基本介紹
- 中文名：趙亮
- 國籍：中國
- 職業：教師
- 畢業院校：南方醫科大學
- 學位/學歷：博士
- 專業方向：外科學（骨外）
- 職務：副教授、主任醫師
- 主要成就：闡明臍帶間充質幹細胞和磷酸鈣骨水泥複合物組織工程骨在骨組織再生修復中的作用
- 學術代表作：A self-setting iPSMSC-alginate-calcium phosphate paste for bone tissue engineering
工作經歷,研究方向,主要學術成績,個人榮譽,學術任職,學術專著,發表論文,發明專利,
工作經歷
2011.12–至今 南方醫科大學南方醫院 - 副教授
2014.6–2014.8 美國紐約特種外科醫院 – 訪問教授
2011.3–2011.12 廣東省第二十七批援藏醫療隊
2010.5–2011.3 南方醫科大學南方醫院 - 講師
2009.4–2010.4 美國馬里蘭大學 - 博士後
2007.7–2009.3 美國堪薩斯大學 - 博士後
2003.6–2006.6 南方醫科大學南方醫院 - 醫師、助教
研究方向
骨與軟骨再生修復，幹細胞與再生醫學 / 外科學（骨外）
主要學術成績
闡明臍帶間充質幹細胞和磷酸鈣骨水泥複合物組織工程骨在骨組織再生修復中的作用。
臍帶間充質幹細胞和可控梯度釋放生物材料支架在組織工程骨軟骨在軟骨缺損修復中的作用。
個人榮譽
2011年廣東省援建西藏優秀醫療隊成員。主要從事骨與軟骨組織再生修復和醫用生物材料方向研究。
國家科學技術獎勵評審專家。
廣東省運動醫學專業委員會委員。
廣州市首屆珠江科技新星。
南方醫科大學和南方醫院雙國家傑出青年培養對象。
廣東省高校千百十工程培養對象。
學術任職
中國殘疾人康復協會肢殘康復專業委員會委員
廣東省運動醫學專業委員會委員
學術專著
Nano-Apatitic Composite Scaffolds for Stem Cell Delivery and Bone Tissue Engineering. Book chapter in Nanotechnology forDental Applications (2012)。
人工髓核置換術. 見：楊述華 主編，實用脊柱外科學，北京：人民軍醫出版社，2004.844。
下腰痛的臨床療效評分, 人工髓核假體置換術. 見：金大地，瞿東濱，Charles D.Ray 主編。
脊柱椎間關節成形術，北京：科學技術文獻出版社，2004。
人工髓核置換術. 見：候樹勛 主編，脊椎外科學，北京：人民軍醫出版社，2005, 482。
發表論文
[1] Gengtao Qiu, Ping Wang, Jinyu Sun, Yang Song, Guangjun Li, Hockin H. K. Xu*, Zhao Liang*(co-corresponding author). Bone regeneration in minipigs via calcium phosphate cement scaffold delivering autologous BMSCs and platelet-rich plasma. J Tissue Engineering and Regenerative Medicine. 2017.18. doi: 10.1002/term.2416. [Epub ahead of print]
[2] Wenchuan Chen, Xian Liu, Qianmin Chen, Chongyun Bao, Zhao Liang*(co-corresponding author), Zhimin Zhu, Hockin H.K. Xu*. Angiogenic and osteogenic regeneration in rats via calcium phosphate scaffold and endothelial cell coculture with hBMSCs, hUCMSCs, hiPSC-MSCs and hESC-MSCs. J Tissue Engineering and Regenerative Medicine. 2017 Jan 18. doi: 10.1002/term.2395. [Epub ahead of print]
[3] Xian Liu, Wenchuan Chen, Chi Zhang, Wahwah Thein-Han, Kevin Hu, Mark A. Reynolds, Chunyun Bao, Ping Wang, Zhao Liang*(co-corresponding author), Hockin H. K. Xu*. Co-seeding human endothelial cells with hiPSC-derived mesenchymal stem cells on calcium phosphate scaffold enhances osteogenesis and vascularization in rats. Tissue Engineering Part A. February 2017, ahead of print. doi:10.1089/ten.TEA.2016.0485.
[4] Yang Song, Chi Zhang, Ping Wang, Lin Wang, Chunyun Bao,Michael D. Weir, Mark A. Reynolds, Ren Ke, Zhao Liang*(co-corresponding author), Hockin H. K. Xu*. Engineering bone regeneration with novel cell-laden hydrogel microfiber-injectable calcium phosphate scaffold. Materials Science & Engineering C-Materials for Biological Applications. (Accepted Feb. 2017)
[5] Lin Wang, Xianju Xie, Michael D. Weir, Ashraf F. Fouad, Zhao Liang*(co-corresponding author), Hockin H. K. Xu*. Effect of bioactive dental adhesive on periodontal and endodontic pathogens. Journal of Materials Science: Materials in Medicine. 2016.27(11):168.
[7] Gengtao Qiu, Ping Wang, Guangjun Li,Zhanjun Shi, Michael D. Weir,Jinyu Sun, Yang Song, Jixing Wang, Huakun H. Xu*, Zhao Liang*(co-corresponding author).Minipig-BMSCs combined with a self-setting calcium phosphate paste for bone tissue engineering. Mol Cell Biochem. 2016.58(11):748-756.
[8] Wang Lin, Wang Ping, Weir Michael, Reynolds Mark, Zhao Liang*(co-corresponding author), Huakun H. Xu*. Hydrogel fibers encapsulating hiPSC-MSCs, hESC-MSCs and hUCMSCs in injectable calcium phosphate scaffold for bone tissue engineering. Biomedical Materials. 2016.11(6):065008.(journal's Highlights)
[9]Lin Wang, Chi Zhang, Chunyan Li, Michael D. Weir, Ping Wang, Mark A. Reynolds, Zhao Liang*(co-corresponding author), Hockin H.K. Xu. Injectable calcium phosphate with hydrogel fibers encapsulating induced pluripotent, dental pulp and bone marrow stem cells for bone repair. Materials Science and Engineering:C. 69:1125-1136(2016).
[10] Ping Wang, Yang Song, Michael D. Weir, Jinyu Sun, Zhao Liang*(co-corresponding author), Carl G. Simon, Hockin Xu. A self-setting iPSMSC-alginate-calcium phosphate paste for bone tissue engineering. Dental Materials. 32(2):252-63(2016).
[11] Wang Ping, Liu Xian, Zhao Liang*(co-corresponding author), Michael Weir, Sun Jirun, Chen Wenchuan, Man Yi, Xu Huakun*. Bone tissue engineering via human induced pluripotent, umbilical cord and bone marrow mesenchymal stem cells in rat cranium. Acta Biomaterialia. 18:236-48(2015).
[12] Shi Zhe, Zhao Liang*(co-corresponding author), Qiu Gengtao, He Ruixuan, Michael S. Detamore*. The effect of extended passaging on the phenotype and osteogenic potential of human umbilical cord mesenchymal stem cells. Mol Cell Biochem. 401:155–164,(2015).
[13] P Wang, Zhao, L, W Chen, X. Liu, MD Weir, HHK Xu. Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration. J Dent Res, 2014.(Epub ahead)
[14] Wang Ping, Zhao Liang*(co-corresponding author), Liu Jason, Michael D Weir, Xuedong Zhou*, Xu Huakun*. Bone tissue engineering via nanostructured calcium phosphate biomaterials and stem cells. Bone Research.2:1-13(2014).
[15] Dormer N, Singh M, Zhao L, Detamore MS. Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals. Journal of Biomedical Materials Research: Part A.100(1):162-70,2012.
[16] Wang, L, Liang Zhao, Michael S. Detamore. Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral. tissue engineering. J Tissue Eng Regen Med. 5(9): 712-721(2011).
[17] Zhao, L, M Tang, MD Weir, MS Detamore, HHK Xu. Osteogenic media and rhBMP-2-induced differentiation of umbilical cord mesenchymal stem cells encapsulated in alginate microbeads and integrated in an injectable calcium phosphate-chitosan fibrous scaffold. Tissue Eng Part A. 17(7-8): 969-979(2011).
[18] Zhao, L. and M. S. Detamore. Chondrogenic differentiation of stem cells in human umbilical cord stroma with PGA and PLLA scaffolds. J Biomed Sci Eng. 3(11): 1041-1049(2010).
[19] Xu, H.H, M.S, Liang Zhao. Umbilical cord stem cell seeding on fast-resorbable calcium phosphate bone cement. Tissue Eng Part A. 16(9): 2743-2753 (2010).
[20 ]Xu, H. H, L. Zhao, M.D. Weir. Stem cell-calcium phosphate constructs for bone engineering. J Dent Res. 89(12): 1482-1488(2010).
[21] Zhao, L, Burguera EF, Xu Huakun, Amin N, Ryou H, Arola DD. Fatigue and human umbilical cord stem cell seeding characteristics of calcium phosphate-chitosan-biodegradable fiber scaffolds. Biomaterials. 31(5): 840-847(2010).
[22] Zhao, L, Weir MD(co-first author), Xu Huakun. An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering. Biomaterials. 31(25): 6502-6510(2010).
[23] Zhao, L, Weir MD, Xu Huakun. Human umbilical cord stem cell encapsulation in calcium phosphate scaffolds for bone engineering. Biomaterials. 31(14): 3848-3857(2010).
發明專利
[1] 趙亮.一種基於聚乳酸-羥基乙酸共聚物的生長因子梯度釋放微球支架及其製備方法和套用:中國,ZL201110215643.4[P].2013.09.18
[2] 趙亮.一種可注射強化型磷石灰/水凝膠微囊組織工程骨及其製備方法和套用:中國,ZL201010270416.7[P].2013.09.18
