo, Jia-yi Wang, Xiao-hong Zhuang, Ling Zhong, Kang Liao, Yan Zeng, Yong-jun Lu* . Complete nucleotide sequence of pCTX-M360, an intermediate plasmid between pEL60 and pCTX-M3, from a multidrug resistantKlebsiella pneumoniaeisolated in China. Antimicrobial Agents and Chemotherapy, 2009, 53(12):5291-5293
  58. Ming-jia Yu, Jun Ren, Yong-lun Zeng, Shi-ning Zhou and Yong-jun Lu*. TheLegionella pneumophilaDps homolog is regulated by iron and involved in multiple stress tolerance.Journal of Basic Microbiology，2009, 49: 1–8.
二、 主編教材：《生物技術綜合實驗》, 2017，中山大學出版社，第1版；2019年第二次印刷。

相關詞條

熱門詞條

聯絡我們