田大成(南京大學生命科學學院教授)

田大成，南京大學生命科學學院教授。

基本介紹

• 中文名：田大成
• 專業方向：分子和基因組的進化、植物功能基因組和生物信息學
• 職稱：教授
• 任職院校：南京大學

研究方向

從事分子和基因組的進化、植物功能基因組和生物信息學的研究。主要研究方向：

（1）植物抗病基因的結構、功能、起源、變異及保存

（2）DNA insertion/deletion對遺傳變異的影響

（3）基因組的非對稱性及其非對稱DNA的遺傳效應

（4）腫瘤基因組體細胞突變的分子遺傳機制

科研成果

Selected publications:

Yang S, Wang L, Huang J, Zhang X, Yuan Y, Chen J-Q, Hurst LD*, Tian D* (2015). Parent-progeny sequencing indicates higher mutation rates in heterozygotes. Nature doi:10.1038/nature14649 (IF5y=41.5)

Tian D*, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J & Chen JQ. (2008) Single-nucleotide mutation rate increases close to indels in eukaryotes. Nature 455:105-108

Tian D, Shaw B, Chen J, Kreitman M, Bergelson J (2003) Fitness cost of R-gene mediated resistance in Arabidopsis thaliana. Nature 424:74-77

Bergelson J, Kreitman M, Stahl E, Tian D (2001) Evolutionary dynamics of plant R-genes. Science 292:2281-2285

Yang S, Li J, Zhang XH, Zhang QJ, Huang J, Chen JQ, Hartl DL, Tian D*. (2013) Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease. Proc Natl Acad Sci 110: 18572-18577

Yang S, Yuan Y, Wang L, Li J, Wang W, Liu H, Chen JQ, Hurst LD, Tian D*. (2012) Great majority of recombination events in Arabidopsis are gene conversion events. Proc Natl Acad Sci 109 :20992-20997

Araki H, Tian D, Goss EM, Jakob K, Halldorsdottir SS, Kreitman M and Bergelson J. (2006) Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis. Proc Natl Acad Sci 103:5587-5892

Tian D, Akashi H, Stahl E, Bergelson J, Kreitman M (2002) Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci 99:11525-1153

Yue J-X, Meyers BC, Chen J-Q, Tian D*, Yang S. (2012) Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes. New Phytologist 193: 1049–1063 (IF=6.736)

Zhu L, Wang Q, Tang P, Araki H, Tian D*. (2009) Genome-wide association between insertions/deletions and the nucleotide diversity in bacteria. Mol Biol Evol 26:2353-2361 (IF=10.353)

Chen JQ, Wu Y, Yang H, Bergelson J, Kreitman M, Tian D*. (2009) Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria. Mol Biol Evol 26:1523-31 (IF=10.353)

Sun X, Zhang Y, Yang S, Chen JQ, Hohn B, Tian D* (2008) Insertion DNA promotes ectopic recombination during meiosis in Arabidopsis. Mol Biol Evol 25:2079-2083 (IF=10.353)

Gu T, Tan S, Gou X, Araki H, Tian D*. (2010) Avoidance of long mononucleotide repeats in codon pair usage. Genetics 186:1077-1084

Shen J, Araki H, Chen L, Chen JQ, Tian D* (2006) Unique evolutionary mechanism in R-genes under the presence/absence polymorphism in Arabidopsis thaliana. Genetics 172 (2):1243-50

所獲榮譽

2022年6月28日，入選2022年度生命科學部國家傑出青年科學基金項目和國家自然科學基金創新研究群體項目專家評審組名單。