郝大程

郝大程

郝大程,畢業於西安交通大學,大連交通大學環境與化學工程學院教授、碩士生導師。

基本介紹

人物經歷,科研項目,主要論文,主要專利,社會兼職,所獲榮譽,

人物經歷

1989/09-1994/07,西安交通大學醫學院,學士
2000/07 - 2002/12,新加坡國立大學醫學院,科學碩士
2003/02-2004/08,香港科技大學生物系,研究助理
2004/09-2008/01,中科院大連化學物理研究所藥用資源開發組,工學博士
2008/04-2010/01,中國醫科院藥用植物研究所中草藥物質基礎與資源利用教育部重點實驗室,博士後
2011/07-2019/10 ,大連交通大學,環境化工學院/生物技術研究所,副教授
其中2012.11-2013.10,英國John Innes Centre,代謝生物學系,訪問學者(CSC資助)
2019.11至今,大連交通大學,環境化工學院/環境科學與工程系,教授

科研項目

主持或參加的縱橫向課題
1.國家自然科學基金面上項目(與中科院套用生態研究所合作),秸稈覆蓋下土壤線蟲-微生物碳通道對微生物殘留物積累的調控機制,2020-2023,13.4萬元,在研,主持
2.遼寧省教育廳科研項目,基於仿生裝置和根際的土壤有機物污染原位自持修復,2019.07-2022.07, 4萬元,在研,主持
3.遼寧省自然科學基金,20180550190,土壤PAH污染的仿生修復和根際修復研究,2018.07-2021,在研,主持.
4.遼寧省研究生教育教學改革研究計畫項目,毒物代謝酶細胞色素P450 2J2研究,2016.07-2018.12,結題,主持
5.遼寧省自然科學基金,2015020663, 遼寧省毛茛科藥用植物親緣學研究初探,2015.07-2017.12,結題,主持 ,,
6.教育部48批留學回國人員科研啟動基金,20141685,紅豆杉紫杉烷糖苷生物合成調控,2015,3萬元,結題,主持
7.國家留學基金,201208210122,鼠尾草屬藥用植物的轉錄組和代謝組研究,2012.11-2013.10,已結題,主持
8.第2批中國博士後科學基金特別資助,200902069,紅豆杉基因組和轉錄組研究,2009.10-2010.09,10萬元,已結題,主持
9.遼寧省教育廳科研項目,2009A120,海膽毒物代謝酶基因研究,2009.09-2011.08,2萬元,已結題,主持
10.第44批中國博士後科學基金一等資助,20080440019,貝母屬藥用植物的化學分類和分子分類研究,2008.10-2009.09,5萬元,已結題,主持

主要論文

Gao R(undergraduate), Hao DC(co-first author & corresponding author), Hu
WL, Song S, Li SY, Ge GB. Transcriptome profile of polycyclic aromatic
hydrocarbon-degrading fungi isolated from Taxus rhizosphere. Curr Sci. 2019;116(7): 1218-28
Hao DC. Ranunculales medicinal plants:
Biodiversity, chemodiversity and pharmacotherapy. London: Elsevier/Academic
Press 2018 ISBN: 978-0128142325
Hao DC, Xiao PG, Liu C(undergraduate). Traditional
Tibetan medicinal plants: a highlighted resource for novel therapeutic
compounds. Future Med Chem. 2018; 10(21): 2537–55
Ma HY(graduate student), Yang JD, Hou J, Zou LW, Jin Q, Hao DC (co-correspondingauthor), Ning J, Ge GB, Yang L. Comparative metabolism of DDAO benzoate in
liver microsomes from various species. Toxicol In Vitro. 2017. 44:280-286
Hao DC, Xiao PG. 藥用植物親緣學導論An Introduction of Plant Pharmacophylogeny.Beijing: 化學工業出版社Chemical Industry Press; 1 edition (Jan.2017) ISBN:978-7-122-28201-9 full text in Chinese 2019大連市科學著作獎二等獎
Hao DC, Song SM, Mu J, Hu WL, Xiao PG.Unearthing
microbial diversity of Taxus rhizosphere via MiSeq high-throughput amplicon
sequencing and isolate characterization. Sci Rep. 2016;6:22006
Hao DC, Ge GB, Xiao PG, Wang P, Yang L. Drug Metabolism and Pharmacokinetic
Diversity of Ranunculaceae Medicinal Compounds. Curr Drug Metab. 2015;16(4):294-321
Hao DC, Xiao PG, Ma HY, Peng Y, He CN. Mining chemodiversity from biodiversity:
pharmacophylogeny of medicinal plants of Ranunculaceae.
Chin J Nat Med.
2015;13(7):507-20
Hao DC, Gu XJ, Xiao PG. Medicinal plants: Chemistry, biology and omics
[M].Oxford: Elsevier-Woodhead, 2015. ISBN 9780081000854
專著2018大連市科學著作獎三等獎
Hao DC, Chen SL, Osbourn A, Kontogianni VG, Liu LW, Jordán MJ. Temporal transcriptome changes induced
by methyl jasmonate in Salvia sclarea. Gene. 2015; 558(1):41-53
Hao DC, Xiao PG, Liu M, Peng Y, He CN. Pharmaphylogeny vs. pharmacophylogenomics:
molecular phylogeny, evolution and drug discovery. Yao Xue Xue Bao. 2014;49(10):1387-94
Hao DC, Xiao PG. Network pharmacology: a Rosetta Stone for traditional Chinese
medicine. Drug Dev Res. 2014; 75(5):299-312
Hao DC, Xiao B, Xiang Y, Dong XW, Xiao PG. Deleterious nonsynonymous single nucleotide
polymorphisms in human solute carriers: the first comparison of three
prediction methods. Eur J Drug Metab Pharmacokinet. 2013;38(1):53-62
Hao DC, Gu XJ,Xiao PG, et al. Chemical and biological research of Clematis medicinalresources [J]. Chin Sci Bull, 2013, 58: 1120.
Hao DC, Yang L,Xiao PG, Liu M. Identification of Taxus microRNAs and their targets with
high-throughput sequencing and degradome analysis. Physiol Plant. 2012;
146(4):388-403
Hao DC, Ma P, Mu
J, Chen SL, Xiao PG, Peng Y, Huo L, Xu L, Sun C. De novo characterization of
the root transcriptome of a traditional Chinese medicinal plant Polygonum
cuspidatum. SciChinaLife Sci. 2012; 55(5):452-66
Hao DC, Ge GB,
Xiao PG, Zhang Y, Yang L. The first insight into the tissue specific taxus
transcriptome via Illumina second generation sequencing. PLoS One.
2011;6(6):e21220

主要專利

Hao DC, Song SM(graduate student), Hu WL. 發明專利授權CN201510411623.2一種產漆酶真菌菌株的分離最佳化方法及套用(Isolating laccase-producing fungal strains from Taxus rhizosphere,their optimization, and applications in dye decolorization). 2018. Patent no. of
the fungal strain:CCTCC M 2014543
Hao DC, Hu WL(graduate student), Song
SM,Zhu XH. 發明專利授權CN201510411700.4一種紅豆杉根際多環芳烴降解菌的篩選方法及套用(Screening polycyclic aromatic hydrocarbon-degrading fungi from Taxus rhizosphere and their applications). 2018. Patent no. of the fungal
strain:CCTCC M 2014542
Hao DC,Men YL(undergraduate).
CN201822059291.8一種基於人工智慧的實時遠程動態立體投影裝置A real-time remote dynamic stereo projection device based on
artificial intelligence,實用新型專利,授權2019
Men YL(undergraduate), Hao DC.
CN201821846282.7日晷式太陽追蹤器Sundial sun tracker,實用新型專利,授權2019

社會兼職

學術期刊編委:生物技術通報,Chinese Herbal Medicines(核心期刊);BMC
Complementary and Alternative Medicine, Pakistan Journal of Botany (SCI)
大連市科技局評審專家

所獲榮譽

11年省自然科學學術成果二等獎一項(2011-LNL1150)。
12年省自然科學學術成果二等獎一項(2012-LNL0006)。
14年大連市自然科學優秀學術論文一等獎(2014-19)和省自然科學學術成果三等獎一項(2014-LNL0003)

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