陳士林，首席研究員，現任中國中醫科學院中藥研究所所長，世界衛生組織傳統醫學合作中心主任，國際歐亞科學院院士，CGCM（中藥全球化聯盟）副主席。曾任中國醫學科學院藥用植物研究所所長、香港理工大學客座教授，並在英國皇家植物園丘園接受專業培訓、哈佛醫學院Mclean醫院做訪問學者等。現兼任日本東京藥科大學客座教授、中國藥學會中藥與天然藥物專業委員會主任委員、“瀕危藥材繁育”國家工程實驗室主任、美國藥典傳統中藥諮詢組委員等。
基本介紹
- 中文名：陳士林
- 國籍：中國
- 民族：漢族
- 職業：所長
- 畢業院校：成都中醫藥大學
- 代表作品：《中國藥典中藥材DNA條形碼標準序列》《中國中藥材產地生態適宜性數值區劃》《本草基因組學》等
主要成就,科研成就,榮譽表彰,社會任職,
主要成就
科研成就
陳士林在國際上創建了基於ITS2的中草藥DNA條形碼鑑定方法體系，完成專著《中國藥典中藥材DNA條形碼標準序列》，從基因層面解決中草藥物種真偽鑑定的難題，被評為2016中國十大醫學進展；
通過全基因組解析提出靈芝為首箇中藥基原藥用模式真菌，被Nature China 選為中國最佳研究亮點推介；
完成並發表人參、丹參、赤芝、菊花、卷柏、穿心蓮、紫芝等全基因組圖譜和相關組學研究，成功培育並獲批4箇中藥材新品種證書或良種證書，開拓奠定《本草基因組學》學科基礎並由科學出版社出版，列為全國高等醫藥院校規劃教材；
完成並編著《中國中藥材產地生態適宜性數值區劃》，避免中藥材盲目引種栽培，主持無公害種植項目成功推廣套用；
獲教育部高校成果科技進步一等獎1項，國家科技進步二等獎3項。
獲國家發明專利和美國專利授權36項，發表論文400餘篇，其中SCI 論文200餘篇，包括國際著名期刊Nature Communications，PNAS等，論文被他引1.5萬餘次，H指數58（Google Scholar）,連續四年入選Elsevier高被引中國學者榜單。
主要論文
1. Shilin Chen*.; Xu, J.; Liu, C.; Zhu, Y.; Nelson, D. R.; Zhou, S.; Li, C.; Wang, L.; Guo, X.; Sun, Y.; H Luo, Y Li, J Song, B Henrissat, A Levasseur, J Qian, J Li, X Luo, L Shi, LHe, L Xiang, X Xu, Y Niu, Q Li, Mira V. Han, H Yan, J Zhang, H Chen, A Lv, ZWang, M Liu, David C. Schwartz & C Sun*. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature communications 2012, 3, 913.
2. Song, C; Liu, Y; Song, A; Dong, G; Zhao, H; Sun, W; Ramakrishnan, Shyam; Wang, Y; Wang, S; Li, T; Niu, Y; Jiang, J; Dong, B; Xia, Y; Chen, S; Hu, Z; Chen, F; Chen, Shilin, The Chrysanthemum nankingense genome provides insights into the evolution and diversification of chrysanthemum flowers and medicinal traits. Molecular plant, 2018 Vol: 11（12）: 1482-1491
3. Shilin Chen*.; Song, J.; Sun, C.; Xu, J.; Zhu, Y.; Verpoorte, R.; Fan, T.-P.*, Herbal genomics: Examining the biology of traditional medicines. Science 2015, 347 (6219), S27-S29.
4. Xu J , Chu Y, Liao B, Xiao S, Yin Q, Bai R, Su H, Dong L, Li X, Qian J, Zhang J, Zhang Y, Zhang X, Wu M, Zhang J, Li G, Zhang L, Chang Z, Zhang Y, Jia Z, Liu Z, Daniel Afreh, Ruth Nahurira8, Zhang L, Cheng R, Zhu Y, Zhu G, Rao W, Zhou C, Qiao L, Huang Z, Cheng Yung-Chi, Chen Shilin, Panax ginseng genome examination for ginsenoside biosynthesisGigaScience doi: 10.1093 gix093, 2017
5.Sun W; Leng L; Yin Q; Xu M; Huang M; Xu Z; Zhang Y; Yao H; Wang C; Xiong C; Chen S; Jiang C; Xie N; Zheng X; Wang Y; Song C; Reuben J. Peters，The medicinal plant Andrographispaniculate genome provides insight into biosynthesis of the bioactive diterpenoid neoandrographolide,Plant J2018
6. China Plant BOL Group, DZ LI et al., Comparative analysis of a large dataset indicates that internal transcribed spacer (ITS) should be incorporated into the core barcode for seed plants.Proceedings of the National Academy of Sciences of the USA 2011, 108, 19641-19646.
7. Z Xu, T Xin, Dorothea Bartels,Y Li, W Gu,H Yao,S Liu,H Yu,X Pu, J Zhou, J Xu, C Xi ,H Lei Jingyuan Song,Shilin Chen.Genome analysis of the ancient tracheophyte Selaginella tamariscinareveals evolutionary features relevant to the acquisition of desiccation tolerance.Mol Plant2018.
8.Xu, Z.; Peters, R. J.; Weirather, J.; Luo, H.; Liao, B.; Zhang, X.; Zhu, Y.; Ji, A.; Zhang, B.; Hu, S.; Au, K. F.; Song, J*.; Shilin Chen*., Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis. The Plant Journal 2015.
9. Shilin Chen*.; Pang, X.; Song, J.; Shi, L.; Yao, H.; Han, J.; Leon, C., A renaissance in herbal medicine identification: from morphology to DNA.Biotechnology advances2014, 32 (7), 1237-1244.
10. H Xu, J Song, H Luo, Y Zhang, Q Li, Y Zhu, J Xu, Y Li, C Song, B Wang, W Sun, G Shen, X Zhang, J Qian, A Ji, Z Xu, X Luo, L He, C Li, C Sun, H Yan, G Cui, X Li, Xi Li, J Wei, J Liu,Y Wang, A Hayward, D Nelson, Z Ning, RJ. Peters, X Qi, S Chen. Analysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza Mol Plant2016, Volume 9, Issue 6, p949–952.
11. Pang, X.; Song, J.; Zhu, Y.; Xu, H.; Huang, L.; ShiLin Chen*. Applying plant DNA barcodes for Rosaceae species identification. Cladistics 2011, 27 (2), 165-170.
12. Zhu, Y.; Luo, H.; Zhang, X.; Song, J.; Sun, C.; Ji, A.; Xu, J.; ShiLin Chen*., Abundant and selective RNA-editing events in the medicinal mushroom Ganoderma lucidum. Genetics 2014, 196 (4), 1047-1057.
13. Li, X.; Yang, Y.; Henry, R. J.; Rossetto, M.; Wang, Y.; ShiLin Chen*, Plant DNA barcoding: from gene to genome. Biological Reviews 2015, 90 (1), 157-166.
14.D Zhang; C Jiang; C Huang; D Wen; J Lu; S Chen; T Zhang; Y Shi; J Xue; W Ma; L Xiang; W Sun;Shilin Chen,The light-induced transcription factor FtMYB116 promotes accumulation of rutin in Fagopyrum tataricum.Plant Cell & Environment2018
15. Jung Chao Yuntao Dai Robert Verpoorted Wing Lame Yung-Chi Chenge Li-Heng Pao Wei Zhang Shilin Chen Major achievements of evidence-based traditional Chinese medicine in treating major diseases Biochemical Pharmacology Volume 139, 1 September 2017, Pages 94-10
16. Huang Z,, Xu J,, Xiao S, Liao B,Gao Y, Zhai C, Qiu X, Xu W and Chen Shilin Comparative optical genome analysis of two pangolin species: Manis pentadactyla and Manis javanica. Giga Science 2016,5, 1-5
17. Li, Q.; Li, Y.; Song, J.*; Xu, H.; Xu, J.; Zhu, Y.; Li, X.; Gao, H.; Dong, L.; Qian, J.; Sun, C, Shilin Chen*., High-accuracy de novo assembly and SNP detection of chloroplast genomes using a SMRT circular consensus sequencing strategy. New Phytologist 2014, 204 (4), 1041-1049.
18.C Wang, X Su, W Sun, S Zhou, J Zheng, M Zhang, M Sun, J Xue, X Liu, J Xing, Shilin Chen.,Efficient production of succinic acid from herbal extraction residue hydrolysate,Bioresource Technology2018
榮譽表彰
獲吳階平醫藥創新獎、Agilent Thought Leadership Award等榮譽。獲教育部高校成果科技進步一等獎1項，國家科技進步二等獎3項。
社會任職
現為教育部長江學者創新團隊負責人
擔任Pharmaceutical Crops共同主編，APSB，Chinese Medicine，CHM，《藥學學報》等刊副主編
