譚彩萍

譚彩萍，女，1981年3月生，湖南省常德市人，博士，中山大學化學與化學工程學院副教授。

基本介紹

• 中文名：譚彩萍
• 出生地：湖南省常德市
• 出生日期：1981年3月
• 畢業院校：中山大學
• 學位/學歷：博士
• 職業：教師
• 專業方向：生物無機化學
• 任職院校：中山大學

人物經歷

教育經歷

1998.09—2002.06 華南師範大學化學與環境學院，學士；

2002.09—2008.06 中山大學化學與化學工程學院，博士。

工作經歷

2008.03—2011.03 中山大學生命科學學院，博士後；

2011.04—2016.01 中山大學化學與化學工程學院，講師；

2016.02—2017-02 美國芝加哥大學，訪問學者；

2016.01—至今 中山大學化學與化學工程學院，副教授。

講授課程

本科生課程《無機化學》、《化學生物學綜合實驗》、《現代無機化學進展》、《基礎化學實驗》、《普通化學》。

科研方向

從事的學科領域為生物無機化學。研究興趣包括靶向性金屬抗腫瘤藥物的設計、抗腫瘤活性及機制研究。近兩年，以與腫瘤發生、發展的關鍵的蛋白分子為靶點，設計了系列的金屬配合物作為新穎的抑制劑，並研究了它們的抗腫瘤作用機制。主要研究的靶點包括組蛋白去乙醯化酶（Histone deacetylases, HDACs）和細胞周期素依賴性激酶（Cyclin-dependent kinases, CDKs）等。

學術成果

科研項目

1.廣東省自然科學基金（傑出青年基金），2015.08-2019.08，100萬元。

2.國家自然科學基金（面上項目），2018.01-2021.12，64.0萬元。

3.國家自然科學基金（面上項目），2016.01-2019.12，77.6萬元。

4.廣東省“百千萬工程青年拔尖人才”，2016.08-2019.08，10萬元。

5.高校基本科研業務費青年教師重點培育項目，2016.01-2017.12，30萬元。

6.國家高技術研究發展計畫(863計畫)子課題，2012.01-2015.12，92.5萬元。

7.國家自然科學基金(青年科學基金項目)，2013.01-2015.012，25萬元。

8.廣州市科技計畫項目，2014.01-2016.12，8萬元。

9.高校基本科研業務費青年教師培育項目，2013.01-2015.12，10萬元。

10.第四十四批中國博士後科學基金，2008.03-2010.03，3萬元。

論著一覽

2017

1. Cao, J. J.,Tan, C. P.*, Chen, M. H., Wu, N., Yao, D. Y., Liu, X. G., Ji, L.-N., Mao, Z. W.* Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium (III) complexes.Chemical Science2017, 8, 631-640.IF: 8.668

2. Chen, M. H., Wang, F. X., Cao, J. J.,Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Light-Up Mitophagy in Live Cells with Dual-Functional Theranostic Phosphorescent Iridium(III) Complexes.ACS Applied Materials & Interfaces,2017, 9 (15), 13304-13314.IF: 7.504

3. Zhang, D. Y., Zheng, Y.,Tan, C. P.*, Sun, J. H., Zhang, W.,Ji, L. N. and Mao, Z. W.* Graphene Oxide Decorated with Ru(II)–Polyethylene Glycol Complex for Lysosome-Targeted Imaging and Photodynamic/Photothermal Therapy.ACS Applied Materials & Interfaces2017, 9 (8), 6761-6771.IF: 7.504

4. Wang, F. X., Chen, M. H., Lin, Y. N., Zhang, H.,Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Dual Functions of Cyclometalated Iridium(III) Complexes: Anti-Metastasis and Lysosome-Damaged Photodynamic Therapy.ACS Applied Materials & Interfaces,2017,9(49), 42471–42481.IF: 7.504

5. Zhang, D. Y., Zheng, Y., Zhang, H., He, L.,Tan, C. P.*, Sun, J. H., Zhang, W., Peng, X. Y., Ji, L. N. and Mao, Z. W.* Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy.Nanoscale, 2017,9, 18966-18976.IF: 7.367

6. Xue, S. S.,Tan, C. P.*, Chen, M. H., Cao, J. J., Zhang, D. Y., Ye, R. R., Ji, L. N. and Mao, Z. W.* Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-beta-cyclodextrin complex and an adamantane-functionalized peptide.Chemical Communications2017,53 (5), 842-845.IF: 6.319(Front Cover)

7. Wu, N., Cao, J. J., Wu, X. W.,Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Iridium(III) Complexes with Five-Membered Heterocyclic Ligands for Combined Photodynamic Therapy and Photoactivated Chemotherapy.Dalton Transactions2017,46, 13482-13491.IF: 4.029

8. Zheng, Y., He, L., Zhang, D. Y.,Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Mixed-ligand iridium(III) complexes as photodynamic anticancer agents.Dalton Transactions2017, 46, 11395-11407.IF: 4.029

9. Ye, R. R.，Cao, J. J.，Tan, C. P.，Ji, L. N.，Mao, Z. W.*， Valproic Acid-Functionalized Cyclometalated Iridium(III)Complexes as Mitochondria-Targeting Anticancer Agents.Chemistry-A European Journal2017,23(60), 15166-15176.IF: 5.317

2016

10. Wang, F. X., Chen, M. H., Hu, X. Y., Ye, R. R.,Tan, C. P.*, Ji, L. N. and Mao, Z. W. Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents.Scientific Reports2016, 6, 38954.IF: 4.259

11. Ye, R. R.,Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Coumarin-appended phosphorescent cyclometalated iridium(III) complexes as mitochondria-targeted theranostic anticancer agents.Dalton Transactions2016, 45(33), 13042-13051.IF: 4.029(Front Cover)

12. Ye, R. R.,Tan, C. P.*, Chen, M. H., Hao, L., Ji, L. N. and Mao, Z. W.* Mono- and dinuclear phosphorescent rhenium(I) complexes: impact of subcellular localization on anticancer mechanisms.Chemistry-A European Journal2016, 22(23), 7800-7809.IF: 5.317

13. Zhang, W., Shen, J., Su, H., Mu, G., Sun, J. H.,Tan, C. P., Liang, X. J., Ji, L. N., Mao, Z. W.* Co-delivery of cisplatin prodrug and chlorin e6 by mesoporous silica nanoparticles for chemo-photodynamic combination therapy to combat drug resistance.ACS Applied Materials & Interfaces2016, 8(21), 13332-13340.IF: 7.504

2015

14. He, L., Li, Y.,Tan, C. P.*, Ye, R. R., Chen, M. H., Cao, J. J., Ji, L. N. and Mao, Z. W.* Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents.Chemical Science2015, 6, 5409-5418.IF: 8.668(Back Cover)

15. Ye, R. R.,Tan, C. P.*, Lin, Y. N., Ji, L. N., Mao, Z. W.* A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction.Chemical Communications2015,51(39),8353-8356.IF: 6.319

16. Li, Y.,Tan, C. P. (Co-first author), He, L., Ji, L. N., Mao, Z. W.* Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents.Biomaterials2015, 39, 95-104.IF: 8.402

17. Zhang, W., Li, Y., Sun, J. H.,Tan, C. P., Ji, L. N., Mao, Z. W.* Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells.Chemical Communications2015, 51(10), 1807-1810.IF: 6.319

18. Li, J. M., Zhang, W., Su, H., Wang, Y. Y.,Tan, C. P., Ji, L. N., Mao, Z. W.* Reversal of multidrug resistance in MCF-7/ADR cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-beta-cyclodextrin nanocarrier.International Journal of Nanomedicine2015, 10, 3147-3162.IF: 4.300

2014

19. He, L.,Tan, C. P.*, Ye, R. R., Zhao, Y. Z., Liu, Y. H., Zhao, Q., Ji, L. N., Mao, Z. W.* Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes.Angewandte Chemie International Edition2014, 53(45), 12137-12141.IF: 11.994

20. Ye, R. R.,Tan, C. P.*,He, L., Chen, M. H., Ji, L. N., Mao, Z. W.* Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy.Chemical Communications2014, 50(75), 10945-10948.IF: 6.319

21. He, L., Liao, S. Y., Tan, C. P.*, Lu, Y. Y., Xu, C. X., Ji, L. N., Mao, Z. W.* Cyclometalated iridium(III)-beta-carboline complexes as potent autophagy-inducing agents.Chemical Communications2014, 50(42), 5611-5614.IF: 6.319

22.Tan, C. P., Lu, Y. Y., Ji, L. N., Mao, Z. W.* Metallomics insights into the programmed cell death induced by metal-based anticancer compounds.Metallomics2014, 6(5), 978-995.IF: 3.975(Front Cover)

23. Zhao, M. X., Zhao, M., Zeng, E. Z., Li, Y., Li, J. M., Cao, Q.,Tan, C. P.,Ji, L. N., Mao, Z. W.* Enhanced anti-cancer efficacy to cancer cells by doxorubicin loaded water-soluble amino acid-modified beta-cyclodextrin platinum complexes.Journal of Inorganic Biochemistry2014, 137, 31-39.IF: 3.348

24. Li, Y., Liu, G. F.*,Tan, C. P.,Ji, L. N., Mao, Z. W.* Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes.Metallomics2014, 6(8), 1460-1468.IF: 3.975

2013

25. Ye, R. R., Ke, Z. F.,Tan, C. P.*, He, L., Ji, L. N., Mao, Z. W.* Histone-deacetylase-targeted fluorescent ruthenium(II) polypyridyl complexes as potent anticancer agents.Chemistry-A European Journal2013, 19(31), 10160-10169.IF: 5.317(Front Cover)

26. He, L., Liao, S. Y.,Tan, C. P.*, Ye, R. R., Xu, Y. W., Zhao, M., Ji, L. N., Mao, Z. W.* Ruthenium-arene-carboline complexes as potent inhibitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studies.Chemistry-A European Journal2013, 19(36), 12152-12160.IF: 5.317

2012

27. Zheng, X. H., Zhong, Y. F.,Tan, C. P., Ji, L. N., Mao, Z. W.* Pt(II) squares as selective and effective human telomeric G-quadruplex binders and potential cancer therapeutics.Dalton Transactions2012,41(38), 11807-11812.IF: 4.177

28. Wang, H. L., De Yonker, N. J., Gao, H.,Tan, C. P., Zhang, X. T., Ji, L. N., Zhao, C. Y.*, Mao, Z. W.* Aquation and dimerization of osmium(II) anticancer complexes: a density functional theory study.Rsc Advances2012, 2(2), 436-446.IF: 3.289

29. Li, J. M., Wang, Y. Y., Zhao, M. X.,Tan, C. P., Li, Y. Q., Le, X. Y., Ji, L. N., Mao, Z. W.* Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking.Biomaterials2012,33(9), 2780-2790.IF: 8.387

2011

30.Tan, C. P., Wu, S. H., Lai, S. S., Wang, M. X., Chen, Y., Zhou, L. J., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes.Dalton Transactions2011,40(34), 8611-8621.IF: 4.029

31.Tan, C. P., Hu, S., Liu, J.*, Ji, L. N.* Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium-DMSO complexes containing 2,2'-biimidazole.European Journal of Medicinal Chemistry2011, 46(5), 1555-1563.IF: 4.519

32. Zhao, M. X., Li, J. M., Du, L. Y.,Tan, C. P., Xia, Q.*, Mao, Z. W.*, Ji, L. N. Targeted cellular uptake and sirna silencing by quantum-dot nanoparticles coated with beta-cyclodextrin coupled to amino acids.Chemistry-A European Journal2011, 17(18), 5171-5179.IF: 5.317

33. Li, J. M., Zhao, M. X., Su, H., Wang, Y. Y.,Tan, C. P., Ji, L. N., Mao, Z. W.* Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging.Biomaterials2011, 32(31), 7978-7987.IF: 8.402

2003-2010

34.Tan, C. P.,Lai, S. S., Wu, S. H., Hu, S., Zhou, L. J., Chen, Y., Wang, M. X., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Nuclear permeable ruthenium(II) beta-carboline complexes induce autophagy to antagonize mitochondrial-mediated apoptosis.Journal of Medicinal Chemistry2010, 53(21), 7613-7624.IF: 6.259

35.Tan, C. P., Liu, J.*, Li, H., Zheng, W. J., Shi, S., Chen, L. M., Ji, L. N.* Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes.Journal of Inorganic Biochemistry2008,102(2), 347-358.IF: 3.348

36.Tan, C. P., Liu, J.*, Chen, L. M., Shi, S., Ji, L. N.* Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes.Journal of Inorganic Biochemistry2008, 102(8), 1644-1653.IF: 3.348

37. Liu, Y. N., Shi, S., Mei, W. J.,Tan, C. P., Chen, L. M., Liu, J.*, Zheng, W. J.*, Ji, L. N. In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues.European Journal of Medicinal Chemistry2008, 43(9), 1963-1970.IF: 3.348

38. Liu, J.*, Zheng, W. J.*, Shi, S.,Tan, C. P., Chen, J. C., Zheng, K. C., Ji, L. N. Synthesis, antitumor activity and structure-activity relationships of a series of Ru(II) complexes.Journal of Inorganic Biochemistry2008, 102(2), 193-202.IF: 3.348

39. Chen, L. M., Liu, J.*, Chen, J. C.,Tan, C. P., Shi, S., Zheng, K. C., Ji, L. N.* Synthesis, characterization, DNA-binding and spectral properties of complexes [Ru(L)(4)(dppz)](2+) (L = Im and MeIm).Journal of Inorganic Biochemistry2008, 102(2), 330-341.IF: 3.348

40. Chen, L. M., Liu, J.*, Chen, J. C., Shi, S.,Tan, C. P., Zheng, K. C., Ji, L. N.* Experimental and theoretical studies on the DNA-binding and spectral properties of water-soluble complex [Ru(MeIm)(4)(dpq)](2+).Journal of Molecular Structure2008, 881(1-3), 156-166.IF: 1.753

41. Shi, S., Liu, J.*, Li, J., Zheng, K. C., Huang, X. M.,Tan, C. P., Chen, L. M., Ji, L. N.* Synthesis, characterization and DNA-binding of novel chiral complexes Delta- and Lambda-[Ru(bpy)(2)L](2+) (L = o-mopip and p-mopip).Journal of Inorganic Biochemistry2006, 100(3), 385-395.IF: 3.348

42. Shi, S., Liu, J.*, Li, J., Zheng, K. C.,Tan, C. P., Chen, L. M., Ji, L. N.* Electronic effect of different positions of the -NO2 group on the DNA-intercalator of chiral complexes [Ru(bpy)(2)L](2+) (L = o-npip, m-npip and p-npip).Dalton Transactions2005, 11, 2038-2046.IF: 4.029

43. Liu, J.*, Mei, W. J., Xu, A. W.,Tan, C. P., Shi, S., Ji, L. N. Synthesis, characterization and antiviral activity against influenza virus of a series of novel manganese-substituted rare earth borotungstates heteropolyoxometalates.Antiviral Research2004, 62(1), 65-71.IF: 4.271

44. Liu, J.*, Mei, W. J., Xu, A. W.,Tan, C. P., Ji, L. N. Synthesis, characterization and antiviral activity of nickel-substituted rare earth molybdosilicic heteropoly blues.Transition Metal Chemistry2003, 28(5), 500-505.IF: 1.358