蘭瑩，甘肅省蘭州市人，博士，博士後，副教授，碩士生導師。教育部學位論文中心評審專家，Food Chemistry等期刊審稿人，西北農林科技大學安康市中藥材試驗示範站功能食品研發專家。
基本介紹
- 中文名：蘭瑩
- 國籍：中國
- 出生地：甘肅省蘭州市
- 畢業院校：中國海洋大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：食品營養與健康
- 任職院校：西北農林科技大學
人物經歷,研究方向,研究成果,授權發明專利,主持科研項目,
人物經歷
2006.09-2010.06 海南大學生命科學與農學院，學士
2010.09-2012.06 西北農林科技大學動物醫學院，碩士
2013.09-2016.06 中國海洋大學醫藥學院，博士
2012.08-2013.08 天津南開允公醫藥科技有限公司 工程師
2016.07-2018.06 西北農林科技大學食品科學與工程學院，博士後
2018.07-至今 西北農林科技大學食品科學與工程學院，講師/副教授
研究方向
1. 天然產物活性多糖結構與功能研究：研究食物來源多糖的提取、分離及結構解析，通過動物實驗研究其潛在的功能及分子機制。
2. 食品功能因子改善腸、腦、肝臟健康研究：通過動物實驗、細胞實驗、分子生物學手段等研究食物中功能因子保護腸道屏障、調節腸道菌群、維持腸道免疫穩態、神經保護、改善肝臟脂代謝紊亂的作用和分子機制。
3. 食品功能因子的利用：基於食源性多糖和功能因子的生物活性研發相關功能食品。
研究成果
1.Ying Lan, Zhiyuan Ma, Lili Chang, Jing Peng, Mengqi Zhang, Qingyang Sun, Ruixue Qiao, Xinglin Hou, Xuechao Ding, Qiang Zhang, Qiang Peng, Juane Dong*, Xuebo Liu*.Sea buckthorn polysaccharide ameliorates high-fat diet induced mice neuroinflammation and synaptic dysfunction via regulating gut dysbiosis. International Journal of Biological Macromolecules, 2023,236:123797.
2.Ma Zhiyuan, Sun Qingyang, Chang Lili, Peng Jing, Zhang Mengqi, Ding Xuechao, Zhang Qiang, Liu Guoku, Liu Xuebo, Lan Ying*. A natural anti-obesity reagent derived from sea buckthorn polysaccharides: Structure characterization and anti-obesity evaluation in vivo. Food Chemistry, 2022,375:131884.
3.Lan Ying, Sun Qingyang, Ma Zhiyuan, Peng Jing, Zhang Mengqi, Wang Chi, Zhang Xiaotian, Yan Xianfang, Chang Lili, Hou Xinglin, Qiao Ruixue, Mulati Aiziguli, Zhou Yuan, Zhang Qiang, Liu Zhigang*, Liu Xuebo*. Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota- SCFAs-liver axis. Food &Function, 2022,13:2925-2937.
4.Zhang Li#, Lan Ying#, Wang Yan, Yang Yiying, Han Wenzheng, Li Jingyan, Wang Yutang*, Liu Xuebo. Secoisolariciresinol diglucoside ameliorates high fat diet-induced colon inflammation and regulates gut microbiota in mice. Food & Function, 2022,13:3009-3022.
5.Mulati Aiziguli, Zhang Xin, Zhao Tong, Ren Bo, Wang Luanfeng, Liu Xiaoning, Lan Ying*, Liu Xuebo*. Isorhamnetin attenuates high-fat and high-fructose diet induced cognitive impairments and neuroinflammation by mediating MAPK and NF kappa B signaling pathways. Food & Function, 2021,12:9261-9272.
6.Hou, Xinglin, Wu, Xiaoxia, Lan, Ying*, Liu, Haomiao, Che, Jiaxing. Anti-fatigue function and safety assessment of Olea europae extracl compounded with L-carnitine tartrate. Journal of Food Science and Technology. 2021,39:104-115.
7.Lan Ying, Liu Yong, He Yanli, Liu Feng, Xv Huixin, Feng Kun, Zhang Zhenkun, Shi Zhaoyu, Zhang Xiaolei, Zhang Lijuan*. A single injection of bleomycin reduces glycosaminoglycan sulfation up to 30 days in the C57BL/6 mouse model of lung fibrosis. International Journal of Biological Macromolecules, 2020,160:319-327.
8.Lan Ying*, Li Xiulian, Liu Yong, He Yanli, Hao Cui, Wang Hua, Jin Liying, Zhang Guoqing, Zhang Shufeng, Zhou Aimin, Zhang Lijuan*. Pingyangmycin inhibits glycosaminoglycan sulphation in both cancer cells and tumor tissues. Journal of Cellular and Molecular Medicine, 2020,24:3419-3430.
9.Lan Ying, Li Xiulian, Liu Xuebo, Hao Cui, Song Ni, Ren Sumei, Wang Wei, Feng Ningchuan*, Zhang Lijuan*. Genistein enhances or reduces glycosaminoglycan quantity in a cell type-specific manner. Cellular Physiology & Biochemistry. 2018, 47:1667-1681.
10.Lan Ying, Zeng Xuan, Guo Zhihua, Zeng Pengjiao, Hao Cui, Zhao Xia, Yu Guangli*, Zhang Lijuan*. Polyguluronate sulfate and its oligosaccharides but not heparin promotes FGF19/FGFR1c signiling. Journal of Ocean University of China, 2017,16:532-536.
11.Lan Ying, Hao Cui, Zeng Xuan, He Yanli, Zeng Pengjiao, Guo Zhihua, Zhang Lijuan*. Serum glycoprotein-derived N-and O-linked glycans as cancer biomarkers. American Journal of Cancer Research. 2016,6:2390–2415.
12.He Yanli#, Lan Ying#, Liu Yong, Yu Haibo, Han Zhangrun, Li Xiulian, Zhang Lijuan*. Pingyangmycin and bleomycin share the same cytotoxicity pathway. Molecules, 2016,21:862.
13.侯興琳, 張同軍, 蘭瑩*.沙棘亞麻籽油軟膠囊降血脂功能及其安全性評價. 中國油脂. 2021,47(11):30-37+79.
14.蘭瑩, 郝翠, 張麗娟*. 聚甘露糖醛酸硫酸酯及寡糖在表達FGF1c的BaF3細胞中可激活FGF1/19/21信號通路. 中國海洋藥物. 2017, 36(1):1-6.
15.蘭瑩, 歐陽五慶*, 吳小利, 吳敬超. 複方酮康唑納米乳的研製及其體外經皮吸收. 中國獸醫學報. 2013, 33 (5): 770-775.
16.蘭瑩, 歐陽五慶*. 羅紅黴素納米乳的製備及體外抑菌效果研究. 畜牧與獸醫. 2012, 44 (6): 70-74.
17.蘭瑩, 歐陽五慶*, 宋冠男, 孫江宏, 吳敬超. 複方丙酸氯倍他索納米乳的製備及安全性評價. 西北農林科技大學學報. 2012, 40 (3): 29-33.
授權發明專利
1. 一種葉黃素微膠囊的製備方法及葉黃素微膠囊速溶飲料. CN2017102796245
2. 一種具有抗氧化功能的彩色馬鈴薯飲料. CN2018104577459
3. 一種高效溫和降低卵白蛋白致敏性的方法. CN2017103000223
4. Method for efficiently and mildly reducing ovalbumin allergenicity. US101779555B2
5. 一種血液降解得到並檢測單糖的方法在癌症檢測中的套用. CN201410211976
6. 一種複方丙酸氯倍他索納米藥物及其製備方法. CN201110243324
7. 一種水包油型複方酮康唑納米藥物及其製備方法. CN201110246053
主持科研項目
1. 國家自然科學基金青年項目, NO. 32202041, 2023-2025.
2. 中國博士後科學基金面上一等資助, NO. 2020M680161, 2021-2022.
3. 陝西省重點研發計畫項目, NO. 2023-YBNY-187, 2023-2025.
4. 西北農林科技大學博士科研啟動基金, NO. Z109021807, 2018 -2021.
