人物經歷
2002年9月—2006年6月,華東理工大學,化學與分子工程學院,本科
2006年9月—2011年6月,華東理工大學,藥學院,碩博連讀(導師:施小新教授,龍億濤教授)
2008年7月—2009年2月,法國Cachan高等師範學校,聯合培養(導師:Prof. Juan Xie)
2011年7月—2013年6月,華東理工大學,化學與分子工程學院,博士後(合作導師:陳凱先院士)
2013年7月—2014年8月,華東理工大學,化學與分子工程學院,講師
2014年9月—,華東理工大學,化學與分子工程學院,副研究員(2015,2017年分別獲碩士和博士生導師資格)
研究方向
醫學為導向的化學生物學研究,課題組主要圍繞以下兩方面開展基礎與套用研究:
1、靶向重要生命與疾病過程的生物基(糖、多肽等)分子探針和超分子材料構建;
2、臨床醫學為導向的新型光學體外診斷試劑盒研發。
主要成就
以第一/通訊作者在包括Nature Commun., Angew. Chem. Int. Ed., Adv. Mater., J. Am. Chem. Soc., Chem. Sci., Chem. Soc. Rev.等學術刊物發表SCI論文90餘篇(IF大於8的15篇),論文被引用1800餘次,ESI高被引論文6篇,ESI熱點論文2篇,H因子26,以第一發明人申請國家發明專利8項(3項授權)。多次在國際會議(6次)及國際知名學術機構(6次)做口頭和邀請報告,獲國家優秀青年科學基金,上海市青年科技啟明星計畫,上海市優秀博士學位論文等榮譽獎勵。多項研究工作被英國皇家化學會“Global challenges: Health & Food”專欄(該專欄旨在亮點介紹應對全球健康與食品重大挑戰的優秀工作),美國C&EN(化學與工程新聞網)和Materials Views China等國際學術媒介亮點介紹。
獲獎記錄
國家優秀青年科學基金項目(2017)
上海市青年科技啟明星計畫(2016)
上海市優秀博士學位論文(2013)
華東理工大學青年英才計畫(2014)
華東理工大學優秀博士論文(2013)
法國大使館留學獎學金(2008)
科研項目
國家重大基礎研究計畫(學術骨幹,首席科學家:田禾院士)
愛滋病和病毒性肝炎等重大傳染病防治科技重大專項(子任務負責人,在研)
國家自然科學基金優秀青年科學基金項目(項目負責人,在研)
國家自然科學基金面上項目(項目負責人,在研)
國家自然科學基金青年基金(項目負責人,已結題)
中國博士後科研基金特別資助(項目負責人,已結題)
中國博士後科研基金一等面上資助(項目負責人,已結題)
中央高校基本科研業務費探索專項基金(項目負責人,已結題)
代表性論著
[1] J. Zhang, Y. Fu, H.-H. Han, Y. Zang, J. Li,* X.-P. He,H. Tian,* Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes.Nature Commun. 2017, in press.
[2] X.-P. He,* X.-L. Hu, T. D. James,* J. Yoon,* H. Tian,* Multiplexed photoluminescent sensors: Towards improved disease diagnostics. Chem. Soc. Rev. 2017, in press. (Tutorial review)
[3] X.-P. He, Y. Zang, T. D. James, J. Li,* G.-R. Chen,* Probing disease-related proteins with fluorogenic composite materials. Chem. Soc. Rev. 2015, 44, 4239-4248. (ESI highly cited paper; Tutorial review)
[4] X.-P. He,* Y.-L. Zeng, X.-Y. Tang, N. Li, D.-M. Zhou,* G.-R. Chen, H. Tian,* Rapid identification of the receptor-binding specificity of influenza A viruses by fluorogenic glycofoldamers. Angew. Chem. Int. Ed. 2016, 55, 13995-13999. (ESI hot paper; Inside back cover)
[5] Y.-H. Ma, W.-T. Dou, Y.-F. Pan, L.-W. Dong, Y.-X. Tan, X.-P. He,* H. Tian, H.-Y. Wang,* Fluorogenic 2D peptidosheet unravels CD47 as a potential biomarker for profiling hepatocellular carcinoma and cholangiocarcinoma tissues. Adv. Mater. 2017, 29, 1604253. (ESI highly cited paper; Inside back cover)
[6] D.-K. Ji, Y. Zhang, Y. Zang, J. Li,* G.-R. Chen, X.-P. He,* H. Tian, Targeted intracellular production of reactive oxygen species by a 2D molybdenum disulfide glycosheet. Adv. Mater. 2016, 28, 9356-9363. (ESI hot paper)
[7] H.-L. Zhang, X.-L. Wei, Y. Zang, J.-Y. Cao, S. Liu, X.-P. He,* Q. Chen, Y.-T. Long, J. Li,* G.-R. Chen,* K. Chen, Fluorogenic probing of specific recognitions between sugar ligands and glycoprotein receptors on cancer cells by an economic graphene nanocomposite. Adv. Mater. 2013, 25, 4097-4101. (Front cover)
[8] X.-L. Hu, Y. Zang, J. Li,* G.-R. Chen, T. D. James, X.-P. He,* H. Tian, Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites. Chem. Sci. 2016, 7, 4004-4008. (Highlighted by “Global challenges: Health & Food”; Front cover)
[9] K.-B. Li, N. Li, Y. Zang, G.-R. Chen, J. Li,* T. D. James, X.-P. He,* H. Tian, Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules. Chem. Sci. 2016, 7, 6325-6329. (Front cover)
[10] X.-P. He,* B.-W. Zhu, Y. Zang, J. Li,* G.-R. Chen, H. Tian, Y.-T. Long,* Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone–decorated graphene electrodes. Chem. Sci. 2015, 6, 1996-2001. (Highlighted by “Global challenges: Health & Food”)
[11] D.-K. Ji, G.-R. Chen, X.-P. He,* H. Tian, Simultaneous detection of diverse glycoligand–receptor recognitions using a single-excitation, dual-emission graphene composite. Adv. Funct. Mater. 2015, 25, 3483-3487. (Back cover)
[12] J.-X. Song, X.-Y. Tang, D.-M. Zhou,* W, Zhang, T. D. James, X.-P. He,* H. Tian, A fluorogenic 2D glycosheet for the simultaneous identification of human– and avian–receptor specificity in influenza viruses. Mater. Horiz. 2017, 4, 431-436.
[13] J.-D. Zhang, J. Mei, X.-L. Hu, X.-P. He,* H. Tian, Ratiometric detection of β-amyloid and discrimination from lectins by a supramolecular AIE glyconanoparticle. Small 2016, 12, 6562-6567. (Highlighted by MaterialsViews China)
[14] X.-P. He, H. Tian,* Photoluminescence architectures for disease diagnosis: From graphene to thin-layer transition metal dichalcogenides and oxides. Small 2016, 12, 144-160. (ESI highly cited paper; Highlighted by MaterialsViews China; Review article)
[15] X.-P. He, X.-W. Wang, X.-P. Jin, H. Zhou, X.-X. Shi, G.-R. Chen, Y.-T. Long,* Epimeric monosaccharide-quinone hybrids on gold electrodes toward the electrochemical probing of specific carbohydrate–protein recognitions. J. Am. Chem. Soc. 2011, 133, 3649-3657.