金美花
博士
天津醫科大學副教授，碩士生導師
天津市“131”創新型人才培養工程第二層次
天津市高校“優秀青年教師資助計畫”
基本介紹
- 中文名：金美花
- 國籍：中國
- 民族：朝鮮族
- 出生地：吉林延邊
- 出生日期：1980.8
- 職業：教師
- 畢業院校：韓國嶺南大學
- 學位/學歷：博士
- 專業方向：藥理學
- 研究方向：抗炎免疫機理研究，腫瘤免疫治療
- 辦公室：天津醫科大學藥學院B樓303室
個人簡介,工作經歷,研究方向,主要科研項目,主要論文,主要社會兼職,
個人簡介
天津醫科大學副教授，碩士生導師
金美花，博士，天津醫科大學副教授，碩士生導師
天津市“131”創新型人才培養工程第二層次
天津市高校“優秀青年教師資助計畫”
工作經歷
2009.03-2011.02 韓國嶺南大學 藥學院 助教授
2011.01月-至今 天津醫科大學 藥學院 副教授
研究方向
研究方向為天然非甾體抗炎新藥篩選及其抗炎免疫機理研究；免疫治療藥物的研發。
主要科研項目
1. 國家自然科學基金青年科學基金項目：以旋覆花內酯活性化合物為探針研究抗哮喘多重分子作用機制以及先導化合物的發現，項目編號：81202542，2013.01-2015.12，項目負責人
2. 天津市科委自然科學基金一般項目：以ABLOO為探針研究其抗哮喘多重分子機制及協同作用，項目編號：13JCYBJC24800，2013.04-2016.03，項目負責人
3. 高等學校博士學科點專項科研基金新教師類項目：以旋覆花內酯活性化合物為探針研究抗哮喘多重分子作用機制，項目編號：20121202120009，2013.01-2015.12，項目負責人
主要論文
Xiaoqing Wang, Sheng-An Tang, Ran Wang, Yuling Qiu, Mei Hua Jin*(共同通訊作者), Dexin Kong*. Inhibitory effects of JEUD-38, a new sesquiterpene lactone from Inula japonica Thunb, on LPS-induced iNOS expression in RAW264.7 cells. Inflammation 2014
Mei Hua Jin, Qianxiang Zhou, Eunkyung Lee, Shingo Dan, Hong Quan Duan, and Dexin Kong.* AS252424, a PI3Kg Inhibitor, downregulates inflammatory responsiveness in mouse bone marrow-derived mast cells. Inflammation 2014, 37(4):1254-1260
Sheng-An Tang, Hong Zhu, Nan Qin, Jing-Ya Zhou, Eunkyung Lee, De-Xin Kong, Mei-Hua Jin* (共同通訊作者), Hong-Quan Duan*. Anti-inflammatory Terpenes from Flowers of Inula japonica. Planta Med. 2014,80(7):583-589
Meihua Jin, Wennan Zhao, Yanwen Zhang, Motomasa Kobayashi, Hongquan Duan,* and Dexin Kong*. Antiproliferative effect of aaptamine on human chronic myeloid leukemia K562 cells. Int. J. Mol. Sci. 2011,12(11):7352-7359
Meihua JIN, Kun Ho SON*, and Hyeun Wook CHANG*, Luteolin-7-O-glucoside suppresses leukotriene C4 production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cg 1 in activated mouse bone marrow-derived mast cells. Biol. Pharm. Bull. 2011, 34(7):1032—1036
Meihua Jin, Yue Lu, Ju Hye Yang, Tae Hyung Jo, Young In Park, Chong-Kil Lee, Sang-Jo Park, Kun Ho Son*, and Hyeun Wook Chang*. Anti-inflammatory activity of 6-Hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of Yam (Dioscorea batatas) through inhibition of prostaglandin D2 and leukotriene C4 production in mouse bone marrow-derived mast cells. Arch. Pharm. Res. 2011, 34(9):1495-1501
Yue LU, Meihua JIN（共同第一作者）, Sang-Jo PARK, Kun Ho SON, Jong-Keun SON*, and Hyeun Wook CHANG*. Batatasin I, a naturally occurring phenanthrene derivative, isolated from tuberous roots of Dioscorea batatas suppresses eicosanoids generation and degranulation in bone marrow derived-mast cells. Biol. Pharm. Bull. 2011, 34(7): 1021—1025
Meihua Jin, Seok-Jong Suh, Ju Hye Yang, Yue Lu, Su Jeong Kim, Soonyoul Kwon, Tae Hyung Jo, Jin Wan Kim, Young In Park, Ghe Whan Ahn, Chong-Kil Lee, Cheorl-Ho Kim, Jong-Keun Son, Kun Ho Son*, Hyeun Wook Chang*. Anti-inflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW264.7 cells via NF-kB and ERK1/2 inactivation. Food Chem.Toxicol. 2010, 48(11): 3073-3079.
Meihua JIN, Eunkyung LEE, Ju Hye YANG, Yue LU, SangGu KANG, Young-Chae CHANG, Seung Ho LEE, Seok-Jong SUH, Cheorl-Ho KIM, and Hyeun Wook CHANG*. Deoxypodophyllotoxin inhibits the expression of intercellular adhesion molecule-1 induced by tumor necrosis factor-a in murine lung epithelial cells. Biol. Pharm. Bull. 2010, 33(1): 1-5.
Meihua JIN, Ju Hye YANG, Eunkyung LEE, Yue LU, Soonyoul KWON, Kun Ho SON, Jong Keun SON, and Hyeun Wook CHANG*. Antiasthmatic Activity of Luteolin-7-O- glucoside from Ailanthus altissima through the Down regulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model. Biol. Pharm. Bull. 2009, 32(9): 1500-1503.
Meihua JIN, KiHwan BAE, Hyeun Wook CHANG*, and Jong Keun SON*. Anti- inflammatory Compounds from the Leaves of Ailanthus altissima. Biomol. Ther. 2009, 17(1): 86-91.
Meihua JIN, Tae Chul MOON, Zhejiu QUAN, Eunkyung LEE, Yun Kyung KIM, Ju Hae YANG, Seok-Jong SUH, Tae Cheon JEONG, Seung Ho LEE, Cheorl-Ho KIM*, and Hyeun Wook CHANG*. The naturally occurring flavolignan, deoxypodophyllotoxin, inhibits lipopolysaccharide-induced iNOS expression require inhibition of NF-κB activation in RAW264.7 macrophage cells. Biol. Pharm. Bull. 2008, 31(7): 1312-1315.(Highlighted paper selected by Editor-in-chief)
Jin Mei Hua, Tae Chul Moon,Tae Gyun Hong, Kyong Min Park, Jong Keun Son, and Hyeun Wook Chang*. 5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)- psoralen Isolated from Angelica dahurica inhibits Cyclooxygenase-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells. Arch. Pharm. Res. 2008, 31(5): 617-621
Tae Chul Moon, Meihua Jin（共同第一作者）, Jong Keun Son, and Hyeun Wook Chang*. The Effects of Isoimperatorin Isolated from Angelica dahurica on Cyclooxygenase-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells. Arch. Pharm. Res. 2008, 31(2): 210-215.
Se Jong Kim, Meihua Jin（共同第一作者）, Eunkyung Lee, Tae Chul Moon, Zhejiu Quan, Kun Ho Son, Kil-Ung Kim, Jong Kun Son, Hyeun Wook Chang*. Effects of Methyl Gallate on Arachidonic Acid Metabolizing Enzymes: Cyclooxygenase-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells. Arch. Pharm. Res. 2006, 29 (10): 874-878.
Mei Hua JIN, Jumin YOOK, Eunkyung LEE, Chang Xin LIN, Zhejiu QUAN, Kun Ho SON, Ki Hwan BAE, Hyun Pyo KIM, Sam Sik KANG, and Hyeun Wook CHANG*. Anti-inflammatory activity of Ailanthus altissima in Ovalbumin-Induced Lung Inflammation. Biol. Pharm. Bull. 2006, 29(5): 884-888.
朱虹，唐生安，秦楠，段宏泉，金美花*. 旋覆花中化學成分及其活性研究。中國中藥雜誌 2014, 39(1):83-8
金美花，孔德新*. 分子靶向藥物PI3K抑制劑的研究進展。藥品評價2012, 9(5): 20-25
主要社會兼職
2004年09月-至今，韓國藥學會，會員
