教學課程
教學內容
本科生課程:植物生物技術;生物學實驗;生命科學探秘(通識課)
研究生課程:基因工程II
教師發展
ISW國際認證引導員,參與和組織校內外教師培訓3期以上,涉及對教師教學設計、教學理念和教學方法的引導與培訓。
教學改革
獲得校級課堂教學改革項目1項;
獲得校級課程思政建設項目1項;
發表教改論文1篇
《植物生物技術》課程思政案例獲得學校課程思政示範案例
研究方向
1、功能性天然產物的開發與生物合成。主要涉及,植物天然產物羅漢果苷、甜菊糖苷等萜類化合物的生物合成,和黃酮類、酚酸類化合物的合成;醫美功能性產品的生物合成,包括肽類、抗氧化化合物的生物催化與合成生物學;
2、重要酶類化合物的催化機理解析;
3、微生物合成底盤細胞的搭建和代謝途徑分子調控機制研究。
科研項目
主持項目
橫向項目:
1.2021.09-2024.08 冬蟲夏草的人工侵染技術,企業橫向,300萬元,在研;
2. 2019.01-2021.12 多酶體系泛酸的生物合成,企業橫向,100萬元,在研;
縱向項目:
1. 2021.01-2025.12 浙江省新品種選育重大科技專項子課題,2021C02064-5-4,45萬元,在研;
2. 2021.01-2023.12 中藥半枝蓮新克羅烷型二萜的合成途徑研究,LY21H280009,10萬元,在研;
3. 2017.01-2019.12 國家自然科學基金青年基金,31600181,20萬元 ,已結題;
4. 2016.01-2020.12 浙江省新品種選育重大科技專項子課題,2016C02050-10-3,22.5萬元,已結題;
5. 2016.01-2018 .12 浙江省自然科學基金青年基金,LQ16C020003 ,5萬元 ,已結題;
部分參與項目
1. 2016.01-2019.12 國家自然科學基金面上項目,典型人工納米材料干擾擬南芥生長繁殖及其與除草劑的複合毒理,21577128,78萬元,結題,已結題;
2. 2017.01-2019.12 浙江省自然科學基金面上項目,LY17B020012,8萬元,已結題;
3. 2016.03-2018.12 泛酸手性中間體不對稱合成關鍵技術的研究開發,企業橫向,100萬元,已結題。
科研成果
1. 趙嫚,彭莉,成浩,應向賢,汪釗. 2020. 微生物甲硫氨酸合成調控的綜合研究進展與展望. 食品與發酵工業. 10.13995/j.cnki.11-1802/ts.024785.
2. Zhao M*, Wang W, Wei L, Chen P, Peng L, Qin Z, Yuan F, Wang Z, Ying X*. 2019. The evolution and biocatalysis of FAD2 indicate its correlation to the content of seed oil in plants. International Journal of Molecular Sciences 20(4):849.
3. Zhao M*, Wang W, Wei L, Chen P, Yuan F, Wang Z, Ying X*. 2018. Molecular evolution and expression divergence of three key Met biosynthetic genes in plants: CGS, HMT and MMT. PeerJ 6:e6023.
4. Zhao M*, Wang W, Wei L, Chen P, Yuan F, Zhu D, Wang Z, Ying X*. 2018. Molecular evolution and expression divergence of HMT gene family in plants. International Journal Molecular Science 19:1248
5. Zhao M*, Ying X, Sun J, Zhao W. 2017. Molecular evolution of Coq1 gene family in eukaryotes. Journal of Systematics and Evolution 55(5):417-425.
6. Zhao M, Gao L, Zhang L, Bai Y, Chen L, Yu M, Cheng F, Sun J, Wang Z, Ying X. 2017. Asymmetric reduction of ketopantolactone using a strictly (R)-stereoselective carbonyl reductase through efficient NADPH regeneration and the substrate constant-feeding strategy. Biotechnology Letters 39:1741-1746.
7. Zhao M, Gu Y, He L, Chen Q and He CY. 2015. Sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans. BMC Plant Biology 15:120.
8. Zhao M, He LL, Gu Y, Wang Y, Chen QS and He CY. 2014. Genome-wide analyses of a plant-specific LIM-domain gene family implicate its evolutionary role in plant diversification. Genome Biology and Evolution 6(4):1000-1012.
9. Gong PC#, Zhao M# and He CY. 2014. Slow co-evolution of the MAGO and Y14 protein families is required for the maintenance of their obligate heterodimerization mode. PLoS ONE 9(1), e84842. (#Co-first author)
10. He LL, Zhao M, Wang Y, Gai JY and He CY. 2013. Phylogeny, structural evolution and functional diversification of the plant PHOSPHATE1 gene family: a focus on Glycine max. BMC Evolutionary Biology 13, 103.
11. Zhao J#, Tian Y#, Zhang JS, Zhao M, Gong PC, Riss S, Saedler R and He CY. 2013. The euAP1 protein MPF3 represses MPF2 to specify floral calyx identity and displays crucial roles in “Chinese lantern” development in Physalis. The Plant Cell 25, 2002-2021. (#Co-first author)
12. He LL, Zhao J, Zhao M and He CY. 2011. Current development and application of soybean genomics. Frontiers in Biology 6(4), 337-348.
13. Zhang JS#, Li Z#, Zhao J, Zhang S, Quan H, Zhao M and He CY. 2014. Deciphering the Physalis double-layered-lantern 1 mutant provides insights into functional divergence of the GLOBOSA duplicates within the Solanaceae. Plant Physiology 164, 748-764. (#Co-first author)
育人成果
指導具備獨立思考,綜合解決問題能力的研究生10餘名;本科生10餘名
指導第十五屆“挑戰杯”全國大學生課外學術科技作品競賽,國家級,三等獎
社會服務
浙江省植物學會青年理事
ISW國際認證引導員