人物經歷
2013年本科畢業於清華大學
2018年獲瑞士洛桑聯邦理工(EPFL)優等博士學位(PhD with Distinction),並於蘇黎世聯邦理工(ETH)藥學系完成博士後研究。
2018 – 2021 蘇黎世聯邦理工 (ETHZ),藥學系 博士後
2021–至今南方科技大學生物醫學工程系 副教授
研究方向
研究思路為從複雜的醫學、生命現象出發,提煉出普遍的基礎科學問題;將先進的儀器表征、分析方法引入到新型醫藥材料的探索之中;最終利用這些理論技術開發創新藥物及其遞送方式。特別關注口服藥物遞送領域,將材料表界面,超分子化學,3D列印等概念和工具用於設計新的藥物分子及遞送體系,解決臨床上未被滿足的需求。
研究興趣
實驗室擁有多學科高度交叉的研究背景,包括材料物理化學,藥學,同步輻射及中子散射大型儀器表征等。研究思路為從複雜的醫學、生命現象出發,提煉出普遍的基礎科學問題;將先進的儀器表征、分析方法引入到新型醫藥材料的探索之中;最終利用這些理論技術開發創新藥物及其遞送方式。特別關注口服藥物遞送領域,將材料表界面,超分子化學,3D列印等概念和工具用於設計新的藥物分子及遞送體系,解決臨床上未被滿足的需求。
主要成就
曾獲瑞士聯邦理工學者人才計畫(ETH Fellow)、藥學青年科學家、國家優秀自費留學生獎學金、德國海因茨-邁爾-萊布尼茨研究所年度論文等多項榮譽;發表學術論文多篇,包括PNAS, Nat. Commun., Sci. Adv., Angew. Chem. Int. Ed., Acc. Chem. Res., Adv. Drug Deliv. Rev. 等國際知名期刊;在口服藥物遞送領域科研成果已進入人體實驗階段,與多個跨國藥企長期合作。
獲獎記錄
2012年 清華大學於曹簡禹獎學金
2016年 德國海因茨-邁爾-萊布尼茨研究所年度最佳論文
2018年 EPFL Distinction 榮譽博士學位
2018年 國家優秀自費留學獎學金
2019年 蘇黎世聯邦理工學者人才計畫 (ETH Fellow)
2020年 蘇黎世聯邦理工-藥學青年科學家獎
代表文章
[1] "Physical methods for enhancing drug absorption from the gastrointestinal tract." Z. Luo, N. Paunović, J-C Leroux. Adv. Drug Deliv. Rev., 175 (2021): 113914
[2] "Determination and evaluation of the nonadditivity in wetting of molecularly heterogeneous surfaces." Z. Luo, A. Murello, D. M. Wilkins, F. Kovacik, J. Kohlbrecher, A. Radulescu, H. I. Okur, Q. K. Ong, S. Roke, M. Ceriotti, F. Stellacci. PNAS, 116, no. 51 (2019): 25516-25523
[3] "Mass spectrometry and Monte Carlo method mapping of nanoparticle ligand shell morphology." Z. Luo, Y. Zhao, T. Darwish, Y. Wang, J. Hou, F. Stellacci. Nat. Comm., 9, no. 1 (2018): 4478.
[4] "Quantitative 3D determination of self-assembled structures on nanoparticles using small angle neutron scattering." Z. Luo, D. Marson, Q. K. Ong, A. Loiudice, J. Kohlbrecher, A. Radulescu, A. Krause-Heuer, T. Darwish, S. Balog, R. Buonsanti, D. I. Svergun, P. Posocco, F. Stellacci. Nat. Comm., 9, no. 1 (2018): 1343.
[5] "Evolution of the Ligand Shell Morphology during Ligand Exchange Reactions on Gold Nanoparticles." Z. Luo‡, J. Hou‡, L. Menin, Q. K. Ong, F. Stellacci. Angew. Chem., Int. Ed. 129, no. 43 (2017): 13706-13710.
[6] "Characterization of Ligand Shell for Mixed-Ligand Coated Gold Nanoparticles." Q. K. Ong‡, Z. Luo‡, F. Stellacci. Acc. Chem. Res., 50, no. 8 (2017): 1911-1919.
[7] "Multi-dimensional characterization of mixed ligand nanoparticles using small angle neutron scattering." Z. Luo*, Y. Yang, A. Radulescu, J. Kohlbrecher, T. Darwish, Q. K. Ong, S. Guldin, F. Stellacci*. Chem. Mater., 31, no. 17 (2019): 6750-6758
[8] "Digital light 3D printing of customized bioresorbable airway stents with silicone-like mechanical properties." N. Paunović, Y. Bao, F. Coulter, K. Masania, A. Geks, K. Klein, A. Rafsanjani, J. Cadalbert, P. W. Kronen, N. Kleger, A. Karol, Z. Luo, F. Rüber, D. Brambilla, B. von Rechenberg, D. Franzen, A. R. Studart, J-C Leroux. Sci. Adv., 7, (2021): eabe9499
[9] "Continuous color tuning of single-fluorophore emission via polymerization-mediated through-space charge transfer." S. Ye, T. Tian, A.J. Christofferson, S. Erikson S, J. Jagielski, Z. Luo, S. Kumar, C-J Shih, J-C Leroux, Bao Y. Sci. Adv., 7, (2021): eabd1794.
[10] "Solvent-Free Three-Dimensional Printing of Biodegradable Elastomers Using Liquid Macrophotoinitiators." M. Sandmeier, N. Paunović, R. Conti, L. Hofmann, J. Wang, Z. Luo, K. Masania, N. Wu, N. Kleger, F. B. Coulter, A. R. Studart, H. Grützmacher, J-C Leroux, Y. Bao, Macromolecules, 54, no. 17 (2021), 7830–7839
[11] "Quantification of surface composition and segregation on AuAg bimetallic nanoparticles by MALDI MS." S. Liao, Z. Luo, J. Metternich, R. Zenobi, F. Stellacci. Nanoscale, 12 (2020): 22639-22644
[12] "Comparative characterization of non-monodisperse gold nanoparticle populations by X-ray scattering and electron microscopy." Y. Yang, S. Liao, Z. Luo, R. Qi, NM Fhionnlaoich, F. Stellacci, S. Guldin. Nanoscale,12 (2020): 12007-12013
[13] "Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies." K. Anna, S. R. Mulay, M. Motrapu, Z. Luo, H-J Anders, M. E. Ivarsson, J-C Leroux. Adv. Sci (2020): 1903337
[14] "Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture." S. Simona, C. Martinelli, A. Palazzo, R. M. Iacobazzi, M. Perrone, Q. K. Ong, Z. Luo et al. PLoS One,15, no. 3 (2020): e0224002.
[15] "Synthesis and Characterization of Amphiphilic Gold Nanoparticles." P. Guven, P. Silva, Z. Luo, U. Cendrowska, M. Gasbarri, S. Jones, F. Stellacci. J. Vis. Exp., 149 (2019): e58872
[16] "On the van der Waals interactions of n-alkanethiol covered Surfaces: From planar to curved surfaces." F. Cometto, Z. Luo, S. Zhao, J. Olmos-Asar, M. Mariscal, Q. Ong, K. Kern, F. Stellacci, and M. Lingenfelder. Angew. Chem., Int. Ed. 129, no. 52 (2017): 16753-16757.
[17] "Freestanding Ultrathin Nanoparticle Membranes Assembled at Transient Liquid–Liquid Interfaces." B. Le Ouay, S. Guldin, Z. Luo, S. Allegri, and F. Stellacci. Adv. Mat. Interfaces, 3, no. 15 (2016): 1600191
[18] "Glutathione as the end capper for cyclodextrin/PEG polyrotaxanes." Q. Song, Z. Luo, X. Tong, Y. Du, and Y. Huang. Chinese J. Polym. Sci., 32, no. 8 (2014): 1003-1009.