邵文威，女，博士，天津大學副教授
基本介紹
- 中文名：邵文威
- 學位/學歷：博士
- 職業：教師
- 專業方向：基因治療領域
- 任職院校：天津大學
個人經歷,研究方向,學術成果,
個人經歷
教育背景
2010.09-2015.07 北京大學醫學部，免疫系，博士
2007.09-2010.07 中國農業大學，理科試驗班 (生命科學類)，本科
工作經歷
2019.06-至今天津大學，醫學工程於轉化醫學研究院，副教授
2016.03-2018.08 美國北卡羅萊納大學，博士後
研究方向
基於腺相關病毒（adenovirus associated virus，AAV）的基因治療；結合免疫學，細胞生物學，分子生物學等，探索並最佳化可套用於臨床基因治療的AAV載體。
學術成果
1. Wenwei Shao, Lauriel F. Earley, Zheng Cai, Xiaojing Chen, Junjiang Sun, Ting He, Meng Deng, Matthew L. Hirsch, Jenny Ting, R. Jude Samulski, and Chengwen Li. Double-stranded RNA Innate Immune Response Activation from Long-term Adeno-associated Virus Vector Transduction. JCI Insight. 2018 Jun 21
2. Wenwei Shao, Xiaojing Chen, Richard J Samulski, Matthew L Hirsch, Chengwen Li. Inhibition of antigen presentation during AAV gene therapy using virus peptides. Hum Mol Genet. 2018 Feb 15
3. Junjiang Sun, Wenwei Shao (co-first author), Xiaojing Chen, Elizabeth P. Merricks, Lauren Wimsey, Yasmina L. Abajas, Paul E. Monahan, Richard J. Samulski, Timothy C. Nichols and Chengwen Li. Re-administration of the same AAV serotype improves hemostasis in hemophilia A dogs. Mol Ther Methods Clin Dev. 2018 Aug
4. Wenwei Shao, Chi Zhang, Enyang Liu, Long Zhang, Junfan Ma, Zhu Zhu, Xiaoting Gong, Xiaoyan Qiu. Identification of Liver Epithelial Cell-derived Ig Expression in μ-chain-deficient mice. Sci Rep. 2016 Mar 29
5. Wenwei Shao, Fanlei Hu, Junjiang Ma, Chi Zhang, Qinyuan Liao, Zhu Zhu, Enyang Liu, Xiaoyan Qiu. Epithelial cells are a source of natural IgM that contribute to innate immune responses. Int J Biochem Cell Biol. 2016 Apr
6. Ma J, Jiang D, Gong X, Shao W, Zhu Z, Xu W, Qiu X.Free immunoglobulin light chain (FLC) promotes murine colitis and colitis-associated colon carcinogenesis by activating the inflammasome. Sci Rep. 2017 Jul 12.
7. Zhu Z, Zhang M, Shao W, Wang P, Gong X, Ma J, Qiu X, Wang B. Immunoglobulin M, a novel molecule of myocardial cells of mice. Int J Biochem Cell Biol. 2017 Jul
8. Liao Q, Liu W, Liu Y, Wang F, Wang C, Zhang J, Chu M, Jiang D, Xiao L, Shao W, Sheng Z, Tao X, Huo L, Yin CC, Zhang Y, Lee G, Huang J, Li Z, Qiu X. Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis. Oncotarget. 2015 Nov 24
9. Liu Y, Liu D, Wang C, Liao Q, Huang J, Jiang D, Shao W, Yin CC, Zhang Y, Lee G, Qiu X, Binding of the monoclonal antibody RP215 to immunoglobulin G in metastatic lung adenocarcinomas is correlated with poor prognosis. Histopathology. 2015 Nov
10. Jiang D, Ge J, Liao Q, Ma J, Liu Y, Huang J, Wang C, Xu W, Zheng J, Shao W, Lee G, Qiu X. IgG and IgA with potential microbial-binding activity are expressed by normal human skin epidermal cells. Int J Mol Sci. 2015 Jan 23
11. Huang J, Xiao L, Gong X, Shao W, Yin Y, Liao Q, Meng Y, Zhang Y, Ma D, Qiu X. Cytokine-like Molecule CCDC134 Contributes to CD8 T-cell Effector Functions in Cancer Immunotherapy. Cancer Res. 2014 Aug 14
科研項目
2012-2016 Non B-Ig作為一種潛在的細胞 骨架相關蛋白在腫瘤發生髮展中的作用（81272237，國家自然科學基金面上項目），參與人
2013-2017 一個新細胞因子CCDC134在腫 瘤免疫中的功能和機制研究（81372254，國家自然科學基金面上項目），參與人
