石曉鐘，男，博士，華南理工大學生物科學與工程學院教授。
基本介紹
- 中文名：石曉鐘
- 國籍：中國
- 畢業院校：中國科學院上海生命科學研究院
- 學位/學歷：博士
- 職業：教師
- 專業方向：生物學，生理學
- 職務：博士生導師
- 任職院校：華南理工大學生物科學與工程學院
- 職稱：教授
- 性別：男
人物經歷,主講課程,科研方向,學術成果,
人物經歷
教育榆旋經歷
1997：廈門大學，理學學士；
2002：中國科學院上海生命科學研究院，理學博士；
工作經歷
2002年加入美國德州大學西南醫學中心，從事博士後研罪危晚究；
2007年加入明尼蘇達州立大學醫學院，任職籃歡符晚助理教授；
2016年加入華南理工大學生物科學與工程學院，任職教授。
主講課程
參與本科生教學，主講本科生理論課《幹細胞前沿技術》，《癌症生物學》，《幹細胞生物學》，以及本科生實驗課《細胞生跨烏炒物學實驗》，以及研究生課程《分子生物學實驗方法》；參與本科生導師制，指導大學一年級至大學四年級畢業生，定期召開本科生座談會；並為研究生講授分子生物學技術講座。
科研方向
長期從事基因表達的轉錄調控領域研究，主要研究方向為骨骼肌分化過程中的轉錄調控。研究過榜挨兵燥程中使用的技術包括：生物化學、分子生物學、細胞生物學、動物體內基因敲除和轉基因技術，及胚胎幹細胞體外培養等。主要發現了Myod-Kbtbd5-E2f1/DP1信號傳導殼漏洪途凶拒員徑在骨骼肌分化過程中的重要意義，闡明了CK2-Sds3/ Sin3-Foxk1-Foxo4/Mef2信號傳導途徑在骨骼肌幹細胞激活和分化中的調節功能，以及分析了Flk1-Etv2-Flt1調控網路中胚層發育分化中的調節功能。
學術成果
科研項目
在美國的學習工作期間，先後參與或承擔多項MDA, NIH項目課題或子課題研究；加入華南理工大學生物科學與工程學院後，主持國家自然科學基金面上項目。
代表性成果
1. Naoko Koyano-Nakagawa, Xiaozhong Shi, Tara L Rasmussen, Satyabrata Das, Camille A Walter, Daniel J Garry. Feedback Mechanisms Regulate Ets Variant 2 (Etv2) gene expression and hematoendothelial lineages. J Biol Chem. 2015, 290 (47): 28107-28119.
2. Wuming Gong, Rachel M Gohla, Kathy M Bowlin, Naoko Koyano-Nakagawa, Daniel J Garry, Xiaozhong Shi*. Kelch repeat and BTB domain-containing protein 5 (Kbtbd5) regulates skeletal muscle myogenesis through the E2F1-DP1 complex. J Biol Chem, 2015, 290(24):15350-61.
3. Xiaozhong Shi, Kathy M Zirbes, Tara L Rasmussen, Anwarul Ferdous, Mary G Garry, Naoko Koyano-Nakagawa, Daniel J Garry. The transcription factor, Mesp1, interacts with cAMP responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. J Biol Chem, 2015, 290(15): 9614-9625;
4. Xiaozhong Shi, Jai Richard, Katie M Zirbes, Wuming Gong, Gufa Lin, Michael Kyba, Jamie A Thomson, Naoko Koyano-Nakagawa, Daniel J Garry. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Dev Biol. 2014, 389(2):208-218;
5. Sunny S Chan, Xiaozhong Shi, Akira Toyama, Robert W Arpke, Abhijit Dandapat, Michelina Iacovino, Jin-Joo Kang, Gengyun Le, Hannah R Hagen, Daniel J Garry, Michael Kyba. Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner, Cell Stem Cell, 2013: 12, 587-601.
6. Kathy M Bowlin, Laurence J Embree, Mary G Garry, Daniel J Garry, Xiaozhong Shi*. Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage. Differentiation. 2013，86(4-5):184-91.
7. Xiaozhong Shi, Alicia M Wallis, Robert D Gerard, Kevin A Voelker, Robert W Grange, Ronald A Depinho, Mary G Garry, Daniel J Garry. Foxk1 promotes muscle stem cell proliferation by repressing Foxo4 and Mef2c factors. Journal of Cell Science, 2012, 125:5329-5337;
8. Xiaozhong Shi, David C Seldin, Daniel Garry. Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors. Biochemical Journal, 2012, 446, 349-357;
9. Xiaozhong Shi*, Daniel J Garry*. Myogenic regulatory factors transactivate the Tceal7 gene and modulate muscle differentiation. Biochem J. Jun 1 2010;428(2):213-221.
10. Xiaozhong Shi, Kathy M Bowlin, Daniel J Garry. Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors. Stem Cells. Mar 31 2010;28(3):462-469;
3. Xiaozhong Shi, Kathy M Zirbes, Tara L Rasmussen, Anwarul Ferdous, Mary G Garry, Naoko Koyano-Nakagawa, Daniel J Garry. The transcription factor, Mesp1, interacts with cAMP responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. J Biol Chem, 2015, 290(15): 9614-9625;
4. Xiaozhong Shi, Jai Richard, Katie M Zirbes, Wuming Gong, Gufa Lin, Michael Kyba, Jamie A Thomson, Naoko Koyano-Nakagawa, Daniel J Garry. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Dev Biol. 2014, 389(2):208-218;
5. Sunny S Chan, Xiaozhong Shi, Akira Toyama, Robert W Arpke, Abhijit Dandapat, Michelina Iacovino, Jin-Joo Kang, Gengyun Le, Hannah R Hagen, Daniel J Garry, Michael Kyba. Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner, Cell Stem Cell, 2013: 12, 587-601.
6. Kathy M Bowlin, Laurence J Embree, Mary G Garry, Daniel J Garry, Xiaozhong Shi*. Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage. Differentiation. 2013，86(4-5):184-91.
7. Xiaozhong Shi, Alicia M Wallis, Robert D Gerard, Kevin A Voelker, Robert W Grange, Ronald A Depinho, Mary G Garry, Daniel J Garry. Foxk1 promotes muscle stem cell proliferation by repressing Foxo4 and Mef2c factors. Journal of Cell Science, 2012, 125:5329-5337;
8. Xiaozhong Shi, David C Seldin, Daniel Garry. Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors. Biochemical Journal, 2012, 446, 349-357;
9. Xiaozhong Shi*, Daniel J Garry*. Myogenic regulatory factors transactivate the Tceal7 gene and modulate muscle differentiation. Biochem J. Jun 1 2010;428(2):213-221.
10. Xiaozhong Shi, Kathy M Bowlin, Daniel J Garry. Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors. Stem Cells. Mar 31 2010;28(3):462-469;
