基本介紹
- 中文名：蕭颯
- 畢業院校：日本京都大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：分子微生物學
- 任職院校：西北農林科技大學
- 籍貫：吉林
人物經歷,研究方向,講授課程,科研項目,發表論文,SCI論文,中文論文,
人物經歷
1986-1990年 北京農學院畜牧專業 學士
1992-1993年 中國科學院研究生院在職研究堡獄整斷生基礎課學習阿碑習
1996-2001年 日本京都大學分子微生物學專業 博士
1990-1996年 中國科學院遺傳研究所，實習研究員
2002-2006年 美國紐約西奈山醫學院，博士後
2007-2013年 美國馬里蘭大學獸醫學院，研究助理
2013.09-至今 西北農林科技大學動物醫學院，教授
研究方向
1.新城疫病毒及其他禽副粘病毒的遺傳學特旬戶歸性及流行病學。
2.新城疫病毒的神經致病機理。
3.病毒的分子致病機制。
4.病毒與宿主的相互作用。
5.RNA病毒的反向遺傳系統、診斷及疫苗的研發。
講授課程
獸醫傳染病料凝悼學，獸醫流行病學，獸醫傳染病學實驗，獸醫傳染病學實習，動物疫病防控專題。
科研項目
1.國家自然科學基金面上項目陵臘符戲（31572533），主持。
2.西北農林科技大學人才引進科研虹仔啟動資龍閥凝金。
發表論文
SCI論文
1.Guo Y, Zhao J, Chang X, Yao W, Wang H, Wang W, Wang X, Zhang S, Yang Z, Xiao S. α2,3- and α2,6-Linked Sialic Acids are Important for Cell Binding and Replication of Newcastle Disease Virus in Chicken Primary Neuronal Cells. Acta Virologica. 2018. In press.
2.Wang X, Wang X, Jia Y, Wang C, Tang Q, Han Q, Xiao S, Yang Z. Coadministration of Recombinant Adenovirus Expressing GM-CSF with Inactivated H5N1 Avian Influenza Vaccine Increased the Immune Responses and Protective Efficacy Against a Wild Bird Source of H5N1 Challenge.J Interferon Cytokine Res. 2017. 37(10):467-473.
3.Wang Y, Bi Y, Yu W, Wei N, Wang W, Wei Q, Wang X, Zhang S, Yang Z, Xiao S. Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif "RRQRRL" are critical for fusogenic activity. Virol J. 2017. 14(1):185.
4.Wang Y, Yu W, Huo N, Wang W, Guo Y, Wei Q, Wang X, Zhang S, Yang Z, Xiao S. Comprehensive analysis of amino acid sequence diversity at the F protein cleavage site of Newcastle disease virus in fusogenic activity. PLoS One. 2017. 12(9):e0183923.
5.Ren S, Xie X, Wang Y, Tong L, Gao X, Jia Y, Wang H, Fan M, Zhang S, Xiao S, Wang X, Yang Z. Molecular characterisation of a Class I Newcastle disease virus strain isolated from pigeon in China. 2016. Avian Pathol. 7:1-34.
6.Kim SH, Xiao S, Collins PL, Samal SK. LaSota F Cleavage Motif-Mediated Fusion Activity Is Affected by Other Regions of F Protein from Different Genotype Newcastle Disease Virus in a Chimeric Virus: Implication for Virulence Attenuation. 2016. J Gen Virol. doi:10.1099.
7.Gao X, Hu X, Tong L, Liu D, Chang X, Wang H, Dang R, Wang X, Xiao S, Du E, Yang Z. Construction of a camelid VHH yeast two-hybrid library and the selection of VHH against haemagglutinin-neuraminidase protein of the Newcastle disease virus. 2016. BMC Vet Res. 12(1):39.
8.Liu Q, Yang Z, Hao H, Cheng S, Fan W, Du E, Xiao S, Wang X, Zhang S. Development of a SYBR Green real-time RT-PCR assay for the detection of avian encephalomyelitis virus. J. Virol. Methods. 2014 Sep;206:46-50.
9.Paldurai A, Xiao S, Kim SH, Kumar S, Nayak B, Samal S, Collins PL, Samal SK. Naturally occurring six- and twelve-nucleotide inserts do not affect Newcastle disease virus replication and pathogenesis. PLoS One. 2014 Aug 5;9(8):e103951.
10.Kim SH, Paldurai, A, Xiao S, Collins PL, Samal SK. Modified Newcastle Disease Virus Vectors Expressing the H5 Hemagglutinin Induce Enhanced Protection against Highly Pathogenic H5N1 Avian Influenza Virus in Chickens. Vaccine. 2014 Jul 31;32(35):4428-35.
11.Paldurai A, Kim SH, Nayak B, Xiao S, Shive H, Collins PL, Samal SK. Evaluation of the contributions of the individual viral genes to Newcastle disease virus virulence and pathogenesis. J. Virol. 2014 Aug 1;88(15):8579-8596.
12.Kim SH*, Xiao S*, Paldurai A, Collins PL, Samal SK. Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus.J. Gen. Virol. 2014 Feb; 95(Pt 2):331-6. *Co-author.
13.Khattar SK, Nayak B, Kim SH, Xiao S, Samal S, Paldurai A, Buchholz UJ, Collins PL, Samal SK. Evaluation of the replication, pathogenicity, and immunogenicity of avian paramyxovirus (APMV) serotypes 2, 3, 4, 5, 7, and 9 in rhesus macaques. PLoS One. 2013 Oct 10;8(10):e75456.
14.Kim SH, Wanasen N, Paldurai A, Xiao S, Collins PL, Samal SK. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS One. 2013 Aug 28;8(8):e74022.
15.Xiao S, Paldurai A, Nayak B, Mirande A, Collins PL & Samal SK. Complete genome sequence of a highly virulent Newcastle disease virus strain currently circulating in Mexico. Genome Announcement. 2013. Jan;1(1). doi:pii: e00177-12. 10.1128/genomeA.00177-12.
16.Parthiban M, Manimaran K, Xiao S, Nayak B, Paldurai A, Kim SH, Ladman BS, Preskenis LA, Gelb Jr.G, Collins PL and Samal SK. Complete genome sequence of an avian paramyxovirus type 4 from North America reveals a shorter genome and new genotype. Genome Announcement. 2013. Jan;1(1). doi:pii: e00075-12. 10.1128/genomeA.00075-12.
17.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation in vitro but not Increased Replication and Pathogenicity in Chickens and Ducks. PLoS One. 2013;8(1):e50598.
18.Samuel A, Nayak B, Paldurai A, Xiao S, Aplogan GL, Awoume KA, Webby RJ, Ducatez MF, Collins PL, Samal SK. Phylogenetic and pathotypic characterization of Newcastle disease viruses circulating in West Africa and the efficacy of a current vaccine. Journal of Clinical Microbiology. 2013 Mar;51(3):771-81.
19.Xiao S, Nayak B, Samuel A, Paldurai A, Kanabagattebasavarajappa M, Prajitno TY, Bharoto EE, Collins PL, Samal SK. Generation by reverse genetics of an effective, stable, live-attenuated Newcastle disease virus vaccine based on a currently circulating, highly virulent Indonesian strain. PLoS One. 2012. 7(12):e52751.
20.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks. PLoS One. 2012. 7(4): e34927.
21.Xiao S, Paldurai A, Nayak B, Samuel A, Bharoto EE, Prajitno TY, Collins PL, Samal SK. Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia. J. Virol. 2012. 86(10): 5969-5970.
22.Xiao S, Khattar SK, Subbiah M, Collins PL, Samal SK. Mutation of the F protein cleavage site of avian paramyxovirus-7 results in furin cleavage, fusion promotion and increased replication in vitro, but not increased replication, tissue tropism, or virulence in chickens. J. Virol. 2012.86(7): 3828-3838.
中文論文
1.畢友坤，屈陽，衛巧林，王文彬，趙傑，霍娜，張淑霞，王興龍，楊增岐，蕭颯*。我國新城疫病毒強毒株 F48E9 致病性細化分型的鑑定。畜牧與獸醫，2018，50（2）：91-96。
2.王重陽，任善會，賈燕青，王相偉，高小龍，張淑霞，蕭颯，王興龍*，楊增岐*。新城疫病毒LaSota及F48E9 毒株P和V及W蛋白C端功能域的原核表達及其多克隆抗體的製備。中國獸醫科學，2017，47(4)：411-418。
3.範文濤，杜恩岐，高小龍，蕭 颯，李志軍，范莉莉，郝華芳，王興龍，黨如意，張淑霞*，楊增岐*。禽腦脊髓炎病毒VP1蛋白納米抗體的篩選及活性檢測。中國獸醫學報，2016，36(1):12-17。
4.高小龍，胡湘雲，付向晶，王燕平，仝麗娜，王海新，王興龍，張淑霞，蕭 颯，杜恩岐*，楊增岐*。新城疫病毒F蛋白納米抗體的篩選及活性鑑定。畜牧獸醫學報，2016,47（8）：1645-1651。
5.王興龍，邱立，黨如意，楊增岐*，張淑霞，蕭颯。獸醫教學中的生物安全問題及對策建議。安徽農學通報，2015，21（2）:93-95.
4.Wang Y, Yu W, Huo N, Wang W, Guo Y, Wei Q, Wang X, Zhang S, Yang Z, Xiao S. Comprehensive analysis of amino acid sequence diversity at the F protein cleavage site of Newcastle disease virus in fusogenic activity. PLoS One. 2017. 12(9):e0183923.
5.Ren S, Xie X, Wang Y, Tong L, Gao X, Jia Y, Wang H, Fan M, Zhang S, Xiao S, Wang X, Yang Z. Molecular characterisation of a Class I Newcastle disease virus strain isolated from pigeon in China. 2016. Avian Pathol. 7:1-34.
6.Kim SH, Xiao S, Collins PL, Samal SK. LaSota F Cleavage Motif-Mediated Fusion Activity Is Affected by Other Regions of F Protein from Different Genotype Newcastle Disease Virus in a Chimeric Virus: Implication for Virulence Attenuation. 2016. J Gen Virol. doi:10.1099.
7.Gao X, Hu X, Tong L, Liu D, Chang X, Wang H, Dang R, Wang X, Xiao S, Du E, Yang Z. Construction of a camelid VHH yeast two-hybrid library and the selection of VHH against haemagglutinin-neuraminidase protein of the Newcastle disease virus. 2016. BMC Vet Res. 12(1):39.
8.Liu Q, Yang Z, Hao H, Cheng S, Fan W, Du E, Xiao S, Wang X, Zhang S. Development of a SYBR Green real-time RT-PCR assay for the detection of avian encephalomyelitis virus. J. Virol. Methods. 2014 Sep;206:46-50.
9.Paldurai A, Xiao S, Kim SH, Kumar S, Nayak B, Samal S, Collins PL, Samal SK. Naturally occurring six- and twelve-nucleotide inserts do not affect Newcastle disease virus replication and pathogenesis. PLoS One. 2014 Aug 5;9(8):e103951.
10.Kim SH, Paldurai, A, Xiao S, Collins PL, Samal SK. Modified Newcastle Disease Virus Vectors Expressing the H5 Hemagglutinin Induce Enhanced Protection against Highly Pathogenic H5N1 Avian Influenza Virus in Chickens. Vaccine. 2014 Jul 31;32(35):4428-35.
11.Paldurai A, Kim SH, Nayak B, Xiao S, Shive H, Collins PL, Samal SK. Evaluation of the contributions of the individual viral genes to Newcastle disease virus virulence and pathogenesis. J. Virol. 2014 Aug 1;88(15):8579-8596.
12.Kim SH*, Xiao S*, Paldurai A, Collins PL, Samal SK. Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus.J. Gen. Virol. 2014 Feb; 95(Pt 2):331-6. *Co-author.
13.Khattar SK, Nayak B, Kim SH, Xiao S, Samal S, Paldurai A, Buchholz UJ, Collins PL, Samal SK. Evaluation of the replication, pathogenicity, and immunogenicity of avian paramyxovirus (APMV) serotypes 2, 3, 4, 5, 7, and 9 in rhesus macaques. PLoS One. 2013 Oct 10;8(10):e75456.
14.Kim SH, Wanasen N, Paldurai A, Xiao S, Collins PL, Samal SK. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS One. 2013 Aug 28;8(8):e74022.
15.Xiao S, Paldurai A, Nayak B, Mirande A, Collins PL & Samal SK. Complete genome sequence of a highly virulent Newcastle disease virus strain currently circulating in Mexico. Genome Announcement. 2013. Jan;1(1). doi:pii: e00177-12. 10.1128/genomeA.00177-12.
16.Parthiban M, Manimaran K, Xiao S, Nayak B, Paldurai A, Kim SH, Ladman BS, Preskenis LA, Gelb Jr.G, Collins PL and Samal SK. Complete genome sequence of an avian paramyxovirus type 4 from North America reveals a shorter genome and new genotype. Genome Announcement. 2013. Jan;1(1). doi:pii: e00075-12. 10.1128/genomeA.00075-12.
17.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation in vitro but not Increased Replication and Pathogenicity in Chickens and Ducks. PLoS One. 2013;8(1):e50598.
18.Samuel A, Nayak B, Paldurai A, Xiao S, Aplogan GL, Awoume KA, Webby RJ, Ducatez MF, Collins PL, Samal SK. Phylogenetic and pathotypic characterization of Newcastle disease viruses circulating in West Africa and the efficacy of a current vaccine. Journal of Clinical Microbiology. 2013 Mar;51(3):771-81.
19.Xiao S, Nayak B, Samuel A, Paldurai A, Kanabagattebasavarajappa M, Prajitno TY, Bharoto EE, Collins PL, Samal SK. Generation by reverse genetics of an effective, stable, live-attenuated Newcastle disease virus vaccine based on a currently circulating, highly virulent Indonesian strain. PLoS One. 2012. 7(12):e52751.
20.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks. PLoS One. 2012. 7(4): e34927.
21.Xiao S, Paldurai A, Nayak B, Samuel A, Bharoto EE, Prajitno TY, Collins PL, Samal SK. Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia. J. Virol. 2012. 86(10): 5969-5970.
22.Xiao S, Khattar SK, Subbiah M, Collins PL, Samal SK. Mutation of the F protein cleavage site of avian paramyxovirus-7 results in furin cleavage, fusion promotion and increased replication in vitro, but not increased replication, tissue tropism, or virulence in chickens. J. Virol. 2012.86(7): 3828-3838.
中文論文
1.畢友坤，屈陽，衛巧林，王文彬，趙傑，霍娜，張淑霞，王興龍，楊增岐，蕭颯*。我國新城疫病毒強毒株 F48E9 致病性細化分型的鑑定。畜牧與獸醫，2018，50（2）：91-96。
2.王重陽，任善會，賈燕青，王相偉，高小龍，張淑霞，蕭颯，王興龍*，楊增岐*。新城疫病毒LaSota及F48E9 毒株P和V及W蛋白C端功能域的原核表達及其多克隆抗體的製備。中國獸醫科學，2017，47(4)：411-418。
3.範文濤，杜恩岐，高小龍，蕭 颯，李志軍，范莉莉，郝華芳，王興龍，黨如意，張淑霞*，楊增岐*。禽腦脊髓炎病毒VP1蛋白納米抗體的篩選及活性檢測。中國獸醫學報，2016，36(1):12-17。
4.高小龍，胡湘雲，付向晶，王燕平，仝麗娜，王海新，王興龍，張淑霞，蕭 颯，杜恩岐*，楊增岐*。新城疫病毒F蛋白納米抗體的篩選及活性鑑定。畜牧獸醫學報，2016,47（8）：1645-1651。
5.王興龍，邱立，黨如意，楊增岐*，張淑霞，蕭颯。獸醫教學中的生物安全問題及對策建議。安徽農學通報，2015，21（2）:93-95.
